Faculty

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Chaim O. Jacob, MD, PhD
Professor of Medicine
Medicine
HMR 705 Health Sciences Campus Los Angeles
+1 323 442 1822

Overview

Dr. Jacob's research interests include genetics and pathogenesis of systemic lupus erythematosus (SLE). He continues his groundbreaking work in discovering and characterizing new genes important to the development of SLE.

Dr. Jacob earned his medical degree from Tel Aviv University, Sackler School of Medicine. He then went on to complete graduate school at The Weizmann Institute of Science, followed by a Rheumatology Fellowship at Stanford University School of Medicine.

Awards

The Henry Kunkel Society: Elected Member, 2009

Southern California Chapter of Arthritis Foundation: Klinenberg Award, 2000

The Reticulo Endothelial Society: Presidential Award, 1987

National Arthritis Foundation: Klinenberg Award, 2001-2002

J.F. Kennedy Memorial Prize

Irvington House Institute for Medical Research: Fellow, 1988-1990

National Arthritis Foundation: Professor of Medicine, 2001-2002

Professor of Medicine

Southern California Chapter of Arthritis Foundation: Professor of Medicine, 2000

The Reticulo Endothelial Society: Professor of Medicine, 1987

Irvington House Institute for Medical Research: Professor of Medicine, 1988-1990

The Henry Kunkel Society: Professor of Medicine, 2009

The Henry Kunkel Society: award or honor for, 2009

Irvington House Institute for Medical Research: award or honor for, 1988-1990

Southern California Chapter of Arthritis Foundation: award or honor for, 2000

award or honor for

National Arthritis Foundation: award or honor for, 2001-2002

The Reticulo Endothelial Society: award or honor for, 1987

Irvington House Institute for Medical Research: start date, 1988-1990

start date

National Arthritis Foundation: start date, 2001-2002

Southern California Chapter of Arthritis Foundation: start date, 2000

The Reticulo Endothelial Society: full name, 1987

The Henry Kunkel Society: full name, 2009

National Arthritis Foundation: full name, 2001-2002

full name

Irvington House Institute for Medical Research: full name, 1988-1990

Southern California Chapter of Arthritis Foundation: full name, 2000

email address

The Henry Kunkel Society: email address, 2009

Irvington House Institute for Medical Research: email address, 1988-1990

Southern California Chapter of Arthritis Foundation: email address, 2000

The Reticulo Endothelial Society: email address, 1987

National Arthritis Foundation: email address, 2001-2002

Irvington House Institute for Medical Research: person in primary position, 1988-1990

Southern California Chapter of Arthritis Foundation: person in primary position, 2000

person in primary position

The Reticulo Endothelial Society: person in primary position, 1987

The Henry Kunkel Society: person in primary position, 2009

National Arthritis Foundation: person in primary position, 2001-2002

The Reticulo Endothelial Society: is primary position, 1987

National Arthritis Foundation: is primary position, 2001-2002

Irvington House Institute for Medical Research: is primary position, 1988-1990

is primary position

The Henry Kunkel Society: is primary position, 2009

Irvington House Institute for Medical Research: Jacob, Chaim, 1988-1990

The Reticulo Endothelial Society: Jacob, Chaim, 1987

The Henry Kunkel Society: Jacob, Chaim, 2009

Jacob, Chaim

National Arthritis Foundation: Jacob, Chaim, 2001-2002

National Arthritis Foundation: HR job title, 2001-2002

The Henry Kunkel Society: HR job title, 2009

Southern California Chapter of Arthritis Foundation: HR job title, 2000

The Reticulo Endothelial Society: HR job title, 1987

Irvington House Institute for Medical Research: HR job title, 1988-1990

Irvington House Institute for Medical Research: Department, 1988-1990

Department

The Henry Kunkel Society: Department, 2009

National Arthritis Foundation: Department, 2001-2002

Southern California Chapter of Arthritis Foundation: Department, 2000

The Reticulo Endothelial Society: Department, 1987

Irvington House Institute for Medical Research: Organization, 1988-1990

Organization

Southern California Chapter of Arthritis Foundation: Organization, 2000

The Henry Kunkel Society: Organization, 2009

National Arthritis Foundation: Organization, 2001-2002

The Reticulo Endothelial Society: Organization, 1987

position in department

Irvington House Institute for Medical Research: position in department, 1988-1990

Southern California Chapter of Arthritis Foundation: position in department, 2000

