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Jacek K Pinski, MD, PhD

Associate Professor of Medicine

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Phone +1 323 865 3929
Email pinski@med.usc.edu
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Overview

After completing a fellowship at the Johns Hopkins Cancer Center in Baltimore, Dr. Pinski came to the Keck School of Medicine at USC as an Assistant Professor of Medicine. A former Research Assistant Professor at the Endocrine, Polypeptide and Cancer Institute at the Tulane University School of Medicine, Dr. Pinski is currently the Co-Director of the USC/Norris Comprehensive Cancer Center’s Prostate Cancer Research Center.

Dr. Pinski is also a member of the Rehabilitation Research and Development Section for the United States Department of Veteran Affairs. He has received funding for seven research studies and in 2006 was invited to lecture in Austraila at the 3rd Annual Pacific Rim Breast and Prostate Cancer Meeting. Dr. Pinski has had over 60 peer reviewed articles published and has given presentations all across the globe.

Awards

  • Stop Cancer Research Career Development Award, 2002
  • Wright Award, 2002
  • ACS/IRG Award, 2002
  • Whitney Award, 2002
  • GlaxoSmithKline: Fellowship Award, 2001
  • Johns Hopkins University: Fellowship Research Award, 2001
  • American Association for Cancer Research: Translational Research Award, 2001
  • Stop Cancer Award Special Seed Award, 2001

Publications

  • A phase I study of intravenous fenretinide (4-HPR) for patients with malignant solid tumors Cancer Chemother Pharmacol. 2021 04; 87(4):525-532. . View in PubMed
  • Phase 2 trial of monoamine oxidase inhibitor phenelzine in biochemical recurrent prostate cancer Prostate Cancer Prostatic Dis. 2021 03; 24(1):61-68. . View in PubMed
  • Baseline Circulating Tumor Cell Count as a Prognostic Marker of PSA Response and Disease Progression in Metastatic Castrate-Sensitive Prostate Cancer (SWOG S1216) Clin Cancer Res. 2021 04 01; 27(7):1967-1973. . View in PubMed
  • Expression of the luteinizing hormone receptor (LHR) in ovarian cancer BMC Cancer. 2019 Nov 15; 19(1):1114. . View in PubMed
  • Randomized Phase II Trial of Abiraterone Alone or With Dasatinib in Men With Metastatic Castration-resistant Prostate Cancer (mCRPC)Clin Genitourin Cancer. 2019 08; 17(4):241-247. e1. . View in PubMed
  • A Phase II Trial of the Aurora Kinase A Inhibitor Alisertib for Patients with Castration-resistant and Neuroendocrine Prostate Cancer: Efficacy and Biomarkers Clin Cancer Res. 2019 01 01; 25(1):43-51. . View in PubMed
  • Influence of the facility caseload on the subsequent survival of men with localized prostate cancer undergoing radical prostatectomy Cancer. 2019 11 01; 125(21):3853-3863. . View in PubMed
  • Frequencies and expression levels of programmed death ligand 1 (PD-L1) in circulating tumor RNA (ctRNA) in various cancer types Biochem Biophys Res Commun. 2018 06 07; 500(3):621-625. . View in PubMed
  • A Phase II Trial of AEZS-108 in Castration- and Taxane-Resistant Prostate Cancer Clin Genitourin Cancer. 2017 12; 15(6):742-749. . View in PubMed
  • Epidermal Growth Factor Receptor, Excision-Repair Cross-Complementation Group 1 Protein, and Thymidylate Synthase Expression in Penile CancerClin Genitourin Cancer. 2016 10; 14(5):450-456. e1. . View in PubMed
  • Novel Gene Expression Signature Predictive of Clinical Recurrence After Radical Prostatectomy in Early Stage Prostate Cancer Patients Prostate. 2016 10; 76(14):1239-56. . View in PubMed
