Faculty

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D. Brent Polk, MD
Professor of Pediatrics
Pediatrics
CHL Mail Stop 71 Off Campus Los Angeles
+1 323 361 2278

Publications

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Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios. Gut. 2013 Jan; 62(1):73-82. View in: PubMed

Epidermal growth factor receptor inhibits colitis-associated cancer in mice. J Clin Invest. 2012 Aug 1; 122(8):2780-92. View in: PubMed

Epidermal growth factor receptor inhibits colitis-associated cancer in mice. J Clin Invest. 2012 Aug; 122(8):2780-92. View in: PubMed

Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. Am J Physiol Gastrointest Liver Physiol. 2012 Mar; 302(5):G504-14. View in: PubMed

Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. Am J Physiol Gastrointest Liver Physiol. 2012 Mar 01; 302(5):G504-14. View in: PubMed

ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival. Lab Invest. 2012 Mar; 92(3):437-50. View in: PubMed

Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios. Gut. 2012 Jan 20. View in: PubMed

Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. PLoS One. 2012; 7(5):e36418. View in: PubMed

Transactivation of EGFR by LPS induces COX-2 expression in enterocytes. PLoS One. 2012; 7(5):e38373. View in: PubMed

Characterization of a probiotic-derived soluble protein which reveals a mechanism of preventive and treatment effects of probiotics on intestinal inflammatory diseases. Gut Microbes. 2012 Jan-Feb; 3(1):25-8. View in: PubMed

Characterization of a probiotic-derived soluble protein which reveals a mechanism of preventive and treatment effects of probiotics on intestinal inflammatory diseases. Gut Microbes. 2012 Jan 1; 3(1):25-8. View in: PubMed

STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction. Inflamm Bowel Dis. 2011 Nov; 17(11):2224-34. View in: PubMed

Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology. 2011 Nov; 141(5):1696-708. e1-2. View in: PubMed

Probiotics and immune health. Curr Opin Gastroenterol. 2011 Oct; 27(6):496-501. View in: PubMed

Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2011 Oct; 301(4):G656-66. View in: PubMed

Alanyl-glutamine promotes intestinal epithelial cell homeostasis in vitro and in a murine model of weanling undernutrition. Am J Physiol Gastrointest Liver Physiol. 2011 Oct; 301(4):G612-22. View in: PubMed

Specific epidermal growth factor receptor autophosphorylation sites promote mouse colon epithelial cell chemotaxis and restitution. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G368-76. View in: PubMed

TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G220-9. View in: PubMed

TNF-a converting enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survival. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G338-46. View in: PubMed

Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J Clin Invest. 2011 Jun 1; 121(6):2242-53. View in: PubMed

Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J Clin Invest. 2011 Jun; 121(6):2242-53. View in: PubMed

KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1. Exp Cell Res. 2011 Feb 15; 317(4):452-63. View in: PubMed

Sprouty keeps bowel kinases regular in colon cancer, while miR-21 targets Sprouty. Cancer Biol Ther. 2011 Jan 1; 11(1):122-4. View in: PubMed

Sprouty keeps bowel kinases regular in colon cancer, while miR-21 targets Sprouty. Cancer Biol Ther. 2011 Jan 01; 11(1):122-4. View in: PubMed

KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-? production. KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-? production. Gastroenterology. 2011 Jan; 140(1):265-74. View in: PubMed

ErbB4 promotes cyclooxygenase-2 expression and cell survival in colon epithelial cells. Lab Invest. 2010 Oct; 90(10):1415-24. View in: PubMed

Disruption of NF-kappaB signalling by ancient microbial molecules: novel therapies of the future? Gut. Disruption of NF-kappaB signalling by ancient microbial molecules: novel therapies of the future? Gut. 2010 Apr; 59(4):421-6. View in: PubMed

Endoscopic ultrasound to guide the combined medical and surgical management of pediatric perianal Crohn's disease. Inflamm Bowel Dis. 2010 Mar; 16(3):461-8. View in: PubMed

Probiotics: progress toward novel therapies for intestinal diseases. Curr Opin Gastroenterol. 2010 Mar; 26(2):95-101. View in: PubMed

Functional analysis of the p40 and p75 proteins from Lactobacillus casei BL23. J Mol Microbiol Biotechnol. 2010; 19(4):231-41. View in: PubMed

