Amir H. Kashani, MD, PhD 2017-04-19T14:10:00+00:00
 

Faculty

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Amir H. Kashani, MD, PhD
Assistant Professor of Clinical Ophthalmology
Ophthalmology
HC4 4900 1450 San Pablo Street Off Campus Los Angeles
+1 323 442 6578

Overview

Amir H. Kashani, MD, PhD, attended Johns Hopkins School of Medicine where he obtained both his MD and PhD in Neuroscience in 2006. He completed his ophthalmology residency at the USC Roski Eye Institute and fellowship in vitreoretinal surgery at the top-rated Associated Retinal Consultants in Royal Oak, Michigan. He was awarded both the Heed and Michel’s Fellowships (National Honors) during his training. Dr. Kashani is an NIH funded clinician-scientist who is studying the role of ischemia and hypoxia in the pathophysiology of retinal vascular diseases like diabetic retinopathy. Dr. Kashani also treats patients with medical and surgical retinal diseases including diabetic retinopathy, retinal vein occlusions, age-related macular degeneration and retinal detachments among other common retinal diseases. He also specializes in complex retinal detachment surgeries.

In the laboratory, Dr. Kashani is developing novel diagnostic and therapeutic methods to diagnose and treat retinal diseases. His investigates the use of advanced imaging spectroscopy and optical coherence tomography methods to improve the early detection of chronic diseases like diabetic retinopathy and retinal venous occlusion. Dr. Kashani is the principal investigator for a clinical trial to test a novel stem cell therapy for severe vision loss from advanced dry age-related macular degeneration. In recognition of his cutting edge research Dr. Kashani has been recognized internatioinally by his peers. In 2016 he was named as one of the top 150 innovators in the field of medical and surgical retina by Ocular Surgery News. In 2017 he was named as one of the top 50 "rising stars" world-wide in the field of ophthalmology by The Ophthalmologist.

Dr. Kashani has co-authored more than 40 peer reviewed articles in the scientific literature, several subject reviews, and recently co-authored an ophthalmology book entitled "Optical Coherence Tomography and OCT Angiography: Clinical Reference and Case Studies."

Awards

USC Department of Ophthalmology: Resident Research Award, 2008

Ron G. Michel's Fellowhship

Henry and Lilian Nesburn Award

Heed Resident Research Symposium (Rank #4)

ARVO: Retinal Research Foundation Grant, 2006

Johns Hopkins School of Medicine: Medical Student Research Fellowship, 2000

Association for Research in Vision and Ophthalmology: Member, 2009

Medical Scientist Training Program Fellowship (MSTP)

ARVO Research Travel Grant

Society of Heed Scholars: Heed Ophthalmic Foundation Fellow, 2012

Ocular Surgery News: Nominated to 150 leading innovators in medical and surgical retina, 2016

The Ophthalmologist: Rising Stars Power List, 2017

Publications

Moysidis SN, Koulisis N, Patel VR, Kashani AH, Rao NA, Humayun MS, Rodger DC. THE SECOND BLIND SPOT: SMALL RETINAL VESSEL VASCULOPATHY AFTER VACCINATION AGAINST NEISSERIA MENINGITIDIS AND YELLOW FEVER. Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S18-S23. View in: PubMed

Kim AY, Rodger DC, Shahidzadeh A, Chu Z, Koulisis N, Burkemper B, Jiang X, Pepple KL, Wang RK, Puliafito CA, Rao NA, Kashani AH. Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography. Am J Ophthalmol. 2016 Nov; 171:101-112. View in: PubMed

Zhang Y, Kashani AH, Hubbard GB. Diagnostic and Therapeutic Challenges. Retina. 2016 Sep 27. View in: PubMed

Koss MJ, Falabella P, Stefanini FR, Pfister M, Thomas BB, Kashani AH, Brant R, Zhu D, Clegg DO, Hinton DR, Humayun MS. Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs. Graefes Arch Clin Exp Ophthalmol. 2016 Aug; 254(8):1553-65. View in: PubMed

