Faculty

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Ahmad Besaratinia, PhD
Associate Professor of Research Preventive Medicine
Preventive Medicine
NRT 1509A 1450 Biggy Street Health Sciences Campus Los Angeles
+1 323 442 0088

Publications

Tommasi S, Zheng A, Besaratinia A. Expression of epigenetic modifiers is not significantly altered by exposure to secondhand smoke. Lung Cancer. 2015 Dec; 90(3):598-603. View in: PubMed

Tommasi S, Zheng A, Besaratinia A. Exposure of mice to secondhand smoke elicits both transient and long-lasting transcriptional changes in cancer-related functional networks. Int J Cancer. 2015 May 15; 136(10):2253-63. View in: PubMed

Besaratinia A, Tommasi S. The lingering question of menthol in cigarettes. Cancer Causes Control. 2015 Feb; 26(2):165-9. View in: PubMed

Besaratinia A, Tommasi S. Epigenetics of human melanoma: promises and challenges. J Mol Cell Biol. 2014 Oct; 6(5):356-67. View in: PubMed

Besaratinia A, Tommasi S. Electronic cigarettes: The road ahead. Prev Med. 2014 Sep; 66:65-7. View in: PubMed

Tommasi S, Zheng A, Yoon JI, Besaratinia A. Epigenetic targeting of the Nanog pathway and signaling networks during chemical carcinogenesis. Carcinogenesis. 2014 Aug; 35(8):1726-36. View in: PubMed

Besaratinia A, Cockburn M, Tommasi S. Alterations of DNA methylome in human bladder cancer. Epigenetics. 2013 Oct 1; 8(10):1013-22. View in: PubMed

Besaratinia A, Tommasi S. Genotoxicity of tobacco smoke-derived aromatic amines and bladder cancer: current state of knowledge and future research directions. FASEB J. 2013 Jun; 27(6):2090-100. View in: PubMed

Tommasi S, Zheng A, Weninger A, Bates SE, Li XA, Wu X, Hollstein M, Besaratinia A. Mammalian cells acquire epigenetic hallmarks of human cancer during immortalization. Nucleic Acids Res. 2013 Jan 7; 41(1):182-95. View in: PubMed

Tommasi S, Zheng A, Yoon JI, Li AX, Wu X, Besaratinia A. Whole DNA methylome profiling in mice exposed to secondhand smoke. Epigenetics. 2012 Nov; 7(11):1302-14. View in: PubMed

Besaratinia A, Li H, Yoon JI, Zheng A, Gao H, Tommasi S. A high-throughput next-generation sequencing-based method for detecting the mutational fingerprint of carcinogens. Nucleic Acids Res. 2012 Aug; 40(15):e116. View in: PubMed

Kim SI, Yoon JI, Tommasi S, Besaratinia A. New experimental data linking secondhand smoke exposure to lung cancer in nonsmokers. FASEB J. 2012 May; 26(5):1845-54. View in: PubMed

Lereau M, Gouas D, Villar S, Besaratinia A, Hautefeuille A, Berthillon P, Martel-Planche G, Nogueira da Costa A, Ortiz-Cuaran S, Hantz O, Pfeifer GP, Hainaut P, Chemin I. Interactions between hepatitis B virus and aflatoxin B(1): effects on p53 induction in HepaRG cells. J Gen Virol. 2012 Mar; 93(Pt 3):640-50. View in: PubMed

Yoon JI, Kim SI, Tommasi S, Besaratinia A. Organ specificity of the bladder carcinogen 4-aminobiphenyl in inducing DNA damage and mutation in mice. Cancer Prev Res (Phila). 2012 Feb; 5(2):299-308. View in: PubMed

Pfeifer GP, Besaratinia A. UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer. Photochem Photobiol Sci. 2012 Jan; 11(1):90-7. View in: PubMed

Besaratinia A, Pfeifer GP. Measuring the formation and repair of UV damage at the DNA sequence level by ligation-mediated PCR. Methods Mol Biol. 2012; 920:189-202. View in: PubMed

Kim SI, Arlt VM, Yoon JI, Cole KJ, Pfeifer GP, Phillips DH, Besaratinia A. Whole body exposure of mice to secondhand smoke induces dose-dependent and persistent promutagenic DNA adducts in the lung. Mutat Res. 2011 Nov 1; 716(1-2):92-8. View in: PubMed