  • Predictors of time to biochemical recurrence in a radical prostatectomy cohort within the PSA-era Can Urol Assoc J. 2016 Jan-Feb; 10(1-2):E17-22. . View in PubMed
  • Effects of luteinizing hormone receptor signaling in prostate cancer cells Prostate. 2015 Feb; 75(2):141-50. . View in PubMed
  • Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression PLoS One. 2015; 10(2):e0117758. . View in PubMed
  • Phase I, dose-escalation study of the targeted cytotoxic LHRH analog AEZS-108 in patients with castration- and taxane-resistant prostate cancer Clin Cancer Res. 2014 Dec 15; 20(24):6277-83. . View in PubMed
  • A Phase II trial of a combination herbal supplement for men with biochemically recurrent prostate cancer Prostate Cancer Prostatic Dis. 2014 Dec; 17(4):359-65. . View in PubMed
  • Differential effects of RUNX2 on the androgen receptor in prostate cancer: synergistic stimulation of a gene set exemplified by SNAI2 and subsequent invasiveness Cancer Res. 2014 May 15; 74(10):2857-68. . View in PubMed
  • Epidermal growth factor receptor-targeted therapy in squamous cell carcinoma of the penis: a report of 3 cases Urology. 2014 Jan; 83(1):159-65. . View in PubMed
  • Efficacy of oxaliplatin plus pemetrexed in chemotherapy pretreated metastatic castration-resistant prostate cancer Clin Genitourin Cancer. 2013 Dec; 11(4):416-22. . View in PubMed
  • Baseline 18F-FDG PET/CT parameters as imaging biomarkers of overall survival in castrate-resistant metastatic prostate cancer J Nucl Med. 2013 Aug; 54(8):1195-201. . View in PubMed
  • LHRH and LHR genotypes and prostate cancer incidence and survival Int J Mol Epidemiol Genet. 2013; 4(4):228-34. . View in PubMed
  • Prospective evaluation of 18F-NaF and 18F-FDG PET/CT in detection of occult metastatic disease in biochemical recurrence of prostate cancer Clin Nucl Med. 2012 Jul; 37(7):637-43. . View in PubMed
  • AEZS-108 : a targeted cytotoxic analog of LHRH for the treatment of cancers positive for LHRH receptors Expert Opin Investig Drugs. 2012 Jun; 21(6):891-9. . View in PubMed
  • Immune response to sipuleucel-T in prostate cancer Cancers (Basel). 2012 Apr 18; 4(2):420-41. . View in PubMed
  • Ethnic differences in neuroendocrine expression in prostate cancer tissue Anticancer Res. 2011 Nov; 31(11):3897-901. . View in PubMed
  • Vaccine therapy with sipuleucel-T (Provenge) for prostate cancer Maturitas. 2011 Aug; 69(4):296-303. . View in PubMed
  • Effect of luteinizing hormone on the steroidogenic pathway in prostate cancer Prostate. 2011 Jun 01; 71(8):892-8. . View in PubMed
  • Luteinizing hormone-releasing hormone receptor targeted agents for prostate cancer Expert Opin Investig Drugs. 2011 Jun; 20(6):769-78. . View in PubMed
  • Advanced prostate cancer: new agents, new questions Oncology (Williston Park). 2011 May; 25(6):509512. . View in PubMed
  • Phase I clinical trial of pegylated liposomal Doxorubicin and docetaxel in patients with advanced solid tumors Am J Clin Oncol. 2011 Feb; 34(1):27-31. . View in PubMed
  • Use of analogs of peptide hormones conjugated to cytotoxic radicals for chemotherapy targeted to receptors on tumors Curr Drug Deliv. 2011 Jan; 8(1):11-25. . View in PubMed
  • The relationship between proangiogenic gene expression levels in prostate cancer and their prognostic value for clinical outcomes Prostate. 2010 Nov 01; 70(15):1692-700. . View in PubMed
  • Expression of receptors for luteinizing hormone-releasing hormone (LH-RH) in prostate cancers following therapy with LH-RH agonists Clin Cancer Res. 2010 Sep 15; 16(18):4675-80. . View in PubMed
