Faculty

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Amir Goldkorn, MD
Associate Professor of Medicine
Medicine
NOR 3444 Health Sciences Campus Los Angeles
+1 323 442 7721

Overview

Dr. Goldkorn’s laboratory-based research program focuses on developing the therapeutic and biomarker potential of circulating tumor cells, cancer stem cells, and telomerase. Graduate students, postdocs and medical students in the laboratory conduct experiments ranging from basic molecular research to translational medicine assays for clinical trials. These research activities synergize with our clinical activities and provide unique opportunities to translate our laboratory and clinical advances into better care for our patients.

Dr. Goldkorn earned his medical degree from the UCLA School of Medicine. He then went on to complete his fellowship in hematology-oncology and post-doctoral research at University of California, San Francisco.

Awards

American Federation for Medical Research: Outstanding Investigator Award, 2015

Western Society of Clinical Investigation: Elected Member, 2014

American Society of Clinical Oncology: Merit Award, 2012

Stop Cancer Foundation: Research Career Development Award, 2007-2010

American Society of Clinical Oncology: Qoung Investigatgr Award, 2006-2007

American Society of Clinical Oncology: Young Investigator Award, 2006-2007

UCLA School of Medicine: Letters of Distinction, 1996-1997

Harvard University: Harvard College Scholarship, 1990-1994

Publications

Validation of the Association of RECIST Changes With Survival in Men With Metastatic Castration-Resistant Prostate Cancer Treated on SWOG Study S0421. Clin Genitourin Cancer. 2017 May 10. View in: PubMed

Circulating Tumor Cells in Genitourinary Malignancies: An Evolving Path to Precision Medicine. Front Oncol. 2017; 7:6. View in: PubMed

Telomere and Telomerase Therapeutics in Cancer. Genes (Basel). 2016 May 26; 7(6). View in: PubMed

AXIN2 expression predicts prostate cancer recurrence and regulates invasion and tumor growth. Prostate. 2016 May; 76(6):597-608. View in: PubMed

Telomere and Telomerase Therapeutics in Cancer. Genes (Basel). 2016; 7(6). View in: PubMed

Editorial Comment. J Urol. 2015 Sep; 194(3):798. View in: PubMed

Exosome-mediated transfer of microRNAs within the tumor microenvironment and neuroblastoma resistance to chemotherapy. J Natl Cancer Inst. 2015 Jul; 107(7). View in: PubMed

Circulating tumor cell telomerase activity as a prognostic marker for overall survival in SWOG 0421: a phase III metastatic castration resistant prostate cancer trial. Int J Cancer. 2015 Apr 15; 136(8):1856-62. View in: PubMed

Circulating tumor cells in prostate cancer: a better predictor of survival than prostate specific antigen? Expert Rev Anticancer Ther. Circulating tumor cells in prostate cancer: a better predictor of survival than prostate specific antigen? Expert Rev Anticancer Ther. 2014 Nov; 14(11):1257-60. View in: PubMed

New prostate cancer drugs: extending and improving life. Lancet Oncol. 2014 Sep; 15(10):1052-4. View in: PubMed

Circulating tumor cell counts are prognostic of overall survival in SWOG S0421: a phase III trial of docetaxel with or without atrasentan for metastatic castration-resistant prostate cancer. J Clin Oncol. 2014 Apr 10; 32(11):1136-42. View in: PubMed

Serum Biomarkers of Bone Metabolism in Castration-Resistant Prostate Cancer Patients With Skeletal Metastases: Results From SWOG 0421. J Natl Cancer Inst. 2014 Apr 1; 106(4):dju013. View in: PubMed

Serum biomarkers of bone metabolism in castration-resistant prostate cancer patients with skeletal metastases: results from SWOG 0421. J Natl Cancer Inst. 2014 Apr; 106(4):dju013. View in: PubMed

Cancer cells acquire a drug resistant, highly tumorigenic, cancer stem-like phenotype through modulation of the PI3K/Akt/ß-catenin/CBP pathway. Int J Cancer. 2014 Jan 01; 134(1):43-54. View in: PubMed

Cancer cells acquire a drug resistant, highly tumorigenic, cancer stem-like phenotype through modulation of the PI3K/Akt/ß-catenin/CBP pathway. Int J Cancer. 2014 Jan 1; 134(1):43-54. View in: PubMed

Circulating tumor cells in prostate cancer. Cancers (Basel). 2013 Dec 04; 5(4):1676-90. View in: PubMed

Efficacy of oxaliplatin plus pemetrexed in chemotherapy pretreated metastatic castration-resistant prostate cancer. Clin Genitourin Cancer. 2013 Dec; 11(4):416-22. View in: PubMed

Docetaxel and atrasentan versus docetaxel and placebo for men with advanced castration-resistant prostate cancer (SWOG S0421): a randomised phase 3 trial. Lancet Oncol. 2013 Aug; 14(9):893-900. View in: PubMed

Therapeutic windows and opportunity cost cast upon prostate cancer's fatal shore. Ann Oncol. 2013 Jul; 24(7):1717-20. View in: PubMed

Circulating tumor cells in prostate cancer. Cancers (Basel). 2013; 5(4):1676-90. View in: PubMed

Perillyl alcohol for the treatment of temozolomide-resistant gliomas. Mol Cancer Ther. 2012 Nov; 11(11):2462-72. View in: PubMed

Prostate tumor cells with cancer progenitor properties have high telomerase activity and are rapidly killed by telomerase interference. Prostate. 2011 Sep 15; 71(13):1390-400. View in: PubMed

Telomerase targeted therapy in cancer and cancer stem cells. Clin Adv Hematol Oncol. 2011 Jun; 9(6):442-55. View in: PubMed

Cancer cells cyclically lose and regain drug-resistant highly tumorigenic features characteristic of a cancer stem-like phenotype. Mol Cancer Ther. 2011 Jun; 10(6):938-48. View in: PubMed

A cancer detection platform which measures telomerase activity from live circulating tumor cells captured on a microfilter. Cancer Res. 2010 Aug 15; 70(16):6420-6. View in: PubMed

Reprogramming murine telomerase rapidly inhibits the growth of mouse cancer cells in vitro and in vivo. Mol Cancer Ther. 2010 Feb; 9(2):438-49. View in: PubMed

Targeted therapy in renal cancer. Ther Adv Med Oncol. 2009 Nov; 1(3):183-205. View in: PubMed

Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells. Cancer Res. 2006 Jun 1; 66(11):5763-71. View in: PubMed

Assembly of mutant-template telomerase RNA into catalytically active telomerase ribonucleoprotein that can act on telomeres is required for apoptosis and cell cycle arrest in human cancer cells. Cancer Res. 2006 Jun 01; 66(11):5763-71. View in: PubMed

Cortical variability and asymmetry in normal aging and Alzheimer's disease. Cereb Cortex. 1998 Sep; 8(6):492-509. View in: PubMed

Sulcal variability in the Alzheimer's brain: correlations with cognition. Neurology. 1998 Jan; 50(1):145-51. View in: PubMed

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