Besaratinia A, Yoon JI, Schroeder C, Bradforth SE, Cockburn M, Pfeifer GP. Wavelength dependence of ultraviolet radiation-induced DNA damage as determined by laser irradiation suggests that cyclobutane pyrimidine dimers are the principal DNA lesions produced by terrestrial sunlight. FASEB J. 2011 Sep; 25(9):3079-91. View in: PubMed

Besaratinia A, Pfeifer GP. Uveal melanoma and GNA11 mutations: a new piece added to the puzzle. Pigment Cell Melanoma Res. 2011 Feb; 24(1):18-20. View in: PubMed

Kim SI, Hollstein M, Pfeifer GP, Besaratinia A. Unveiling the methylation status of CpG dinucleotides in the substituted segment of the human p53 knock-in (Hupki) mouse genome. Mol Carcinog. 2010 Dec; 49(12):999-1006. View in: PubMed

Besaratinia A, Pfeifer GP. Applications of the human p53 knock-in (Hupki) mouse model for human carcinogen testing. FASEB J. 2010 Aug; 24(8):2612-9. View in: PubMed

Hendriks G, Calléja F, Besaratinia A, Vrieling H, Pfeifer GP, Mullenders LH, Jansen JG, de Wind N. Transcription-dependent cytosine deamination is a novel mechanism in ultraviolet light-induced mutagenesis. Curr Biol. 2010 Jan 26; 20(2):170-5. View in: PubMed

Tommasi S, Kim SI, Zhong X, Wu X, Pfeifer GP, Besaratinia A. Investigating the epigenetic effects of a prototype smoke-derived carcinogen in human cells. PLoS One. 2010; 5(5):e10594. View in: PubMed

Besaratinia A, Kim SI, Hainaut P, Pfeifer GP. In vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure. Gastroenterology. 2009 Sep; 137(3):1127-37, 1137. e1-5. View in: PubMed

Pfeifer GP, Besaratinia A. Mutational spectra of human cancer. Hum Genet. 2009 Jun; 125(5-6):493-506. View in: PubMed

Besaratinia A, Pfeifer GP. DNA-lesion mapping in mammalian cells. Methods. 2009 May; 48(1):35-9. View in: PubMed

Besaratinia A. Acrolein: excessive cytotoxicity or potent mutagenicity? Chem Res Toxicol. 2009 May; 22(5):751-3; author reply 753-4. View in: PubMed

Besaratinia A, Pfeifer GP. Sunlight ultraviolet irradiation and BRAF V600 mutagenesis in human melanoma. Hum Mutat. 2008 Aug; 29(8):983-91. View in: PubMed

Besaratinia A, Pfeifer GP. Second-hand smoke and human lung cancer. Lancet Oncol. 2008 Jul; 9(7):657-66. View in: PubMed

Besaratinia A, Kim SI, Pfeifer GP. Rapid repair of UVA-induced oxidized purines and persistence of UVB-induced dipyrimidine lesions determine the mutagenicity of sunlight in mouse cells. FASEB J. 2008 Jul; 22(7):2379-92. View in: PubMed

Kim SI, Pfeifer GP, Besaratinia A. Lack of mutagenicity of acrolein-induced DNA adducts in mouse and human cells. Cancer Res. 2007 Dec 15; 67(24):11640-7. View in: PubMed

Besaratinia A, Kim SI, Bates SE, Pfeifer GP. Riboflavin activated by ultraviolet A1 irradiation induces oxidative DNA damage-mediated mutations inhibited by vitamin C. Proc Natl Acad Sci U S A. 2007 Apr 3; 104(14):5953-8. View in: PubMed

Kim SI, Pfeifer GP, Besaratinia A. Mutagenicity of ultraviolet A radiation in the lacI transgene in Big Blue mouse embryonic fibroblasts. Mutat Res. 2007 Apr 1; 617(1-2):71-8. View in: PubMed

Besaratinia A, Pfeifer GP. A review of mechanisms of acrylamide carcinogenicity. Carcinogenesis. 2007 Mar; 28(3):519-28. View in: PubMed

