Faculty

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David R. Hinton, MD
Professor of Pathology
Gavin S. Herbert Professorship in Vision Research
Associate Dean For Vision Science
Vice Chair of Pathology
Director, Dean's Research Scholars Program
Exam Committee Facilitator
Pathology
NRT 7503 Off Campus Los Angeles
+1 323 442 6617

Overview

Dr Hinton investigates the pathogenesis of blinding retinal diseases including age related macular degeneration (AMD) and proliferative vitreoretinopathy(PVR). In particular, he is interested in how alterations in the retinal microenvironment can promote the development of intraocular fibrosis, proliferative membranes and neovascular choroidal responses. His work has established the central role of the retinal pigment epithelial (RPE) cell in these disorders, and has demonstrated novel mechanisms for growth factor activation of the RPE with resulting alterations in migration, proliferation and gene expression. He has developed and validated several in vitro and in vivo models of PVR and choroidal neovascularization and has used these models to elucidate basic mechanisms of disease and to evaluate novel therapeutic approaches to the disorders. He is especially interested in therapeutic approaches involving manipulation of growth factor receptors and their intracellular signaling pathways. He has now extended this work into investigating genetic polymorphisms that result in susceptibility to these disorders in human populations. Most recently, Dr Hinton’s lab has been evaluating endogenous neuroprotectants (eg pigment epithelial derived factor) and chaperones (alpha B crystallin) for their therapeutic potential. He has also developed methods for differentiating RPE cells from human embryonic stem cells and is evaluating these cells for their potential for cellular therapy for patients with AMD. In a collaborative Program Project with investigators at the Cleveland Clinic, Dr Hinton investigates the immunopathogenesis of demyelinating diseases of the brain and spinal cord in animal models.

Publications

Endoplasmic reticulum-mitochondrial crosstalk: a novel role for the mitochondrial peptide humanin. Neural Regen Res. 2017 Jan; 12(1):35-38. View in: PubMed

Aqueous Angiography with Fluorescein and Indocyanine Green in Bovine Eyes. Transl Vis Sci Technol. 2016 Nov; 5(6):5. View in: PubMed

Aqueous Angiography-Mediated Guidance of Trabecular Bypass Improves Angiographic Outflow in Human Enucleated Eyes. Invest Ophthalmol Vis Sci. 2016 Sep 1; 57(11):4558-65. View in: PubMed

Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs. Graefes Arch Clin Exp Ophthalmol. 2016 Aug; 254(8):1553-65. View in: PubMed

Survival and Functionality of hESC-Derived Retinal Pigment Epithelium Cells Cultured as a Monolayer on Polymer Substrates Transplanted in RCS Rats. Invest Ophthalmol Vis Sci. 2016 May 1; 57(6):2877-87. View in: PubMed

aB-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition. Am J Pathol. 2016 Apr; 186(4):859-73. View in: PubMed

An Innovative Surgical Technique for Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigmented Epithelium in Yucatan Mini Pigs: Preliminary Results. Ophthalmic Surg Lasers Imaging Retina. 2016 Apr 1; 47(4):342-51. View in: PubMed

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. Invest Ophthalmol Vis Sci. 2016 Mar 1; 57(3):1238-53. View in: PubMed

Molecular mechanisms of subretinal fibrosis in age-related macular degeneration. Exp Eye Res. 2016 Jan; 142:19-25. View in: PubMed

Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione. PLoS One. 2016; 11(10):e0165150. View in: PubMed

Targeting of exon VI-skipping human RGR-opsin to the plasma membrane of pigment epithelium and co-localization with terminal complement complex C5b-9. Mol Vis. 2016; 22:213-23. View in: PubMed

Aqueous Angiography: Real-Time and Physiologic Aqueous Humor Outflow Imaging. PLoS One. 2016; 11(1):e0147176. View in: PubMed

Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration. Biochim Biophys Acta. 2016 Jan; 1860(1 Pt B):258-68. View in: PubMed

Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis. J Neuroinflammation. 2016; 13(1):46. View in: PubMed

SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization. Cytokine. 2015 Dec; 76(2):549-52. View in: PubMed

