Faculty

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Akil Merchant, MD
Assistant Professor of Medicine
Medicine
NRT 3501 Health Sciences Campus Los Angeles
+1 323 442 7796

Overview

Dr. Merchant is Assistant Professor of Medicine at the USC Keck School of Medicine and practices at USC Norris Comprehensive Cancer Center. He attended medical school and residency at Baylor College of Medicine in Houston and then trained in Medical Oncology at Johns Hopkins University in Baltimore, where he joined the faculty as a junior investigator. Dr. Merchant was recruited to USC Norris Cancer Center in 2012, where his laboratory focuses on overcoming the resistance of leukemia stem cells to chemotherapy. He is the winner of numerous awards including the American Society of hematology Scholar Award, the American Society of Clinical Oncology Young Investigator Award, and the American Association for Cancer Research Fellowship. His research is currently funded by the NIH and the Whittier foundation.

Awards

Baylor College of Medicine : Caroline Law Award in Rheumatology, 2002

American Society of Hematology : Travel Award, 2007

AACR: Scholar-in-Training Award, 2009

Baylor College of Medicine : award conferred by, 2002

AACR: award conferred by, 2009

American Society of Hematology : award conferred by, 2007

American Society of Hematology : Department, 2007

AACR: Department, 2009

Baylor College of Medicine : Department, 2002

Baylor College of Medicine : ORNG Application Instance for Person, 2002

American Society of Hematology : ORNG Application Instance for Person, 2007

AACR: ORNG Application Instance for Person, 2009

Baylor College of Medicine : full name, 2002

AACR: full name, 2009

American Society of Hematology : full name, 2007

Baylor College of Medicine : person in primary position, 2002

AACR: person in primary position, 2009

American Society of Hematology : person in primary position, 2007

Baylor College of Medicine : last name, 2002

AACR: last name, 2009

American Society of Hematology : last name, 2007

American Society of Hematology : HR job title, 2007

AACR: HR job title, 2009

American Society of Hematology : has ORNG Application Instance Data, 2007

AACR: has ORNG Application Instance Data, 2009

Baylor College of Medicine : has ORNG Application Instance Data, 2002

AACR: sort order, 2009

Baylor College of Medicine : sort order, 2002

American Society of Hematology : Assistant Professor, 2007

Baylor College of Medicine : Assistant Professor, 2002

AACR: Assistant Professor, 2009

Baylor College of Medicine : email address, 2002

AACR: email address, 2009

American Society of Hematology : email address, 2007

American Society of Hematology : start date, 2007

AACR: start date, 2009

Baylor College of Medicine : start date, 2002

American Society of Hematology : ct_data, 2007

Baylor College of Medicine : ct_data, 2002

AACR: ct_data, 2009

American Society of Hematology : workplace homepage, 2007

Baylor College of Medicine : workplace homepage, 2002

AACR: workplace homepage, 2009

Baylor College of Medicine : label, 2002

American Society of Hematology : label, 2007

American Society of Hematology : Faculty Rank, 2007

Baylor College of Medicine : Faculty Rank, 2002

AACR: Faculty Rank, 2009

AACR: is primary position, 2009

American Society of Hematology : is primary position, 2007

Baylor College of Medicine : is primary position, 2002

American Society of Hematology : preferred title, 2007

AACR: preferred title, 2009

Baylor College of Medicine : preferred title, 2002

AACR: Agent, 2009

American Society of Hematology : Agent, 2007

Baylor College of Medicine : http://orng.info/ontology/orng#ApplicationInstance^^ORNG Application Instance^^10543-120, 2002

American Society of Hematology : http://orng.info/ontology/orng#ApplicationInstance^^ORNG Application Instance^^10543-120, 2007

AACR: http://orng.info/ontology/orng#ApplicationInstance^^ORNG Application Instance^^10543-120, 2009

American Society of Hematology : Person ID, 2007

Baylor College of Medicine : Person ID, 2002

AACR: Person ID, 2009

American Society of Hematology : has faculty rank, 2007

AACR: has faculty rank, 2009

Baylor College of Medicine : has faculty rank, 2002

Baylor College of Medicine : ORNG Application Instance Data value, 2002

American Society of Hematology : ORNG Application Instance Data value, 2007

AACR: ORNG Application Instance Data value, 2009

American Society of Hematology : Medicine, 2007

AACR: Medicine, 2009

Baylor College of Medicine : Medicine, 2002

Baylor College of Medicine : Keck School of Medicine of USC, 2002

American Society of Hematology : Keck School of Medicine of USC, 2007

AACR: Keck School of Medicine of USC, 2009

Baylor College of Medicine : Agent, 2002

AACR: Position, 2009

Baylor College of Medicine : Position, 2002

American Society of Hematology : Position, 2007

Baylor College of Medicine : HR job title, 2002

AACR: Organization, 2009

American Society of Hematology : Organization, 2007

Baylor College of Medicine : Organization, 2002

AACR: first name, 2009

Baylor College of Medicine : first name, 2002

American Society of Hematology : first name, 2007

Publications

Primary cilia are present on human blood and bone marrow cells and mediate Hedgehog signaling. Exp Hematol. 2016 Sep 7. View in: PubMed

Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia. Sci Transl Med. 2015 Jun 10; 7(291):291ra96. View in: PubMed

Activation of liver X receptors inhibits hedgehog signaling, clonogenic growth, and self-renewal in multiple myeloma. Mol Cancer Ther. 2014 Jul; 13(7):1873-81. View in: PubMed

Chloroquine improves survival and hematopoietic recovery after lethal low-dose-rate radiation. Int J Radiat Oncol Biol Phys. 2012 Nov 1; 84(3):800-6. View in: PubMed

Not so benign haematology: anaemia of the elderly. Br J Haematol. 2012 Jan; 156(2):173-85. View in: PubMed

The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels. Blood. 2011 Dec 15; 118(25):6572-9. View in: PubMed

Mantle cell lymphoma activation enhances bortezomib sensitivity. Blood. 2010 Nov 18; 116(20):4185-91. View in: PubMed

Targeting Hedgehog--a cancer stem cell pathway. Clin Cancer Res. 2010 Jun 15; 16(12):3130-40. View in: PubMed

Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors. Blood. 2010 Mar 25; 115(12):2391-6. View in: PubMed

Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926. PLoS One. 2010; 5(12):e15262. View in: PubMed

Smoothening the controversial role of hedgehog in hematopoiesis. Cell Stem Cell. 2009 Jun 5; 4(6):470-1. View in: PubMed

GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J Biol Chem. 2009 Apr 3; 284(14):9074-82. View in: PubMed

Hematopoietic fingerprints: an expression database of stem cells and their progeny. Cell Stem Cell. 2007 Nov; 1(5):578-91. View in: PubMed

Molecular profiling of hematopoietic stem cells. Methods Mol Med. 2007; 134:1-16. View in: PubMed

Evidence for diversity in transcriptional profiles of single hematopoietic stem cells. PLoS Genet. 2006 Sep 29; 2(9):e159. View in: PubMed

Differential mRNA processing in hematopoietic stem cells. Stem Cells. 2006 Mar; 24(3):662-70. View in: PubMed

Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol. 2004 Oct; 2(10):e301. View in: PubMed

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