Patrick Hsieh, MD

Dr. Hsieh was a distinguished scholar at the Howard Hughes Medical Institute in 1998 where he performed research in the field of neuro-genetics at the National Institutes of Health. He completed a surgical internship and neurosurgery residency at Northwestern University McGaw Medical Center where he also received specialized training in spinal deformity surgery and advanced minimally invasive spine surgery. Additionally, Dr. Hsieh has specialized training in spinal oncology and complex spinal reconstructive surgery at Johns Hopkins University. Dr. Hsieh’s research interests include prospective outcome studies on spinal oncology surgery, spinal deformity surgery and minimally invasive spine procedures. He is particularly interested in clinical trials on the management of Chordomas and other primary spinal tumors. Dr. Hsieh also studies spinal biomechanics and the application of osteobiologics and nanoparticles for spine reconstructions. Additionally, his expertise and interests includes chordoma and sacral tumors and scoliosis. Dr. Hsieh has participated in five major research studies throughout his training, as well as over a dozen major presentations at national conferences. He has also co-authored over 15 peer-reviewed journal articles in scientific publications.

• Pasadena Magazine: Top Doctor, 2011
• Congress of Neurological Surgeons Depuy Spine Fellowship Award, 2007

• Radiographic Risk Factors for Adjacent Segment Disease Following Anterior Cervical Discectomy and Fusion (ACDF): A Systematic Review and Meta-Analysis Global Spine J. 2024 Mar 12; 21925682241237500. . View in PubMed
• Comparison of Different Osteobiologics in Terms of Imaging Modalities and Time Frames for Fusion Assessment in Anterior Cervical Discectomy and Fusion: A Systematic Review Global Spine J. 2024 Feb; 14(2_suppl):141S-162S. . View in PubMed
• AO Spine Guideline for the Use of Osteobiologics (AOGO) in Anterior Cervical Discectomy and Fusion for Spinal Degenerative Cases Global Spine J. 2024 Feb; 14(2_suppl):6S-13S. . View in PubMed
• What Is the Evidence Supporting Osteobiologic Use in Revision Anterior Cervical Discectomy and Fusion? Global Spine J. 2024 Feb; 14(2_suppl):173S-178S.. View in PubMed
• Top 25 Most-Cited Articles on Robotic-Assisted Lumbar Spine Surgery Int J Spine Surg. 2023 Dec 12. . View in PubMed
• Surgeon Preferences Worldwide in Wound Drain Utilization in Open Lumbar Fusion Surgery for Degenerative Pathologies Global Spine J. 2023 Oct 28; 21925682231210184. . View in PubMed
• Using machine learning and big data for the prediction of venous thromboembolic events after spine surgery: A single-center retrospective analysis of multiple models on a cohort of 6869 patients J Craniovertebr Junction Spine. 2023 Jul-Sep; 14(3):221-229. . View in PubMed
• Clinical risk factors associated with the development of adjacent segment disease in patients undergoing ACDF: A systematic review Spine J. 2023 01; 23(1):146-156. . View in PubMed
• Comparison of Surgical Outcomes Between Anterior and Posterior Cervical Fusions Stratified by Levels Decompressed Clin Spine Surg. 2023 06 01; 36(5):E206-E211. . View in PubMed
• SPINE20 recommendations 2023: One Earth, one family, one future WITHOUT spine DISABILITY Brain Spine. 2023; 3:102688. . View in PubMed
• SPINE20 recommendations 2022: spine care-working together to recover stronger Eur Spine J. 2022 Nov 03. . View in PubMed
• Lumbar surgical drains do not increase the risk of infections in patients undergoing spine surgery Eur Spine J. 2022 07; 31(7):1775-1783. . View in PubMed
