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Ambrose Yaw-Shong Jong, PhD
Associate Professor of Pediatrics
CHLA 4650 W. Sunset Blvd. Off Campus Los Angeles
+1 323 361 5647


Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotine. Sci Rep. 2017 Jan 11; 7:40467. View in: PubMed

Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells. J Extracell Vesicles. 2017; 6(1):1294368. View in: PubMed

Pathogenic Triad in Bacterial Meningitis: Pathogen Invasion, NF-?B Activation, and Leukocyte Transmigration that Occur at the Blood-Brain Barrier. Front Microbiol. 2016; 7:148. View in: PubMed

Coexpression Network Analysis of Benign and Malignant Phenotypes of SIV-Infected Sooty Mangabey and Rhesus Macaque. PLoS One. 2016; 11(6):e0156170. View in: PubMed

The 14-3-3 gene function of Cryptococcus neoformans is required for its growth and virulence. J Microbiol Biotechnol. 2015 Oct 6. View in: PubMed

How Cryptococcus interacts with the blood-brain barrier. Future Microbiol. 2015 Oct; 10:1669-82. View in: PubMed

Exosome-Mediated Transfer of microRNAs Within the Tumor Microenvironment and Neuroblastoma Resistance to Chemotherapy. J Natl Cancer Inst. 2015 Jul; 107(7). View in: PubMed

Alpha7 nicotinic acetylcholine receptor is required for blood-brain barrier injury-related CNS disorders caused by Cryptococcus neoformans and HIV-1 associated comorbidity factors. BMC Infect Dis. 2015; 15(1):352. View in: PubMed

Factors required for activation of urease as a virulence determinant in Cryptococcus neoformans. MBio. 2013; 4(3):e00220-13. View in: PubMed

Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors. PLoS One. 2013; 8(4):e62164. View in: PubMed

Hyaluronic Acid Receptor CD44 Deficiency Is Associated with Decreased Cryptococcus neoformans Brain Infection. J Biol Chem. 2012 May 4; 287(19):15298-306. View in: PubMed

The Autophagy Regulator Rubicon Is a Feedback Inhibitor of CARD9-Mediated Host Innate Immunity. Cell Host Microbe. 2012 Mar 15; 11(3):277-89. View in: PubMed

Retinoid-Regulated FGF8f Secretion by Osteoblasts Bypasses Retinoid Stimuli to Mediate Granulocytic Differentiation of Myeloid Leukemia Cells. Mol Cancer Ther. 2012 Feb; 11(2):267-76. View in: PubMed

Identification of Genes from the Fungal Pathogen Cryptococcus neoformans Related to Transmigration into the Central Nervous System. PLoS One. 2012; 7(9):e45083. View in: PubMed

Cryptococcus neoformans-derived microvesicles enhance the pathogenesis of fungal brain infection. PLoS One. 2012; 7(11):e48570. View in: PubMed

Lipid raft/caveolae signaling is required for Cryptococcus neoformans invasion into human brain microvascular endothelial cells. J Biomed Sci. 2012; 19:19. View in: PubMed

Vimentin and PSF Act in Concert to Regulate IbeA+ E. coli K1 Induced Activation and Nuclear Translocation of NF-?B in Human Brain Endothelial Cells. PLoS One. 2012; 7(4):e35862. View in: PubMed

Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3). J Biol Chem. 2011 Oct 7; 286(40):34761-9. View in: PubMed

HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to human brain microvascular endothelial cells via gp41 core-induced membrane activities. Biochem J. 2011 Sep 15; 438(3):457-66. View in: PubMed

Recruitment of a7 nicotinic acetylcholine receptor to caveolin-1-enriched lipid rafts is required for nicotine-enhanced Escherichia coli K1 entry into brain endothelial cells. Future Microbiol. 2011 Aug; 6(8):953-66. View in: PubMed

[Effect of HIV-1gp41 ectodomain on Cryptococcus neoformans-induced cytoskeletal changes in human brain microvascular endothelial cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2011 Mar; 31(3):478-81. View in: PubMed

Cryptococcus neoformans mediator protein Ssn8 negatively regulates diverse physiological processes and is required for virulence. PLoS One. 2011; 6(4):e19162. View in: PubMed

Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor. PLoS One. 2011; 6(9):e25016. View in: PubMed

Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation. FASEB J. 2010 Mar; 24(3):833-43. View in: PubMed

Evolving role of laminin receptors in microbial pathogenesis and therapeutics of CNS infection. Future Microbiol. 2009 Oct; 4(8):959-62. View in: PubMed

Lactobacillus rhamnosus GG Suppresses Meningitic E. coli K1 Penetration across Human Intestinal Epithelial Cells In Vitro and Protects Neonatal Rats against Experimental Hematogenous Meningitis. Int J Microbiol. 2009; 2009:647862. View in: PubMed

Identification of IbeR as a stationary-phase regulator in meningitic Escherichia coli K1 that carries a loss-of-function mutation in rpoS. J Biomed Biotechnol. 2009; 2009:520283. View in: PubMed

Involvement of Escherichia coli K1 ibeT in bacterial adhesion that is associated with the entry into human brain microvascular endothelial cells. Med Microbiol Immunol. 2008 Dec; 197(4):337-44. View in: PubMed

Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells requires protein kinase C-alpha activation. Cell Microbiol. 2008 Sep; 10(9):1854-65. View in: PubMed

Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells. Cell Microbiol. 2008 Jun; 10(6):1313-26. View in: PubMed

Cdc6 knockdown inhibits human neuroblastoma cell proliferation. Mol Cell Biochem. 2008 Apr; 311(1-2):189-97. View in: PubMed

Focal point theory models for dissecting dynamic duality problems of microbial infections. J Biomed Biotechnol. 2008; 2008:856314. View in: PubMed

Infectomic analysis of gene expression profiles of human brain microvascular endothelial cells infected with Cryptococcus neoformans. J Biomed Biotechnol. 2008; 2008:375620. View in: PubMed

PSF is an IbeA-binding protein contributing to meningitic Escherichia coli K1 invasion of human brain microvascular endothelial cells. Med Microbiol Immunol. 2007 Sep; 196(3):135-43. View in: PubMed

Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection. Eukaryot Cell. 2007 Aug; 6(8):1486-96. View in: PubMed

The evolving role of infectomics in drug discovery. Expert Opin Drug Discov. 2007 Jul; 2(7):961-75. View in: PubMed

HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to HBMEC. Biochem Biophys Res Commun. 2007 May 18; 356(4):899-905. View in: PubMed

The histopathology of Candida albicans invasion in neonatal rat tissues and in the human blood-brain barrier in culture revealed by light, scanning, transmission and immunoelectron microscopy. Histol Histopathol. 2006 Oct; 21(10):1029-41. View in: PubMed

CPS1, a homolog of the Streptococcus pneumoniae type 3 polysaccharide synthase gene, is important for the pathobiology of Cryptococcus neoformans. Infect Immun. 2006 Jul; 74(7):3930-8. View in: PubMed

Increased p21 expression and complex formation with cyclin E/CDK2 in retinoid-induced pre-B lymphoma cell apoptosis. FEBS Lett. 2006 Jun 26; 580(15):3687-93. View in: PubMed

Spatial distribution of nerve sprouting after myocardial infarction in mice. Heart Rhythm. 2006 Jun; 3(6):728-36. View in: PubMed

Downregulation of human Cdc6 protein using a lentivirus RNA interference expression vector. Methods Mol Biol. 2006; 342:287-93. View in: PubMed

Blood-brain barrier drug discovery for central nervous system infections. Curr Drug Targets Infect Disord. 2005 Mar; 5(1):65-72. View in: PubMed

Cryptococcus neoformans induces alterations in the cytoskeleton of human brain microvascular endothelial cells. J Med Microbiol. 2003 Nov; 52(Pt 11):961-70. View in: PubMed

Binding of Candida albicans enolase to plasmin(ogen) results in enhanced invasion of human brain microvascular endothelial cells. J Med Microbiol. 2003 Aug; 52(Pt 8):615-22. View in: PubMed

Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma. Am J Pathol. 2003 Jun; 162(6):1961-74. View in: PubMed

Use of inverse PCR to clone cDNA ends. Methods Mol Biol. 2003; 221:51-8. View in: PubMed