Besaratinia A, Pfeifer GP. Investigating human cancer etiology by DNA lesion footprinting and mutagenicity analysis. Carcinogenesis. 2006 Aug; 27(8):1526-37. View in: PubMed

Choi JH, Besaratinia A, Lee DH, Lee CS, Pfeifer GP. The role of DNA polymerase iota in UV mutational spectra. Mutat Res. 2006 Jul 25; 599(1-2):58-65. View in: PubMed

Besaratinia A, Synold TW, Chen HH, Chang C, Xi B, Riggs AD, Pfeifer GP. DNA lesions induced by UV A1 and B radiation in human cells: comparative analyses in the overall genome and in the p53 tumor suppressor gene. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10058-63. View in: PubMed

Besaratinia A, Pfeifer GP. Investigating DNA adduct-targeted mutagenicity of tamoxifen: preferential formation of tamoxifen-DNA adducts in the human p53 gene in SV40 immortalized hepatocytes but not endometrial carcinoma cells. Biochemistry. 2005 Jun 14; 44(23):8418-27. View in: PubMed

Pfeifer GP, You YH, Besaratinia A. Mutations induced by ultraviolet light. Mutat Res. 2005 Apr 1; 571(1-2):19-31. View in: PubMed

Besaratinia A, Pfeifer GP. DNA adduction and mutagenic properties of acrylamide. Mutat Res. 2005 Feb 7; 580(1-2):31-40. View in: PubMed

Besaratinia A, Bates SE, Synold TW, Pfeifer GP. Similar mutagenicity of photoactivated porphyrins and ultraviolet A radiation in mouse embryonic fibroblasts: involvement of oxidative DNA lesions in mutagenesis. Biochemistry. 2004 Dec 14; 43(49):15557-66. View in: PubMed

Besaratinia A, Pfeifer GP. Biological consequences of 8-methoxypsoralen-photoinduced lesions: sequence-specificity of mutations and preponderance of T to C and T to a mutations. J Invest Dermatol. 2004 Dec; 123(6):1140-6. View in: PubMed

Yoon JH, Besaratinia A, Feng Z, Tang MS, Amin S, Luch A, Pfeifer GP. DNA damage, repair, and mutation induction by (+)-Syn and (-)-anti-dibenzo[a,l]pyrene-11,12-diol-13,14-epoxides in mouse cells. Cancer Res. 2004 Oct 15; 64(20):7321-8. View in: PubMed

Besaratinia A, Pfeifer GP. Genotoxicity of acrylamide and glycidamide. J Natl Cancer Inst. 2004 Jul 7; 96(13):1023-9. View in: PubMed

Besaratinia A, Synold TW, Xi B, Pfeifer GP. G-to-T transversions and small tandem base deletions are the hallmark of mutations induced by ultraviolet a radiation in mammalian cells. Biochemistry. 2004 Jun 29; 43(25):8169-77. View in: PubMed

Besaratinia A, Pfeifer GP. Enhancement of the mutagenicity of benzo(a)pyrene diol epoxide by a nonmutagenic dose of ultraviolet A radiation. Cancer Res. 2003 Dec 15; 63(24):8708-16. View in: PubMed

Besaratinia A, Pfeifer GP. Weak yet distinct mutagenicity of acrylamide in mammalian cells. J Natl Cancer Inst. 2003 Jun 18; 95(12):889-96. View in: PubMed

Besaratinia A, Bates SE, Pfeifer GP. Mutational signature of the proximate bladder carcinogen N-hydroxy-4-acetylaminobiphenyl: inconsistency with the p53 mutational spectrum in bladder cancer. Cancer Res. 2002 Aug 1; 62(15):4331-8. View in: PubMed

Van Schooten FJ, Besaratinia A, Besarati Nia A, De Flora S, D'Agostini F, Izzotti A, Camoirano A, Balm AJ, Dallinga JW, Bast A, Haenen GR, Van't Veer L, Baas P, Sakai H, Van Zandwijk N. Effects of oral administration of N-acetyl-L-cysteine: a multi-biomarker study in smokers. Cancer Epidemiol Biomarkers Prev. 2002 Feb; 11(2):167-75. View in: PubMed

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