• Demographic, clinical, and operative risk factors associated with postoperative adjacent segment disease in patients undergoing lumbar spine fusions: a systematic review and meta-analysis Spine J. 2022 06; 22(6):1038-1069. . View in PubMed
• The performance of frailty in predictive modeling of short-term outcomes in the surgical management of metastatic tumors to the spine Spine J. 2022 04; 22(4):605-615. . View in PubMed
• Use of Autologous Stem Cells in Lumbar Spinal Fusion: A Systematic Review of Current Clinical Evidence Global Spine J. 2021 Oct; 11(8):1281-1298. . View in PubMed
• Autologous Stem Cells in Cervical Spine Fusion Global Spine J. 2021 Jul; 11(6):950-965. . View in PubMed
• The influence of modifiable risk factors on short-term postoperative outcomes following cervical spine surgery: A retrospective propensity score matched analysis EClinicalMedicine. 2021 Jun; 36:100889. . View in PubMed
• Global Spine J. 2021 Apr; 11(1_suppl):30S-36S. . View in PubMed
• Inclusion of Frailty Improves Predictive Modeling for Postoperative Outcomes in Surgical Management of Primary and Secondary Lumbar Spine Tumors World Neurosurg. 2021 09; 153:e454-e463. . View in PubMed
• Impact of a Perioperative Protocol on Length of ICU and Hospital Stay in Complex Spine Surgery J Neurosurg Anesthesiol. 2021 Jan; 33(1):65-72. . View in PubMed
• Development of AOSpine BOnE (Bone Osteobiologics and Evidence) Classification Global Spine J. 2020 Oct; 10(7):871-874. . View in PubMed
• Copy number variant hotspots in Han Taiwanese population induced pluripotent stem cell lines – lessons from establishing the Taiwan human disease iPSC Consortium Bank J Biomed Sci. 2020 Sep 04; 27(1):92. . View in PubMed
• Comparison of Minimally Invasive Versus Open Transforaminal Interbody Lumbar Fusion Global Spine J. 2020 Apr; 10(2 Suppl):143S-150S. . View in PubMed
• The DOWN Questionnaire: A Novel Screening Tool for Cervical Spondylotic Myelopathy Global Spine J. 2019 Sep; 9(6):607-612. . View in PubMed
• Allogenic Stem Cells in Spinal Fusion: A Systematic Review Global Spine J. 2019 May; 9(1 Suppl):22S-38S. . View in PubMed
• Cell Therapy for Treatment of Intervertebral Disc Degeneration: A Systematic Review Global Spine J. 2019 May; 9(1 Suppl):39S-52S. . View in PubMed
• Simulation of Dural Repair in Minimally Invasive Spine Surgery With the Use of a Perfusion-Based Cadaveric Model Oper Neurosurg (Hagerstown). 2019 12 01; 17(6):616-621. . View in PubMed
• Trends and Costs of External Electrical Bone Stimulators and Grafting Materials in Anterior Lumbar Interbody Fusion Asian Spine J. 2018 Dec; 12(6):973-980. . View in PubMed
• Risk Factors Associated with Reconstructive Complications Following Sacrectomy Plast Reconstr Surg Glob Open. 2018 Nov; 6(11):e2002. . View in PubMed
• Arm Pain Versus Neck Pain: A Novel Ratio as a Predictor of Post-Operative Clinical Outcomes in Cervical Radiculopathy Patients Int J Spine Surg. 2018 Oct; 12(5):629-637. . View in PubMed
• MRI kinematic analysis of T1 sagittal motion between cervical flexion and extension positions in 145 patients Eur Spine J. 2018 05; 27(5):1034-1041. . View in PubMed
• Paraplegic patients: how to measure balance and what is normal or functional? Eur Spine J. 2018 02; 27(Suppl 1):109-114.. View in PubMed
• The primary diagnosis and the coexisting anxiety disorders have no impact on the additional surgical procedure after spinal cord stimulators implantation: An analysis of 11,029 patients J Clin Neurosci. 2018 Jan; 47:208-213. . View in PubMed
• Effect of mental health on post-operative infection rates following cervical spine fusion procedures J Orthop. 2017 Dec; 14(4):501-506. . View in PubMed
