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Ambrose Yaw-Shong Jong, PhD
Associate Professor of Pediatrics
CHLA 4650 W. Sunset Blvd. Off Campus Los Angeles
+1 323 361 5647


Wang S, Peng L, Gai Z, Zhang L, Jong A, Cao H, Huang SH. Pathogenic Triad in Bacterial Meningitis: Pathogen Invasion, NF-?B Activation, and Leukocyte Transmigration that Occur at the Blood-Brain Barrier. Front Microbiol. 2016; 7:148. View in: PubMed

Yang ZW, Jiang YH, Ma C, Silvestri G, Bosinger SE, Li BL, Jong A, Zhou YH, Huang SH. Coexpression Network Analysis of Benign and Malignant Phenotypes of SIV-Infected Sooty Mangabey and Rhesus Macaque. PLoS One. 2016; 11(6):e0156170. View in: PubMed

Li J, Chang YC, Wu CH, Liu J, Kwon-Chung KJ, Huang SH, Shimada H, Fante R, Fu X, Jong A. The 14-3-3 gene function of Cryptococcus neoformans is required for its growth and virulence. J Microbiol Biotechnol. 2015 Oct 6. View in: PubMed

Tseng HK, Huang TY, Wu AY, Chen HH, Liu CP, Jong A. How Cryptococcus interacts with the blood-brain barrier. Future Microbiol. 2015 Oct; 10:1669-82. View in: PubMed

Challagundla KB, Wise PM, Neviani P, Chava H, Murtadha M, Xu T, Kennedy R, Ivan C, Zhang X, Vannini I, Fanini F, Amadori D, Calin GA, Hadjidaniel M, Shimada H, Jong A, Seeger RC, Asgharzadeh S, Goldkorn A, Fabbri M. Exosome-Mediated Transfer of microRNAs Within the Tumor Microenvironment and Neuroblastoma Resistance to Chemotherapy. J Natl Cancer Inst. 2015 Jul; 107(7). View in: PubMed

Zhang B, Yu JY, Liu LQ, Peng L, Chi F, Wu CH, Jong A, Wang SF, Cao H, Huang SH. Alpha7 nicotinic acetylcholine receptor is required for blood-brain barrier injury-related CNS disorders caused by Cryptococcus neoformans and HIV-1 associated comorbidity factors. BMC Infect Dis. 2015; 15(1):352. View in: PubMed

Singh A, Panting RJ, Varma A, Saijo T, Waldron KJ, Jong A, Ngamskulrungroj P, Chang YC, Rutherford JC, Kwon-Chung KJ. Factors required for activation of urease as a virulence determinant in Cryptococcus neoformans. MBio. 2013; 4(3):e00220-13. View in: PubMed

Huang SH, Wang L, Chi F, Wu CH, Cao H, Zhang A, Jong A. Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors. PLoS One. 2013; 8(4):e62164. View in: PubMed

Jong A, Wu CH, Gonzales-Gomez I, Kwon-Chung KJ, Chang YC, Tseng HK, Cho WL, Huang SH. Hyaluronic Acid Receptor CD44 Deficiency Is Associated with Decreased Cryptococcus neoformans Brain Infection. J Biol Chem. 2012 May 4; 287(19):15298-306. View in: PubMed

Yang CS, Rodgers M, Min CK, Lee JS, Kingeter L, Lee JY, Jong A, Kramnik I, Lin X, Jung JU. The Autophagy Regulator Rubicon Is a Feedback Inhibitor of CARD9-Mediated Host Innate Immunity. Cell Host Microbe. 2012 Mar 15; 11(3):277-89. View in: PubMed

Chaudhry P, Yang X, Wagner M, Jong A, Wu L. Retinoid-Regulated FGF8f Secretion by Osteoblasts Bypasses Retinoid Stimuli to Mediate Granulocytic Differentiation of Myeloid Leukemia Cells. Mol Cancer Ther. 2012 Feb; 11(2):267-76. View in: PubMed

Chi F, Bo T, Wu CH, Jong A, Huang SH. Vimentin and PSF Act in Concert to Regulate IbeA+ E. coli K1 Induced Activation and Nuclear Translocation of NF-?B in Human Brain Endothelial Cells. PLoS One. 2012; 7(4):e35862. View in: PubMed

Huang SH, Wu CH, Chang YC, Kwon-Chung KJ, Brown RJ, Jong A. Cryptococcus neoformans-derived microvesicles enhance the pathogenesis of fungal brain infection. PLoS One. 2012; 7(11):e48570. View in: PubMed