Myd88 Initiates Early Innate Immune Responses and Promotes CD4 T Cells during Coronavirus Encephalomyelitis. J Virol. 2015 Sep 15; 89(18):9299-312. View in: PubMed

Stem cell based therapies for age-related macular degeneration: The promises and the challenges. Prog Retin Eye Res. 2015 Sep; 48:1-39. View in: PubMed

Inhibition of DNA Methylation and Methyl-CpG-Binding Protein 2 Suppresses RPE Transdifferentiation: Relevance to Proliferative Vitreoretinopathy. Invest Ophthalmol Vis Sci. 2015 Aug 1; 56(9):5579-89. View in: PubMed

Interleukin-10 is a critical regulator of white matter lesion containment following viral induced demyelination. Glia. 2015 Jun 30. View in: PubMed

TGF-ß2 secretion from RPE decreases with polarization and becomes apically oriented. Cytokine. 2015 Feb; 71(2):394-6. View in: PubMed

Polarized human embryonic stem cell-derived retinal pigment epithelial cell monolayers have higher resistance to oxidative stress-induced cell death than nonpolarized cultures. Stem Cells Transl Med. 2015 Jan; 4(1):10-20. View in: PubMed

Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy. Sci Rep. 2015; 5:16386. View in: PubMed

Astrocyte response to IFN-? limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis. J Neuroinflammation. 2015; 12(1):79. View in: PubMed

Attenuation of choroidal neovascularization by histone deacetylase inhibitor. PLoS One. 2015; 10(3):e0120587. View in: PubMed

IL-18 is not therapeutic for neovascular age-related macular degeneration. Nat Med. 2014 Dec 4; 20(12):1372-5. View in: PubMed

Sodium iodate induced retinal degeneration: new insights from an old model. Neural Regen Res. 2014 Dec 1; 9(23):2044-5. View in: PubMed

Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-a. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16754-9. View in: PubMed

Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. Science. 2014 Nov 21; 346(6212):1000-3. View in: PubMed

DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):16082-7. View in: PubMed

Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells. J Control Release. 2014 Oct 10; 191:4-14. View in: PubMed

Distinct CD4 T cell effects on primary versus recall CD8 T cell responses during viral encephalomyelitis. Immunology. 2014 Sep 4. View in: PubMed

Ceramide inhibits connective tissue growth factor expression by human retinal pigment epithelial cells. Cytokine. 2014 Aug; 68(2):137-40. View in: PubMed

IL-27 Limits Central Nervous System Viral Clearance by Promoting IL-10 and Enhances Demyelination. J Immunol. 2014 Jul 1; 193(1):285-94. View in: PubMed

PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis. J Neuroimmunol. 2014 May 15; 270(1-2):1-12. View in: PubMed

Protection of Retina by aB Crystallin in Sodium Iodate Induced Retinal Degeneration. PLoS One. 2014; 9(5):e98275. View in: PubMed

Ifit2 Deficiency Results in Uncontrolled Neurotropic Coronavirus Replication and Enhanced Encephalitis via Impaired Alpha/Beta Interferon Induction in Macrophages. J Virol. 2014 Jan; 88(2):1051-64. View in: PubMed

Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system. Virology. 2013 Dec; 447(1-2):112-20. View in: PubMed

IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis. J Neuroimmunol. 2013 Oct 15; 263(1-2):43-54. View in: PubMed

Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer. Invest Ophthalmol Vis Sci. 2013 Jul; 54(7):5087-96. View in: PubMed

In vivo detection of hESC-RPE cells via confocal near-infrared fundus reflectance. Ophthalmic Surg Lasers Imaging Retina. 2013 Jul-Aug; 44(4):380-4. View in: PubMed

Antiapoptotic properties of a-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells. Invest Ophthalmol Vis Sci. 2013 Apr; 54(4):2787-98. View in: PubMed

Astrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis. J Virol. 2013 Mar; 87(6):3382-92. View in: PubMed

GRP78 plays an essential role in adipogenesis and postnatal growth in mice. FASEB J. 2013 Mar; 27(3):955-64. View in: PubMed