• A Novel Lumbar Motion Segment Classification to Predict Changes in Segmental Sagittal Alignment After Lateral Interbody Fixation Global Spine J. 2017 Oct; 7(7):642-647. . View in PubMed
• Transpedicular Corpectomy and Cage Placement in the Treatment of Traumatic Lumbar Burst Fractures Clin Spine Surg. 2017 Oct; 30(8):360-366. . View in PubMed
• Bisphosphonate’s and Intermittent Parathyroid Hormone’s Effect on Human Spinal Fusion: A Systematic Review of the Literature Asian Spine J. 2017 Jun; 11(3):484-493. . View in PubMed
• The Clinical Correlations between Diabetes, Cigarette Smoking and Obesity on Intervertebral Degenerative Disc Disease of the Lumbar Spine Asian Spine J. 2017 Jun; 11(3):337-347. . View in PubMed
• Risk and Cost of Reoperation After Single-Level Posterior Cervical Foraminotomy: A Large Database Study Global Spine J. 2017 Apr; 7(2):116-122. . View in PubMed
• Adjacent segment disease requiring reoperation in cervical total disc arthroplasty: A literature review and update J Clin Neurosci. 2017 Mar; 37:20-24. . View in PubMed
• A Portable Shoulder-Mounted Camera System for Surgical Education in Spine Surgery Surg Technol Int. 2017 Feb 07; 30:462-467. . View in PubMed
• The use of a novel perfusion-based cadaveric simulation model with cerebrospinal fluid reconstitution comparing dural repair techniques: a pilot study Spine J. 2017 09; 17(9):1335-1341. . View in PubMed
• Kinematic evaluation of cervical sagittal balance and thoracic inlet alignment in degenerative cervical spondylolisthesis using kinematic magnetic resonance imaging Spine J. 2017 09; 17(9):1272-1284. . View in PubMed
• A response to a commentary by DrDaniel J. Cher. Spine J. 2017 01; 17(1):159. . View in PubMed
• New Clinical-Pathological Classification of Intraspinal Injury Following Traumatic Acute Complete Thoracic Spinal Cord Injury: Postdurotomy/Myelotomy Observations From the INSPIRE Trial Neurosurgery. 2017 09 01; 64(CN_suppl_1):105-109. . View in PubMed
• Minimally invasive L5-S1 oblique lumbar interbody fusion with anterior plate Neurosurg Focus. 2016 Jul; 41 Video Suppl 1:1. . View in PubMed
• Introduction to Lumbosacral and Sacropelvic Fixation Strategies Neurosurg Focus. 2016 Jul; 41 Video Suppl 1:1. . View in PubMed
• S-1 and S-2-alar-iliac screw fixation via intraoperative navigation Neurosurg Focus. 2016 Jul; 41 Video Suppl 1:1. . View in PubMed
• Introduction: Degenerative cervical myelopathy: diagnostic, assessment, and management strategies, surgical complications, and outcome prediction Neurosurg Focus. 2016 Jun; 40(6):E1. . View in PubMed
• Intracranial complications associated with spinal surgery Eur Spine J. 2016 Mar; 25(3):888-94. . View in PubMed
• Effects of fusion and conservative treatment on disc degeneration and rates of subsequent surgery after thoracolumbar fracture J Neurosurg Spine. 2016 Mar; 24(3):476-82. . View in PubMed
• Postoperative complications in patients undergoing minimally invasive sacroiliac fusion Spine J. 2016 11; 16(11):1324-1332. . View in PubMed
• Complications associated with the Dynesys dynamic stabilization system: a comprehensive review of the literature Neurosurg Focus. 2016 Jan; 40(1):E2. . View in PubMed
• Spinal Motion Preservation Surgery Biomed Res Int. 2015; 2015:372502. . View in PubMed
• Material Science in Cervical Total Disc Replacement Biomed Res Int. 2015; 2015:719123. . View in PubMed
• Effect of false lumen partial thrombosis on repaired acute type A aortic dissectionJ Thorac Cardiovasc Surg. 2014 Nov; 148(5):2140-2146. e3. . View in PubMed
• Outcomes following attempted en bloc resection of cervical chordomas in the C-1 and C-2 region versus the subaxial region: a multiinstitutional experience J Neurosurg Spine. 2014 Sep; 21(3):348-56. . View in PubMed