Retinoid-induced G1 arrest and differentiation activation are associated with a switch to cyclin-dependent kinase-activating kinase hypophosphorylation of retinoic acid receptor alpha. J Biol Chem. 2002 Nov 8; 277(45):43369-76. View in: PubMed

Enhanced Escherichia coli invasion of human brain microvascular endothelial cells is associated with alternations in cytoskeleton induced by nicotine. Cell Microbiol. 2002 Aug; 4(8):503-14. View in: PubMed

Infectomics: genomics and proteomics of microbial infections. Funct Integr Genomics. 2002 Apr; 1(6):331-44. View in: PubMed

Inverse PCR. Genomic DNA cloning. Methods Mol Biol. 2002; 192:301-7. View in: PubMed

Gene cloning and expression profiling by rapid amplification of gene inserts with universal vector primers. Methods Mol Biol. 2002; 192:309-14. View in: PubMed

A novel genetic island of meningitic Escherichia coli K1 containing the ibeA invasion gene (GimA): functional annotation and carbon-source-regulated invasion of human brain microvascular endothelial cells. Funct Integr Genomics. 2001 Sep; 1(5):312-22. View in: PubMed

Traversal of Candida albicans across human blood-brain barrier in vitro. Infect Immun. 2001 Jul; 69(7):4536-44. View in: PubMed

Cellular mechanisms of microbial proteins contributing to invasion of the blood-brain barrier. Cell Microbiol. 2001 May; 3(5):277-87. View in: PubMed

Further characterization of Escherichia coli brain microvascular endothelial cell invasion gene ibeA by deletion, complementation, and protein expression. J Infect Dis. 2001 Apr 1; 183(7):1071-8. View in: PubMed

MAT1-modulated CAK activity regulates cell cycle G(1) exit. Mol Cell Biol. 2001 Jan; 21(1):260-70. View in: PubMed

Loss control of Mcm5 interaction with chromatin in cdc6-1 mutated in CDC-NTP motif. DNA Cell Biol. 2000 Jul; 19(7):447-57. View in: PubMed

Identification and characterization of Saccharomyces cerevisiae Cdc6 DNA-binding properties. Mol Biol Cell. 2000 May; 11(5):1673-85. View in: PubMed

The essential role of Saccharomyces cerevisiae CDC6 nucleotide-binding site in cell growth, DNA synthesis, and Orc1 association. J Biol Chem. 1999 Mar 19; 274(12):8291-8. View in: PubMed

RNA antisense abrogation of MAT1 induces G1 phase arrest and triggers apoptosis in aortic smooth muscle cells. J Biol Chem. 1999 Feb 26; 274(9):5564-72. View in: PubMed

Saccharomyces cerevisiae Cdc6 stimulates Abf1 DNA binding activity. J Biol Chem. 1998 Jan 16; 273(3):1298-302. View in: PubMed

A simple and sensitive ribonucleotide reductase assay. J Biomed Sci. 1998; 5(1):62-8. View in: PubMed

Expression and preparation of fusion proteins from recombinant lambda gt11 phages. Methods Mol Biol. 1997; 69:241-5. View in: PubMed

Rapid amplification of gene ends (RAGE) from gene libraries by anchored PCR. Methods Mol Biol. 1997; 67:295-300. View in: PubMed

Interaction between yeast Cdc6 protein and B-type cyclin/Cdc28 kinases. Mol Biol Cell. 1996 Nov; 7(11):1723-35. View in: PubMed

Intracellular location of the Saccharomyces cerevisiae CDC6 gene product. DNA Cell Biol. 1996 Oct; 15(10):883-95. View in: PubMed

Pulsed field gel electrophoresis labeling method to study the pattern of Saccharomyces cerevisiae chromosomal DNA synthesis during the G1/S phase of the cell cycle. Anal Biochem. 1995 May 1; 227(1):32-9. View in: PubMed

Temporal and spatial distributions of yeast nucleoside diphosphate kinase activities and its association with the Cdc8p. Cell Mol Biol Res. 1995; 41(5):333-46. View in: PubMed

Efficient induction and preparation of fusion proteins from recombinant phage lambda gt11 clones. Trends Genet. 1994 Jun; 10(6):183. View in: PubMed

Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth. DNA Cell Biol. 1994 May; 13(5):461-71. View in: PubMed