Review: Epigenetic mechanisms in ocular disease. Mol Vis. 2013; 19:665-74. View in: PubMed

MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitis. ASN Neuro. 2013; 5(5). View in: PubMed

TLR-Independent and P2X7-Dependent Signaling Mediate Alu RNA-Induced NLRP3 Inflammasome Activation in Geographic Atrophy. Invest Ophthalmol Vis Sci. 2013; 54(12):7395-401. View in: PubMed

Novel roles for a-crystallins in retinal function and disease. Prog Retin Eye Res. 2012 Nov; 31(6):576-604. View in: PubMed

Green Tea Polyphenols Precondition against Cell Death Induced by Oxygen-Glucose Deprivation via Stimulation of Laminin Receptor, Generation of Reactive Oxygen Species, and Activation of Protein Kinase C{epsilon}. J Biol Chem. 2012 Oct 5; 287(41):34694-708. View in: PubMed

Angiofibrotic response to vascular endothelial growth factor inhibition in diabetic retinal detachment: report no. 1. Arch Ophthalmol. 2012 Sep 1; 130(9):1127-34. View in: PubMed

Deficiency of aB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction. Free Radic Biol Med. 2012 Sep 1; 53(5):1111-22. View in: PubMed

ERK1/2 activation is a therapeutic target in age-related macular degeneration. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13781-6. View in: PubMed

Mesh-supported submicron parylene-C membranes for culturing retinal pigment epithelial cells. Biomed Microdevices. 2012 Aug; 14(4):659-67. View in: PubMed

Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9. Angiogenesis. 2012 Jun; 15(2):213-27. View in: PubMed

DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88. Cell. 2012 May 11; 149(4):847-59. View in: PubMed

CD4 T Cells Promote CD8 T Cell Immunity at the Priming and Effector Site during Viral Encephalitis. J Virol. 2012 Mar; 86(5):2416-27. View in: PubMed

Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis. J Neuroinflammation. 2012; 9:269. View in: PubMed

A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer. Ophthalmic Res. 2012; 48(4):186-91. View in: PubMed

Mechanism of RPE Cell Death in a-Crystallin Deficient Mice: A Novel and Critical Role for MRP1-Mediated GSH Efflux. PLoS One. 2012; 7(3):e33420. View in: PubMed

IFN-? protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils. J Neuroinflammation. 2012; 9:104. View in: PubMed

IFN-? Signaling to Astrocytes Protects from Autoimmune Mediated Neurological Disability. PLoS One. 2012; 7(7):e42088. View in: PubMed

A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas. Cancer. 2011 Nov 1; 117(21):4905-15. View in: PubMed

Methionine sulfoxide reductase A: Structure, function and role in ocular pathology. World J Biol Chem. 2011 Aug 26; 2(8):184-92. View in: PubMed

Regulation of fibronectin-EDA through CTGF domain-specific interactions with TGFß2 and its receptor TGFßRII. Invest Ophthalmol Vis Sci. 2011 Jul; 52(8):5068-78. View in: PubMed

Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis. J Virol. 2011 Jul; 85(13):6702-13. View in: PubMed

CXCR3-dependent plasma blast migration to the central nervous system during viral encephalomyelitis. J Virol. 2011 Jul; 85(13):6136-47. View in: PubMed

Transcriptional regulation of bone morphogenetic protein 4 by tumor necrosis factor and its relationship with age-related macular degeneration. FASEB J. 2011 Jul; 25(7):2221-33. View in: PubMed

Sonoporation enhances chemotherapeutic efficacy in retinoblastoma cells in vitro. Invest Ophthalmol Vis Sci. 2011 May; 52(6):3868-73. View in: PubMed

Antenatal maternal stress alters functional brain responses in adult offspring during conditioned fear. Brain Res. 2011 Apr 18; 1385:163-74. View in: PubMed

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature. 2011 Mar 17; 471(7338):325-30. View in: PubMed

Polarized secretion of PEDF from human embryonic stem cell-derived RPE promotes retinal progenitor cell survival. Invest Ophthalmol Vis Sci. 2011 Mar; 52(3):1573-85. View in: PubMed