The Reticulo Endothelial Society: position in department, 1987

The Henry Kunkel Society: position in department, 2009

Southern California Chapter of Arthritis Foundation: last name, 2000

The Henry Kunkel Society: last name, 2009

Irvington House Institute for Medical Research: last name, 1988-1990

The Reticulo Endothelial Society: last name, 1987

last name

Southern California Chapter of Arthritis Foundation: Faculty Rank, 2000

Faculty Rank

The Henry Kunkel Society: Faculty Rank, 2009

Irvington House Institute for Medical Research: Faculty Rank, 1988-1990

National Arthritis Foundation: Faculty Rank, 2001-2002

National Arthritis Foundation: sort order, 2001-2002

The Reticulo Endothelial Society: sort order, 1987

Southern California Chapter of Arthritis Foundation: sort order, 2000

Irvington House Institute for Medical Research: sort order, 1988-1990

The Henry Kunkel Society: sort order, 2009

Person

The Reticulo Endothelial Society: Person, 1987

National Arthritis Foundation: Person, 2001-2002

Irvington House Institute for Medical Research: Person, 1988-1990

Southern California Chapter of Arthritis Foundation: Person, 2000

The Henry Kunkel Society: Person, 2009

Southern California Chapter of Arthritis Foundation: Jacob, Chaim, 2000

National Arthritis Foundation: last name, 2001-2002

The Henry Kunkel Society: start date, 2009

The Reticulo Endothelial Society: start date, 1987

Irvington House Institute for Medical Research: award conferred by, 1988-1990

Southern California Chapter of Arthritis Foundation: award conferred by, 2000

sort order

National Arthritis Foundation: award conferred by, 2001-2002

The Henry Kunkel Society: award conferred by, 2009

National Arthritis Foundation: type, 2001-2002

Irvington House Institute for Medical Research: type, 1988-1990

The Reticulo Endothelial Society: type, 1987

Southern California Chapter of Arthritis Foundation: type, 2000

type

The Reticulo Endothelial Society: Person ID, 1987

Irvington House Institute for Medical Research: Person ID, 1988-1990

Southern California Chapter of Arthritis Foundation: Person ID, 2000

National Arthritis Foundation: Person ID, 2001-2002

Person ID

Irvington House Institute for Medical Research: end date, 1988-1990

National Arthritis Foundation: end date, 2001-2002

The Reticulo Endothelial Society: Keck School of Medicine of USC, 1987

Irvington House Institute for Medical Research: Keck School of Medicine of USC, 1988-1990

Keck School of Medicine of USC

Southern California Chapter of Arthritis Foundation: Keck School of Medicine of USC, 2000

National Arthritis Foundation: Keck School of Medicine of USC, 2001-2002

The Henry Kunkel Society: Keck School of Medicine of USC, 2009

workplace homepage

The Henry Kunkel Society: workplace homepage, 2009

National Arthritis Foundation: workplace homepage, 2001-2002

Irvington House Institute for Medical Research: workplace homepage, 1988-1990

Southern California Chapter of Arthritis Foundation: workplace homepage, 2000

The Reticulo Endothelial Society: workplace homepage, 1987

position in organization

Irvington House Institute for Medical Research: position in organization, 1988-1990

Southern California Chapter of Arthritis Foundation: position in organization, 2000

The Reticulo Endothelial Society: position in organization, 1987

The Henry Kunkel Society: position in organization, 2009

National Arthritis Foundation: position in organization, 2001-2002

The Reticulo Endothelial Society: award conferred by, 1987

The Reticulo Endothelial Society: Faculty Rank, 1987

Southern California Chapter of Arthritis Foundation: is primary position, 2000

preferred title

Southern California Chapter of Arthritis Foundation: preferred title, 2000

The Reticulo Endothelial Society: preferred title, 1987

National Arthritis Foundation: preferred title, 2001-2002

The Henry Kunkel Society: preferred title, 2009

Southern California Chapter of Arthritis Foundation: first name, 2000

first name

National Arthritis Foundation: first name, 2001-2002

The Reticulo Endothelial Society: first name, 1987

Irvington House Institute for Medical Research: first name, 1988-1990

The Henry Kunkel Society: first name, 2009

The Henry Kunkel Society: Agent, 2009

Agent

National Arthritis Foundation: Agent, 2001-2002

Southern California Chapter of Arthritis Foundation: Agent, 2000

The Reticulo Endothelial Society: Agent, 1987

Irvington House Institute for Medical Research: Agent, 1988-1990

Medicine

The Reticulo Endothelial Society: Medicine, 1987

The Henry Kunkel Society: type, 2009

The Henry Kunkel Society: Person ID, 2009

The Henry Kunkel Society: Medicine, 2009

Irvington House Institute for Medical Research: Medicine, 1988-1990

Southern California Chapter of Arthritis Foundation: Medicine, 2000

National Arthritis Foundation: Medicine, 2001-2002

Irvington House Institute for Medical Research: Professor, 1988-1990

Professor

Southern California Chapter of Arthritis Foundation: Professor, 2000

The Henry Kunkel Society: Professor, 2009

The Reticulo Endothelial Society: Professor, 1987

National Arthritis Foundation: Professor, 2001-2002

National Arthritis Foundation: Award or Honor Receipt, 2001-2002

The Reticulo Endothelial Society: Award or Honor Receipt, 1987

Irvington House Institute for Medical Research: Award or Honor Receipt, 1988-1990