Long M, Huang SH, Wu CH, Shackleford GM, Jong A. Lipid raft/caveolae signaling is required for Cryptococcus neoformans invasion into human brain microvascular endothelial cells. J Biomed Sci. 2012; 19:19. View in: PubMed

Tseng HK, Liu CP, Price MS, Jong AY, Chang JC, Toffaletti DL, Betancourt-Quiroz M, Frazzitta AE, Cho WL, Perfect JR. Identification of Genes from the Fungal Pathogen Cryptococcus neoformans Related to Transmigration into the Central Nervous System. PLoS One. 2012; 7(9):e45083. View in: PubMed

Huang SH, Long M, Wu CH, Kwon-Chung KJ, Chang YC, Chi F, Lee S, Jong A. Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3). J Biol Chem. 2011 Oct 7; 286(40):34761-9. View in: PubMed

Huang SH, Wu CH, Jiang S, Bahner I, Lossinsky AS, Jong AY. HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to human brain microvascular endothelial cells via gp41 core-induced membrane activities. Biochem J. 2011 Sep 15; 438(3):457-66. View in: PubMed

Chi F, Wang L, Zheng X, Jong A, Huang SH. Recruitment of a7 nicotinic acetylcholine receptor to caveolin-1-enriched lipid rafts is required for nicotine-enhanced Escherichia coli K1 entry into brain endothelial cells. Future Microbiol. 2011 Aug; 6(8):953-66. View in: PubMed

LONG M, CAO H, Jong A. [Effect of HIV-1gp41 ectodomain on Cryptococcus neoformans-induced cytoskeletal changes in human brain microvascular endothelial cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2011 Mar; 31(3):478-81. View in: PubMed

Wang LI, Lin YS, Liu KH, Jong AY, Shen WC. Cryptococcus neoformans mediator protein Ssn8 negatively regulates diverse physiological processes and is required for virulence. PLoS One. 2011; 6(4):e19162. View in: PubMed

Chi F, Wang L, Zheng X, Wu CH, Jong A, Sheard MA, Shi W, Huang SH. Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor. PLoS One. 2011; 6(9):e25016. View in: PubMed

Wang A, Alimova IN, Luo P, Jong A, Triche TJ, Wu L. Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation. FASEB J. 2010 Mar; 24(3):833-43. View in: PubMed

Huang SH, Jong A. Evolving role of laminin receptors in microbial pathogenesis and therapeutics of CNS infection. Future Microbiol. 2009 Oct; 4(8):959-62. View in: PubMed

Chi F, Wang Y, Gallaher TK, Wu CH, Jong A, Huang SH. Identification of IbeR as a stationary-phase regulator in meningitic Escherichia coli K1 that carries a loss-of-function mutation in rpoS. J Biomed Biotechnol. 2009; 2009:520283. View in: PubMed

Huang SH, He L, Zhou Y, Wu CH, Jong A. Lactobacillus rhamnosus GG Suppresses Meningitic E. coli K1 Penetration across Human Intestinal Epithelial Cells In Vitro and Protects Neonatal Rats against Experimental Hematogenous Meningitis. Int J Microbiol. 2009; 2009:647862. View in: PubMed

Zou Y, He L, Chi F, Jong A, Huang SH. Involvement of Escherichia coli K1 ibeT in bacterial adhesion that is associated with the entry into human brain microvascular endothelial cells. Med Microbiol Immunol. 2008 Dec; 197(4):337-44. View in: PubMed

Jong A, Wu CH, Prasadarao NV, Kwon-Chung KJ, Chang YC, Ouyang Y, Shackleford GM, Huang SH. Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells requires protein kinase C-alpha activation. Cell Microbiol. 2008 Sep; 10(9):1854-65. View in: PubMed

Jong A, Wu CH, Shackleford GM, Kwon-Chung KJ, Chang YC, Chen HM, Ouyang Y, Huang SH. Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells. Cell Microbiol. 2008 Jun; 10(6):1313-26. View in: PubMed

Feng L, Barnhart JR, Seeger RC, Wu L, Keshelava N, Huang SH, Jong A. Cdc6 knockdown inhibits human neuroblastoma cell proliferation. Mol Cell Biochem. 2008 Apr; 311(1-2):189-97. View in: PubMed

Jong A, Wu CH, Zhou W, Chen HM, Huang SH. Infectomic analysis of gene expression profiles of human brain microvascular endothelial cells infected with Cryptococcus neoformans. J Biomed Biotechnol. 2008; 2008:375620. View in: PubMed

