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Heinz-Josef Lenz, MD

Professor of Medicine

J. Terrence Lanni Chair in Gastrointestinal Cancer Research

Co-Director, USC Center for Molecular Pathway and Drug Discovery

Co-Director of the USC Norris Center for Cancer Drug Development

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Phone +1 323 865 3967
Email lenz@usc.edu
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Overview

Heinz-Josef Lenz, M.D., FACP, is the Associate Director for Clinical Research and Co-Leader of the Gastrointestinal Cancers Program at the USC Norris Comprehensive Cancer Center. Dr. Lenz is Professor of Medicine and Preventive Medicine, Section Head of GI Oncology in the Division of Medical Oncology and Co-Director of the Colorectal Center at the Keck School of Medicine of the University of Southern California.

Dr. Lenz received his medical degree from Johannes-Gutenberg Universität in Mainz, Germany, in 1985. He completed a residency in Hematology and Oncology at the University Hospital Tübingen in Germany, a clerkship in Oncology at George Washington University in Washington, DC, and a clerkship in Hematology at Beth Israel Hospital of Harvard Medical School in Boston, Massachusetts. He served subsequent fellowships in Biochemistry and Molecular Biology at the USC Norris Comprehensive Cancer Center.

An active researcher, Dr. Lenz focuses on topics including the regulation of gene expression involved in drug resistance, patients at high risk of developing colorectal cancer, and determination of carcinogenesis, methods of early detection, and better surveillance of these cancers. He is a member of several professional societies, including the American Association for Cancer Research, the American Gastroenterology Association, and the National Society of Genetic Counselors. He also serves on the National Advisory Board of a number of professional organizations. Dr. Lenz is the author of numerous peer-reviewed publications and invited papers, reviews, and editorials. He also serves as Co-Chair of the GI Committee and Correlative Science Committee for SWOG. He is a member of the NCI Task Force for Gastroesophageal Cancer, the NCI Steering Committee and the NCI Translational Science Committee. In addition to having an NCI-funded laboratory, he was a recipient of the ASCO Young Investigator Award, the ASCO Career Development Award, and the STOP Cancer Career Development Award. He received in 2021 the USC Mentoring Award as well as highly cited researchers in the world. He has been select as influential leader by the LA Business Journal in 2021 and 2023.

As Deputy Cancer Center Director for Research Programs and Co-Director for the Center for Cancer Drug Development, Dr. Lenz oversees the programmatic and clinical activities of the Gastrointestinal Cancers, Genitourinary Cancers, Women’s Cancers, and Leukemia and Lymphoma Programs.

Awards

  • USC: USC Mentoring Award for Postdoctoral Fellows, 2021
  • Western Society of Clinical Investigation: Outstanding Investigator Award, 2016
  • The WunderGlo Foundation: 1st Annual Cancer Warrior Award, 2012
  • 2003 Annual Retreat on Cancer Research: The Gallo Award, 2003
  • USC: Bob Chandler Courage Award, 2003
  • Conquer Cancer Foundation: ASCO Career Development Award, 1995-1998
  • Conquer Cancer Foundation: ASCO Young Investigator Award, 1994

Publications

  • Modified FOLFOX6 plus bevacizumab with and without nivolumab for first-line treatment of metastatic colorectal cancer: phase 2 results from the CheckMate 9X8 randomized clinical trial J Immunother Cancer. 2024 Mar 13; 12(3). . View in PubMed
  • HER2 Gene Expression Levels Are Predictive and Prognostic in Patients With Metastatic Colorectal Cancer Enrolled in CALGB/SWOG 80405 J Clin Oncol. 2024 Mar 08; JCO2301507. . View in PubMed
