Faculty

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Akil Merchant, MD
Assistant Professor of Medicine
Medicine
NRT 3501 Health Sciences Campus Los Angeles
+1 323 442 7796

Overview

Dr. Merchant is Assistant Professor of Medicine at the USC Keck School of Medicine and practices at USC Norris Comprehensive Cancer Center. He attended medical school and residency at Baylor College of Medicine in Houston and then trained in Medical Oncology at Johns Hopkins University in Baltimore, where he joined the faculty as a junior investigator. Dr. Merchant was recruited to USC Norris Cancer Center in 2012, where his laboratory focuses on overcoming the resistance of leukemia stem cells to chemotherapy. He is the winner of numerous awards including the American Society of hematology Scholar Award, the American Society of Clinical Oncology Young Investigator Award, and the American Association for Cancer Research Fellowship. His research is currently funded by the NIH and the Whittier foundation.

Awards

Baylor College of Medicine : Caroline Law Award in Rheumatology, 2002

American Society of Hematology : Travel Award, 2007

AACR: Scholar-in-Training Award, 2009

Publications

Singh M, Chaudhry P, Merchant AA. Primary cilia are present on human blood and bone marrow cells and mediate Hedgehog signaling. Exp Hematol. 2016 Sep 7. View in: PubMed

Lim Y, Gondek L, Li L, Wang Q, Ma H, Ma H, Chang E, Huso DL, Foerster S, Marchionni L, McGovern K, Watkins DN, Peacock CD, Levis M, Smith BD, Merchant AA, Small D, Matsui W. Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia. Sci Transl Med. 2015 Jun 10; 7(291):291ra96. View in: PubMed

Agarwal JR, Wang Q, Tanno T, Rasheed Z, Merchant A, Ghosh N, Borrello I, Huff CA, Parhami F, Matsui W. Activation of liver X receptors inhibits hedgehog signaling, clonogenic growth, and self-renewal in multiple myeloma. Mol Cancer Ther. 2014 Jul; 13(7):1873-81. View in: PubMed

Lim Y, Hedayati M, Merchant AA, Zhang Y, Yu HH, Kastan MB, Matsui W, Deweese TL. Chloroquine improves survival and hematopoietic recovery after lethal low-dose-rate radiation. Int J Radiat Oncol Biol Phys. 2012 Nov 1; 84(3):800-6. View in: PubMed

Merchant AA, Roy CN. Not so benign haematology: anaemia of the elderly. Br J Haematol. 2012 Jan; 156(2):173-85. View in: PubMed

Merchant AA, Singh A, Matsui W, Biswal S. The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels. Blood. 2011 Dec 15; 118(25):6572-9. View in: PubMed

Brennan SK, Meade B, Wang Q, Merchant AA, Kowalski J, Matsui W. Mantle cell lymphoma activation enhances bortezomib sensitivity. Blood. 2010 Nov 18; 116(20):4185-91. View in: PubMed

Merchant AA, Matsui W. Targeting Hedgehog--a cancer stem cell pathway. Clin Cancer Res. 2010 Jun 15; 16(12):3130-40. View in: PubMed

Merchant A, Joseph G, Wang Q, Brennan S, Matsui W. Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors. Blood. 2010 Mar 25; 115(12):2391-6. View in: PubMed

Lin TL, Wang QH, Brown P, Peacock C, Merchant AA, Brennan S, Jones E, McGovern K, Watkins DN, Sakamoto KM, Matsui W. Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926. PLoS One. 2010; 5(12):e15262. View in: PubMed

Merchant AA, Matsui W. Smoothening the controversial role of hedgehog in hematopoiesis. Cell Stem Cell. 2009 Jun 5; 4(6):470-1. View in: PubMed

Beauchamp E, Bulut G, Abaan O, Chen K, Merchant A, Matsui W, Endo Y, Rubin JS, Toretsky J, Uren A. GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J Biol Chem. 2009 Apr 3; 284(14):9074-82. View in: PubMed

Chambers SM, Boles NC, Lin KY, Tierney MP, Bowman TV, Bradfute SB, Chen AJ, Merchant AA, Sirin O, Weksberg DC, Merchant MG, Fisk CJ, Shaw CA, Goodell MA. Hematopoietic fingerprints: an expression database of stem cells and their progeny. Cell Stem Cell. 2007 Nov; 1(5):578-91. View in: PubMed

Bowman TV, Merchant AA, Goodell MA. Molecular profiling of hematopoietic stem cells. Methods Mol Med. 2007; 134:1-16. View in: PubMed

Ramos CA, Bowman TA, Boles NC, Merchant AA, Zheng Y, Parra I, Fuqua SA, Shaw CA, Goodell MA. Evidence for diversity in transcriptional profiles of single hematopoietic stem cells. PLoS Genet. 2006 Sep 29; 2(9):e159. View in: PubMed

Bowman TV, McCooey AJ, Merchant AA, Ramos CA, Fonseca P, Poindexter A, Bradfute SB, Oliveira DM, Green R, Zheng Y, Jackson KA, Chambers SM, McKinney-Freeman SL, Norwood KG, Darlington G, Gunaratne PH, Steffen D, Goodell MA. Differential mRNA processing in hematopoietic stem cells. Stem Cells. 2006 Mar; 24(3):662-70. View in: PubMed

Venezia TA, Merchant AA, Ramos CA, Whitehouse NL, Young AS, Shaw CA, Goodell MA. Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol. 2004 Oct; 2(10):e301. View in: PubMed

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