  • The disintegrin contortrostatin in combination with docetaxel is a potent inhibitor of prostate cancer in vitro and in vivo Prostate. 2010 Sep 01; 70(12):1359-70. . View in PubMed
  • Clinical and correlative results of SWOG S0354: a phase II trial of CNTO328 (siltuximab), a monoclonal antibody against interleukin-6, in chemotherapy-pretreated patients with castration-resistant prostate cancer Clin Cancer Res. 2010 Jun 01; 16(11):3028-34. . View in PubMed
  • Oral fenretinide in biochemically recurrent prostate cancer: a California cancer consortium phase II trial Clin Genitourin Cancer. 2009 Jan; 7(1):43-50. . View in PubMed
  • Gene profiling and pathway analysis of neuroendocrine transdifferentiated prostate cancer cells Prostate. 2009 Jan 01; 69(1):12-23. . View in PubMed
  • A phase II study of high-dose calcitriol combined with mitoxantrone and prednisone for androgen-independent prostate cancer BJU Int. 2008 Dec; 102(11):1601-6. . View in PubMed
  • Both beta-actin and GAPDH are useful reference genes for normalization of quantitative RT-PCR in human FFPE tissue samples of prostate cancer Prostate. 2008 Oct 01; 68(14):1555-60. . View in PubMed
  • Prognostic value of the androgen receptor and its coactivators in patients with D1 prostate cancer Anticancer Res. 2008 Jan-Feb; 28(1B):425-30. . View in PubMed
  • Diet and prostate cancer risk reduction Expert Rev Anticancer Ther. 2008 Jan; 8(1):43-50. . View in PubMed
  • The AKT inhibitor perifosine in biochemically recurrent prostate cancer: a phase II California/Pittsburgh cancer consortium trial Clin Genitourin Cancer. 2007 Dec; 5(7):433-7. . View in PubMed
  • Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival Hum Pathol. 2007 Oct; 38(10):1547-52. . View in PubMed
  • Evolving treatment paradigms for locally advanced and metastatic prostate cancer Expert Rev Anticancer Ther. 2006 Nov; 6(11):1639-51. . View in PubMed
  • Locus-wide chromatin remodeling and enhanced androgen receptor-mediated transcription in recurrent prostate tumor cells Mol Cell Biol. 2006 Oct; 26(19):7331-41. . View in PubMed
  • Genistein-induced neuroendocrine differentiation of prostate cancer cells Prostate. 2006 Aug 01; 66(11):1136-43. . View in PubMed
  • Prognostic significance of neuroendocrine expression in lymph node-positive prostate cancer Urology. 2006 Jun; 67(6):1247-52. . View in PubMed
  • Postchemotherapy residual masses in advanced seminoma: current management and outcomes Expert Rev Anticancer Ther. 2005 Oct; 5(5):869-74. . View in PubMed
  • Discovery and preclinical evaluation of a novel class of small-molecule compounds in hormone-dependent and -independent cancer cell lines Mol Cancer Ther. 2005 Jul; 4(7):1105-13. . View in PubMed
  • EphB4 expression and biological significance in prostate cancer Cancer Res. 2005 Jun 01; 65(11):4623-32. . View in PubMed
  • Ethnic differences in neuroendocrine cell expression in normal human prostatic tissue Urology. 2005 May; 65(5):1008-12. . View in PubMed
  • Glucose metabolism of human prostate cancer mouse xenografts Mol Imaging. 2005 Apr-Jun; 4(2):91-7. . View in PubMed
  • Prostate cancer metastases to bone: pathophysiology, pain management, and the promise of targeted therapy Eur J Cancer. 2005 Apr; 41(6):932-40. . View in PubMed
  • Prognosis of patients with lymph node positive prostate cancer following radical prostatectomy: long-term results J Urol. 2004 Dec; 172(6 Pt 1):2252-5. . View in PubMed
