Faculty

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Alicia A. McDonough, PhD
Professor of Cell & Neurobiology
Cell and Neurobiology
MMR 508 1333 San Pablo Street Health Sciences Campus Los Angeles
+1 323 442 1238

Overview

Alicia McDonough is Professor of Cell and Neurobiology at the Keck School of Medicine of the University of Southern California in Los Angeles, CA. She earned an A.B. in Physiology at UC Berkeley, the Ph.D. in Physiology at the Univ. Hawaii, and was a postdoctoral scholar at UC San Francisco Cardiovascular Research Institute, and Columbia University under the outstanding mentorship PS Timiras, SK Hong and IS Edelman, respectively. She joined the faculty of the University of Southern California School of Medicine in 1981 where she first studied the assembly of sodium pump subunits, and defined the molecular mechanisms of sodium pump isoform regulation in cardiac and skeletal muscle by potassium, hormones, and during heart failure. The McDonough lab then initiated studies to determining the renal mechanisms responsible for regulation of sodium, blood pressure and potassium balance, how homeostasis is disrupted in disease states and corrected therapeutically. By investigating ion transporters’ phosphorylation, abundance, subcellular distribution and activity, the lab has more recently defined how stimuli such as dietary sodium and potassium, AngII, injury, and cytokines increase renal sodium transport and how the resultant hypertension provokes intrarenal responses to decrease sodium reabsorption (via pressure natriuresis). These projects have engaged the McDonough lab with expert collaborators across the USA and around the world. Dr. McDonough is a recipient of an AHA Established Investigator Award (1984-89), the 2009 E.H. Starling Distinguished Lectureship from American Physiological Society, the 2014 Donald Seldin Lectureship from the AHA Council on the Kidney in Cardiovascular Disease, and teaching awards. She serves on editorial boards, numerous study sections, committees for the APS, AHA and ASN and has enjoys teaching medical and PhD students.

Publications

McDonough AA. ISN Forefronts Symposium 2015: Maintaining Balance Under Pressure-Hypertension and the Proximal Tubule. KI Rep. 2016 Sep; 1(3):166-176. View in: PubMed

Pei L, Solis G, Nguyen MT, Kamat N, Magenheimer L, Zhuo M, Li J, Curry J, McDonough AA, Fields TA, Welch WJ, Yu AS. Paracellular epithelial sodium transport maximizes energy efficiency in the kidney. J Clin Invest. 2016 Jul 1; 126(7):2509-18. View in: PubMed

Norlander AE, Saleh MA, Kamat NV, Ko B, Gnecco J, Zhu L, Dale BL, Iwakura Y, Hoover RS, McDonough AA, Madhur MS. Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II-Induced Hypertension. Hypertension. 2016 Jul; 68(1):167-74. View in: PubMed

Zhang J, Rudemiller NP, Patel MB, Karlovich NS, Wu M, McDonough AA, Griffiths R, Sparks MA, Jeffs AD, Crowley SD. Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron. Cell Metab. 2016 Feb 9; 23(2):360-8. View in: PubMed

Farah LX, Valentini V, Pessoa TD, Malnic G, McDonough AA, Girardi AC. The physiological role of glucagon-like peptide-1 in the regulation of renal function. Am J Physiol Renal Physiol. 2016 Jan 15; 310(2):F123-7. View in: PubMed

Carneiro de Morais CP, Polidoro JZ, Ralph DL, Pessoa TD, Oliveira-Souza M, Barauna VG, Rebouças NA, Malnic G, McDonough AA, Girardi AC. Proximal tubule NHE3 activity is inhibited by beta-arrestin-biased angiotensin II type 1 receptor signaling. Am J Physiol Cell Physiol. 2015 Oct 15; 309(8):C541-50. View in: PubMed

McDonough AA, Nguyen MT. Maintaining Balance Under Pressure: Integrated Regulation of Renal Transporters During Hypertension. Hypertension. 2015 Sep; 66(3):450-5. View in: PubMed

Nguyen MT, Han J, Ralph DL, Veiras LC, McDonough AA. Short-term nonpressor angiotensin II infusion stimulates sodium transporters in proximal tubule and distal nephron. Physiol Rep. 2015 Sep; 3(9). View in: PubMed