Factors supporting intrathecal humoral responses following viral encephalomyelitis. J Virol. 2011 Mar; 85(6):2589-98. View in: PubMed

Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis. Biochem Biophys Res Commun. 2011 Feb 11; 405(2):244-9. View in: PubMed

Vitreal oxygenation in retinal ischemia reperfusion. Invest Ophthalmol Vis Sci. 2011 Feb; 52(2):1035-42. View in: PubMed

VEGF and PEDF Secretion in ARPE-19 and fhRPE Cells. Invest Ophthalmol Vis Sci. 2011; 52(12):9047. View in: PubMed

Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis. Am J Pathol. 2010 Dec; 177(6):2827-36. View in: PubMed

Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species. J Neurosci Res. 2010 Dec; 88(16):3644-55. View in: PubMed

Enhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis. J Immunol. 2010 Nov 1; 185(9):5607-18. View in: PubMed

A comparison of hypoxia-inducible factor-a in surgically excised neovascular membranes of patients with diabetes compared with idiopathic epiretinal membranes in nondiabetic patients. Retina. 2010 Oct; 30(9):1472-8. View in: PubMed

Recombinant human VEGF165b inhibits experimental choroidal neovascularization. Invest Ophthalmol Vis Sci. 2010 Aug; 51(8):4282-8. View in: PubMed

Aquaporin-1-mediated cerebral edema following traumatic brain injury: effects of acidosis and corticosteroid administration. J Neurosurg. 2010 May; 112(5):1095-104. View in: PubMed

alphaB-crystallin regulation of angiogenesis by modulation of VEGF. Blood. 2010 Apr 22; 115(16):3398-406. View in: PubMed

Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration. Vision Res. 2010 Mar 31; 50(7):643-51. View in: PubMed

Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death Differ. 2010 Mar; 17(3):488-98. View in: PubMed

Gamma interferon signaling in oligodendrocytes is critical for protection from neurotropic coronavirus infection. J Virol. 2010 Mar; 84(6):3111-5. View in: PubMed

Neutrophils compromise retinal pigment epithelial barrier integrity. J Biomed Biotechnol. 2010; 2010:289360. View in: PubMed

aB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells. PLoS One. 2010; 5(10):e12578. View in: PubMed

Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: relevance to age-related macular degeneration. Aging (Albany NY). 2010; 2(1):28-42. View in: PubMed

Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):413-20. View in: PubMed

Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro. Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):543-52. View in: PubMed

RNase L mediated protection from virus induced demyelination. PLoS Pathog. 2009 Oct; 5(10):e1000602. View in: PubMed

What determines the switch between atrophic and neovascular forms of age related macular degeneration? - the role of BMP4 induced senescence. Aging (Albany NY). 2009 Aug; 1(8):740-5. View in: PubMed

Regulated secretion of complement factor H by RPE and its role in RPE migration. Graefes Arch Clin Exp Ophthalmol. 2009 May; 247(5):651-9. View in: PubMed

BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration. J Biol Chem. 2009 Apr 3; 284(14):9529-39. View in: PubMed

There are three major families of crystallins: misnaming of alphaB crystallin. Acta Physiol (Oxf). 2009 Apr; 195(4):503; author reply 503. View in: PubMed

Regulation of thioredoxin by ceramide in retinal pigment epithelial cells. Exp Eye Res. 2009 Mar; 88(3):410-7. View in: PubMed

Snap-frozen brain tissue sections stored with desiccant at ambient laboratory conditions without chemical fixation are resistant to degradation for a minimum of 6 months. Appl Immunohistochem Mol Morphol. 2009 Mar; 17(2):165-71. View in: PubMed

Immunocytochemical analysis of retinal neurons under electrical stimulation. Brain Res. 2009 Feb 19; 1255:89-97. View in: PubMed

A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells. Nat Protoc. 2009; 4(5):662-73. View in: PubMed

Memory CD4+ T-cell-mediated protection from lethal coronavirus encephalomyelitis. J Virol. 2008 Dec; 82(24):12432-40. View in: PubMed

Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med. 2008 Oct 2; 359(14):1456-63. View in: PubMed

Connective tissue growth factor as a mediator of intraocular fibrosis. Invest Ophthalmol Vis Sci. 2008 Sep; 49(9):4078-88. View in: PubMed

The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells. Cell Death Differ. 2008 Sep; 15(9):1460-71. View in: PubMed

The immune response to herpes simplex virus type 1 infection in susceptible mice is a major cause of central nervous system pathology resulting in fatal encephalitis. J Virol. 2008 Jul; 82(14):7078-88. View in: PubMed

Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol. 2008 May; 246(5):677-83. View in: PubMed

CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus. J Virol. 2008 Mar; 82(5):2130-9. View in: PubMed

N-(4-hydroxyphenyl) retinamide augments laser-induced choroidal neovascularization in mice. Invest Ophthalmol Vis Sci. 2008 Mar; 49(3):1210-20. View in: PubMed

Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia. Exp Eye Res. 2008 Feb; 86(2):355-65. View in: PubMed

Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells. J Virol. 2008 Jan; 82(1):300-10. View in: PubMed

Pathology of damaging electrical stimulation in the retina. Exp Eye Res. 2007 Jul; 85(1):23-33. View in: PubMed

Population-based study of early age-related macular degeneration: role of the complement factor H Y402H polymorphism in bilateral but not unilateral disease. Ophthalmology. 2007 Jan; 114(1):99-103. View in: PubMed

In vivo models of proliferative vitreoretinopathy. Nat Protoc. 2007; 2(1):67-77. View in: PubMed

alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. Mol Vis. 2007; 13:566-77. View in: PubMed

Thrombospondin-1 expression in RPE and choroidal neovascular membranes. Yan Ke Xue Bao. 2006 Dec; 22(4):265-74. View in: PubMed

Liver X receptor activation decreases the severity of experimental autoimmune encephalomyelitis. J Neurosci Res. 2006 Nov 1; 84(6):1225-34. View in: PubMed

Altered neuroantigen-specific cytokine secretion in a Th2 environment reduces experimental autoimmune encephalomyelitis. J Neuroimmunol. 2006 Sep; 178(1-2):30-9. View in: PubMed

Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells. Biochem Biophys Res Commun. 2006 Aug 11; 346(4):1200-6. View in: PubMed

Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor. Exp Eye Res. 2006 Jul; 83(1):212-22. View in: PubMed

Mouse hepatitis virus pathogenesis in the central nervous system is independent of IL-15 and natural killer cells. Virology. 2006 Jun 20; 350(1):206-15. View in: PubMed

Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Am J Pathol. 2006 May; 168(5):1722-36. View in: PubMed

MMP-2 and MMP-9 secretion by rpe is stimulated by angiogenic molecules found in choroidal neovascular membranes. Retina. 2006 Apr; 26(4):454-61. View in: PubMed

CNS viral infection diverts homing of antibody-secreting cells from lymphoid organs to the CNS. Eur J Immunol. 2006 Mar; 36(3):603-12. View in: PubMed

Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination. Am J Pathol. 2006 Mar; 168(3):796-804. View in: PubMed

Sequential induction of angiogenic growth factors by TNF-alpha in choroidal endothelial cells. J Neuroimmunol. 2006 Feb; 171(1-2):45-56. View in: PubMed

Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Mol Vis. 2006; 12:532-80. View in: PubMed

Characterization of brimonidine transport in retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):287-94. View in: PubMed

Stimulation of apical and basolateral VEGF-A and VEGF-C secretion by oxidative stress in polarized retinal pigment epithelial cells. Mol Vis. 2006; 12:1649-59. View in: PubMed

Soluble EphB4 regulates choroidal endothelial cell function and inhibits laser-induced choroidal neovascularization. Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4772-9. View in: PubMed

Neuropilin-1 expression by endothelial cells and retinal pigment epithelial cells in choroidal neovascular membranes. Am J Ophthalmol. 2005 Dec; 140(6):1044-1050. View in: PubMed

