Faculty

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Amir H. Kashani, MD, PhD
Assistant Professor of Clinical Ophthalmology
Ophthalmology
HC4 4900 1450 San Pablo Street Off Campus Los Angeles
+1 323 442 6578

Overview

Amir H. Kashani, MD, PhD, attended Johns Hopkins School of Medicine where he obtained both his MD and PhD in Neuroscience in 2006. He completed his ophthalmology residency at the USC Roski Eye Institute and fellowship in vitreoretinal surgery at the top-rated Associated Retinal Consultants in Royal Oak, Michigan. He was awarded both the Heed and Michel’s Fellowships (National Honors) during his training. Dr. Kashani is an NIH funded clinician-scientist who is studying the role of ischemia and hypoxia in the pathophysiology of retinal vascular diseases like diabetic retinopathy. Dr. Kashani also treats patients with medical and surgical retinal diseases including diabetic retinopathy, retinal vein occlusions, age-related macular degeneration and retinal detachments among other common retinal diseases. He also specializes in complex retinal detachment surgeries.

In the laboratory, Dr. Kashani is developing novel diagnostic and therapeutic methods to diagnose and treat retinal diseases. His investigates the use of advanced imaging spectroscopy and optical coherence tomography methods to improve the early detection of chronic diseases like diabetic retinopathy and retinal venous occlusion. Dr. Kashani is the principal investigator for a clinical trial to test a novel stem cell therapy for severe vision loss from advanced dry age-related macular degeneration. In recognition of his cutting edge research Dr. Kashani has been recognized internatioinally by his peers. In 2016 he was named as one of the top 150 innovators in the field of medical and surgical retina by Ocular Surgery News. In 2017 he was named as one of the top 50 "rising stars" world-wide in the field of ophthalmology by The Ophthalmologist.

Dr. Kashani has co-authored more than 40 peer reviewed articles in the scientific literature, several subject reviews, and recently co-authored an ophthalmology book entitled "Optical Coherence Tomography and OCT Angiography: Clinical Reference and Case Studies."

Awards

The Ophthalmologist: Rising Stars Power List, 2017

Ocular Surgery News: Nominated to 150 leading innovators in medical and surgical retina, 2016

Society of Heed Scholars: Heed Ophthalmic Foundation Fellow, 2012

Ron G. Michel's Fellowhship

Heed Resident Research Symposium (Rank #4)

Association for Research in Vision and Ophthalmology: Member, 2009

Henry and Lilian Nesburn Award

USC Department of Ophthalmology: Resident Research Award, 2008

ARVO Research Travel Grant

ARVO: Retinal Research Foundation Grant, 2006

Johns Hopkins School of Medicine: Medical Student Research Fellowship, 2000

Medical Scientist Training Program Fellowship (MSTP)

Publications

Diagnostic and Therapeutic Challenges. Retina. 2017 Sep; 37(9):1805-1808. View in: PubMed

Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications. Prog Retin Eye Res. 2017 Jul 29. View in: PubMed

Quantitative microvascular analysis of retinal venous occlusions by spectral domain optical coherence tomography angiography. PLoS One. 2017; 12(4):e0176404. View in: PubMed

THE SECOND BLIND SPOT: SMALL RETINAL VESSEL VASCULOPATHY AFTER VACCINATION AGAINST NEISSERIA MENINGITIDIS AND YELLOW FEVER. Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S18-S23. View in: PubMed

Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography. Am J Ophthalmol. 2016 Nov; 171:101-112. View in: PubMed

Diagnostic and Therapeutic Challenges. Retina. 2016 Sep 27. View in: PubMed

Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs. Graefes Arch Clin Exp Ophthalmol. 2016 Aug; 254(8):1553-65. View in: PubMed

Quantifying Microvascular Density and Morphology in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2016 Jul 01; 57(9):OCT362-70. View in: PubMed

