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Michael S. Rafii, MD, PhD
Associate Professor of Clinical Neurology
Neurology
ATR 9860 Mesa Rim Road Health Sciences Campus San Diego
+1 858 964 0638

Overview

Michael Rafii, MD, PhD is Associate Professor of Clinical Neurology at the Keck School of Medicine of the University of Southern California (USC) and Clinical Director of the Alzheimer’s Therapeutic Research Institute (ATRI). He received his MD and PhD degrees from Brown University School of Medicine and conducted neurogenetics research at Harvard Medical School. He holds two patents for protein-based therapeutics resulting from his work while a graduate student.

Dr. Rafii completed his residency in Neurology at the Johns Hopkins Hospital, where he was chief resident. He then undertook a fellowship in dementia and cognitive disorders at UC San Diego. He is board-certified by the American Board of Neurology and Psychiatry. His book, 'First Aid for the Neurology Boards' is one of the most widely used resources in preparation for taking the Neurology Board Examination.

Dr. Rafii’s research focuses on the design and conduct of clinical trials for Alzheimer's disease including Alzheimer’s disease in people with Down syndrome. Dr. Rafii also serves on the National Task Group on Intellectual Disabilities and Dementia Practices of the American Academy of Developmental Medicine. He is ad hoc member of the NIH study section on Developmental Brain Disorders and co-editor of the textbook 'Common Pathogenic Mechanisms between Down Syndrome and Alzheimer's Disease: Steps toward Therapy.'

He previously served as Medical Director of the Alzheimer’s Disease Cooperative Study (ADCS), Director of the UC San Diego Memory Disorders Clinic and Director of the Neurology Residency Training program at UC San Diego.

Dr. Rafii holds a joint appointment at UC San Diego.

Awards

The Johns Hopkins Hospital: Preziosi Outstanding Neurology Resident Award, 2006

The Johns Hopkins Hospital: Alpha Omega Alpha , 2006

The Johns Hopkins University/Sinai Hospital: Intern of the Year, 2003

Brown University: Aronson Prize for Excellence in Neuroscience, 2002

Brown University School of Medicine: Aronson Prize for Excellence in Neuroscience, 2002

The Johns Hopkins Hospital: award conferred by, 2006

Brown University School of Medicine: award conferred by, 2002

The Johns Hopkins University/Sinai Hospital: award conferred by, 2003

Brown University School of Medicine: award or honor for, 2002

The Johns Hopkins Hospital: award or honor for, 2006

The Johns Hopkins University/Sinai Hospital: award or honor for, 2003

The Johns Hopkins University/Sinai Hospital: Neurology, 2003

The Johns Hopkins Hospital: Neurology, 2006

Brown University School of Medicine: Neurology, 2002

The Johns Hopkins Hospital: full name, 2006

Brown University School of Medicine: full name, 2002

The Johns Hopkins University/Sinai Hospital: full name, 2003

Brown University School of Medicine: HR job title, 2002

The Johns Hopkins Hospital: HR job title, 2006

The Johns Hopkins University/Sinai Hospital: HR job title, 2003

The Johns Hopkins University/Sinai Hospital: person in primary position, 2003

The Johns Hopkins Hospital: person in primary position, 2006

Brown University School of Medicine: person in primary position, 2002

The Johns Hopkins University/Sinai Hospital: is primary position, 2003

The Johns Hopkins Hospital: is primary position, 2006

Brown University School of Medicine: is primary position, 2002

The Johns Hopkins Hospital: last name, 2006

The Johns Hopkins University/Sinai Hospital: last name, 2003

Brown University School of Medicine: last name, 2002

Brown University School of Medicine: Department, 2002

The Johns Hopkins Hospital: Department, 2006

The Johns Hopkins University/Sinai Hospital: Department, 2003

The Johns Hopkins University/Sinai Hospital: Rafii, Michael, 2003

The Johns Hopkins Hospital: Rafii, Michael, 2006

Brown University School of Medicine: Rafii, Michael, 2002

The Johns Hopkins University/Sinai Hospital: position in department, 2003

The Johns Hopkins Hospital: position in department, 2006

Brown University School of Medicine: position in department, 2002

The Johns Hopkins Hospital: Faculty Rank, 2006

The Johns Hopkins University/Sinai Hospital: Faculty Rank, 2003

Brown University School of Medicine: Faculty Rank, 2002

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Brown University School of Medicine: sort order, 2002

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The Johns Hopkins University/Sinai Hospital: Person ID, 2003

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The Johns Hopkins University/Sinai Hospital: Keck School of Medicine of USC, 2003

The Johns Hopkins Hospital: Keck School of Medicine of USC, 2006

Brown University School of Medicine: Keck School of Medicine of USC, 2002

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The Johns Hopkins University/Sinai Hospital: label, 2003

Brown University School of Medicine: label, 2002

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The Johns Hopkins University/Sinai Hospital: position in organization, 2003

