Faculty

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Afsaneh Barzi, MD
Assistant Professor of Clinical Medicine
Medical Director
Medicine
NOR 3440 Health Sciences Campus Los Angeles
+1 323 865 3829

Overview

Barzi earned her M.D. from Tehran University of Medical Sciences, then went on to earn a Master’s in Health Informatics and a Doctorate in Public Health Management and Policy Sciences from the University of Texas Health Science Center in Houston. She recently completed a fellowship in hematology and oncology at the Cleveland Clinic’s Taussig Cancer Center.

Her research interests are the development of new cancer therapies as well as healthcare economics and metrics of healthcare quality for improving patient care. Dr. Barzi has proposed a phase II study to investigate the overall survival benefit of adding lapatinib to docetaxel in a second line setting in patients with trastuzumab-resistant, HER2-positive gastric cancer.

“Delivery of personalized treatment to gastric cancer patients has lagged behind other diseases,” Barzi says. “My goal is to establish a second-line treatment for these patients that are HER2-positive and to better understand the mechanisms of resistance to HER2-targeted therapy, paving the way for new therapies that can overcome that resistance.”

Awards

National Cancer Institute: Travel Award for Markers in Cancer, 2013

Southwest Oncology Group: Young Investigator Award, 2011

Publications

Access to high-volume surgeons and the opportunity cost of performing radical prostatectomy by low-volume providers. Urol Oncol. 2017 Jul; 35(7):459. e15-459. e24. View in: PubMed

DNA mismatch repair deficiency and hereditary syndromes in Latino patients with colorectal cancer. Cancer. 2017 Oct 01; 123(19):3732-3743. View in: PubMed

Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of KRAS Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers. Clin Cancer Res. 2017 Jul 15; 23(14):3657-3666. View in: PubMed

Single nucleotide polymorphisms in the IGF-IRS pathway are associated with outcome in mCRC patients enrolled in the FIRE-3 trial. Int J Cancer. 2017 Jul 15; 141(2):383-392. View in: PubMed

Tandem repeat variation near the HIC1 (hypermethylated in cancer 1) promoter predicts outcome of oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. Cancer. 2017 Jul 14. View in: PubMed

. View in: PubMed

Colorectal cancer statistics, 2017. CA Cancer J Clin. 2017 May 06; 67(3):177-193. View in: PubMed

Comparative effectiveness of screening strategies for colorectal cancer. Cancer. 2017 May 01; 123(9):1516-1527. View in: PubMed

Single nucleotide polymorphisms in the IGF-IRS pathway are associated with outcome in mCRC patients enrolled in the FIRE-3 trial. Int J Cancer. 2017 Apr 01. View in: PubMed

Stomach Cancer Disparity among Korean Americans by Tumor Characteristics: Comparison with Non-Hispanic Whites, Japanese Americans, South Koreans, and Japanese. Cancer Epidemiol Biomarkers Prev. 2017 Apr; 26(4):587-596. View in: PubMed

Access to high-volume surgeons and the opportunity cost of performing radical prostatectomy by low-volume providers. Urol Oncol. 2017 Mar 08. View in: PubMed

Comparative effectiveness of screening strategies for colorectal cancer. Cancer. 2017 Jan 24. View in: PubMed

Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of KRAS Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers. Clin Cancer Res. 2017 Jan 17. View in: PubMed

Genetic variants of DNA repair-related genes predict efficacy of TAS-102 in patients with refractory metastatic colorectal cancer. Ann Oncol. 2017 05 01; 28(5):1015-1022. View in: PubMed

Stomach cancer disparity among Korean Americans by tumor characteristics: comparison with non-Hispanic whites, Japanese Americans, South Koreans, and Japanese. Cancer Epidemiol Biomarkers Prev. 2016 Dec 01. View in: PubMed

Metastatic Colorectal Cancer in Hispanics: Treatment Outcomes in a Treated Population. Clin Colorectal Cancer. 2016 Dec; 15(4):e221-e227. View in: PubMed

Metastatic Colorectal Cancer in Hispanics: Treatment Outcomes if a Treated Popudation. Clin Colgrectal Cancer. 2016 Dec; 15(4):e221-e227. View in: PubMed

A genetic variant in Rassf1a predicts outcome in mCRC patients treated with cetuximab plus chemotherapy: results from FIRE-3 and JACCRO 05 and 06 trials. Pharmacogenomics J. 2016 Oct 04. View in: PubMed

Impact of sex, age, and ethnicity/race on the survival of patients with rectal cancer in the United States from 1988 to 2012. Oncotarget. 2016 Aug 16; 7(33):53668-53678. View in: PubMed

Impact of sex, age, and ethnicity/race on the survival of patients with rectal cancer in the United States from 1988 to 2012. Oncotarget. 2016 Jul 19. View in: PubMed