Southern California Chapter of Arthritis Foundation: Award or Honor Receipt, 2000

Award or Honor Receipt

The Henry Kunkel Society: Award or Honor Receipt, 2009

has faculty rank

National Arthritis Foundation: has faculty rank, 2001-2002

Irvington House Institute for Medical Research: has faculty rank, 1988-1990

Southern California Chapter of Arthritis Foundation: has faculty rank, 2000

The Reticulo Endothelial Society: has faculty rank, 1987

The Henry Kunkel Society: has faculty rank, 2009

National Arthritis Foundation: label, 2001-2002

The Henry Kunkel Society: label, 2009

Southern California Chapter of Arthritis Foundation: label, 2000

Irvington House Institute for Medical Research: label, 1988-1990

label

The Reticulo Endothelial Society: label, 1987

Irvington House Institute for Medical Research: preferred title, 1988-1990

Southern California Chapter of Arthritis Foundation: Position, 2000

Position

Irvington House Institute for Medical Research: Position, 1988-1990

The Henry Kunkel Society: Position, 2009

National Arthritis Foundation: Position, 2001-2002

The Reticulo Endothelial Society: Position, 1987

National Arthritis Foundation: position in department, 2001-2002

Southern California Chapter of Arthritis Foundation: photo, 2000

The Reticulo Endothelial Society: photo, 1987

The Henry Kunkel Society: photo, 2009

National Arthritis Foundation: photo, 2001-2002

photo

Irvington House Institute for Medical Research: photo, 1988-1990

HR job title

Publications

Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture. Arthritis Rheumatol. 2016 Apr; 68(4):932-43. View in: PubMed

Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA. Ann Rheum Dis. 2016 Jan; 75(1):242-52. View in: PubMed

Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus. Clin Immunol. 2015 Dec; 161(2):157-62. View in: PubMed

Erratum: IgG1 protects against renal disease in a mouse model of cryoglobulinaemia. Nature. 2015 Oct 29; 526(7575):728. View in: PubMed

Differential Development of Systemic Lupus Erythematosus in NZM 2328 Mice Deficient in Discrete Pairs of BAFF Receptors. Arthritis Rheumatol. 2015 Sep; 67(9):2523-35. View in: PubMed

Systemic Lupus Erythematosus-associated Neutrophil Cytosolic Factor 2 Mutation Affects the Structure of NADPH Oxidase Complex. J Biol Chem. 2015 May 15; 290(20):12595-602. View in: PubMed

Lupus Risk Variant Increases pSTAT1 Binding and Decreases ETS1 Expression. Am J Hum Genet. 2015 May 7; 96(5):731-9. View in: PubMed

Nomenclature of Toso, Fas Apoptosis Inhibitory Molecule 3, and IgM FcR. J Immunol. 2015 May 1; 194(9):4055-7. View in: PubMed

207 Structural basis of the effect of systemic lupus erythematosus (SLE)-associated mutations on the activity of NADPH oxidase. J Biomol Struct Dyn. 2015 May; 33 Suppl 1:139-40. View in: PubMed

IgG1 protects against renal disease in a mouse model of cryoglobulinaemia. Nature. 2015 Jan 22; 517(7535):501-4. View in: PubMed

The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share. Hum Mol Genet. 2015 Jan 15; 24(2):582-96. View in: PubMed

Two Functional Lupus-Associated BLK Promoter Variants Control Cell-Type- and Developmental-Stage-Specific Transcription. Am J Hum Genet. 2014 Apr 3; 94(4):586-98. View in: PubMed

Lupus risk variants in the PXK locus alter B-cell receptor internalization. Front Genet. 2014; 5:450. View in: PubMed

ABIN1 dysfunction as a genetic basis for lupus nephritis. J Am Soc Nephrol. 2013 Nov; 24(11):1743-54. View in: PubMed

Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry. J Rheumatol. 2013 Jun; 40(6):842-9. View in: PubMed

Development of systemic lupus erythematosus in NZM 2328 mice in the absence of any single BAFF receptor. Arthritis Rheum. 2013 Apr; 65(4):1043-54. View in: PubMed

Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. Ann Rheum Dis. 2013 Mar; 72(3):437-44. View in: PubMed

Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS Genet. 2013; 9(2):e1003222. View in: PubMed

Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4. PLoS Genet. 2013; 9(7):e1003554. View in: PubMed

PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes. PLoS One. 2013; 8(8):e69404. View in: PubMed

Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries. Ann Rheum Dis. 2012 Nov; 71(11):1809-14. View in: PubMed

Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus. Arthritis Rheum. 2012 Nov; 64(11):3695-705. View in: PubMed

Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations. Arthritis Rheum. 2012 Nov; 64(11):3687-94. View in: PubMed

Evaluation of TRAF6 in a large multiancestral lupus cohort. Arthritis Rheum. 2012 Jun; 64(6):1960-9. View in: PubMed

Genetics of rheumatoid arthritis: an impressionist perspective. Rheum Dis Clin North Am. 2012 May; 38(2):243-57. View in: PubMed

Dispensability of APRIL to the development of systemic lupus erythematosus in NZM 2328 mice. Arthritis Rheum. 2012 May; 64(5):1610-9. View in: PubMed

Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus. Ann Rheum Dis. 2012 May; 71(5):694-9. View in: PubMed

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as Susceptibility Loci for Systemic Lupus Erythematosus in a Large-Scale Multiracial Replication Study. Am J Hum Genet. 2012 Apr 6; 90(4):648-60. View in: PubMed

Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus. Arthritis Rheum. 2012 Feb; 64(2):485-92. View in: PubMed

Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):E59-67. View in: PubMed

A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap. PLoS Genet. 2011 Dec; 7(12):e1002406. View in: PubMed

Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study. Arthritis Rheum. 2011 Nov; 63(11):3493-501. View in: PubMed

Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Ann Rheum Dis. 2011 Oct; 70(10):1752-7. View in: PubMed

Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups. Arthritis Rheum. 2011 Sep; 63(9):2755-63. View in: PubMed

Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus. Arthritis Rheum. 2011 Jul; 63(7):2049-57. View in: PubMed

Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. PLoS Genet. 2011 May; 7(5):e1002079. View in: PubMed

B Cell and BAFF dependence of IFN-a-exaggerated disease in systemic lupus erythematosus-prone NZM 2328 mice. J Immunol. 2011 Apr 15; 186(8):4984-93. View in: PubMed

Reflections on Darwinian Evolution - Is there a Jewish Perspective? Rambam Maimonides Med J. Reflections on Darwinian Evolution - Is there a Jewish Perspective? Rambam Maimonides Med J. 2011 Apr; 2(2):e0044. View in: PubMed

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet. 2011 Mar; 43(3):253-8. View in: PubMed

Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. PLoS Genet. 2011 Mar; 7(3):e1001323. View in: PubMed

Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes. PLoS Genet. 2011 Feb; 7(2):e1001311. View in: PubMed

Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study. Am J Hum Genet. 2011 Jan 7; 88(1):83-91. View in: PubMed

The role of genetic variation near interferon-kappa in systemic lupus erythematosus. J Biomed Biotechnol. 2010; 2010. View in: PubMed

On anti-tumor necrosis factor-induced systemic lupus erythematosus. J Rheumatol. 2010 Jan; 37(1):3-5. View in: PubMed

Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease. J Immunol. 2009 Nov 1; 183(9):6021-9. View in: PubMed

A polymorphism within IL21R confers risk for systemic lupus erythematosus. Arthritis Rheum. 2009 Aug; 60(8):2402-7. View in: PubMed

Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6256-61. View in: PubMed

High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups. Arthritis Rheum. 2009 Apr; 60(4):1085-95. View in: PubMed

Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE). Hum Mol Genet. 2009 Mar 15; 18(6):1171-80. View in: PubMed

Accelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand Mixed 2328 mice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathway. J Immunol. 2009 Feb 15; 182(4):2532-41. View in: PubMed

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet. 2008 Feb; 40(2):204-10. View in: PubMed

Function2Gene: a gene selection tool to increase the power of genetic association studies by utilizing public databases and expert knowledge. BMC Bioinformatics. 2008; 9:311. View in: PubMed

Identification of novel susceptibility genes in childhood-onset systemic lupus erythematosus using a uniquely designed candidate gene pathway platform. Arthritis Rheum. 2007 Dec; 56(12):4164-73. View in: PubMed

Paucity of clinical disease despite serological autoimmunity and kidney pathology in lupus-prone New Zealand mixed 2328 mice deficient in BAFF. J Immunol. 2006 Aug 15; 177(4):2671-80. View in: PubMed

The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain. J Biol Chem. 2005 Mar 11; 280(10):9618-26. View in: PubMed

A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. Nat Genet. 2004 Aug; 36(8):837-41. View in: PubMed

Pivotal role of Stat4 and Stat6 in the pathogenesis of the lupus-like disease in the New Zealand mixed 2328 mice. J Immunol. 2003 Aug 1; 171(3):1564-71. View in: PubMed

Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis. J Immunol. 2003 May 1; 170(9):4818-25. View in: PubMed

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