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Brown University School of Medicine: Organization, 2002

The Johns Hopkins Hospital: preferred title, 2006

Brown University School of Medicine: preferred title, 2002

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The Johns Hopkins University/Sinai Hospital: first name, 2003

The Johns Hopkins Hospital: Agent, 2006

Brown University School of Medicine: Agent, 2002

The Johns Hopkins University/Sinai Hospital: Agent, 2003

Brown University School of Medicine: first name, 2002

Brown University School of Medicine: Associate Professor, 2002

The Johns Hopkins Hospital: Associate Professor, 2006

The Johns Hopkins University/Sinai Hospital: Associate Professor, 2003

The Johns Hopkins University/Sinai Hospital: Position, 2003

Brown University School of Medicine: Position, 2002

The Johns Hopkins Hospital: Position, 2006

Brown University School of Medicine: photo, 2002

The Johns Hopkins Hospital: photo, 2006

The Johns Hopkins University/Sinai Hospital: photo, 2003

The Johns Hopkins Hospital: has faculty rank, 2006

The Johns Hopkins University/Sinai Hospital: has faculty rank, 2003

Brown University School of Medicine: has faculty rank, 2002

Publications

Targeting tau protein in Alzheimer's disease. Lancet. 2016 Nov 15. View in: PubMed

Advances in Alzheimer's disease drug development. BMC Med. 2015; 13(1):62. View in: PubMed

The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome. Front Behav Neurosci. 2015; 9:239. View in: PubMed

A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease. Alzheimers Dement. 2014 Sep; 10(5):571-81. View in: PubMed

Neuropsychiatric symptoms and regional neocortical atrophy in mild cognitive impairment and Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2014 Mar; 29(2):159-65. View in: PubMed

Pro: Are we ready to translate Alzheimer's disease modifying therapies to people with Down syndrome? Alzheimers Res Ther. Pro: Are we ready to translate Alzheimer's disease modifying therapies to people with Down syndrome? Alzheimers Res Ther. 2014; 6(5-8):60. View in: PubMed

Preclinical Alzheimer's disease therapeutics. J Alzheimers Dis. 2014 Jan 1; 42(0):S545-9. View in: PubMed

An expanded role for neuroimaging in the evaluation of memory impairment. AJNR Am J Neuroradiol. 2013 Nov-Dec; 34(11):2075-82. View in: PubMed

The National Task Group on Intellectual Disabilities and Dementia Practices consensus recommendations for the evaluation and management of dementia in adults with intellectual disabilities. Mayo Clin Proc. 2013 Aug; 88(8):831-40. View in: PubMed

Update on Alzheimer's disease therapeutics. Rev Recent Clin Trials. 2013 Jun; 8(2):110-8. View in: PubMed

Down's syndrome and Alzheimer's disease: towards secondary prevention. Nat Rev Drug Discov. 2012 Sep; 11(9):655-6. View in: PubMed

A phase II trial of huperzine A in mild to moderate Alzheimer disease. Neurology. 2011 Apr 19; 76(16):1389-94. View in: PubMed

Functional brain imaging in the clinical assessment of consciousness. PLoS Biol. 2010; 8(11):e1000548. View in: PubMed

The pulse of drug development for Alzheimer's disease. Rev Recent Clin Trials. 2010 Jan; 5(1):57-62. View in: PubMed

High-throughput, fully automated volumetry for prediction of MMSE and CDR decline in mild cognitive impairment. Alzheimer Dis Assoc Disord. 2009 Apr-Jun; 23(2):139-45. View in: PubMed

Recent developments in Alzheimer's disease therapeutics. BMC Med. 2009; 7:7. View in: PubMed

Primary care screening for dementia and mild cognitive impairment. JAMA. 2008 Mar 12; 299(10):1132; author reply 1133-4. View in: PubMed

Biglycan binds to alpha- and gamma-sarcoglycan and regulates their expression during development. J Cell Physiol. 2006 Nov; 209(2):439-47. View in: PubMed

Compendium of cerebrovascular diseases. Int Rev Psychiatry. 2006 Oct; 18(5):395-407. View in: PubMed

Biglycan regulates the expression and sarcolemmal localization of dystrobrevin, syntrophin, and nNOS. FASEB J. 2006 Aug; 20(10):1724-6. View in: PubMed

Case 14: a woman with bilateral Bell's palsy. MedGenMed. 2006; 8(4):23. View in: PubMed

Orolingual angioedema associated with ACE inhibitor use after rtPA treatment of acute stroke. Neurology. 2005 Dec 27; 65(12):1906. View in: PubMed

Agrin and microvascular damage in Alzheimer's disease. Neurobiol Aging. 2000 Mar-Apr; 21(2):349-55. View in: PubMed

Agrin in Alzheimer's disease: altered solubility and abnormal distribution within microvasculature and brain parenchyma. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6468-72. View in: PubMed

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