Giani JF, Bernstein KE, Janjulia T, Han J, Toblli JE, Shen XZ, Rodriguez-Iturbe B, McDonough AA, Gonzalez-Villalobos RA. Salt Sensitivity in Response to Renal Injury Requires Renal Angiotensin-Converting Enzyme. Hypertension. 2015 Sep; 66(3):534-42. View in: PubMed

Giani JF, Shah KH, Khan Z, Bernstein EA, Shen XZ, McDonough AA, Gonzalez-Villalobos RA, Bernstein KE. The intrarenal generation of angiotensin II is required for experimental hypertension. Curr Opin Pharmacol. 2015 Apr; 21:73-81. View in: PubMed

McDonough AA, Veiras LC, Minas JN, Ralph DL. Considerations when quantitating protein abundance by immunoblot. Am J Physiol Cell Physiol. 2015 Mar 15; 308(6):C426-33. View in: PubMed

Kamat NV, Thabet SR, Xiao L, Saleh MA, Kirabo A, Madhur MS, Delpire E, Harrison DG, McDonough AA. Renal transporter activation during angiotensin-II hypertension is blunted in interferon-?-/- and interleukin-17A-/- mice. Hypertension. 2015 Mar; 65(3):569-76. View in: PubMed

Giani JF, Janjulia T, Kamat N, Seth DM, Blackwell WL, Shah KH, Shen XZ, Fuchs S, Delpire E, Toblli JE, Bernstein KE, McDonough AA, Gonzalez-Villalobos RA. Renal angiotensin-converting enzyme is essential for the hypertension induced by nitric oxide synthesis inhibition. J Am Soc Nephrol. 2014 Dec; 25(12):2752-63. View in: PubMed

Arystarkhova E, Ralph DL, Liu YB, Bouley R, McDonough AA, Sweadner KJ. Paradoxical activation of the sodium chloride cotransporter (NCC) without hypertension in kidney deficient in a regulatory subunit of Na,K-ATPase, FXYD2. Physiol Rep. 2014 Dec 1; 2(12). View in: PubMed

Brasen JC, Burford JL, McDonough AA, Holstein-Rathlou NH, Peti-Peterdi J. Local pH domains regulate NHE3-mediated Na? reabsorption in the renal proximal tubule. Am J Physiol Renal Physiol. 2014 Dec 1; 307(11):F1249-62. View in: PubMed

Patel HH, McDonough AA. Of mice and men: modeling cardiovascular complexity in diabetes. Focus on "Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart". Am J Physiol Cell Physiol. 2014 Sep 15; 307(6):C497-8. View in: PubMed

Giani JF, Janjulia T, Taylor B, Bernstein EA, Shah K, Shen XZ, McDonough AA, Bernstein KE, Gonzalez-Villalobos RA. Renal generation of angiotensin II and the pathogenesis of hypertension. Curr Hypertens Rep. 2014 Sep; 16(9):477. View in: PubMed

Rengarajan S, Lee DH, Oh YT, Delpire E, Youn JH, McDonough AA. Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis. Am J Physiol Renal Physiol. 2014 May; 306(9):F1059-68. View in: PubMed

Nguyen MT, Lee DH, Delpire E, McDonough AA. Differential regulation of Na+ transporters along nephron during ANG II-dependent hypertension: distal stimulation counteracted by proximal inhibition. Am J Physiol Renal Physiol. 2013 Aug 15; 305(4):F510-9. View in: PubMed

Li HC, Du Z, Barone S, Rubera I, McDonough AA, Tauc M, Zahedi K, Wang T, Soleimani M. Proximal tubule specific knockout of the Na?/H? exchanger NHE3: effects on bicarbonate absorption and ammonium excretion. J Mol Med (Berl). 2013 Aug; 91(8):951-63. View in: PubMed

Gonzalez-Villalobos RA, Janjoulia T, Fletcher NK, Giani JF, Nguyen MT, Riquier-Brison AD, Seth DM, Fuchs S, Eladari D, Picard N, Bachmann S, Delpire E, Peti-Peterdi J, Navar LG, Bernstein KE, McDonough AA. The absence of intrarenal ACE protects against hypertension. J Clin Invest. 2013 May; 123(5):2011-23. View in: PubMed