  • Evidence for a causal link between intra-pancreatic fat deposition and pancreatic cancer: A prospective cohort and Mendelian randomization study Cell Rep Med. 2024 Feb 20; 5(2):101391. . View in PubMed
  • Differential responses to immune checkpoint inhibitors are governed by diverse mismatch repair gene alterations Clin Cancer Res. 2024 Feb 13. . View in PubMed
  • Predictive value of CDC37 gene expression for targeted therapy in metastatic colorectal cancer Eur J Cancer. 2024 Feb 10; 201:113914. . View in PubMed
  • A phase II study of guadecitabine combined with irinotecan vs regorafenib or TAS-102 in irinotecan-refractory metastatic colorectal cancer patients Int J Cancer. 2024 Feb 05. . View in PubMed
  • DNA Mutational Profiling in Patients With Colorectal Cancer Treated With Standard of Care Reveals Differences in Outcome and Racial Distribution of Mutations J Clin Oncol. 2024 Feb 01; 42(4):399-409. . View in PubMed
  • Onvansertib in Combination with FOLFIRI and Bevacizumab in Second-line Treatment of KRAS-mutant Metastatic Colorectal Cancer: A Phase 1b Clinical Study Clin Cancer Res. 2024 Jan 17. . View in PubMed
  • A Randomized Phase III Study of Arfolitixorin versus Leucovorin with 5-Fluorouracil, Oxaliplatin, and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer: The AGENT Trial Cancer Res Commun. 2024 Jan 04; 4(1):28-37. . View in PubMed
  • A revised nomenclature for the lemur family of protein kinases Commun Biol. 2024 01 08; 7(1):57. . View in PubMed
  • CCR5 and CCL5 gene expression in colorectal cancer: comprehensive profiling and clinical value J Immunother Cancer. 2024 01 11; 12(1). . View in PubMed
  • Sexual dysfunction among early-onset colorectal cancer survivors: Sex-specific correlates of sexual health discussions between patients and providers Cancer Causes Control. 2024 Jan; 35(1):111-120. . View in PubMed
  • Mesothelin expression correlates with elevated inhibitory immune activity in patients with colorectal cancer Res Sq. 2023 Dec 28. . View in PubMed
  • The role of total neoadjuvant therapy in locally advanced rectal cancer: a survey of specialists attending the All-Ireland Colorectal Cancer Conference 2022 including lead investigators of OPRA, PRODIGE-23 and RAPIDO Ir J Med Sci. 2023 Dec 23. . View in PubMed
  • Gene signatures derived from transcriptomic-causal networks stratified colorectal cancer patients for effective targeted therapy Res Sq. 2023 Dec 15. . View in PubMed
  • Non-canonical MLL1 activity regulates centromeric phase separation and genome stability Nat Cell Biol. 2023 Nov; 25(11):1637-1649. . View in PubMed
  • Corrigendum to “Evaluating sex as a predictive marker for response to bevacizumab in metastatic colorectal carcinoma: Pooled analysis of 3369 patients in the ARCAD database” Eur J Cancer2023 Jan;178:162-170. Eur J Cancer. 2023 Nov; 194:113339. . View in PubMed
  • Integration of Patient-Derived Organoids and Organ-on-Chip Systems: Investigating Colorectal Cancer Invasion within the Mechanical and GABAergic Tumor Microenvironment bioRxiv. 2023 Sep 17. . View in PubMed
  • Reduced Tumor Size of Untreated Papillary Thyroid Carcinoma After Immune Checkpoint Inhibitor-Induced Thyroiditis AACE Clin Case Rep. 2023 Sep-Oct; 9(5):162-165. . View in PubMed
  • PBRM1 mutations might render a subtype of biliary tract cancers sensitive to drugs targeting the DNA damage repair system NPJ Precis Oncol. 2023 Jul 03; 7(1):64. . View in PubMed
  • The influence of frailty on perioperative outcomes in patients undergoing surgical resection of liver metastases: a nationwide readmissions database study Ann Gastroenterol. 2023 May-Jun; 36(3):333-339. . View in PubMed
  • Genetic Evidence Causally Linking Pancreas Fat to Pancreatic Cancer: A Mendelian Randomization Study medRxiv. 2023 Apr 26. . View in PubMed
