Welcome to the Eli and Edythe Broad-CIRM Center for Regenerative Medicine and Stem Cell Research. Our investigators are exploring the normal mechanisms that build, maintain and repair our body systems, to develop knowledge-based approaches for regenerative medicine. Investigators are exploring kidney, liver, neural, blood, cardiovascular, skeletal and skin disease models. The center serves as a hub for USC Stem Cell, connecting researchers, and enabling research, in stem cell biology and regenerative medicine across the University of Southern California.
Andy McMahon (Director)
5/22/2013
Interview with Sir John Gurdon
Nobel Laureate Sir John Gurdon visited the USC Health Sciences Campus on May 19. After presenting a public lecture, he was interviewed by Madeline Andrews, a Ph.D. student who conducts research in the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC. To read the transcript of the interview, please click here.
4/26/2013
Novel Role for An Ancient Pathway Discovered
Recent work from the McMahon group sheds new light on the molecular processes balancing the maintenance of embryo stem cells, and their loss of stem cell properties and commitment to more specialized cell types. To read more, please click here.
4/24/2013
CIRM STAR Students Won 1st and 3rd Place at High School Science Fair
Every year, the Eli and Edythe Broad CIRM Center hosts about 20 high school students in a Summer Program partially funded by CIRM STAR program. As part of the program, two students from Bravo Medical Magnet High School, Elton Zhou (Right) and Wisia Wong (left), conducted research at Dr. Toshio Miki’s lab in the summer of 2012. Mr. Zhou’s project, “Changes in the Number of Stem Cell Marker-Positive Cells within the Fetal Mouse Amnion” won 1st place and Ms. Wong’s project, “Xeno-free Cyropreservation of Human Amniotic Epithelial Cells” was placed 3rd at the Bravo Medical Magnet High School Science and Engineering Fair 2013. To read more about our high school summer program, please click here.
4/11/2013
Unraveling the Mystery of Pluripotency in ES Cells
Using advanced sequencing technology, Center faculty Wange Lu's group, in collaboration with Dr. Kai Wang of Zilkha Neurogenetics Institute explores the mystery of pluripotency by mapping out the interaction between DNA elements using genetic loci of two important pluripotency genes OCT4 and SOX2. Their finding shows that chromosome elements can interact transiently and dynamically with long-range target regions on the same chromosome or a different chromosome. The study is published in Scientific Report.
3/5/2013
An Important Factor Identified in Reprogramming
How is the stem cell state programmed? A new study in Dr. Qi-Long Ying’s group highlights the role of Gbx2, a DNA-binding regulatory factor, in switching fibroblasts to induced pluripotent stem cells. The study is published online in Journal of Cell Science.
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Using cutting-edge time-lapse photography, USC researchers have discovered clues to the development of the head at the cellular level, which could point scientists to a better understanding of how organs and birth defects form in humans.
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2012 Nobel Prize winner Sir John Gurdon talks about the advances that have been made since he was able to replace the immature nucleus in a frog egg cell with the nucleus from a mature intestinal cell. The modified egg developed into a normal frog with the DNA of the mature cells.
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Discovering that mouse hair has a circadian clock — a 24-hour cycle of growth followed by restorative repair — USC researchers and colleagues suspect that hair loss in humans from toxic cancer radiotherapy and chemotherapy might be minimized if these treatments are given late in the day.
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Alligators may help scientists learn how to stimulate tooth regeneration in people, according to new research led by the Keck School of Medicine of USC.
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With an initial commitment from the Keck School of Medicine of USC, a new USC initiative has been introduced to support collaborative research in regenerative medicine and stem cell biology across the university, facilitating the critical move from basic research into clinical applications.
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In his brief tenure as director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Andrew McMahon has published three articles, in two key areas of his research, that give insight to both the research that is being carried out at the center and the critical role basic science plays in developing 21st century medical breakthroughs.
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Andrew McMahon was officially welcomed into his role at USC and installed as the inaugural holder of the W. M. Keck Provost Professorship of Stem Cell Biology and Regenerative Medicine on Oct. 16 at a reception held on the Health Sciences campus in his honor and hosted by USC President C. L. Max Nikias.
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California Institute for Regenerative Medicine awards USC researcher $5.7 million
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