• Introduction: vertebral osteomyelitis and spinal epidural abscess Neurosurg Focus. 2014 Aug; 37(2):1 p preceding E1. . View in PubMed
• The indications and timing for operative management of spinal epidural abscess: literature review and treatment algorithm Neurosurg Focus. 2014 Aug; 37(2):E8. . View in PubMed
• Introduction: Costs and benefits of modern-day spine care Neurosurg Focus. 2014 Jun; 36(6):Introduction. . View in PubMed
• Editorial: Comparing minimally invasive, hybrid, and open surgical techniques for adult spinal deformity Neurosurg Focus. 2014 May; 36(5):E16. . View in PubMed
• Spinal cord mapping J Clin Neurophysiol. 2013 Dec; 30(6):604-12. . View in PubMed
• Computed tomography for clearance of cervical spine injury in the unevaluable patient World Neurosurg. 2013 Sep-Oct; 80(3-4):405-13. . View in PubMed
• Minimally invasive posterior atlantoaxial fusion: a cadaveric and clinical feasibility study World Neurosurg. 2013 Sep-Oct; 80(3-4):414-21. . View in PubMed
• Considering the cost of spine surgeries: is it necessary? World Neurosurg. 2013 Jul-Aug; 80(1-2):71-3.. View in PubMed
• Efficacy of surgical treatment for lumbar stenosis with the X-STOP: an issue in need of closer inspection World Neurosurg. 2013 Jul-Aug; 80(1-2):74-7. . View in PubMed
• Diffusion tensor imaging correlates with the clinical assessment of disease severity in cervical spondylotic myelopathy and predicts outcome following surgery AJNR Am J Neuroradiol. 2013 Feb; 34(2):471-8. . View in PubMed
• Posterior-only approach for en bloc sacrectomy: clinical outcomes in 36 consecutive patients Neurosurgery. 2012 Aug; 71(2):357-64; discussion 364. . View in PubMed
• Minimally invasive lumbar intradural extramedullary tumor resection Neurosurg Focus. 2012 Jul; 33(Suppl 1):1. . View in PubMed
• Complications of spine surgery Neurosurg Focus. 2011 Oct; 31(4):1 p preceding E1. . View in PubMed
• Thoracic discectomy and plating Neurosurg Focus. 2011 Apr; 30(4):E16. . View in PubMed
• Ossification of the posterior longitudinal ligament: genetics and pathophysiology Neurosurg Focus. 2011 Mar; 30(3):E6. . View in PubMed
• Conservative management of ossification of the posterior longitudinal ligamentA review. Neurosurg Focus. 2011 Mar; 30(3):E2. . View in PubMed
• IntroductionOssification of the posterior longitudinal ligament. Neurosurg Focus. 2011 Mar; 30(3):1 p preceding E1. . View in PubMed
• Diffusion tensor imaging in the assessment of ossification of the posterior longitudinal ligament: a report on preliminary results in 3 cases and review of the literature Neurosurg Focus. 2011 Mar; 30(3):E14. . View in PubMed
• Posterior vertebral column subtraction osteotomy for the treatment of tethered cord syndrome: review of the literature and clinical outcomes of all cases reported to date Neurosurg Focus. 2010 Jul; 29(1):E6. . View in PubMed
• Minimally invasive circumferential spinal decompression and stabilization for symptomatic metastatic spine tumor: technical case report Neurosurgery. 2010 Mar; 66(3):E620-2. . View in PubMed
• Posterior-only approach for total en bloc spondylectomy for malignant primary spinal neoplasms: anatomic considerations and operative nuances Neurosurgery. 2009 Dec; 65(6 Suppl):173-81; discussion 181. . View in PubMed
• En bloc spondylectomy for treatment of tumor-induced osteomalacia J Neurosurg Spine. 2009 Nov; 11(5):600-4. . View in PubMed
• Intraoperative neurophysiological monitoring during spine surgery: a review Neurosurg Focus. 2009 Oct; 27(4):E6. . View in PubMed