  • Peritoneal metastases from primary appendiceal and colorectal carcinomas demonstrate distinct molecular identities on comprehensive tumor analysis J Surg Oncol. 2023 Apr; 127(5):815-822. . View in PubMed
  • Impact of genetic variants involved in the lipid metabolism pathway on progression free survival in patients receiving bevacizumab-based chemotherapy in metastatic colorectal cancer: a retrospective analysis of FIRE-3 and MAVERICC trials EClinicalMedicine. 2023 Mar; 57:101827. . View in PubMed
  • Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries Nat Genet. 2023 Mar; 55(3):519-520. . View in PubMed
  • Patient Care Satisfaction and Emergency Room Utilization among Young Adult Colorectal Cancer Survivors during the SARS-CoV-2 Pandemic: Lessons Learned J Clin Med. 2023 Jan 06; 12(2). . View in PubMed
  • Disparities among Black and Hispanic colorectal cancer patients: Findings from the California Cancer Registry Cancer Med. 2023 11; 12(22):20976-20988. . View in PubMed
  • Transcriptional Profiling and Consensus Molecular Subtype Assignment to Understand Response and Resistance to Anti-Epidermal Growth Factor Receptor Therapy in Colorectal Cancer JCO Precis Oncol. 2023 07; 7:e2200422. . View in PubMed
  • Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-label, phase 2 study Lancet Oncol. 2023 05; 24(5):496-508. . View in PubMed
  • Mutational analysis of microsatellite-stable gastrointestinal cancer with high tumour mutational burden: a retrospective cohort study Lancet Oncol. 2023 02; 24(2):151-161. . View in PubMed
  • Breast cancer and neurotransmitters: emerging insights on mechanisms and therapeutic directions Oncogene. 2023 02; 42(9):627-637. . View in PubMed
  • Evaluating sex as a predictive marker for response to bevacizumab in metastatic colorectal carcinoma: Pooled analysis of 3,369 patients in the ARCAD database Eur J Cancer. 2023 01; 178:162-170. . View in PubMed
  • Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries Nat Genet. 2023 01; 55(1):89-99. . View in PubMed
  • Dietary fat in relation to all-cause mortality and cancer progression and death among people with metastatic colorectal cancer: Data from CALGB 80405 (Alliance)/SWOG 80405 Int J Cancer. 2023 01 15; 152(2):123-136. . View in PubMed
  • Priorities to Promote Participant Engagement in the Participant Engagement and Cancer Genome Sequencing (PE-CGS) Network Cancer Epidemiol Biomarkers Prev. 2023 04 03; 32(4):487-495. . View in PubMed
  • Phosphorylation and stabilization of EZH2 by DCAF1/VprBP trigger aberrant gene silencing in colon cancer Nat Commun. 2023 04 17; 14(1):2140. . View in PubMed
  • Acquired Genomic Alterations on First-Line Chemotherapy With Cetuximab in Advanced Colorectal Cancer: Circulating Tumor DNA Analysis of the CALGB/SWOG-80405 Trial (Alliance) J Clin Oncol. 2023 01 20; 41(3):472-478. . View in PubMed
  • Bintrafusp Alfa: A Bifunctional Fusion Protein Targeting PD-L1 and TGF-ß, in Patients with Pretreated Colorectal Cancer: Results from a Phase I Trial Oncologist. 2023 02 08; 28(2):e124-e127. . View in PubMed
  • Circadian regulator BMAL1::CLOCK promotes cell proliferation in hepatocellular carcinoma by controlling apoptosis and cell cycle Proc Natl Acad Sci U S A. 2023 01 10; 120(2):e2214829120. . View in PubMed
  • Prevalence of ARID1A Mutations in Cell-Free Circulating Tumor DNA in a Cohort of 71,301 Patients and Association with Driver Co-Alterations Cancers (Basel). 2022 Sep 01; 14(17). . View in PubMed
  • Nivolumab plus low-dose ipilimumab in previously treated patients with microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer: 4-year follow-up from CheckMate 142 Ann Oncol. 2022 10; 33(10):1052-1060. . View in PubMed