Ontogeny of FOXP3(+) regulatory T cells in the postnatal human small intestinal and large intestinal lamina propria. Pediatr Dev Pathol. 2009 Nov-Dec; 12(6):443-9. View in: PubMed

Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology. 2009 Apr; 136(4):1297-1307, e1-3. View in: PubMed

Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling. J Infect Dis. 2009 Mar 1; 199(5):641-51. View in: PubMed

Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling. J Infect Dis. 2009 Mar 01; 199(5):641-51. View in: PubMed

Low levels of tumor necrosis factor alpha increase tumor growth by inducing an endothelial phenotype of monocytes recruited to the tumor site. Cancer Res. 2009 Jan 1; 69(1):338-48. View in: PubMed

Low levels of tumor necrosis factor alpha increase tumor growth by inducing an endothelial phenotype of monocytes recruited to the tumor site. Cancer Res. 2009 Jan 01; 69(1):338-48. View in: PubMed

The ErbB4 growth factor receptor is required for colon epithelial cell survival in the presence of TNF. Gastroenterology. 2009 Jan; 136(1):217-26. View in: PubMed

Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases. Inflamm Bowel Dis. 2008 Nov; 14(11):1585-96. View in: PubMed

TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB. J Biol Chem. 2008 Oct 24; 283(43):29485-94. View in: PubMed

Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11772-7. View in: PubMed

Tumor necrosis factor inhibits ligand-stimulated EGF receptor activation through a TNF receptor 1-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2008 Aug; 295(2):G285-93. View in: PubMed

Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB. Gastroenterology. 2008 Aug; 135(2):539-51. View in: PubMed

Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2008 Apr; 294(4):G1060-9. View in: PubMed

Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G276-85. View in: PubMed

Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol. 2007 May; 27(9):3313-26. View in: PubMed

Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology. 2007 Feb; 132(2):562-75. View in: PubMed

p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration. EMBO J. 2006 Dec 13; 25(24):5683-92. View in: PubMed

Cysteine-rich domains of muc3 intestinal mucin promote cell migration, inhibit apoptosis, and accelerate wound healing. Gastroenterology. 2006 Nov; 131(5):1501-17. View in: PubMed

Probiotics as functional food in the treatment of diarrhea. Curr Opin Clin Nutr Metab Care. 2006 Nov; 9(6):717-21. View in: PubMed

Bmp signaling is required for intestinal growth and morphogenesis. Dev Dyn. 2006 Jun; 235(6):1563-70. View in: PubMed

The role of decay-accelerating factor as a receptor for Helicobacter pylori and a mediator of gastric inflammation. J Biol Chem. 2006 May 12; 281(19):13317-23. View in: PubMed

Regulation of apoptosis during homeostasis and disease in the intestinal epithelium. Inflamm Bowel Dis. 2006 May; 12(5):413-24. View in: PubMed

NODing off and Ramping up. Inflamm Bowel Dis. 2005 Sep; 11(9):860-1. View in: PubMed

Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation. J Clin Invest. 2004 Nov; 114(9):1272-80. View in: PubMed

Commensal bacteria in the gut: learning who our friends are. Curr Opin Gastroenterol. 2004 Nov; 20(6):565-71. View in: PubMed

Epidermal growth factor-stimulated intestinal epithelial cell migration requires Src family kinase-dependent p38 MAPK signaling. J Biol Chem. 2004 Oct 22; 279(43):44513-21. View in: PubMed

Recurrent abdominal pain: symptom subtypes based on the Rome II Criteria for pediatric functional gastrointestinal disorders. J Pediatr Gastroenterol Nutr. 2004 Feb; 38(2):187-91. View in: PubMed

Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms. Am J Physiol Cell Physiol. 2003 Apr; 284(4):C953-61. View in: PubMed

Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. J Biol Chem. 2002 Dec 27; 277(52):50959-65. View in: PubMed

Histopathology of ulcerative colitis in initial rectal biopsy in children. Am J Surg Pathol. 2002 Nov; 26(11):1441-9. View in: PubMed

Research agenda for pediatric gastroenterology, hepatology and nutrition: developmental physiology and pathophysiology. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundation. J Pediatr Gastroenterol Nutr. 2002; 35 Suppl 3:S242-5. View in: PubMed