McDonough AA, Youn JH. Need to quickly excrete K(+)? Turn off NCC. Kidney Int. 2013 May; 83(5):779-82. View in: PubMed

Lee DH, Maunsbach AB, Riquier-Brison AD, Nguyen MT, Fenton RA, Bachmann S, Yu AS, McDonough AA. Effects of ACE inhibition and ANG II stimulation on renal Na-Cl cotransporter distribution, phosphorylation, and membrane complex properties. Am J Physiol Cell Physiol. 2013 Jan 15; 304(2):C147-63. View in: PubMed

Nguyen MT, Yang LE, Fletcher NK, Lee DH, Kocinsky H, Bachmann S, Delpire E, McDonough AA. Effects of K+-deficient diets with and without NaCl supplementation on Na+, K+, and H2O transporters' abundance along the nephron. Am J Physiol Renal Physiol. 2012 Jul; 303(1):F92-F104. View in: PubMed

Avner ED, McDonough AA, Sweeney WE. Transport, cilia, and PKD: must we in (cyst) on interrelationships? Focus on "Increased Na+/H+ exchanger activity on the apical surface of a cilium-deficient cortical collecting duct principal cell model of polycystic kidney disease". Am J Physiol Cell Physiol. 2012 May 15; 302(10):C1434-5. View in: PubMed

McDonough AA, Nguyen MT. How does potassium supplementation lower blood pressure? Am J Physiol Renal Physiol. 2012 May; 302(9):F1224-5. View in: PubMed

Gurley SB, Riquier-Brison AD, Schnermann J, Sparks MA, Allen AM, Haase VH, Snouwaert JN, Le TH, McDonough AA, Koller BH, Coffman TM. AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab. 2011 Apr 6; 13(4):469-75. View in: PubMed

McDonough AA. Mechanisms of proximal tubule sodium transport regulation that link extracellular fluid volume and blood pressure. Am J Physiol Regul Integr Comp Physiol. 2010 Apr; 298(4):R851-61. View in: PubMed

Riquier-Brison AD, Leong PK, Pihakaski-Maunsbach K, McDonough AA. Angiotensin II stimulates trafficking of NHE3, NaPi2, and associated proteins into the proximal tubule microvilli. Am J Physiol Renal Physiol. 2010 Jan; 298(1):F177-86. View in: PubMed

McDonough AA. Motoring down the microvilli. Focus on "PTH-induced internalization of apical membrane NaPi2a: role of actin and myosin VI". Am J Physiol Cell Physiol. 2009 Dec; 297(6):C1331-2. View in: PubMed

Hauck C, Potter T, Bartz M, Wittwer T, Wahlers T, Mehlhorn U, Scheiner-Bobis G, McDonough AA, Bloch W, Schwinger RH, Müller-Ehmsen J. Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1. Eur J Pharmacol. 2009 Nov 10; 622(1-3):7-14. View in: PubMed

Greenlee M, Wingo CS, McDonough AA, Youn JH, Kone BC. Narrative review: evolving concepts in potassium homeostasis and hypokalemia. Ann Intern Med. 2009 May 5; 150(9):619-25. View in: PubMed

Lee DH, Riquier AD, Yang LE, Leong PK, Maunsbach AB, McDonough AA. Acute hypertension provokes acute trafficking of distal tubule Na-Cl cotransporter (NCC) to subapical cytoplasmic vesicles. Am J Physiol Renal Physiol. 2009 Apr; 296(4):F810-8. View in: PubMed

Riquier AD, Lee DH, McDonough AA. Renal NHE3 and NaPi2 partition into distinct membrane domains. Am J Physiol Cell Physiol. 2009 Apr; 296(4):C900-10. View in: PubMed

Youn JH, McDonough AA. Recent advances in understanding integrative control of potassium homeostasis. Annu Rev Physiol. 2009; 71:381-401. View in: PubMed