Characteristics, substrate analysis, and intracellular location of Saccharomyces cerevisiae UMP kinase. Arch Biochem Biophys. 1993 Jul; 304(1):197-204. View in: PubMed

Mutation analysis of Saccharomyces cerevisiae CDC6 promoter: defining its UAS domain and cell cycle regulating element. DNA Cell Biol. 1993 May; 12(4):363-70. View in: PubMed

Amplification of gene ends from gene libraries by polymerase chain reaction with single-sided specificity. Methods Mol Biol. 1993; 15:357-63. View in: PubMed

Functional and structural conservation of Schizosaccharomyces pombe dTMP kinase gene. Biochim Biophys Acta. 1992 Sep 24; 1132(2):222-4. View in: PubMed

Saccharomyces cerevisiae nucleoside-diphosphate kinase: purification, characterization, and substrate specificity. Arch Biochem Biophys. 1991 Dec; 291(2):241-6. View in: PubMed

Molecular characterization of Saccharomyces cerevisiae URA6 gene. DNA sequence, mutagenesis analysis, and cell cycle regulation relevant to its suppression mechanism to cdc8 mutation. J Biol Chem. 1991 Sep 25; 266(27):18287-93. View in: PubMed

Human deoxycytidine kinase. Sequence of cDNA clones and analysis of expression in cell lines with and without enzyme activity. J Biol Chem. 1991 Mar 15; 266(8):5353. View in: PubMed

The CDC4 gene product is associated with the yeast nuclear skeleton. Biochem Biophys Res Commun. 1990 Nov 15; 172(3):1324-30. View in: PubMed

CDC6 mRNA fluctuates periodically in the yeast cell cycle. J Biol Chem. 1990 Nov 15; 265(32):19904-9. View in: PubMed

Purification and characterization of Saccharomyces cerevisiae uridine monophosphate kinase. J Biol Chem. 1990 Nov 5; 265(31):19122-7. View in: PubMed

A protocol for using T7 DNA polymerase in oligonucleotide site-directed mutagenesis. Biotechniques. 1990 May; 8(5):503. View in: PubMed

Mini-prep in ten minutes. Biotechniques. 1990 Feb; 8(2):172-3. View in: PubMed

The Saccharomyces cerevisiae SOC8-1 gene and its relationship to a nucleotide kinase. J Biol Chem. 1989 Sep 15; 264(26):15593-9. View in: PubMed

Human deoxycytidine kinase. Sequence of cDNA clones and analysis of expression in cell lines with and without enzyme activity. J Biol Chem. 1989 Sep 5; 264(25):14762-8. View in: PubMed

Isolation of multiple types of plasminogen activator inhibitors from vascular smooth muscle cells. Thromb Haemost. 1989 Jun 30; 61(3):517-21. View in: PubMed

Molecular cloning of Saccharomyces cerevisiae CDC6 gene. Isolation, identification, and sequence analysis. J Biol Chem. 1989 May 25; 264(15):9022-9. View in: PubMed

Saccharomyces cerevisiae SSB1 protein and its relationship to nucleolar RNA-binding proteins. Mol Cell Biol. 1987 Aug; 7(8):2947-55. View in: PubMed

Isolation of the gene encoding yeast single-stranded nucleic acid binding protein 1. Proc Natl Acad Sci U S A. 1986 Feb; 83(4):877-81. View in: PubMed

Yeast DNA replication. Basic Life Sci. 1986; 40:463-78. View in: PubMed

Multiple species of single-stranded nucleic acid-binding proteins in Saccharomyces cerevisiae. J Biol Chem. 1985 Dec 25; 260(30):16367-74. View in: PubMed

DNA synthesis in yeast cell-free extracts dependent on recombinant DNA plasmids purified from Escherichia coli. Nucleic Acids Res. 1985 Apr 25; 13(8):2943-58. View in: PubMed

Characterization of Saccharomyces cerevisiae thymidylate kinase, the CDC8 gene product. General properties, kinetic analysis, and subcellular localization. J Biol Chem. 1984 Dec 10; 259(23):14394-8. View in: PubMed

The CDC8 gene of yeast encodes thymidylate kinase. J Biol Chem. 1984 Sep 10; 259(17):11052-9. View in: PubMed

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