Faculty

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Nuria Maria Pastor-Soler, MD, PhD
Associate Professor of Medicine
Assistant Dean For Research Mentoring
Medicine
MMR 628 1333 San Pablo St. Off Campus Los Angeles

Overview

Dr. Pastor-Soler's research interests include regulation acid-base homeostasis by the kidney and the study of the vacuolar proton ATPase (V-ATPase) in the kidney and the male reproductive tract. Other research projects in her laboratory study the regulation of sodium transport in the collecting duct by bicarbonate-regulated sAC, and renal salt transport regulation by WNK kinases, to name a few. She is currently studying the molecular and cellular mechanisms by which metabolic pathways in the kidney are affected by acidosis, a known predictor of CKD progression. She is also studying renal cell carcinomas with the aim to confirm a novel biomarker that could be used clinically to assess the presence and severity of this disease.

Dr. Pastor-Soler earned her medical degree from Jefferson Medical College. She then went on to complete her PhD in Biochemistry and Molecular Biology at Jefferson. Dr. Pastor-Soler completed her Nephrology Fellowship at the Brigham and Women's/Massachusetts General Hospital program. She is currently Associate Professor of Medicine in the Division of Nephrology and Hypertension and Assistant Dean for Research Mentoring at Keck School of Medicine of USC. She is also the Director of the Required Scholarly Project Program.

Awards

Women in Nephrology: President, 2016

Council for the Kidney in Cardiovascular Disease, American Heart Association: Chair, 2016

Council for the Kidney in Cardiovascular Disease, American Heart Association: Elected to Vice-Chair, 2014-2016

Department of Medicine, University of Pittsburgh: Junior Scholar Award, 2012-2014

American Physiological Society: Renal Section, Young Investigator Award, 2012

American Society for Clinical Investigation: Member, 2012

Telluride Epithelial Physiology Workshop: Research Recognition Award, 2012

American Physiological Society: Career Enhancement Award, 2011

American Physiological Society: Renal Section, New Investigator Award, 2009

American Society of Nephrology: Carl W. Gottschalk Research Scholar Grant, 2009

Massachusetts General Hospital: Claflin Distinguished Scholar Award, 2005

American Society of Nephrology: Fellow, 2005

P. and E. Brown Foerderer Foundation: Fellowship, 1990-1991

Thomas Jefferson University: Gibbon Scholar, 1989-1996

Dorothy Nepper Marshall Teacher Apprenticeship: Scholar, 1988-1989

Haverford College: Pew Summer Research Foundation Fellowship, 1988

Bryn Mawr College: Full Scholarship, 1986-1989

Abigail Van Buren Scholarship

Armand Hammer United World College: Full Scholarship, 1984-1986

Publications

Role of AMP-activated protein kinase in kidney tubular transport, metabolism, and disease. Curr Opin Nephrol Hypertens. 2017 Sep; 26(5):375-383. View in: PubMed

Sexual Dimorphic Pattern of Renal Transporters and Electrolyte Homeostasis. J Am Soc Nephrol. 2017 Aug 03. View in: PubMed

Role of AMP-activated protein kinase in kidney tubular transport, metabolism, and disease. Curr Opin Nephrol Hypertens. 2017 Jun 12. View in: PubMed

Insulin-like growth factor binding protein 7 and tissue inhibitor of metalloproteinases-2: differential expression and secretion in human kidney tubule cells. Am J Physiol Renal Physiol. 2017 Feb 01; 312(2):F284-F296. View in: PubMed

Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats. Front Physiol. 2017; 8:227. View in: PubMed

Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells. Am J Physiol Renal Physiol. 2016 Nov 01; 311(5):F890-F900. View in: PubMed

Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney. Sci Rep. 2016 Oct 26; 6:35952. View in: PubMed

Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells. Am J Physiol Renal Physiol. 2016 Jun 1; 310(11):F1216-28. View in: PubMed

Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells. Am J Physiol Renal Physiol. 2016 Jun 01; 310(11):F1216-28. View in: PubMed

Muc1 enhances the ß-catenin protective pathway during ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2016 Mar 15; 310(6):F569-79. View in: PubMed

Interactions between HIF-1a and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease. Am J Physiol Renal Physiol. 2015 Sep 01; 309(5):F414-28. View in: PubMed

Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action. J Clin Invest. 2015 Sep; 125(9):3433-48. View in: PubMed

Interactions between HIF-1a and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease. Am J Physiol Renal Physiol. 2015 Sep 1; 309(5):F414-28. View in: PubMed

Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action. J Clin Invest. 2015 Sep 1; 125(9):3433-48. View in: PubMed

Muc1 is protective during kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1452-62. View in: PubMed

Collecting duct intercalated cell function and regulation. Clin J Am Soc Nephrol. 2015 Feb 06; 10(2):305-24. View in: PubMed

Septic acute kidney injury: molecular mechanisms and the importance of stratification and targeting therapy. Crit Care. 2014 Sep 02; 18(5):501. View in: PubMed

Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase. Nat Chem Biol. 2014 Sep; 10(9):707-9. View in: PubMed

Epithelial transport during septic acute kidney injury. Nephrol Dial Transplant. 2014 Jul; 29(7):1312-9. View in: PubMed

Shear stress-dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8506-11. View in: PubMed

Regulation of proximal tubule vacuolar H(+)-ATPase by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol. 2014 May 01; 306(9):F981-95. View in: PubMed

Septic acute kidney injury: molecular mechanisms and the importance of stratification and targeting therapy. Crit Care. 2014; 18(5):501. View in: PubMed

Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells. Am J Physiol Renal Physiol. 2013 Dec 15; 305(12):F1783-95. View in: PubMed

Regulation of large-conductance Ca2+-activated K+ channels by WNK4 kinase. Am J Physiol Cell Physiol. 2013 Oct 15; 305(8):C846-53. View in: PubMed

AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. Am J Physiol Renal Physiol. 2013 Oct 1; 305(7):F943-56. View in: PubMed

AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. Am J Physiol Renal Physiol. 2013 Oct 01; 305(7):F943-56. View in: PubMed

Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: a single center experience. Clin J Am Soc Nephrol. 2013 Sep; 8(9):1533-9. View in: PubMed

AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1. Am J Physiol Renal Physiol. 2013 Sep 1; 305(5):F679-90. View in: PubMed

AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1. Am J Physiol Renal Physiol. 2013 Sep 01; 305(5):F679-90. View in: PubMed

PIP5KIß selectively modulates apical endocytosis in polarized renal epithelial cells. PLoS One. 2013; 8(1):e53790. View in: PubMed

Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9-dependent mechanism. Mol Biol Cell. 2012 Sep; 23(18):3636-46. View in: PubMed

AMP-activated protein kinase regulation of kidney tubular transport. Curr Opin Nephrol Hypertens. 2012 Sep; 21(5):523-33. View in: PubMed

Luminal flow modulates H+-ATPase activity in the cortical collecting duct (CCD). Am J Physiol Renal Physiol. 2012 Jan 01; 302(1):F205-15. View in: PubMed

Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol Renal Physiol. 2011 Sep; 301(3):F622-33. View in: PubMed

AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. Am J Physiol Renal Physiol. 2010 Dec; 299(6):F1308-19. View in: PubMed

SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy. J Mol Cell Cardiol. 2010 Oct; 49(4):683-92. View in: PubMed

PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells. J Biol Chem. 2010 Aug 06; 285(32):24676-85. View in: PubMed

PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells. J Biol Chem. 2010 Aug 6; 285(32):24676-85. View in: PubMed

Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Am J Physiol Renal Physiol. 2010 Jul; 299(1):F167-77. View in: PubMed

Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol. 2010 May; 298(5):F1162-9. View in: PubMed

Role of the energy sensor AMP-activated protein kinase in renal physiology and disease. Am J Physiol Renal Physiol. 2010 May; 298(5):F1067-77. View in: PubMed

Aquaporin 9 expression in the developing rat epididymis is modulated by steroid hormones. Reproduction. 2010 Mar; 139(3):613-21. View in: PubMed

SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states. Cardiovasc Res. 2009 Oct 01; 84(1):111-8. View in: PubMed

AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. Am J Physiol Cell Physiol. 2009 Apr; 296(4):C672-81. View in: PubMed

Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem. 2009 Feb 27; 284(9):5774-83. View in: PubMed

Effect of aldosterone on BK channel expression in mammalian cortical collecting duct. Am J Physiol Renal Physiol. 2008 Sep; 295(3):F780-8. View in: PubMed

Role of NHERF1, cystic fibrosis transmembrane conductance regulator, and cAMP in the regulation of aquaporin 9. J Biol Chem. 2008 Feb 1; 283(5):2986-96. View in: PubMed

Role of NHERF1, cystic fibrosis transmembrane conductance regulator, and cAMP in the regulation of aquaporin 9. J Biol Chem. 2008 Feb 01; 283(5):2986-96. View in: PubMed

Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells. Am J Physiol Cell Physiol. 2008 Feb; 294(2):C488-94. View in: PubMed

Role of acid/base transporters in the male reproductive tract and potential consequences of their malfunction. Physiology (Bethesda). 2005 Dec; 20:417-28. View in: PubMed

Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra). Am J Physiol Renal Physiol. 2005 Jun; 288(6):F1103-12. View in: PubMed

Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling. J Biol Chem. 2005 Mar 04; 280(9):8452-63. View in: PubMed

Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling. J Biol Chem. 2005 Mar 4; 280(9):8452-63. View in: PubMed

Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells. Am J Physiol Renal Physiol. 2004 Sep; 287(3):F501-11. View in: PubMed

Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem. 2003 Dec 05; 278(49):49523-9. View in: PubMed

Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem. 2003 Dec 5; 278(49):49523-9. View in: PubMed

Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells. J Biol Chem. 2003 Jan 10; 278(2):1101-7. View in: PubMed

Modulation of the onset of postnatal development of H(+)-ATPase-rich cells by steroid hormones in rat epididymis. Biol Reprod. 2002 Oct; 67(4):1106-14. View in: PubMed

Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens. Biol Reprod. 2002 Jun; 66(6):1716-22. View in: PubMed

Aquaporin 9 expression along the male reproductive tract. Biol Reprod. 2001 Aug; 65(2):384-93. View in: PubMed

Metachromatic leukodystrophy among southern Alaskan Eskimos: molecular and genetic studies. J Inherit Metab Dis. 1995; 18(3):326-32. View in: PubMed

Metachromatic leukodystrophy in the Navajo Indian population: a splice site mutation in intron 4 of the arylsulfatase A gene. Hum Mutat. 1994; 4(3):199-207. View in: PubMed

Insulin-Like Growth Factor Binding Protein 7 and Tissue Inhibitor of Metalloproteinases-2: Differential Expression and Secretion in Human Kidney Tubule Cells. Am J Physiol Renal Physiol. 2016 Dec 21; ajprenal. 00271. 2016. View in: PubMed

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