Kim AY, Chu Z, Shahidzadeh A, Wang RK, Puliafito CA, Kashani AH. Quantifying Microvascular Density and Morphology in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2016 Jul 1; 57(9):OCT362-70. View in: PubMed

Kashani AH. Stem Cell Therapy in Nonneovascular Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2016 Apr 1; 57(5):ORSFm1-9. View in: PubMed

Kashani AH, Zhang Y, Capone A, Drenser KA, Puliafito C, Moshfeghi AA, Williams GA, Trese MT. Impaired Retinal Perfusion Resulting From Vitreoretinal Traction: A Mechanism of Retinal Vascular Insufficiency. Ophthalmic Surg Lasers Imaging Retina. 2016 Mar 1; 47(3):1-11. View in: PubMed

Murali K, Kang D, Nazari H, Scianmarello N, Cadenas E, Tai YC, Kashani A, Humayun M. Spatial Variations in Vitreous Oxygen Consumption. PLoS One. 2016; 11(3):e0149961. View in: PubMed

Kashani AH, Lee SY, Moshfeghi A, Durbin MK, Puliafito CA. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF RETINAL VENOUS OCCLUSION. Retina. 2015 Nov; 35(11):2323-31. View in: PubMed

Nazari H, Zhang L, Zhu D, Chader GJ, Falabella P, Stefanini F, Rowland T, Clegg DO, Kashani AH, Hinton DR, Humayun MS. Stem cell based therapies for age-related macular degeneration: The promises and the challenges. Prog Retin Eye Res. 2015 Sep; 48:1-39. View in: PubMed

Matsunaga DR, Yi JJ, De Koo LO, Ameri H, Puliafito CA, Kashani AH. Optical Coherence Tomography Angiography of Diabetic Retinopathy in Human Subjects. Ophthalmic Surg Lasers Imaging Retina. 2015 Sep 1; 46(8):796-805. View in: PubMed

Kashani AH, Cheung AY, Robinson J, Williams GA. Longitudinal optical density analysis of subretinal fluid after surgical repair of rhegmatogenous retinal detachment. Retina. 2015 Jan; 35(1):149-56. View in: PubMed

Murali K, Kashani AH, Humayun MS. Whole Vitreous Humor Dissection for Vitreodynamic Analysis. J Vis Exp. 2015; (99). View in: PubMed

Moysidis SN, Koulisis N, Ameri H, Matsunaga D, Yi J, Isozaki VL, Kashani AH, Olmos de Koo LC. MULTIMODAL IMAGING OF GEOGRAPHIC AREAS OF RETINAL DARKENING. Retin Cases Brief Rep. 2015; 9(4):347-51. View in: PubMed

Kashani AH, Brown KT, Chang E, Drenser KA, Capone A, Trese MT. Diversity of retinal vascular anomalies in patients with familial exudative vitreoretinopathy. Ophthalmology. 2014 Nov; 121(11):2220-7. View in: PubMed

Matsunaga D, Yi J, Puliafito CA, Kashani AH. OCT Angiography in Healthy Human Subjects. Ophthalmic Surg Lasers Imaging Retina. 2014 Nov 1; 45(6):510-5. View in: PubMed

Kashani AH, Lopez Jaime GR, Saati S, Martin G, Varma R, Humayun MS. NONINVASIVE ASSESSMENT OF RETINAL VASCULAR OXYGEN CONTENT AMONG NORMAL AND DIABETIC HUMAN SUBJECTS: A Study Using Hyperspectral Computed Tomographic Imaging Spectroscopy. Retina. 2014 Sep; 34(9):1854-60. View in: PubMed

Cheung AY, Kashani AH, Drenser KA. Subretinal peripapillary neovascularization associated with persistent fetal vasculature. Retin Cases Brief Rep. 2014; 8(1):83-6. View in: PubMed

Kashani AH, Learned D, Nudleman E, Drenser KA, Capone A, Trese MT. High Prevalence of Peripheral Retinal Vascular Anomalies in Family Members of Patients with Familial Exudative Vitreoretinopathy. Ophthalmology. 2014 Jan; 121(1):262-8. View in: PubMed