  • Neurotransmitter signaling: a new frontier in colorectal cancer biology and treatment Oncogene. 2022 10; 41(43):4769-4778. . View in PubMed
  • Germline Polymorphisms in Genes Involved in the Antioxidant System Predict the Efficacy of Cetuximab in Metastatic Colorectal Cancer Patients Enrolled in FIRE-3 Trial Clin Colorectal Cancer. 2022 09; 21(3):259-266. . View in PubMed
  • Genetic variants involved in the cGAS-STING pathway predict outcome in patients with metastatic colorectal cancer: Data from FIRE-3 and TRIBE trials Eur J Cancer. 2022 09; 172:22-30. . View in PubMed
  • Benefit from upfront FOLFOXIRI and bevacizumab in BRAFV600E-mutated metastatic colorectal cancer patients: does primary tumour location matter? Br J Cancer. 2022 09; 127(5):957-967.. View in PubMed
  • Dynamic changes in RAS gene status in circulating tumour DNA: a phase II trial of first-line FOLFOXIRI plus bevacizumab for RAS-mutant metastatic colorectal cancer (JACCRO CC-11) ESMO Open. 2022 06; 7(3):100512. . View in PubMed
  • Molecular profiling of signet-ring-cell carcinoma (SRCC) from the stomach and colon reveals potential new therapeutic targets Oncogene. 2022 06; 41(26):3455-3460. . View in PubMed
  • Age and comorbidity association with survival outcomes in metastatic colorectal cancer: CALGB 80405 analysis J Geriatr Oncol. 2022 05; 13(4):469-479. . View in PubMed
  • Impacts of the SARS-CoV-2 Pandemic on Young Adult Colorectal Cancer Survivors J Adolesc Young Adult Oncol. 2022 04; 11(2):229-233. . View in PubMed
  • Prognostic utility of self-reported sarcopenia (SARC-F) in the Multiethnic Cohort J Cachexia Sarcopenia Muscle. 2022 04; 13(2):987-1002. . View in PubMed
  • Efficacy of anti-epidermal growth factor receptor agents in patients with RAS wild-type metastatic colorectal cancer = 70 years Eur J Cancer. 2022 03; 163:1-15. . View in PubMed
  • Molecular characteristics and clinical outcomes of patients with Neurofibromin 1-altered metastatic colorectal cancer Oncogene. 2022 01; 41(2):260-267. . View in PubMed
  • Association of Homologous Recombination-DNA Damage Response Gene Mutations with Immune Biomarkers in Gastroesophageal Cancers Mol Cancer Ther. 2022 01; 21(1):227-236. . View in PubMed
  • Germline polymorphisms in genes maintaining the replication fork predict the efficacy of oxaliplatin and irinotecan in patients with metastatic colorectal cancer Br J Cancer. 2022 01; 126(1):72-78. . View in PubMed
  • Tumor Immunogenomic Features Determine Outcomes in Patients with Metastatic Colorectal Cancer Treated with Standard-of-Care Combinations of Bevacizumab and Cetuximab Clin Cancer Res. 2022 04 14; 28(8):1690-1700. . View in PubMed
  • Assessment of Capecitabine and Bevacizumab With or Without Atezolizumab for the Treatment of Refractory Metastatic Colorectal Cancer: A Randomized Clinical Trial JAMA Netw Open. 2022 02 01; 5(2):e2149040. . View in PubMed
  • Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates CXCR4 mRNA Expression Levels to Potential Clinical Targets Clin Cancer Res. 2022 11 14; 28(22):4957-4967. . View in PubMed
  • DNMT and EZH2 inhibitors synergize to activate therapeutic targets in hepatocellular carcinoma Cancer Lett. 2022 11 01; 548:215899. . View in PubMed
  • ARID1A mutations confer intrinsic and acquired resistance to cetuximab treatment in colorectal cancer Nat Commun. 2022 09 19; 13(1):5478. . View in PubMed
  • Fertility Preservation Discussions Between Young Adult Rectal Cancer Survivors and Their Providers: Sex-Specific Prevalence and Correlates Oncologist. 2022 07 05; 27(7):579-586. . View in PubMed
  • Eliciting anti-cancer immunity by genetically engineered multifunctional exosomes Mol Ther. 2022 09 07; 30(9):3066-3077. . View in PubMed
  • Reprogramming CBX8-PRC1 function with a positive allosteric modulatorCell Chem Biol. 2022 04 21; 29(4):555-571. e11. . View in PubMed