Hepatocyte growth factor protects RPE cells from apoptosis induced by glutathione depletion. Invest Ophthalmol Vis Sci. 2005 Nov; 46(11):4311-9. View in: PubMed

In vivo expression of GFP transgene delivered via a replicating feline leukemia virus. Vet Microbiol. 2005 Oct 31; 110(3-4):181-95. View in: PubMed

Astrocyte expression of a dominant-negative interferon-gamma receptor. J Neurosci Res. 2005 Oct 1; 82(1):20-31. View in: PubMed

Protection from oxidative stress by methionine sulfoxide reductases in RPE cells. Biochem Biophys Res Commun. 2005 Aug 19; 334(1):245-53. View in: PubMed

Expression of a dominant negative IFN-gammareceptor on mouse oligodendrocytes. Glia. 2005 Jul; 51(1):22-34. View in: PubMed

Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization. Lab Invest. 2005 Jun; 85(6):721-33. View in: PubMed

Expression of matrix metalloproteinases and their tissue inhibitor during viral encephalitis. J Virol. 2005 Apr; 79(8):4764-73. View in: PubMed

Long-term stimulation by active epiretinal implants in normal and RCD1 dogs. J Neural Eng. 2005 Mar; 2(1):S65-73. View in: PubMed

Maintenance of CD8+ T cells during acute viral infection of the central nervous system requires CD4+ T cells but not interleukin-2. Viral Immunol. 2005; 18(1):162-9. View in: PubMed

Neutrophils promote experimental choroidal neovascularization. Mol Vis. 2005; 11:414-24. View in: PubMed

A selective cyclic integrin antagonist blocks the integrin receptors alphavbeta3 and alphavbeta5 and inhibits retinal pigment epithelium cell attachment, migration and invasion. BMC Ophthalmol. 2005; 5:16. View in: PubMed

Differential regulation of primary and secondary CD8+ T cells in the central nervous system. J Immunol. 2004 Nov 15; 173(10):6265-73. View in: PubMed

Ceramide-induced apoptosis: role of catalase and hepatocyte growth factor. Free Radic Biol Med. 2004 Jul 15; 37(2):166-75. View in: PubMed

Gene therapy in a murine model for clinical application to multiple sclerosis. Ann Neurol. 2004 Mar; 55(3):390-9. View in: PubMed

Accumulation of NH2-terminal fragment of connective tissue growth factor in the vitreous of patients with proliferative diabetic retinopathy. Diabetes Care. 2004 Mar; 27(3):758-64. View in: PubMed

Mouse strain-dependent heterogeneity of resting limbal vasculature. Invest Ophthalmol Vis Sci. 2004 Feb; 45(2):441-7. View in: PubMed

Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cells. J Virol. 2004 Feb; 78(4):1739-50. View in: PubMed

Hepatocyte growth factor and its role in the pathogenesis of retinal detachment. Invest Ophthalmol Vis Sci. 2004 Jan; 45(1):323-9. View in: PubMed

Developmental retinal apoptosis in Ku86-/- mice. DNA Repair (Amst). 2003 Dec 9; 2(12):1429-34. View in: PubMed

A role for connective tissue growth factor in the pathogenesis of choroidal neovascularization. Arch Ophthalmol. 2003 Sep; 121(9):1283-8. View in: PubMed

Microphthalmia resulting from MSX2-induced apoptosis in the optic vesicle. Invest Ophthalmol Vis Sci. 2003 Jun; 44(6):2404-12. View in: PubMed

Perforin-mediated effector function within the central nervous system requires IFN-gamma-mediated MHC up-regulation. J Immunol. 2003 Mar 15; 170(6):3204-13. View in: PubMed

Neutrophils promote mononuclear cell infiltration during viral-induced encephalitis. J Immunol. 2003 Mar 15; 170(6):3331-6. View in: PubMed

The art of survival during viral persistence. J Neurovirol. 2002 Dec; 8 Suppl 2:53-8. View in: PubMed

Tamoxifen-induced growth arrest and apoptosis in pituitary tumor cells in vitro via a protein kinase C-independent pathway. Cancer Lett. 2002 Nov 28; 185(2):131-8. View in: PubMed