  • Inhibitory effect of IL-6-induced neuroendocrine cells on prostate cancer cell proliferation Prostate. 2004 Nov 01; 61(3):253-9. . View in PubMed
  • Interleukin-6 inhibits the growth of prostate cancer xenografts in mice by the process of neuroendocrine differentiation Int J Cancer. 2004 Sep 10; 111(4):508-13. . View in PubMed
  • A new screening system for proliferation-independent anti-cancer agents Cancer Lett. 2004 Jul 08; 210(1):119-24. . View in PubMed
  • Diagnostic role of [F-18]-FDG positron emission tomography in restaging renal cell carcinoma Clin Nephrol. 2003 Dec; 60(6):395-400. . View in PubMed
  • FDG PET in suspected recurrent and metastatic prostate cancer Oncol Rep. 2003 Sep-Oct; 10(5):1485-8. . View in PubMed
  • Trk receptor inhibition induces apoptosis of proliferating but not quiescent human osteoblasts Cancer Res. 2002 Feb 15; 62(4):986-9. . View in PubMed
  • Inhibition of the growth of Caki-I human renal adenocarcinoma in vivo by luteinizing hormone-releasing hormone antagonist Cetrorelix, somatostatin analog RC-160, and bombesin antagonist RC-3940-II Cancer. 1998 Mar 01; 82(5):909-17. . View in PubMed
  • Luteinizing hormone-releasing hormone antagonist Cetrorelix (SB-75) and bombesin antagonist RC-3940-II inhibit the growth of androgen-independent PC-3 prostate cancer in nude mice Prostate. 1997 Aug 01; 32(3):164-72. . View in PubMed
  • Inhibition of growth of androgen-independent DU-145 prostate cancer in vivo by luteinising hormone-releasing hormone antagonist Cetrorelix and bombesin antagonists RC-3940-II and RC-3950-II Eur J Cancer. 1997 Jun; 33(7):1141-8. . View in PubMed
  • Growth hormone-releasing hormone antagonist MZ-4-71 inhibits in vivo proliferation of Caki-I renal adenocarcinoma Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5810-3. . View in PubMed
  • Regression of rat Dunning R-3327-H prostate carcinoma by treatment with targeted cytotoxic analog of luteinizing hormone-releasing hormone AN-207 containing 2-pyrrolinodoxorubicin Int J Oncol. 1997 May; 10(5):877-84. . View in PubMed
  • Inhibition of in vivo proliferation of androgen-independent prostate cancers by an antagonist of growth hormone-releasing hormone Br J Cancer. 1997; 75(11):1585-92. . View in PubMed
  • Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH) Int J Oncol. 1996 Dec; 9(6):1099-105. . View in PubMed
  • Effect of chronic administration of a new potent agonist of GH-RH(1-29)NH2 on linear growth and GH responsiveness in rats Regul Pept. 1996 Sep 16; 65(3):197-201. . View in PubMed
  • Chronic administration of the luteinizing hormone-releasing hormone (LHRH) antagonist cetrorelix decreases gonadotrope responsiveness and pituitary LHRH receptor messenger ribonucleic acid levels in rats Endocrinology. 1996 Aug; 137(8):3430-6. . View in PubMed
  • Down-regulation of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) in rats by LH-RH antagonist Cetrorelix Proc Natl Acad Sci U S A. 1996 Mar 19; 93(6):2398-402. . View in PubMed
  • Somatostatin analog RC-160 inhibits the growth of human osteosarcomas in nude mice Int J Cancer. 1996 Mar 15; 65(6):870-4. . View in PubMed
  • Inhibition of growth of human osteosarcomas by antagonists of growth hormone-releasing hormone J Natl Cancer Inst. 1995 Dec 06; 87(23):1787-94. . View in PubMed
  • Terminology for luteinizing hormone-releasing hormone antagonists Fertil Steril. 1995 Jul; 64(1):226. . View in PubMed
  • Synthesis and biological evaluation of superactive agonists of growth hormone-releasing hormone Proc Natl Acad Sci U S A. 1995 May 23; 92(11):4872-6. . View in PubMed