  • Homologous Recombination Deficiency Alterations in Colorectal Cancer: Clinical, Molecular, and Prognostic Implications J Natl Cancer Inst. 2022 02 07; 114(2):271-279. . View in PubMed
  • Genome-wide association studies of survival in 1520 cancer patients treated with bevacizumab-containing regimens Int J Cancer. 2022 01 15; 150(2):279-289. . View in PubMed
  • fdrci: FDR confidence interval selection and adjustment for large-scale hypothesis testing Bioinform Adv. 2022; 2(1):vbac047. . View in PubMed
  • Survival in Young-Onset Metastatic Colorectal Cancer: Findings From Cancer and Leukemia Group B (Alliance)/SWOG 80405 J Natl Cancer Inst. 2022 03 08; 114(3):427-435. . View in PubMed
  • Plasma Protein Biomarkers in Advanced or Metastatic Colorectal Cancer Patients Receiving Chemotherapy With Bevacizumab or Cetuximab: Results from CALGB 80405 (Alliance) Clin Cancer Res. 2022 07 01; 28(13):2779-2788. . View in PubMed
  • First-Line Nivolumab Plus Low-Dose Ipilimumab for Microsatellite Instability-High/Mismatch Repair-Deficient Metastatic Colorectal Cancer: The Phase II CheckMate 142 Study J Clin Oncol. 2022 01 10; 40(2):161-170. . View in PubMed
  • Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer Clin Cancer Res. 2022 05 02; 28(9):1863-1870. . View in PubMed
  • Evaluating the impact of age on immune checkpoint therapy biomarkers Cell Rep. 2021 Nov 16; 37(7):110033. . View in PubMed
  • Molecular differences between lymph nodes and distant metastases compared with primaries in colorectal cancer patients NPJ Precis Oncol. 2021 Oct 27; 5(1):95. . View in PubMed
  • Molecular characterization of squamous cell carcinoma of the anal canal J Gastrointest Oncol. 2021 Oct; 12(5):2423-2437. . View in PubMed
  • Clinical Significance of Circulating Tumor Cell Induced Epithelial-Mesenchymal Transition in Patients with Metastatic Colorectal Cancer by Single-Cell RNA-Sequencing Cancers (Basel). 2021 Sep 28; 13(19). . View in PubMed
  • Time from Diagnosis and Correlates of Health-Related Quality of Life among Young Adult Colorectal Cancer Survivors Cancers (Basel). 2021 Aug 11; 13(16). . View in PubMed
  • Human colorectal cancer-on-chip model to study the microenvironmental influence on early metastatic spread iScience. 2021 May 21; 24(5):102509. . View in PubMed
  • Correction to: KSR1 regulates BRCA1 degradation and inhibits breast cancer growth Oncogene. 2021 May; 40(19):3473. . View in PubMed
  • Potential Molecular Cross Talk Among CCR5 Pathway Predicts Regorafenib Responsiveness in Metastatic Colorectal Cancer Patients Cancer Genomics Proteomics. 2021 May-Jun; 18(3):317-324. . View in PubMed
  • Human-specific polymorphic pseudogenization of SIGLEC12 protects against advanced cancer progression FASEB Bioadv. 2021 Feb; 3(2):69-82. . View in PubMed
  • VprBP directs epigenetic gene silencing through histone H2A phosphorylation in colon cancer Mol Oncol. 2021 10; 15(10):2801-2817. . View in PubMed
  • Tumour mutational burden, microsatellite instability, and actionable alterations in metastatic colorectal cancer: Next-generation sequencing results of TRIBE2 study Eur J Cancer. 2021 09; 155:73-84. . View in PubMed
  • Large-scale analysis of KMT2 mutations defines a distinctive molecular subset with treatment implication in gastric cancer Oncogene. 2021 07; 40(30):4894-4905. . View in PubMed
  • Preemptive Versus Reactive Topical Clobetasol for Regorafenib-Induced Hand-Foot Reactions: A Preplanned Analysis of the ReDOS Trial Oncologist. 2021 07; 26(7):610-618. . View in PubMed
  • Distinct genomic landscapes of gastroesophageal adenocarcinoma depending on PD-L1 expression identify mutations in RAS-MAPK pathway and TP53 as potential predictors of immunotherapy efficacy Ann Oncol. 2021 07; 32(7):906-916. . View in PubMed