Yang LE, Sandberg MB, Can AD, Pihakaski-Maunsbach K, McDonough AA. Effects of dietary salt on renal Na+ transporter subcellular distribution, abundance, and phosphorylation status. Am J Physiol Renal Physiol. 2008 Oct; 295(4):F1003-16. View in: PubMed

Hanner F, Schnichels M, Zheng-Fischhöfer Q, Yang LE, Toma I, Willecke K, McDonough AA, Peti-Peterdi J. Connexin 30. 3 is expressed in the kidney but not regulated by dietary salt or high blood pressure. Cell Commun Adhes. 2008 May; 15(1):219-30. View in: PubMed

Zheng D, Perianayagam A, Lee DH, Brannan MD, Yang LE, Tellalian D, Chen P, Lemieux K, Marette A, Youn JH, McDonough AA. AMPK activation with AICAR provokes an acute fall in plasma [K+]. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C126-35. View in: PubMed

Petrovic S, Barone S, Wang Z, McDonough AA, Amlal H, Soleimani M. Slc26a6 (PAT1) deletion downregulates the apical Na+/H+ exchanger in the straight segment of the proximal tubule. Am J Nephrol. 2008; 28(2):330-8. View in: PubMed

Yang LE, Leong PK, McDonough AA. Reducing blood pressure in SHR with enalapril provokes redistribution of NHE3, NaPi2, and NCC and decreases NaPi2 and ACE abundance. Am J Physiol Renal Physiol. 2007 Oct; 293(4):F1197-208. View in: PubMed

Sandberg MB, Riquier AD, Pihakaski-Maunsbach K, McDonough AA, Maunsbach AB. ANG II provokes acute trafficking of distal tubule Na+-Cl(-) cotransporter to apical membrane. Am J Physiol Renal Physiol. 2007 Sep; 293(3):F662-9. View in: PubMed

Lee FN, Oh G, McDonough AA, Youn JH. Evidence for gut factor in K+ homeostasis. Am J Physiol Renal Physiol. 2007 Aug; 293(2):F541-7. View in: PubMed

Sandberg MB, Maunsbach AB, McDonough AA. Redistribution of distal tubule Na+-Cl- cotransporter (NCC) in response to a high-salt diet. Am J Physiol Renal Physiol. 2006 Aug; 291(2):F503-8. View in: PubMed

Elitsur N, Lorenz JN, Hawkins JA, Rudolph JA, Witte D, Yang LE, McDonough AA, Cohen MB. The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response. J Pediatr Gastroenterol Nutr. 2006 Jul; 43 Suppl 1:S74-81. View in: PubMed

Leong PK, Yang LE, Landon CS, McDonough AA, Yip KP. Phenol injury-induced hypertension stimulates proximal tubule Na+/H+ exchanger activity. Am J Physiol Renal Physiol. 2006 Jun; 290(6):F1543-50. View in: PubMed

Chen P, Guzman JP, Leong PK, Yang LE, Perianayagam A, Babilonia E, Ho JS, Youn JH, Wang WH, McDonough AA. Modest dietary K+ restriction provokes insulin resistance of cellular K+ uptake and phosphorylation of renal outer medulla K+ channel without fall in plasma K+ concentration. Am J Physiol Cell Physiol. 2006 May; 290(5):C1355-63. View in: PubMed

Leong PK, Devillez A, Sandberg MB, Yang LE, Yip DK, Klein JB, McDonough AA. Effects of ACE inhibition on proximal tubule sodium transport. Am J Physiol Renal Physiol. 2006 Apr; 290(4):F854-63. View in: PubMed

Yang LE, Maunsbach AB, Leong PK, McDonough AA. Redistribution of myosin VI from top to base of proximal tubule microvilli during acute hypertension. J Am Soc Nephrol. 2005 Oct; 16(10):2890-6. View in: PubMed

McDonough AA, Youn JH. Role of muscle in regulating extracellular [K+]. Semin Nephrol. 2005 Sep; 25(5):335-42. View in: PubMed

Rhee MS, Perianayagam A, Chen P, Youn JH, McDonough AA. Dexamethasone treatment causes resistance to insulin-stimulated cellular potassium uptake in the rat. Am J Physiol Cell Physiol. 2004 Nov; 287(5):C1229-37. View in: PubMed