Stefanini FR, Maia M, Falabella P, Pfister M, Niemeyer M, Kashani AH, Humayun MS, Koss MJ. Profile of ocriplasmin and its potential in the treatment of vitreomacular adhesion. Clin Ophthalmol. 2014; 8:847-56. View in: PubMed

Murad-Kejbou S, Kashani AH, Capone A, Ruby A. Staphylococcus lugdunensis endophthalmitis after intravitreal injection: a case series. Retin Cases Brief Rep. 2014; 8(1):41-4. View in: PubMed

Kashani AH, Aaberg TM, Capone A. Vitreomacular traction as a consequence of posterior hyaloidal contraction after transpupillary thermotherapy. Am J Ophthalmol. 2013 May; 155(5):937-45. View in: PubMed

Alkin Z, Kashani AH, López-Jaime GR, Ruiz García H, Humayun MS, Sadda SR. Quantitative analysis of retinal structures using spectral domain optical coherence tomography in normal rabbits. Curr Eye Res. 2013 Feb; 38(2):299-304. View in: PubMed

Kashani AH, Eliott D. The emergence of Klebsiella pneumoniae endogenous endophthalmitis in the USA: basic and clinical advances. J Ophthalmic Inflamm Infect. 2013; 3(1):28. View in: PubMed

Jaime GR, Kashani AH, Saati S, Martin G, Chader G, Humayun MS. Acute variations in retinal vascular oxygen content in a rabbit model of retinal venous occlusion. PLoS One. 2012; 7(11):e50179. View in: PubMed

Kashani AH, Kirkman E, Martin G, Humayun MS. Hyperspectral computed tomographic imaging spectroscopy of vascular oxygen gradients in the rabbit retina in vivo. PLoS One. 2011; 6(9):e24482. View in: PubMed

Kashani AH, Eliott D. Bilateral Klebsiella pneumoniae (K1 serotype) endogenous endophthalmitis as the presenting sign of disseminated infection. Ophthalmic Surg Lasers Imaging. 2011; 42 Online:e12-4. View in: PubMed

Kashani AH, Zimmer-Galler IE, Shah SM, Dustin L, Do DV, Eliott D, Haller JA, Nguyen QD. Retinal thickness analysis by race, gender, and age using Stratus OCT. Am J Ophthalmol. 2010 Mar; 149(3):496-502. e1. View in: PubMed

Kashani AH, Keane PA, Dustin L, Walsh AC, Sadda SR. Quantitative subanalysis of cystoid spaces and outer nuclear layer using optical coherence tomography in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3366-73. View in: PubMed

Kabir A, Keshvari M, Kashani AH, Alavian SM. Predicting response to HBV vaccination in people with positive anti-HBc but negative HBsAg and anti-HBs. Hum Vaccin. 2008 Sep-Oct; 4(5):379-83. View in: PubMed

Kashani AH, Qiu Z, Jurata L, Lee SK, Pfaff S, Goebbels S, Nave KA, Ghosh A. Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections. J Neurosci. 2006 Aug 9; 26(32):8398-408. View in: PubMed

Kim PM, Aizawa H, Kim PS, Huang AS, Wickramasinghe SR, Kashani AH, Barrow RK, Huganir RL, Ghosh A, Snyder SH. Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration. Proc Natl Acad Sci U S A. 2005 Feb 8; 102(6):2105-10. View in: PubMed

Grinnell AD, Chen BM, Kashani A, Lin J, Suzuki K, Kidokoro Y. The role of integrins in the modulation of neurotransmitter release from motor nerve terminals by stretch and hypertonicity. J Neurocytol. 2003 Jun-Sep; 32(5-8):489-503. View in: PubMed

Redmond L, Kashani AH, Ghosh A. Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription. Neuron. 2002 Jun 13; 34(6):999-1010. View in: PubMed

Yaghmai R, Kashani AH, Geraghty MT, Okoh J, Pomper M, Tangerman A, Wagner C, Stabler SP, Allen RH, Mudd SH, Braverman N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient with cystathionine beta-synthase (CBS) deficiency. Am J Med Genet. 2002 Feb 15; 108(1):57-63. View in: PubMed

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