Matrix metalloproteinase expression correlates with virulence following neurotropic mouse hepatitis virus infection. J Virol. 2002 Aug; 76(15):7374-84. View in: PubMed

Regulation of RPE intercellular junction integrity and function by hepatocyte growth factor. Invest Ophthalmol Vis Sci. 2002 Aug; 43(8):2782-90. View in: PubMed

Novel growth factors involved in the pathogenesis of proliferative vitreoretinopathy. Eye (Lond). 2002 Jul; 16(4):422-8. View in: PubMed

Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants. Curr Biol. 2002 Mar 5; 12(5):397-402. View in: PubMed

Translational research in ophthalmology. Arch Ophthalmol. 2002 Mar; 120(3):389-90. View in: PubMed

Interferon beta affects retinal pigment epithelial cell proliferation via protein kinase C pathways. Ophthalmologica. 2001 Nov-Dec; 215(6):401-7. View in: PubMed

Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor-positive human tumors. Blood. 2001 Sep 15; 98(6):1904-13. View in: PubMed

Systemically expressed soluble Tie2 inhibits intraocular neovascularization. Hum Gene Ther. 2001 Jul 1; 12(10):1311-21. View in: PubMed

Angiopoietin-1 upregulation by vascular endothelial growth factor in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2001 Jun; 42(7):1617-25. View in: PubMed

Response of experimental retinal neovascularization to thiazolidinediones. Arch Ophthalmol. 2001 May; 119(5):709-17. View in: PubMed

Systemic administration of a matrix-targeted retroviral vector is efficacious for cancer gene therapy in mice. Hum Gene Ther. 2001 Jan 20; 12(2):193-204. View in: PubMed

CD8 T cell mediated immunity to neurotropic MHV infection. Adv Exp Med Biol. 2001; 494:299-308. View in: PubMed

Regulation of matrix metalloproteinase (MMP) and tissue inhibitor of matrix metalloproteinase (TIMP) genes during JHMV infection of the central nervous system. Adv Exp Med Biol. 2001; 494:329-34. View in: PubMed

IFN-gamma secreted by virus-specific CD8+ T cells contribute to CNS viral clearance. Adv Exp Med Biol. 2001; 494:335-40. View in: PubMed

Acute CNS infection is insufficient to mediate chronic T cell retention. Adv Exp Med Biol. 2001; 494:349-54. View in: PubMed

Viral induced demyelination. Brain Pathol. 2001 Jan; 11(1):92-106. View in: PubMed

Promotion of adhesion and migration of RPE cells to provisional extracellular matrices by TNF-alpha. Invest Ophthalmol Vis Sci. 2000 Dec; 41(13):4324-32. View in: PubMed

Peroxisome proliferator-activated receptor-gamma ligands inhibit choroidal neovascularization. Invest Ophthalmol Vis Sci. 2000 Jul; 41(8):2309-17. View in: PubMed

The possibility of gene therapy for the treatment of choroidal neovascularization. Ophthalmology. 2000 Jul; 107(7):1364-73. View in: PubMed

Inhibition of metastatic tumor growth in nude mice by portal vein infusions of matrix-targeted retroviral vectors bearing a cytocidal cyclin G1 construct. Cancer Res. 2000 Jul 1; 60(13):3343-7. View in: PubMed

Selective killing of RPE with a vascular endothelial growth factor chimeric toxin. Invest Ophthalmol Vis Sci. 2000 Jul; 41(8):2389-93. View in: PubMed

Contributions of CD8+ T cells and viral spread to demyelinating disease. J Immunol. 2000 Apr 15; 164(8):4080-8. View in: PubMed

Natural history of choroidal neovascularization induced by vascular endothelial growth factor in the primate. Graefes Arch Clin Exp Ophthalmol. 2000 Apr; 238(4):326-33. View in: PubMed

Contributions of Fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system. J Virol. 2000 Mar; 74(5):2447-50. View in: PubMed

Paclitaxel Induces Apoptosis in AIDS-Related Kaposi's Sarcoma Cells. Sarcoma. 2000; 4(1-2):37-45. View in: PubMed

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