Yang LE, Maunsbach AB, Leong PK, McDonough AA. Differential traffic of proximal tubule Na+ transporters during hypertension or PTH: NHE3 to base of microvilli vs. NaPi2 to endosomes. Am J Physiol Renal Physiol. 2004 Nov; 287(5):F896-906. View in: PubMed

Leong PK, Yang LE, Lin HW, Holstein-Rathlou NH, McDonough AA. Acute hypotension induced by aortic clamp vs. PTH provokes distinct proximal tubule Na+ transporter redistribution patterns. Am J Physiol Regul Integr Comp Physiol. 2004 Oct; 287(4):R878-85. View in: PubMed

McDonough AA, Biemesderfer D. Does membrane trafficking play a role in regulating the sodium/hydrogen exchanger isoform 3 in the proximal tubule? Curr Opin Nephrol Hypertens. 2003 Sep; 12(5):533-41. View in: PubMed

Yang LE, Zhong H, Leong PK, Perianayagam A, Campese VM, McDonough AA. Chronic renal injury-induced hypertension alters renal NHE3 distribution and abundance. Am J Physiol Renal Physiol. 2003 May; 284(5):F1056-65. View in: PubMed

Yang LE, Leong PK, Guzman JP, Rhee MS, McDonough AA. Modest K+ restriction provokes insulin resistance of cellular K+ uptake without decrease in plasma K. Ann N Y Acad Sci. 2003 Apr; 986:625-7. View in: PubMed

McDonough AA, Leong PK, Yang LE. Mechanisms of pressure natriuresis: how blood pressure regulates renal sodium transport. Ann N Y Acad Sci. 2003 Apr; 986:669-77. View in: PubMed

Yang LE, Leong PK, Ye S, Campese VM, McDonough AA. Responses of proximal tubule sodium transporters to acute injury-induced hypertension. Am J Physiol Renal Physiol. 2003 Feb; 284(2):F313-22. View in: PubMed

Leong PK, Yang LE, Holstein-Rathlou NH, McDonough AA. Angiotensin II clamp prevents the second step in renal apical NHE3 internalization during acute hypertension. Am J Physiol Renal Physiol. 2002 Nov; 283(5):F1142-50. View in: PubMed

Leong PK, Zhang Y, Yang LE, Holstein-Rathlou NH, McDonough AA. Diuretic response to acute hypertension is blunted during angiotensin II clamp. Am J Physiol Regul Integr Comp Physiol. 2002 Oct; 283(4):R837-42. View in: PubMed

McDonough AA, Thompson CB, Youn JH. Skeletal muscle regulates extracellular potassium. Am J Physiol Renal Physiol. 2002 Jun; 282(6):F967-74. View in: PubMed

Choi CS, Lee FN, McDonough AA, Youn JH. Independent regulation of in vivo insulin action on glucose versus K(+) uptake by dietary fat and K(+) content. Diabetes. 2002 Apr; 51(4):915-20. View in: PubMed

Yang L, Leong PK, Chen JO, Patel N, Hamm-Alvarez SF, McDonough AA. Acute hypertension provokes internalization of proximal tubule NHE3 without inhibition of transport activity. Am J Physiol Renal Physiol. 2002 Apr; 282(4):F730-40. View in: PubMed

Müller-Ehmsen J, McDonough AA, Farley RA, Schwinger RH. Sodium pump isoform expression in heart failure: implication for treatment. Basic Res Cardiol. 2002; 97 Suppl 1:I25-30. View in: PubMed

McDonough AA, Velotta JB, Schwinger RH, Philipson KD, Farley RA. The cardiac sodium pump: structure and function. Basic Res Cardiol. 2002; 97 Suppl 1:I19-24. View in: PubMed

Magyar CE, Zhang Y, Holstein-Rathlou NH, McDonough AA. Downstream shift in sodium pump activity along the nephron during acute hypertension. J Am Soc Nephrol. 2001 Nov; 12(11):2231-40. View in: PubMed

