The Southern California Research Center for ALPD & Cirrhosis

ALPD Banner 2014

Hidekazu Tsukamoto, D.V.M., Ph.D.

Funded in 1999 by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the Southern California Research Center for ALPD and Cirrhosis unifies 58 investigators from major academic institutions in Southern California to pursue a common mission of being a leader in research, training, and outreach for the diseases. The center, since its inception in 1999, has devoted its efforts for development and use of clinically relevant animal models to gain novel insights into the molecular mechanisms underlying the predisposition to advanced ALPD. These efforts culminated to recent groundbreaking discoveries which have significantly advanced our understanding of synergistic ALPD caused by alcohol and a second hit. The center’s interactive environment and infrastructure have facilitated in the past 5 years, a 134% increase in research base to $7.6M/year; 2 new U01/P01 programs; 204 publications; generation of 14 NIH-funded early-stage investigators; transition of 6 postdocs to faculty positions; training 243 graduate and 20 undergraduate students (learn more in Education); and organizing 2 community seminars and 5 international symposia. As a unique national resource, the center has provided to scientific communities across the nation: 526 rodents as ALPD models and 234 model samples for 13 outside investigators; 305 liver cell isolation preparations for 11 investigators; and support for grant acquisition and application by 13 outside investigators since the last renewal.


The 8th International Symposium proceedings are now available through Hepatology International.

9th International Symposium on ALPD and Cirrhosis

Szeged, Hungary
November 21-23, 2014

The website for the 9th ISAPLD/C is now live. 

Congratulations to the US Travel Awardees!

The center will continue to strive as a unique scientific center of excellence in ALPD and cirrhosis by promoting: 1) environment conducive for leading-edge research on the center’s theme: elucidation of the priming and sensitizing mechanisms for ALPD; 2) provision of unique models, innovative genetic approaches and expertise to outside investigators including those at other NIAAA Alcohol Research Centers; 3) comprehensive education and training to foster future generations of scientists in ALPD and cirrhosis; and 4) outreach efforts to disseminate the center’s new findings to lay public, health care workers and scientists in our home and global communities.

Key Center researchers are academically affiliated with renowned institutions such as the University of Southern California (USC), University of California, Los Angeles (UCLA), University of California, San Diego (UCSD), Harbor-UCLA Medical Center, and the Department of Veterans Affairs.

The Research Center is supported by grants (P50 AA011999 and R24 AA012885) from the National Institute on Alcohol Abuse and Alcoholism(NIAAA) and by the Keck School of Medicine of the University of Southern California and provides Unique Scientific Services that Supports Scientists around the world

The Center provides unique expertise to the scientific community through its Core Services. The Animal Core provides the rodent models of intragastric ethanol infusion (iG) as well as animal models for cirrhosis. The Non-parenchymal Liver Cell Core provides freshly isolated or cultured Kupffer, hepatic and sinusoidal endothelial cells. Metabolomic Core supports metabolic analyses particularly tracer-based metabolic flux analysis. More Information and Fee Schedules

International Symposium on ALPD & Cirrhosis for future and past events.
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Major Scientific Breakthroughs by the Center Investigators.
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Support the Center: Learn how to support our research....
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