Quantifying Microvascular Density and Morphology in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2016 Jul 1; 57(9):OCT362-70. View in: PubMed

Impaired Retinal Perfusion Resulting From Vitreoretinal Traction: A Mechanism of Retinal Vascular Insufficiency. Ophthalmic Surg Lasers Imaging Retina. 2016 Mar; 47(3):1-11. View in: PubMed

Impaired Retinal Perfusion Resulting From Vitreoretinal Traction: A Mechanism of Retinal Vascular Insufficiency. Ophthalmic Surg Lasers Imaging Retina. 2016 Mar 1; 47(3):1-11. View in: PubMed

Spatial Variations in Vitreous Oxygen Consumption. PLoS One. 2016; 11(3):e0149961. View in: PubMed

OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF RETINAL VENOUS OCCLUSION. Retina. 2015 Nov; 35(11):2323-31. View in: PubMed

Stem cell based therapies for age-related macular degeneration: The promises and the challenges. Prog Retin Eye Res. 2015 Sep; 48:1-39. View in: PubMed

Optical Coherence Tomography Angiography of Diabetic Retinopathy in Human Subjects. Ophthalmic Surg Lasers Imaging Retina. 2015 Sep; 46(8):796-805. View in: PubMed

Optical Coherence Tomography Angiography of Diabetic Retinopathy in Human Subjects. Ophthalmic Surg Lasers Imaging Retina. 2015 Sep 1; 46(8):796-805. View in: PubMed

Whole vitreous humor dissection for vitreodynamic analysis. J Vis Exp. 2015 May 24; (99):e52759. View in: PubMed

Spleen size in cirrhosis of different etiologies. J Ultrasound Med. 2015 Feb; 34(2):233-8. View in: PubMed

Whole Vitreous Humor Dissection for Vitreodynamic Analysis. J Vis Exp. 2015; (99). View in: PubMed

MULTIMODAL IMAGING OF GEOGRAPHIC AREAS OF RETINAL DARKENING. Retin Cases Brief Rep. 2015; 9(4):347-51. View in: PubMed

Longitudinal optical density analysis of subretinal fluid after surgical repair of rhegmatogenous retinal detachment. Retina. 2015 Jan; 35(1):149-56. View in: PubMed

OCT Angiography in Healthy Human Subjects. Ophthalmic Surg Lasers Imaging Retina. 2014 Nov 1; 45(6):510-5. View in: PubMed

OCT angiography in healthy human subjects. Ophthalmic Surg Lasers Imaging Retina. 2014 Nov-Dec; 45(6):510-5. View in: PubMed

Diversity of retinal vascular anomalies in patients with familial exudative vitreoretinopathy. Ophthalmology. 2014 Nov; 121(11):2220-7. View in: PubMed

Can endoscopic ultrasound distinguish between mediastinal benign lymph nodes and those involved by sarcoidosis, lymphoma, or metastasis? Dig Dis Sci. Can endoscopic ultrasound distinguish between mediastinal benign lymph nodes and those involved by sarcoidosis, lymphoma, or metastasis? Dig Dis Sci. 2014 Sep; 59(9):2191-8. View in: PubMed

Noninvasive assessment of retinal vascular oxygen content among normal and diabetic human subjects: a study using hyperspectral computed tomographic imaging spectroscopy. Retina. 2014 Sep; 34(9):1854-60. View in: PubMed

Staphylococcus lugdunensis endophthalmitis after intravitreal injection: a case series. Retin Cases Brief Rep. 2014; 8(1):41-4. View in: PubMed

Profile of ocriplasmin and its potential in the treatment of vitreomacular adhesion. Clin Ophthalmol. 2014; 8:847-56. View in: PubMed

Subretinal peripapillary neovascularization associated with persistent fetal vasculature. Retin Cases Brief Rep. 2014; 8(1):83-6. View in: PubMed