  • Clinical significance of enterocyte-specific gene polymorphisms as candidate markers of oxaliplatin-based treatment for metastatic colorectal cancer Pharmacogenomics J. 2021 06; 21(3):285-295. . View in PubMed
  • Novel Genomic Differences in Cell-Free Circulating DNA Profiles of Young- Versus Older-Onset Colorectal Cancer J Adolesc Young Adult Oncol. 2021 06; 10(3):336-341. . View in PubMed
  • Phase II study of the histone deacetylase inhibitor vorinostat (Suberoylanilide Hydroxamic Acid; SAHA) in recurrent or metastatic transitional cell carcinoma of the urothelium – an NCI-CTEP sponsored: California Cancer Consortium trial, NCI 6879 Invest New Drugs. 2021 06; 39(3):812-820. . View in PubMed
  • RNA-Binding Protein Polymorphisms as Novel Biomarkers to Predict Outcomes of Metastatic Colorectal Cancer: A Meta-analysis from TRIBE, FIRE-3, and MAVERICC Mol Cancer Ther. 2021 06; 20(6):1153-1160. . View in PubMed
  • Germ line polymorphisms of genes involved in pluripotency transcription factors predict efficacy of cetuximab in metastatic colorectal cancer Eur J Cancer. 2021 06; 150:133-142. . View in PubMed
  • Clocking cancer: the circadian clock as a target in cancer therapy Oncogene. 2021 05; 40(18):3187-3200. . View in PubMed
  • A phase I study of intravenous fenretinide (4-HPR) for patients with malignant solid tumors Cancer Chemother Pharmacol. 2021 04; 87(4):525-532. . View in PubMed
  • Association of Consensus Molecular Subtypes and Molecular Markers With Clinical Outcomes in Patients With Metastatic Colorectal Cancer: Biomarker Analyses From LUME-Colon 1Clin Colorectal Cancer. 2021 03; 20(1):84-95. e8. . View in PubMed
  • Extended RAS Analysis of the Phase III EPIC Trial: Irinotecan + Cetuximab Versus Irinotecan as Second-Line Treatment for Patients with Metastatic Colorectal Cancer Oncologist. 2021 02; 26(2):e261-e269. . View in PubMed
  • IGF-Binding Proteins, Adiponectin, and Survival in Metastatic Colorectal Cancer: Results From CALGB (Alliance)/SWOG 80405 JNCI Cancer Spectr. 2021 02; 5(1). . View in PubMed
  • Role of enterocyte-specific gene polymorphisms in response to adjuvant treatment for stage III colorectal cancer Pharmacogenet Genomics. 2021 01; 31(1):10-16. . View in PubMed
  • Racial differences in survival and response to therapy in patients with metastatic colorectal cancer: A secondary analysis of CALGB/SWOG 80405 (Alliance A151931) Cancer. 2021 10 15; 127(20):3801-3808. . View in PubMed
  • Random survival forests identify pathways with polymorphisms predictive of survival in KRAS mutant and KRAS wild-type metastatic colorectal cancer patients Sci Rep. 2021 06 09; 11(1):12191. . View in PubMed
  • Clinical Validation of a Machine-learning-derived Signature Predictive of Outcomes from First-line Oxaliplatin-based Chemotherapy in Advanced Colorectal Cancer Clin Cancer Res. 2021 02 15; 27(4):1174-1183. . View in PubMed
  • Randomized Trial of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF-Mutant Metastatic Colorectal Cancer (SWOG S1406) J Clin Oncol. 2021 02 01; 39(4):285-294. . View in PubMed
  • Genomic Analysis of Germline Variation Associated with Survival of Patients with Colorectal Cancer Treated with Chemotherapy Plus Biologics in CALGB/SWOG 80405 (Alliance) Clin Cancer Res. 2021 01 01; 27(1):267-275. . View in PubMed
  • Microsatellite Stable Colorectal Liver Metastases-Understanding the Mechanisms of Immune Resistance JAMA Netw Open. 2021 08 02; 4(8):e2119025. . View in PubMed
  • Prognostic and Predictive Impact of Primary Tumor Sidedness for Previously Untreated Advanced Colorectal Cancer J Natl Cancer Inst. 2021 11 29; 113(12):1705-1713. . View in PubMed
  • The Emergence of Baricitinib: A Story of Tortoises Versus Hares Clin Infect Dis. 2021 04 08; 72(7):1251-1252. . View in PubMed