Müller-Ehmsen J, Juvvadi P, Thompson CB, Tumyan L, Croyle M, Lingrel JB, Schwinger RH, McDonough AA, Farley RA. Ouabain and substrate affinities of human Na(+)-K(+)-ATPase alpha(1)beta(1), alpha(2)beta(1), and alpha(3)beta(1) when expressed separately in yeast cells. Am J Physiol Cell Physiol. 2001 Oct; 281(4):C1355-64. View in: PubMed

Wang J, Velotta JB, McDonough AA, Farley RA. All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides. Am J Physiol Cell Physiol. 2001 Oct; 281(4):C1336-43. View in: PubMed

Duchesne R, Klein JD, Velotta JB, Doran JJ, Rouillard P, Roberts BR, McDonough AA, Sands JM. UT-A urea transporter protein in heart: increased abundance during uremia, hypertension, and heart failure. Circ Res. 2001 Jul 20; 89(2):139-45. View in: PubMed

Thompson CB, Dorup I, Ahn J, Leong PK, McDonough AA. Glucocorticoids increase sodium pump alpha(2)- and beta(1)-subunit abundance and mRNA in rat skeletal muscle. Am J Physiol Cell Physiol. 2001 Mar; 280(3):C509-16. View in: PubMed

Müller-Ehmsen J, Wang J, Schwinger RH, McDonough AA. Region specific regulation of sodium pump isoform and Na,Ca-exchanger expression in the failing human heart--right atrium vs left ventricle. Cell Mol Biol (Noisy-le-grand). 2001 Mar; 47(2):373-81. View in: PubMed

Choi CS, Thompson CB, Leong PK, McDonough AA, Youn JH. Short-term K(+) deprivation provokes insulin resistance of cellular K(+) uptake revealed with the K(+) clamp. Am J Physiol Renal Physiol. 2001 Jan; 280(1):F95-F102. View in: PubMed

Magyar CE, Zhang Y, Holstein-Rathlou NH, McDonough AA. Proximal tubule Na transporter responses are the same during acute and chronic hypertension. Am J Physiol Renal Physiol. 2000 Aug; 279(2):F358-69. View in: PubMed

Nakhoul F, Thompson CB, McDonough AA. Developmental change in Na,K-ATPase alpha1 and beta1 expression in normal and hypothyroid rat renal cortex. Am J Nephrol. 2000 May-Jun; 20(3):225-31. View in: PubMed

Magyar CE, McDonough AA. Molecular mechanisms of sodium transport inhibition in proximal tubule during acute hypertension. Curr Opin Nephrol Hypertens. 2000 Mar; 9(2):149-56. View in: PubMed

Thompson CB, Choi C, Youn JH, McDonough AA. Temporal responses of oxidative vs. glycolytic skeletal muscles to K+ deprivation: Na+ pumps and cell cations. Am J Physiol. 1999 Jun; 276(6 Pt 1):C1411-9. View in: PubMed

Zhang Y, Norian JM, Magyar CE, Holstein-Rathlou NH, Mircheff AK, McDonough AA. In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition. Am J Physiol. 1999 May; 276(5 Pt 2):F711-9. View in: PubMed

Schwinger RH, Wang J, Frank K, Müller-Ehmsen J, Brixius K, McDonough AA, Erdmann E. Reduced sodium pump alpha1, alpha3, and beta1-isoform protein levels and Na+,K+-ATPase activity but unchanged Na+-Ca2+ exchanger protein levels in human heart failure. Circulation. 1999 Apr 27; 99(16):2105-12. View in: PubMed

McDonough AA. Can ENaC regulate ICF as well as ECF volume? Focus on "osmotic pressure regulates alpha beta gamma-rENaC expressed in Xenopus oocytes". Am J Physiol. 1998 Nov; 275(5 Pt 1):C1179-81. View in: PubMed

Yip KP, Tse CM, McDonough AA, Marsh DJ. Redistribution of Na+/H+ exchanger isoform NHE3 in proximal tubules induced by acute and chronic hypertension. Am J Physiol. 1998 Oct; 275(4 Pt 2):F565-75. View in: PubMed

Zhang YB, Magyar CE, Holstein-Rathlou NH, McDonough AA. The cytochrome P-450 inhibitor cobalt chloride prevents inhibition of renal Na,K-ATPase and redistribution of apical NHE-3 during acute hypertension. J Am Soc Nephrol. 1998 Apr; 9(4):531-7. View in: PubMed