  • Evaluation of the in vitro and in vivo activity of the L-, D,L- and D-Cit6 forms of the LH-RH antagonist Cetrorelix (SB-75) Int J Pept Protein Res. 1995 May; 45(5):410-7. . View in PubMed
  • Synthesis and biological activities of highly potent antagonists of growth hormone-releasing hormone Proc Natl Acad Sci U S A. 1994 Dec 06; 91(25):12298-302. . View in PubMed
  • Somatostatin analogues and bombesin/gastrin-releasing peptide antagonist RC-3095 inhibit the growth of human glioblastomas in vitro and in vivo Cancer Res. 1994 Nov 15; 54(22):5895-901. . View in PubMed
  • Effects of somatostatin analogue RC-160 and bombesin/gastrin-releasing peptide antagonists on the growth of human small-cell and non-small-cell lung carcinomas in nude mice Br J Cancer. 1994 Nov; 70(5):886-92. . View in PubMed
  • Treatment with luteinizing-hormone-releasing hormone antagonist sb-75 decreases levels of epidermal growth-factor receptor and its messenger-RNA in ov-1063 human epithelial ovarian-cancer xenografts in nude-mice Int J Oncol. 1994 Nov; 5(5):1031-5. . View in PubMed
  • Inhibitory effects of analogs of luteinizing hormone-releasing hormone on the growth of the androgen-independent Dunning R-3327-AT-1 rat prostate cancer Int J Cancer. 1994 Oct 01; 59(1):51-5. . View in PubMed
  • Characterization of bombesin/gastrin-releasing peptide receptors in membranes of MKN45 human gastric cancer Cancer Lett. 1994 Sep 30; 85(1):111-8. . View in PubMed
  • Inhibition of growth of OV-1063 human epithelial ovarian cancer xenografts in nude mice by treatment with luteinizing hormone-releasing hormone antagonist SB-75 Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7090-4. . View in PubMed
  • Inhibition of growth of MKN45 human gastric-carcinoma xenografts in nude mice by treatment with bombesin/gastrin-releasing-peptide antagonist (RC-3095) and somatostatin analogue RC-160 Int J Cancer. 1994 May 15; 57(4):574-80. . View in PubMed
  • Inhibition of human epithelial ovarian cancer cell growth in vitro by agonistic and antagonistic analogues of luteinizing hormone-releasing hormone Proc Natl Acad Sci U S A. 1994 Mar 01; 91(5):1701-5. . View in PubMed
  • Inhibitory effect of bombesin/gastrin-releasing peptide antagonist RC-3095 and luteinizing hormone-releasing hormone antagonist SB-75 on the growth of MCF-7 MIII human breast cancer xenografts in athymic nude mice Cancer. 1994 Feb 15; 73(4):1229-38. . View in PubMed
  • Inhibitory effects of somatostatin analogue RC-160 and bombesin/gastrin-releasing peptide antagonist RC-3095 on the growth of the androgen-independent Dunning R-3327-AT-1 rat prostate cancer Cancer Res. 1994 Jan 01; 54(1):169-74. . View in PubMed
  • Somatostatin receptor expression in lung cancer Eur J Cancer. 1994; 30A(11):1682-7. . View in PubMed
  • Inhibitory effect of bombesin/gastrin-releasing peptide (GRP) antagonists RC-3950-II and RC-3095 on MCF-7 MIII human breast cancer xenografts in nude mice Biomed Pharmacother. 1994; 48(10):465-72. . View in PubMed
  • Effect of somatostatin analog RC-160 and bombesin/gastrin releasing peptide antagonist RC-3095 on growth of PC-3 human prostate-cancer xenografts in nude mice Int J Cancer. 1993 Dec 02; 55(6):963-7. . View in PubMed
  • Antagonists of bombesin/gastrin-releasing peptides as adjuncts to agonists of luteinizing hormone-releasing hormone in the treatment of experimental prostate cancer Cancer. 1993 Dec 01; 72(11):3263-70. . View in PubMed