Zou Y, He L, Wu CH, Cao H, Xie ZH, Ouyang Y, Wang Y, Jong A, Huang SH. PSF is an IbeA-binding protein contributing to meningitic Escherichia coli K1 invasion of human brain microvascular endothelial cells. Med Microbiol Immunol. 2007 Sep; 196(3):135-43. View in: PubMed

Jong A, Wu CH, Chen HM, Luo F, Kwon-Chung KJ, Chang YC, Lamunyon CW, Plaas A, Huang SH. Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection. Eukaryot Cell. 2007 Aug; 6(8):1486-96. View in: PubMed

Huang SH, Wang X, Jong A. The evolving role of infectomics in drug discovery. Expert Opin Drug Discov. 2007 Jul; 2(7):961-75. View in: PubMed

Jong AY, Wu CH, Jiang S, Feng L, Chen HM, Huang SH. HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to HBMEC. Biochem Biophys Res Commun. 2007 May 18; 356(4):899-905. View in: PubMed

Bao GC, Wang JG, Jong A. Increased p21 expression and complex formation with cyclin E/CDK2 in retinoid-induced pre-B lymphoma cell apoptosis. FEBS Lett. 2006 Jun 26; 580(15):3687-93. View in: PubMed

Oh YS, Jong AY, Kim DT, Li H, Wang C, Zemljic-Harpf A, Ross RS, Fishbein MC, Chen PS, Chen LS. Spatial distribution of nerve sprouting after myocardial infarction in mice. Heart Rhythm. 2006 Jun; 3(6):728-36. View in: PubMed

Luo F, Yee JK, Huang SH, Wu LT, Jong AY. Downregulation of human Cdc6 protein using a lentivirus RNA interference expression vector. Methods Mol Biol. 2006; 342:287-93. View in: PubMed

Jong A, Huang SH. Blood-brain barrier drug discovery for central nervous system infections. Curr Drug Targets Infect Disord. 2005 Mar; 5(1):65-72. View in: PubMed

Chen SH, Stins MF, Huang SH, Chen YH, Kwon-Chung KJ, Chang Y, Kim KS, Suzuki K, Jong AY. Cryptococcus neoformans induces alterations in the cytoskeleton of human brain microvascular endothelial cells. J Med Microbiol. 2003 Nov; 52(Pt 11):961-70. View in: PubMed

Jong AY, Chen SH, Stins MF, Kim KS, Tuan TL, Huang SH. Binding of Candida albicans enolase to plasmin(ogen) results in enhanced invasion of human brain microvascular endothelial cells. J Med Microbiol. 2003 Aug; 52(Pt 8):615-22. View in: PubMed

Qiu W, David D, Zhou B, Chu PG, Zhang B, Wu M, Xiao J, Han T, Zhu Z, Wang T, Liu X, Lopez R, Frankel P, Jong A, Yen Y. Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma. Am J Pathol. 2003 Jun; 162(6):1961-74. View in: PubMed

Huang SH, Chen SH, Jong AY. Use of inverse PCR to clone cDNA ends. Methods Mol Biol. 2003; 221:51-8. View in: PubMed

Wang J, Barsky LW, Shum CH, Jong A, Weinberg KI, Collins SJ, Triche TJ, Wu L. Retinoid-induced G1 arrest and differentiation activation are associated with a switch to cyclin-dependent kinase-activating kinase hypophosphorylation of retinoic acid receptor alpha. J Biol Chem. 2002 Nov 8; 277(45):43369-76. View in: PubMed

Chen YH, Chen SH, Jong A, Zhou ZY, Li W, Suzuki K, Huang SH. Enhanced Escherichia coli invasion of human brain microvascular endothelial cells is associated with alternations in cytoskeleton induced by nicotine. Cell Microbiol. 2002 Aug; 4(8):503-14. View in: PubMed

Huang SH, Triche T, Jong AY. Infectomics: genomics and proteomics of microbial infections. Funct Integr Genomics. 2002 Apr; 1(6):331-44. View in: PubMed

Jong AY, T'ang A, Liu DP, Huang SH. Inverse PCR. Genomic DNA cloning. Methods Mol Biol. 2002; 192:301-7. View in: PubMed

Huang SH, Wu HY, Jong AY. Gene cloning and expression profiling by rapid amplification of gene inserts with universal vector primers. Methods Mol Biol. 2002; 192:309-14. View in: PubMed

Jong AY, Stins MF, Huang SH, Chen SH, Kim KS. Traversal of Candida albicans across human blood-brain barrier in vitro. Infect Immun. 2001 Jul; 69(7):4536-44. View in: PubMed

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