• Posterior vertebral column subtraction osteotomy: a novel surgical approach for the treatment of multiple recurrences of tethered cord syndrome J Neurosurg Spine. 2009 Apr; 10(4):278-86. . View in PubMed
• Acute symptomatic cerebellar tonsillar herniation following intraoperative lumbar drainage J Neurosurg. 2009 Apr; 110(4):800-3. . View in PubMed
• Current updates in perioperative management of intracerebral hemorrhage Neurosurg Clin N Am. 2008 Jul; 19(3):401-14v. . View in PubMed
• Perioperative challenges in the surgical management of ankylosing spondylitis Neurosurg Focus. 2008; 24(1):E10. . View in PubMed
• Epidemiology and demographics for primary vertebral tumors Neurosurg Clin N Am. 2008 Jan; 19(1):1-4. . View in PubMed
• Pediatric tumors involving the spinal column Neurosurg Clin N Am. 2008 Jan; 19(1):81-92. . View in PubMed
• Maximizing the potential of minimally invasive spine surgery in complex spinal disorders Neurosurg Focus. 2008; 25(2):E19. . View in PubMed
• Anterior lumbar interbody fusion in comparison with transforaminal lumbar interbody fusion: implications for the restoration of foraminal height, local disc angle, lumbar lordosis, and sagittal balance J Neurosurg Spine. 2007 Oct; 7(4):379-86. . View in PubMed
• A novel approach to sagittal balance restoration following iatrogenic sacral fracture and resulting sacral kyphotic deformityTechnical note. J Neurosurg Spine. 2007 Apr; 6(4):368-72. . View in PubMed
• Current updates in perioperative management of intracerebral hemorrhage Neurol Clin. 2006 Nov; 24(4):745-64. . View in PubMed
• Adjuvant gamma knife stereotactic radiosurgery at the time of tumor progression potentially improves survival for patients with glioblastoma multiforme Neurosurgery. 2005 Oct; 57(4):684-92; discussion 684-92. . View in PubMed
• Surgical strategies for vertebral osteomyelitis and epidural abscess Neurosurg Focus. 2004 Dec 15; 17(6):E4. . View in PubMed
• Posterior endoscopic lumbar discectomy using a thoracoport as a tubular retractor Minim Invasive Neurosurg. 2004 Oct; 47(5):319-23. . View in PubMed
• Computerized tomography-guided stereotactic aspiration of brain abscesses: experience with 28 cases Zhonghua Yi Xue Za Zhi (Taipei). 1999 Jun; 62(6):341-9. . View in PubMed
• Surgical treatment of fixed cervical kyphosis with myelopathy Spine (Phila Pa 1976). 2008 Apr 01; 33(7):771-8. . View in PubMed
• Thoracic pedicle subtraction osteotomy for fixed sagittal spinal deformity Spine (Phila Pa 1976). 2009 Dec 15; 34(26):2893-9. . View in PubMed
• Symptomatic vertebral artery compression by the rod of a C1-C2 posterior fusion construct: case report and review of the literature Spine (Phila Pa 1976). 2011 May 01; 36(10):E678-81. . View in PubMed
• Long-term clinical outcomes following en bloc resections for sacral chordomas and chondrosarcomas: a series of twenty consecutive patients Spine (Phila Pa 1976). 2009 Sep 15; 34(20):2233-9. . View in PubMed
• Reoperation Rates After Single-level Lumbar Discectomy Spine (Phila Pa 1976). 2017 Apr 15; 42(8):E496-E501. . View in PubMed
• En bloc excisions of chordomas in the cervical spine: review of five consecutive cases with more than 4-year follow-up Spine (Phila Pa 1976). 2011 Nov 15; 36(24):E1581-7. . View in PubMed
• Locomotor biomechanics after total sacrectomy: a case report Spine (Phila Pa 1976). 2014 Nov 15; 39(24):E1481-7. . View in PubMed
• Influence of T1 Slope on the Cervical Sagittal Balance in Degenerative Cervical Spine: An Analysis Using Kinematic MRI Spine (Phila Pa 1976). 2016 Feb; 41(3):185-90. . View in PubMed

• Safaee, Michael
• Andras, Lindsay
• Zada, Gabriel
• Demetriades, Demetrios
• Chang, Eric
• Cohen-Gadol, Aaron