Zhang Y, Magyar CE, Norian JM, Holstein-Rathlou NH, Mircheff AK, McDonough AA. Reversible effects of acute hypertension on proximal tubule sodium transporters. Am J Physiol. 1998 Apr; 274(4 Pt 1):C1090-100. View in: PubMed

Guillery EN, Huss DJ, McDonough AA, Klein LC. Posttranscriptional upregulation of Na(+)-K(+)-ATPase activity in newborn guinea pig renal cortex. Am J Physiol. 1997 Aug; 273(2 Pt 2):F254-63. View in: PubMed

Thompson CB, McDonough AA. Skeletal muscle Na,K-ATPase alpha and beta subunit protein levels respond to hypokalemic challenge with isoform and muscle type specificity. J Biol Chem. 1996 Dec 20; 271(51):32653-8. View in: PubMed

Wang J, Schwinger RH, Frank K, Müller-Ehmsen J, Martin-Vasallo P, Pressley TA, Xiang A, Erdmann E, McDonough AA. Regional expression of sodium pump subunits isoforms and Na+-Ca++ exchanger in the human heart. J Clin Invest. 1996 Oct 1; 98(7):1650-8. View in: PubMed

Zhang Y, Mircheff AK, Hensley CB, Magyar CE, Warnock DG, Chambrey R, Yip KP, Marsh DJ, Holstein-Rathlou NH, McDonough AA. Rapid redistribution and inhibition of renal sodium transporters during acute pressure natriuresis. Am J Physiol. 1996 Jun; 270(6 Pt 2):F1004-14. View in: PubMed

McDonough AA, Zhang Y, Shin V, Frank JS. Subcellular distribution of sodium pump isoform subunits in mammalian cardiac myocytes. Am J Physiol. 1996 Apr; 270(4 Pt 1):C1221-7. View in: PubMed

McDonough AA, Thompson CB. Role of skeletal muscle sodium pumps in the adaptation to potassium deprivation. Acta Physiol Scand. 1996 Mar; 156(3):295-304. View in: PubMed

Azuma KK, Balkovetz DF, Magyar CE, Lescale-Matys L, Zhang Y, Chambrey R, Warnock DG, McDonough AA. Renal Na+/H+ exchanger isoforms and their regulation by thyroid hormone. Am J Physiol. 1996 Feb; 270(2 Pt 1):C585-92. View in: PubMed

Magyar CE, Wang J, Azuma KK, McDonough AA. Reciprocal regulation of cardiac Na-K-ATPase and Na/Ca exchanger: hypertension, thyroid hormone, development. Am J Physiol. 1995 Sep; 269(3 Pt 1):C675-82. View in: PubMed

McDonough AA, Wang J, Farley RA. Significance of sodium pump isoforms in digitalis therapy. J Mol Cell Cardiol. 1995 Apr; 27(4):1001-9. View in: PubMed

McDonough AA, Magyar CE, Komatsu Y. Expression of Na(+)-K(+)-ATPase alpha- and beta-subunits along rat nephron: isoform specificity and response to hypokalemia. Am J Physiol. 1994 Oct; 267(4 Pt 1):C901-8. View in: PubMed

Hensley CB, Bersohn MM, Sarma JS, Singh BN, McDonough AA. Amiodarone decreases Na,K-ATPase alpha 2 and beta 2 expression specifically in cardiac ventricle. J Mol Cell Cardiol. 1994 Apr; 26(4):417-24. View in: PubMed

Wang L, McComb JG, Weiss MH, McDonough AA, Zlokovic BV. Nicotine downregulates alpha 2 isoform of Na,K-ATPase at the blood-brain barrier and brain in rats. Biochem Biophys Res Commun. 1994 Mar 30; 199(3):1422-7. View in: PubMed

Bradley ME, Azuma KK, McDonough AA, Mircheff AK, Wood RL. Surface and intracellular pools of Na,K-ATPase catalytic and immuno-activities in rat exorbital lacrimal gland. Exp Eye Res. 1993 Oct; 57(4):403-13. View in: PubMed