  • Inhibition of growth of the human malignant glioma cell line (U87MG) by the steroid hormone antagonist RU486 J Clin Endocrinol Metab. 1993 Nov; 77(5):1388-92. . View in PubMed
  • Somatostatin analog RC-160 and bombesin/gastrin-releasing peptide antagonist RC-3095 inhibit the growth of androgen-independent DU-145 human prostate cancer line in nude mice Cancer Lett. 1993 Jul 30; 71(1-3):189-96. . View in PubMed
  • Recovery of pituitary-gonadal function in male rats after long-term suppression induced by a single injection of microcapsules of LH-RH antagonist cetrorelix (SB-75) J Androl. 1993 May-Jun; 14(3):164-9. . View in PubMed
  • Comparison of GH-stimulation by GH-RH(1-29)NH2 and an agmatine29 GH-RH analog, after intravenous, subcutaneous and intranasal administration and after pulmonary inhalation in rats Int J Pept Protein Res. 1993 Mar; 41(3):246-9. . View in PubMed
  • Development of a radioimmunoassay for some agonists of growth hormone-releasing hormone Int J Pept Protein Res. 1993 Feb; 41(2):162-8. . View in PubMed
  • Evaluation of biological activities of new LH-RH antagonists (T-series) in male and female rats Int J Pept Protein Res. 1993 Jan; 41(1):66-73. . View in PubMed
  • Inhibition of growth of experimental prostate cancer in rats by LH-RH analogs linked to cytotoxic radicals Prostate. 1993; 23(2):165-78. . View in PubMed
  • Inhibitory effects of the new bombesin receptor antagonist RC-3095 on the luteinizing hormone release in rats Neuroendocrinology. 1992 Dec; 56(6):831-7. . View in PubMed
  • Short-chain analogs of luteinizing hormone-releasing hormone containing cytotoxic moieties Proc Natl Acad Sci U S A. 1992 Nov 01; 89(21):10203-7. . View in PubMed
  • High potency of a new bombesin antagonist (RC-3095) in inhibiting serum gastrin levels; comparison of different routes of administration Regul Pept. 1992 Oct 13; 41(3):185-93. . View in PubMed
  • Endocrine effects of new bombesin/gastrin-releasing peptide antagonists in rats Am J Physiol. 1992 Oct; 263(4 Pt 1):E712-7. . View in PubMed
  • Comparison of biological effects of a sustained delivery system and nonencapsulated LH-RH antagonist SB-75 in rats Peptides. 1992 Sep-Oct; 13(5):905-11. . View in PubMed
  • Stimulation by bombesin and inhibition by bombesin/gastrin-releasing peptide antagonist RC-3095 of growth of human breast cancer cell lines Cancer Res. 1992 Aug 15; 52(16):4545-7. . View in PubMed
  • Biological activity and receptor binding characteristics to various human tumors of acetylated somatostatin analogs Proc Soc Exp Biol Med. 1992 May; 200(1):49-56. . View in PubMed
  • Pseudononapeptide bombesin antagonists containing C-terminal Trp or Tpi Peptides. 1992 Mar-Apr; 13(2):267-71. . View in PubMed
  • Blockade of the LH response induced by the agonist D-Trp-6-LHRH in rats by a highly potent LH-RH antagonist SB-75 Prostate. 1992; 20(3):213-24. . View in PubMed
  • Inhibition of growth of MCF-7 MIII human breast carcinoma in nude mice by treatment with agonists or antagonists of LH-RH Breast Cancer Res Treat. 1992; 21(1):35-45. . View in PubMed
  • Effect of microcapsules of luteinizing hormone-releasing hormone antagonist SB-75 and somatostatin analog RC-160 on endocrine status and tumor growth in the Dunning R-3327H rat prostate cancer model Prostate. 1992; 20(4):297-310. . View in PubMed
  • Biological effects and receptor binding affinities of new pseudononapeptide bombesin/GRP receptor antagonists with N-terminal D-Trp or D-Tpi Int J Pept Protein Res. 1991 Dec; 38(6):593-600. . View in PubMed

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