High prevalence of peripheral retinal vascular anomalies in family members of patients with familial exudative vitreoretinopathy. Ophthalmology. 2014 Jan; 121(1):262-8. View in: PubMed

Vitreomacular traction as a consequence of posterior hyaloidal contraction after transpupillary thermotherapy. Am J Ophthalmol. 2013 May; 155(5):937-45. View in: PubMed

The emergence of Klebsiella pneumoniae endogenous endophthalmitis in the USA: basic and clinical advances. J Ophthalmic Inflamm Infect. 2013 Feb 04; 3(1):28. View in: PubMed

Quantitative analysis of retinal structures using spectral domain optical coherence tomography in normal rabbits. Curr Eye Res. 2013 Feb; 38(2):299-304. View in: PubMed

The emergence of Klebsiella pneumoniae endogenous endophthalmitis in the USA: basic and clinical advances. J Ophthalmic Inflamm Infect. 2013; 3(1):28. View in: PubMed

Acute variations in retinal vascular oxygen content in a rabbit model of retinal venous occlusion. PLoS One. 2012; 7(11):e50179. View in: PubMed

Bilateral Klebsiella pneumoniae (K1 serotype) endogenous endophthalmitis as the presenting sign of disseminated infection. Ophthalmic Surg Lasers Imaging. 2011 Feb 10; 42 Online:e12-4. View in: PubMed

Bilateral Klebsiella pneumoniae (K1 serotype) endogenous endophthalmitis as the presenting sign of disseminated infection. Ophthalmic Surg Lasers Imaging. 2011; 42 Online:e12-4. View in: PubMed

Hyperspectral computed tomographic imaging spectroscopy of vascular oxygen gradients in the rabbit retina in vivo. PLoS One. 2011; 6(9):e24482. View in: PubMed

Retinal thickness analysis by race, gender, and age using Stratus OCT. Am J Ophthalmol. 2010 Mar; 149(3):496-502. e1. View in: PubMed

Quantitative subanalysis of cystoid spaces and outer nuclear layer using optical coherence tomography in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3366-73. View in: PubMed

Predicting response to HBV vaccination in people with positive anti-HBc but negative HBsAg and anti-HBs. Hum Vaccin. 2008 Sep-Oct; 4(5):379-83. View in: PubMed

Fluid retention in cirrhosis: pathophysiology and management. QJM. 2008 Feb; 101(2):71-85. View in: PubMed

Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections. J Neurosci. 2006 Aug 9; 26(32):8398-408. View in: PubMed

Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections. J Neurosci. 2006 Aug 09; 26(32):8398-408. View in: PubMed

Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration. Proc Natl Acad Sci U S A. 2005 Feb 8; 102(6):2105-10. View in: PubMed

Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration. Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):2105-10. View in: PubMed

The role of integrins in the modulation of neurotransmitter release from motor nerve terminals by stretch and hypertonicity. J Neurocytol. 2003 Jun-Sep; 32(5-8):489-503. View in: PubMed

Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription. Neuron. 2002 Jun 13; 34(6):999-1010. View in: PubMed

Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient with cystathionine beta-synthase (CBS) deficiency. Am J Med Genet. 2002 Feb 15; 108(1):57-63. View in: PubMed

Meningeal-cutaneous relationships in anencephaly: evidence for a primary mesenchymal abnormality. Hum Pathol. 2001 May; 32(5):553-8. View in: PubMed

Hypertonic enhancement of transmitter release from frog motor nerve terminals: Ca2+ independence and role of integrins. J Physiol. 2001 Jan 15; 530(Pt 2):243-52. View in: PubMed

High dose intramuscular methylprednisolone in experimental Staphylococcus aureus endophthalmitis. J Ocul Pharmacol Ther. 1999 Feb; 15(1):91-6. View in: PubMed

Safety of repeated intravitreous injections of antibiotics and dexamethasone. Retina. 1999; 19(5):437-41. View in: PubMed

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