Faculty

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Florence M Hofman, PhD
Professor of Pathology
Pathology
HMR 315 Health Sciences Campus Los Angeles
+1 323 442 1153

Overview

Dr. Hofman's field of expertise is angiogenesis and the blood-brain-barrier in human primary brain tumors and metastatic breast cancer to the brain. Her approach is to functionally characterize the tumor-associated brain endothelial cells because these cells are the target for anti-vascular therapy in cancer. Her laboratory uses both in vitro and in vivo systems to determine the mechanism(s) of chemoresistance. Once it is understood why these cells are resistant to standard of care drugs, they will identify agents which specifically disrupt the tumor vasculature, resulting in eliminating tumor growth.

Publications

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T cell expansion is regulated by activated Gr-1+ splenocytes. Cell Immunol. 2005 May; 235(1):39-45. View in: PubMed

Functional and phenotypic differences between glioblastoma multiforme-derived and normal human brain endothelial cells. J Neurosurg. 2005 Apr; 102(4):699-705. View in: PubMed

Involvement of CD8+ T-cells in exacerbation of corneal scarring in mice. Curr Eye Res. 2004 Aug-Sep; 29(2-3):145-51. View in: PubMed

Extra-cellular superoxide promotes T cell expansion through inactivation of nitric oxide. J Neuroimmunol. 2004 Aug; 153(1-2):183-9. View in: PubMed

A simple method for isolation and characterization of mouse brain microvascular endothelial cells. J Neurosci Methods. 2003 Nov 30; 130(1):53-63. View in: PubMed

TGF-B2 and soluble p55 TNFR modulate VCAM-1 expression in glioma cells and brain derived endothelial cells. J Neuroimmunol. 1997 Mar; 73(1-2):155-61. View in: PubMed

Soluble tumor necrosis factor receptors are present in human vitreous and shed by retinal pigment epithelial cells. Exp Eye Res. 1996 Sep; 63(3):311-7. View in: PubMed

Induction of intercellular adhesion molecule-1 by tumor necrosis factor-alpha through the 55-kDa receptor is dependent on protein kinase C in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1996 Mar; 37(4):597-606. View in: PubMed

Increased expression of tumor necrosis factor-alpha receptors in the brains of patients with AIDS. J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15; 10(5):511-21. View in: PubMed

Differential effects of tumor necrosis factor-alpha on proliferation, cell surface antigen expression, and cytokine interactions in malignant gliomas. Neurosurgery. 1993 Jan; 32(1):85-94. View in: PubMed

Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10. PL mice. Proc Natl Acad Sci U S A. 1992 Jan 15; 89(2):574-8. View in: PubMed

Lymphokines and immunoregulatory molecules in subacute sclerosing panencephalitis. Clin Immunol Immunopathol. 1991 Mar; 58(3):331-42. View in: PubMed

Cytokine interactions in the central nervous system. Reg Immunol. 1990-1991; 3(5):268-78. View in: PubMed

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