  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 Autophagy. 2021 Jan; 17(1):1-382. . View in PubMed
  • Imaging-Based Machine Learning Analysis of Patient-Derived Tumor Organoid Drug Response Front Oncol. 2021; 11:771173. . View in PubMed
  • Phase I Assessment of Safety and Therapeutic Activity of BAY1436032 in Patients with IDH1-Mutant Solid Tumors Clin Cancer Res. 2021 05 15; 27(10):2723-2733. . View in PubMed
  • The Landscape of Alterations in DNA Damage Response Pathways in Colorectal Cancer Clin Cancer Res. 2021 06 01; 27(11):3234-3242. . View in PubMed
  • BRAF V600E Mutation in First-Line Metastatic Colorectal Cancer: An Analysis of Individual Patient Data From the ARCAD Database J Natl Cancer Inst. 2021 10 01; 113(10):1386-1395. . View in PubMed
  • Site-specific antibody-drug conjugates with variable drug-to-antibody-ratios for AML therapy J Control Release. 2021 08 10; 336:433-442. . View in PubMed
  • Expression of Immuno-Oncologic Biomarkers Is Enriched in Colorectal Cancers and Other Solid Tumors Harboring the A59T Variant of KRAS Cells. 2021 05 21; 10(6). . View in PubMed
  • Evaluating the impact of age on immune checkpoint therapy biomarkers Cell Rep. 2021 08 24; 36(8):109599. . View in PubMed
  • Pan-cancer analysis of RNA expression of ANGIOTENSIN-I-CONVERTING ENZYME 2 reveals high variability and possible impact on COVID-19 clinical outcomes Sci Rep. 2021 03 11; 11(1):5639. . View in PubMed
  • Association of Coffee Intake With Survival in Patients With Advanced or Metastatic Colorectal Cancer JAMA Oncol. 2020 Nov 01; 6(11):1713-1721. . View in PubMed
  • Polymorphisms within Immune Regulatory Pathways Predict Cetuximab Efficacy and Survival in Metastatic Colorectal Cancer Patients Cancers (Basel). 2020 Oct 13; 12(10). . View in PubMed
  • A prospective study to validate the functional assessment of cancer therapy (FACT) for epidermal growth factor receptor inhibitor (EGFRI)-induced dermatologic toxicities FACT-EGFRI 18 questionnaire: SWOG S1013 J Patient Rep Outcomes. 2020 Jul 08; 4(1):54. . View in PubMed
  • Single Nucleotide Polymorphisms in MiRNA Binding Sites of Nucleotide Excision Repair-Related Genes Predict Clinical Benefit of Oxaliplatin in FOLFOXIRI Plus Bevacizumab: Analysis of the TRIBE Trial Cancers (Basel). 2020 Jun 30; 12(7). . View in PubMed
  • Comprehensive tumor profiling reveals unique molecular differences between peritoneal metastases and primary colorectal adenocarcinoma J Surg Oncol. 2020 Jun; 121(8):1320-1328. . View in PubMed
  • Body Mass Index and Weight Loss in Metastatic Colorectal Cancer in CALGB (Alliance)/SWOG 80405 JNCI Cancer Spectr. 2020 Jun; 4(3):pkaa024. . View in PubMed
  • Anti-EGFR Therapy Induces EGF Secretion by Cancer-Associated Fibroblasts to Confer Colorectal Cancer Chemoresistance Cancers (Basel). 2020 May 28; 12(6). . View in PubMed
  • WRN-Mutated Colorectal Cancer Is Characterized by a Distinct Genetic Phenotype Cancers (Basel). 2020 May 22; 12(5). . View in PubMed
  • How we treat left-sided vs right-sided colon cancer Clin Adv Hematol Oncol. 2020 May; 18(5):253-257. . View in PubMed
  • Diabetes and Clinical Outcome in Patients With Metastatic Colorectal Cancer: CALGB 80405 (Alliance) JNCI Cancer Spectr. 2020 Feb; 4(1):pkz078. . View in PubMed
  • Epidermal growth factor receptor mRNA expression: A potential molecular escape mechanism from regorafenib Cancer Sci. 2020 Feb; 111(2):441-450. . View in PubMed
  • Phase II Trial of Neoadjuvant Bevacizumab with Modified FOLFOX7 in Patients with Stage II and III Rectal Cancer Oncologist. 2020 12; 25(12):e1879-e1885. . View in PubMed
  • All You Need to Know About DPYD Genetic Testing for Patients Treated With Fluorouracil and Capecitabine: A Practitioner-Friendly Guide JCO Oncol Pract. 2020 12; 16(12):793-798. . View in PubMed
  • ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper Nat Rev Clin Oncol. 2020 12; 17(12):757-770. . View in PubMed
  • Molecular Characterization of Appendiceal Goblet Cell Carcinoid Mol Cancer Ther. 2020 12; 19(12):2634-2640. . View in PubMed
  • The impact of ARID1A mutation on molecular characteristics in colorectal cancer Eur J Cancer. 2020 11; 140:119-129. . View in PubMed
  • Molecular characteristics of BRCA1/2 and PALB2 mutations in pancreatic ductal adenocarcinoma ESMO Open. 2020 11; 5(6):e000942. . View in PubMed
  • Risk of Persistent Opioid Use following Major Surgery in Matched Samples of Patients with and without Cancer Cancer Epidemiol Biomarkers Prev. 2020 11; 29(11):2126-2133. . View in PubMed
  • The structure-function relationship of oncogenic LMTK3 Sci Adv. 2020 11; 6(46). . View in PubMed
  • Immunogenic cell death pathway polymorphisms for predicting oxaliplatin efficacy in metastatic colorectal cancer J Immunother Cancer. 2020 11; 8(2). . View in PubMed
  • Reply to the letter to the editor ‘Neutropenia in metastatic colorectal cancer receiving trifluridine/tipiracil’ by Colloca et al Ann Oncol. 2020 08; 31(8):1085-1087. . View in PubMed
  • Molecular profile of BRCA-mutated biliary tract cancers ESMO Open. 2020 06; 5(3):e000682. . View in PubMed
  • A phase 1b dose escalation study of Wnt pathway inhibitor vantictumab in combination with nab-paclitaxel and gemcitabine in patients with previously untreated metastatic pancreatic cancer Invest New Drugs. 2020 06; 38(3):821-830. . View in PubMed
  • Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases Sci Adv. 2020 06; 6(23):eaba6752. . View in PubMed
  • Shanghai international consensus on diagnosis and comprehensive treatment of colorectal liver metastases (version 2019) Eur J Surg Oncol. 2020 06; 46(6):955-966. . View in PubMed
  • Molecular Analyses of Left- and Right-Sided Tumors in Adolescents and Young Adults with Colorectal Cancer Oncologist. 2020 05; 25(5):404-413. . View in PubMed
  • Immune phenotype and histopathological growth pattern in patients with colorectal liver metastases Br J Cancer. 2020 05; 122(10):1518-1524. . View in PubMed
  • Overcoming resistance to anti-PD1 and anti-PD-L1 treatment in gastrointestinal malignancies J Immunother Cancer. 2020 05; 8(1). . View in PubMed
  • A polymorphism within the R-spondin 2 gene predicts outcome in metastatic colorectal cancer patients treated with FOLFIRI/bevacizumab: data from FIRE-3 and TRIBE trials Eur J Cancer. 2020 05; 131:89-97. . View in PubMed
  • Cumulative Burden of Colorectal Cancer-Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset CancerGastroenterology. 2020 04; 158(5):1274-1286. e12. . View in PubMed
  • Neutropenia and survival outcomes in metastatic colorectal cancer patients treated with trifluridine/tipiracil in the RECOURSE and J003 trials Ann Oncol. 2020 01; 31(1):88-95. . View in PubMed
  • Relationship between MLH1, PMS2, MSH2 and MSH6 gene-specific alterations and tumor mutational burden in 1057 microsatellite instability-high solid tumors Int J Cancer. 2020 11 15; 147(10):2948-2956. . View in PubMed
  • Comprehensive Genomic Profiling of Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs) Clin Cancer Res. 2020 11 15; 26(22):5943-5951. . View in PubMed
  • Association of Diet Quality With Survival Among People With Metastatic Colorectal Cancer in the Cancer and Leukemia B and Southwest Oncology Group 80405 Trial JAMA Netw Open. 2020 10 01; 3(10):e2023500. . View in PubMed
  • Phase Ib Study of Wnt Inhibitor Ipafricept with Gemcitabine and nab-paclitaxel in Patients with Previously Untreated Stage IV Pancreatic Cancer Clin Cancer Res. 2020 10 15; 26(20):5348-5357. . View in PubMed
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