Molecular Analysis Cores

CHLA Vector Core
The CHLA Vector Core, re-established in January 2010, provides assistance in the design and construction viral vectors, as well as in the production of viral particles for gene-modified in vitro as well as in vivo animal studies. The Vector Core also provides consulting services to help researchers identify their gene transfer needs, determine the best way to produce gene-modified cells, and to assist in experimental troubleshooting. The CHLA Vector Core is located at the Children's Hospital Los Angeles campus at 4650 Sunset Blvd.

DNA Core Facility
This core provides DNA sequencing, oligonucleotide synthesis, protein sequencing and peptide synthesis services to researchers at USC and other institutions. The facility is housed within the Norris Comprehensive Cancer Center.

Genomics Core Facility
This core performs high throughput analyses of genetic (polymorphism/mutation) and epigenetic variations (DNA methylation) that underlie predisposition and progression to cancer. The facility is housed within the Norris Comprehensive Cancer Center.

Proteomics Core Facility
Established in 2008, this core facility provides services associated with the technologies of high-sensitivity and high-resolution mass spectrometry for protein and peptide analysis. The facility is housed in department of molecular microbiology & immunology space and is administered by the department of medicine.

Transgenic/Knockout Mouse Core Facility
This facility was established in 1993 to provide high-quality embryo and stem cell manipulation, microinjection and related services to the USC community, as well as outside researchers. The core handles the production of transgenics, gene targeting and the production of knockouts, construction of targeting vector design, preparation of DNA for injection and in vitro fertilization, re-derivation, as well as cryopreservation.

USC Epigenome Center
USC has established the first dedicated Epigenome Center in the nation, occupying an entire floor of the newly constructed Harlyne Norris Research Tower of the USC/Norris Comprehensive Cancer Center. This 8,500-square-foot facility encompasses a state-of-the-art laboratory (4,800 square feet) and expansive dedicated bioinformatics facilities, including office space for 30 staff programmers, computational biologists, statisticians, and bioinformatics faculty. The Epigenome Center currently has one operational Illumina Genome Analyzer, a second Genome Analyzer version 2 with paired-end read capability on order, and Univesity funds dedicated for the establishment of the Illumina BeadLab, which will be moved to the Center.

University of Southern California University of Southern California