Lescale-Matys L, Putnam DS, McDonough AA. Surplus Na+ pumps: how low-K(+)-incubated LLC-PK1 cells respond to K+ restoration. Am J Physiol. 1993 Oct; 265(4 Pt 1):C887-92. View in: PubMed

Azuma KK, Hensley CB, Tang MJ, McDonough AA. Thyroid hormone specifically regulates skeletal muscle Na(+)-K(+)-ATPase alpha 2- and beta 2-isoforms. Am J Physiol. 1993 Sep; 265(3 Pt 1):C680-7. View in: PubMed

McDonough AA, Farley RA. Regulation of Na,K-ATPase activity. Curr Opin Nephrol Hypertens. 1993 Sep; 2(5):725-34. View in: PubMed

Lescale-Matys L, Putnam DS, McDonough AA. Na(+)-K(+)-ATPase alpha 1- and beta 1-subunit degradation: evidence for multiple subunit specific rates. Am J Physiol. 1993 Mar; 264(3 Pt 1):C583-90. View in: PubMed

McDonough AA, Azuma KK, Lescale-Matys L, Tang MJ, Nakhoul F, Hensley CB, Komatsu Y. Physiologic rationale for multiple sodium pump isoforms. Differential regulation of alpha 1 vs alpha 2 by ionic stimuli. Ann N Y Acad Sci. 1992 Nov 30; 671:156-68; discussion 168-9. View in: PubMed

Tang MJ, McDonough AA. Low K+ increases Na(+)-K(+)-ATPase alpha- and beta-subunit mRNA and protein abundance in cultured renal proximal tubule cells. Am J Physiol. 1992 Aug; 263(2 Pt 1):C436-42. View in: PubMed

Mircheff AK, Bowen JW, Yiu SC, McDonough AA. Synthesis and translocation of Na(+)-K(+)-ATPase alpha- and beta-subunits to plasma membrane in MDCK cells. Am J Physiol. 1992 Feb; 262(2 Pt 1):C470-83. View in: PubMed

Hensley CB, Azuma KK, Tang MJ, McDonough AA. Thyroid hormone induction of rat myocardial Na(+)-K(+)-ATPase: alpha 1-, alpha 2-, and beta 1-mRNA and -protein levels at steady state. Am J Physiol. 1992 Feb; 262(2 Pt 1):C484-92. View in: PubMed

McDonough AA, Hensley CB, Azuma KK. Differential regulation of sodium pump isoforms in heart. Semin Nephrol. 1992 Jan; 12(1):49-55. View in: PubMed

Azuma KK, Hensley CB, Putnam DS, McDonough AA. Hypokalemia decreases Na(+)-K(+)-ATPase alpha 2- but not alpha 1-isoform abundance in heart, muscle, and brain. Am J Physiol. 1991 May; 260(5 Pt 1):C958-64. View in: PubMed

Lescale-Matys L, Hensley CB, Crnkovic-Markovic R, Putnam DS, McDonough AA. Low K+ increases Na,K-ATPase abundance in LLC-PK1/Cl4 cells by differentially increasing beta, and not alpha, subunit mRNA. J Biol Chem. 1990 Oct 15; 265(29):17935-40. View in: PubMed

Horowitz B, Hensley CB, Quintero M, Azuma KK, Putnam D, McDonough AA. Differential regulation of Na,K-ATPase alpha 1, alpha 2, and beta subunit mRNA and protein levels by thyroid hormone. J Biol Chem. 1990 Aug 25; 265(24):14308-14. View in: PubMed

McDonough AA, Tang MJ, Lescale-Matys L. Ionic regulation of the biosynthesis of NaK-ATPase subunits. Semin Nephrol. 1990 Jul; 10(4):400-9. View in: PubMed

West CA, McDonough AA, Masilamani SM, Verlander JW, Baylis C. The renal sodium chloride co-transporter, NCC, is unchanged in the mid pregnant rat and decreased in the late pregnant rat despite avid renal sodium retention. Am J Physiol Renal Physiol. 2015 Apr 29; ajprenal. 00147. 2015. View in: PubMed

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