Prostatectomy at high-volume centers improves outcomes and lowers the costs of care for prostate cancer. Prostate Cancer Prostatic Dis. 2016 Mar; 19(1):84-91. View in: PubMed

Lost in Translation: The Patient-Physician Relationship in the Molecular Era. J Palliat Med. 2015 Nov; 18(11):987-8. View in: PubMed

Cytokeratin-20 and Survivin-Expressing Circulating Tumor Cells Predict Survival in Metastatic Colorectal Cancer Patients by a Combined Immunomagnetic qRT-PCR Approach. Mol Cancer Ther. 2015 Oct; 14(10):2401-8. View in: PubMed

We Don't Know What We Don't Know About Adolescent and Young Adult Patients with Familial Adenomatous Polyposis-Related Colorectal Cancer. J Adolesc Young Adult Oncol. 2015 Sep; 4(3):105-7. View in: PubMed

We Don't Know What We Don't Know About Adolescent and Young Adult Patients with Familial Adenomatous Polyposis-Related Colorectal Cancer. J Adolesc Young Adult Oncol. 2015 Sep 1; 4(3):105-7. View in: PubMed

Variations in genes involved in dormancy associated with outcome in patients with resected colorectal liver metastases. Ann Oncol. 2015 Aug; 26(8):1728-33. View in: PubMed

Pharmacodynamic separation of gemcitabine and erlotinib in locally advanced or metastatic pancreatic cancer: therapeutic and biomarker results. Int J Clin Oncol. 2015 Jun; 20(3):518-24. View in: PubMed

Comparative effectiveness of screening strategies for Lynch syndrome. J Natl Cancer Inst. 2015 Apr; 107(4). View in: PubMed

Cost-effectiveness of genomic testing for colorectal cancer: are we there yet? Oncology (Williston Park). Cost-effectiveness of genomic testing for colorectal cancer: are we there yet? Oncology (Williston Park). 2015 Mar; 29(3):183-4; 186. View in: PubMed

Cost-effectiveness of genomic testing for colorectal cancer: are we there yet? Oncology (Williston Park). Cost-effectiveness of genomic testing for colorectal cancer: are we there yet? Oncology (Williston Park). 2015 Mar; 29(3). View in: PubMed

Association of variants in genes encoding for macrophage-related functions with clinical outcome in patients with locoregional gastric cancer. Ann Oncol. 2015 Feb; 26(2):332-9. View in: PubMed

Prognostic impact of the c-MET polymorphism on the clinical outcome in locoregional gastric cancer patients. Pharmacogenet Genomics. 2014 Dec; 24(12):588-96. View in: PubMed

Single nucleotide polymorphisms in AREG and EREG are prognostic biomarkers in locally advanced gastric cancer patients after surgery with curative intent. Pharmacogenet Genomics. 2014 Nov; 24(11):539-47. View in: PubMed

Angiogenesis in esophageal and gastric cancer: a paradigm shift in treatment. Expert Opin Biol Ther. 2014 Sep; 14(9):1319-32. View in: PubMed

Timeliness of adjuvant chemotherapy for stage III adenocarcinoma of the colon: a measure of quality of care. Clin Colorectal Cancer. 2013 Dec; 12(4):275-9. View in: PubMed

Molecular pathways: Estrogen pathway in colorectal cancer. Clin Cancer Res. 2013 Nov 01; 19(21):5842-8. View in: PubMed

Molecular pathways: estrogen pathway in colorectal cancer. Clin Cancer Res. 2013 Nov 1; 19(21):5842-8. View in: PubMed

Prognostic role of lemur tyrosine kinase-3 germline polymorphisms in adjuvant gastric cancer in Japan and the United States. Mol Cancer Ther. 2013 Oct; 12(10):2261-72. View in: PubMed

Angiogenesis-related agents in esophageal cancer. Expert Opin Biol Ther. 2012 Oct; 12(10):1335-45. View in: PubMed

Screening for Lynch syndrome in the general population-letter. Cancer Prev Res (Phila). 2011 Mar; 4(3):471; author reply 472. View in: PubMed

Myelodysplastic syndromes: a practical approach to diagnosis and treatment. Cleve Clin J Med. 2010 Jan; 77(1):37-44. View in: PubMed

A Bayesian model for triage decision support. Int J Med Inform. 2006 May; 75(5):403-11. View in: PubMed

Ontology Driven Construction of a Knowledgebase for Bayesian Decision Models Based on UMLS. Stud Health Technol Inform. 2005; 116:223-8. View in: PubMed

Self-administered decision support tool for triage: results of a retrospective study. Stud Health Technol Inform. 2002; 85:45-51. View in: PubMed

Combination chemotherapy with 5-fluorouracil and methyl-CCNU for the treatment of advanced gastrointestinal cancer. Tumori. 1979 Jun 30; 65(3):339-44. View in: PubMed

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