Kinase suppressor of Ras determines survival of intestinal epithelial cells exposed to tumor necrosis factor. Cancer Res. 2001 Dec 15; 61(24):8668-75. View in: PubMed

In vivo visualization of pyloric mucosal hypertrophy in infants with hypertrophic pyloric stenosis: is there an etiologic role? AJR Am J Roentgenol. In vivo visualization of pyloric mucosal hypertrophy in infants with hypertrophic pyloric stenosis: is there an etiologic role? AJR Am J Roentgenol. 2001 Oct; 177(4):843-8. View in: PubMed

Activation of peroxisome proliferator-activated receptor gamma suppresses nuclear factor kappa B-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells. J Biol Chem. 2001 Aug 17; 276(33):31059-66. View in: PubMed

Kinase suppressor of ras is necessary for tumor necrosis factor alpha activation of extracellular signal-regulated kinase/mitogen-activated protein kinase in intestinal epithelial cells. Cancer Res. 2001 Feb 01; 61(3):963-9. View in: PubMed

Kinase suppressor of ras is necessary for tumor necrosis factor alpha activation of extracellular signal-regulated kinase/mitogen-activated protein kinase in intestinal epithelial cells. Cancer Res. 2001 Feb 1; 61(3):963-9. View in: PubMed

Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells. J Biol Chem. 1999 Dec 17; 274(51):36631-6. View in: PubMed

Epidermal and hepatocyte growth factors stimulate chemotaxis in an intestinal epithelial cell line. Am J Physiol. 1999 Dec; 277(6 Pt 1):C1149-59. View in: PubMed

Conversion of TNF alpha from antiproliferative to proliferative ligand in mouse intestinal epithelial cells by regulating mitogen-activated protein kinase. Exp Cell Res. 1999 Jun 15; 249(2):349-58. View in: PubMed

Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor kappaB activation in mouse colonocytes. Gastroenterology. 1999 Mar; 116(3):602-9. View in: PubMed

Hypertrophied pyloric mucosa in patients with hypertrophic pyloric stenosis. Pediatr Radiol. 1998 Nov; 28(11):901. View in: PubMed

Epidermal growth factor receptor-stimulated intestinal epithelial cell migration requires phospholipase C activity. Gastroenterology. 1998 Mar; 114(3):493-502. View in: PubMed

Tumor necrosis factor alpha regulates proliferation in a mouse intestinal cell line. Gastroenterology. 1997 Apr; 112(4):1231-40. View in: PubMed

Recurrent necrotizing jejunitis in a child. J Pediatr. 1996 Feb; 128(2):246-9. View in: PubMed

Shc is a substrate of the rat intestinal epidermal growth factor receptor tyrosine kinase. Gastroenterology. 1995 Dec; 109(6):1845-51. View in: PubMed

Impaired human responses to tetanus toxoid in vitamin A-deficient SCID mice reconstituted with human peripheral blood lymphocytes. Infect Immun. 1995 Aug; 63(8):2867-72. View in: PubMed

The antral nipple sign of pyloric mucosal prolapse: endoscopic correlation of a new sonographic observation in patients with pyloric stenosis. J Ultrasound Med. 1995 Apr; 14(4):283-7. View in: PubMed

Cell density-dependent regulation of PLC gamma 1 tyrosine phosphorylation and catalytic activity in an intestinal cell line (IEC-6). J Cell Physiol. 1995 Mar; 162(3):427-33. View in: PubMed

Ontogenic regulation of phospholipase C-gamma 1 activity and expression in the rat small intestine. Gastroenterology. 1994 Jul; 107(1):109-16. View in: PubMed

Intestinal Na+/H+ exchanger activity is up-regulated by bowel resection in the weanling rat. Pediatr Res. 1993 Mar; 33(3):215-20. View in: PubMed

Improved growth and disease activity after intermittent administration of a defined formula diet in children with Crohn's disease. JPEN J Parenter Enteral Nutr. 1992 Nov-Dec; 16(6):499-504. View in: PubMed

Bacterial meningitis presenting with normal cerebrospinal fluid. Pediatr Infect Dis J. 1987 Nov; 6(11):1040-2. View in: PubMed

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