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Natasha Lepore, PhD
Assistant Professor of Research Radiology
CHL Mail Stop 81 Off Campus Los Angeles
+1 310 909 3296


My current work involves the development of numerical tools for the analysis of brain structural and diffusion magnetic resonance imaging data. In particular, these include improvements to tensor-based morphometry, surface and volume registration, segmentation and statistics for group comparisons. I also work on applying these methods to different types of brain imaging data including prematurity, healthy brain development, healthy twins, blindness, deafness, HIV/AIDS, autism and Alzheimer's disease. I am currently an assistant professor in Radiology at the University of Southern California and at Children's Hospital Los Angeles. I graduated with a Bsc in physics and mathematics from the University of Montreal and then obtained a masters in applied mathematics from Cambridge University, in general relativity. My PhD is in theoretical physics (Harvard University), and deals with quantum chaos in quantum billiards living on the plane and the pseudosphere. Afterward, I switched to neuroimaging and became a postdoctoral fellow at the Laboratory of Neuro Imaging, working with Dr Paul Thompson.


Lepore N, Cashin M, Bartley D, Ardelean DS. Atypical monoarthritis presentation in children with oligoarticular juvenile idiopathic arthritis: a case series. Pediatr Rheumatol Online J. 2017 Jan 13; 15(1):2. View in: PubMed

Lao Y, Kang Y, Collignon O, Brun C, Kheibai SB, Alary F, Gee J, Nelson MD, Lepore F, Lepore N. A study of brain white matter plasticity in early blinds using tract-based spatial statistics and tract statistical analysis. Neuroreport. 2015 Dec 16; 26(18):1151-4. View in: PubMed

Poonai N, Li J, Langford C, Lepore N, Taddio A, Gerges S, Stitt L, Teefy J, Manji K, Castelo M, Rieder M, Qui T, Matsui D, Ali S. Intraurethral Lidocaine for Urethral Catheterization in Children: A Randomized Controlled Trial. Pediatrics. 2015 Oct; 136(4):e879-86. View in: PubMed

Gajawelli N, Deoni S, Dirks H, Dean D, O'Muircheartaigh J, Sawardekar S, Ezis A. Characterization of the central sulcus in the brain in early childhood. Conf Proc IEEE Eng Med Biol Soc. 2015 Aug; 2015:149-52. View in: PubMed

Yepes-Calderon F, Velasquez A, Lepore N, Beuf O. Magnetic resonance image enhancement by reducing receptors' effective size and enabling multiple channel acquisition. Conf Proc IEEE Eng Med Biol Soc. 2014 Aug; 2014:2420-3. View in: PubMed

Tsao S, Gajawelli N, Hwang DH, Kriger S, Law M, Chui H, Weiner M, Lepore N. Mapping of ApoE4 Related White Matter Damage using Diffusion MRI. Proc SPIE Int Soc Opt Eng. 2014 Apr 9; 9039:90390H. View in: PubMed

Tsao S, Ma SJ, Michels PA, Gajawelli N, Law M, Chui H, Lepore N. The Power of Hybrid/Fusion Imaging Metrics in Future PACS Systems: A Case Study into the White Matter Hyperintensity Prenumbra using FLAIR and Diffusion MR. Proc SPIE Int Soc Opt Eng. 2014 Apr 9; 9039:90390I. View in: PubMed

Tsao S, Gajawelli N, Zhou J, Shi J, Ye J, Wang Y, Lepore N. Evaluating the Predictive Power of Multivariate Tensor-based Morphometry in Alzheimers Disease Progression via Convex Fused Sparse Group Lasso. Proc SPIE Int Soc Opt Eng. 2014 Mar 21; 9034:90342L. View in: PubMed

Gajawelli N, Lao Y, Apuzzo ML, Romano R, Liu C, Tsao S, Hwang D, Wilkins B, Lepore N, Law M. Neuroimaging Changes in the Brain in Contact versus Noncontact Sport Athletes Using Diffusion Tensor Imaging. World Neurosurg. 2013 Dec; 80(6):824-8. View in: PubMed

Panigrahy A, Wisnowski JL, Furtado A, Lepore N, Paquette L, Bluml S. Neuroimaging biomarkers of preterm brain injury: toward developing the preterm connectome. Pediatr Radiol. 2012 Jan; 42 Suppl 1:33-61. View in: PubMed

Henry LC, Tremblay J, Tremblay S, Lee A, Brun C, Lepore N, Theoret H, Ellemberg D, Lassonde M. Acute and chronic changes in diffusivity measures after sports concussion. J Neurotrauma. 2011 Oct; 28(10):2049-59. View in: PubMed

Brun CC, Lepore N, Pennec X, Chou YY, Lee AD, de Zubicaray G, McMahon KL, Wright MJ, Gee JC, Thompson PM. A nonconservative Lagrangian framework for statistical fluid registration-SAFIRA. IEEE Trans Med Imaging. 2011 Feb; 30(2):184-202. View in: PubMed

Luders E, Toga AW, Lepore N, Gaser C. The underlying anatomical correlates of long-term meditation: larger hippocampal and frontal volumes of gray matter. Neuroimage. 2009 Apr 15; 45(3):672-8. View in: PubMed

Hua X, Leow AD, Lee S, Klunder AD, Toga AW, Lepore N, Chou YY, Brun C, Chiang MC, Barysheva M, Jack CR, Bernstein MA, Britson PJ, Ward CP, Whitwell JL, Borowski B, Fleisher AS, Fox NC, Boyes RG, Barnes J, Harvey D, Kornak J, Schuff N, Boreta L, Alexander GE, Weiner MW, Thompson PM. 3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry. Neuroimage. 2008 May 15; 41(1):19-34. View in: PubMed

Lepore N, Brun CA, Chiang MC, Chou YY, Dutton RA, Hayashi KM, Lopez OL, Aizenstein HJ, Toga AW, Becker JT, Thompson PM. Multivariate statistics of the Jacobian matrices in tensor based morphometry and their application to HIV/AIDS. Med Image Comput Comput Assist Interv. 2006; 9(Pt 1):191-8. View in: PubMed

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