Faculty

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Amy L. Firth, PhD
Assistant Professor of Medicine
Medicine
IRD 720 2020 Zonal Avenue Off Campus Los Angeles
+1 323 442 1833

Overview

Many of us take our lungs for granted yet they perform a function that is critical for life, respiration. Unfortunately millions of Americans suffer from one of a number of debilitating lung diseases making the subconscious action of breathing a very conscious and difficult activity. Studying human lung disease and, in particular, the way in which a lung disease develops in humans is exceptionally difficult in a dish. For me this was the challenge that became the focus of my postdoctoral research at The Salk Institute for Biological Studies – to create a reproducible and effective way to study human lung development and disease in a dish.

My laboratory will focus on utilizing patient derived induced pluripotent stem cells (iPSC) and state-of-the-art gene editing technologies, such as CRISPR, to a) model and study mechanisms of lung disease development and b) investigate approaches for tissue regeneration and stem cell mediated repair of the airway epithelium.

Firth Lab Website

Awards

House of Commons: Finalist, Britain's Top Young Researcher in Biosciences and Medicine, 2005

American Heart Association : Finalist, Cournand and Comroe Young Investigator Award, 2009

American Physiology Society: Caroline tum Suden/Francis A. Hellebrandt Professional Opportunity Award, 2014

House of Commons: ORNG Application Instance for Person, 2005

American Heart Association : ORNG Application Instance for Person, 2009

American Physiology Society: ORNG Application Instance for Person, 2014

House of Commons: full name, 2005

American Heart Association : full name, 2009

House of Commons: person in primary position, 2005

American Physiology Society: person in primary position, 2014

American Heart Association : person in primary position, 2009

American Heart Association : last name, 2009

House of Commons: last name, 2005

American Physiology Society: last name, 2014

American Heart Association : featured_pub_1, 2009

House of Commons: featured_pub_1, 2005

American Physiology Society: featured_pub_1, 2014

American Physiology Society: full name, 2014

House of Commons: has ORNG Application Instance Data, 2005

American Heart Association : has ORNG Application Instance Data, 2009

American Physiology Society: has ORNG Application Instance Data, 2014

House of Commons: sort order, 2005

American Heart Association : sort order, 2009

American Physiology Society: sort order, 2014

American Heart Association : Assistant Professor, 2009

House of Commons: Assistant Professor, 2005

American Physiology Society: Assistant Professor, 2014

American Heart Association : email address, 2009

American Physiology Society: email address, 2014

House of Commons: email address, 2005

American Heart Association : start date, 2009

American Physiology Society: start date, 2014

House of Commons: start date, 2005

American Physiology Society: workplace homepage, 2014

House of Commons: workplace homepage, 2005

American Thoracic Society: workplace homepage, 2017

American Heart Association : workplace homepage, 2009

British Council: workplace homepage, 2017

House of Commons: label, 2005

American Physiology Society: label, 2014

British Council: label, 2017

American Heart Association : label, 2009

American Thoracic Society: label, 2017

American Thoracic Society: award conferred by, 2017

American Heart Association : award conferred by, 2009

House of Commons: award conferred by, 2005

American Physiology Society: award conferred by, 2014

British Council: award conferred by, 2017

House of Commons: Faculty Rank, 2005

American Heart Association : Faculty Rank, 2009

American Thoracic Society: Faculty Rank, 2017

British Council: Faculty Rank, 2017

House of Commons: is primary position, 2005

American Thoracic Society: is primary position, 2017

British Council: is primary position, 2017

American Heart Association : is primary position, 2009

American Physiology Society: is primary position, 2014

British Council: person in primary position, 2017

American Thoracic Society: person in primary position, 2017

House of Commons: Firth, Amy, 2005

American Physiology Society: Firth, Amy, 2014

American Thoracic Society: Firth, Amy, 2017

British Council: Firth, Amy, 2017

American Physiology Society: Assistant Professor of Medicine, 2014

American Heart Association : Assistant Professor of Medicine, 2009

British Council: Assistant Professor of Medicine, 2017

House of Commons: Assistant Professor of Medicine, 2005

American Thoracic Society: Assistant Professor of Medicine, 2017

American Thoracic Society: ORNG Application Instance for Person, 2017

British Council: ORNG Application Instance for Person, 2017

House of Commons: featured_pub_0, 2005

American Heart Association : featured_pub_0, 2009

American Thoracic Society: featured_pub_0, 2017

American Physiology Society: featured_pub_0, 2014

British Council: featured_pub_0, 2017

British Council: position in organization, 2017

House of Commons: position in organization, 2005

American Thoracic Society: position in organization, 2017

American Physiology Society: position in organization, 2014

American Thoracic Society: email address, 2017

British Council: email address, 2017

American Thoracic Society: Person ID, 2017

American Physiology Society: Person ID, 2014

House of Commons: Person ID, 2005

British Council: Person ID, 2017

American Heart Association : Person ID, 2009

American Heart Association : Organization, 2009

British Council: Organization, 2017

House of Commons: Organization, 2005

American Thoracic Society: Organization, 2017

American Thoracic Society: has faculty rank, 2017

American Physiology Society: has faculty rank, 2014

American Heart Association : has faculty rank, 2009

British Council: has faculty rank, 2017

American Thoracic Society: featured_pub_1, 2017

British Council: featured_pub_1, 2017

American Physiology Society: ORNG Application Instance Data value, 2014

American Heart Association : ORNG Application Instance Data value, 2009

House of Commons: ORNG Application Instance Data value, 2005

British Council: ORNG Application Instance Data value, 2017

American Thoracic Society: ORNG Application Instance Data value, 2017

American Thoracic Society: start date, 2017

British Council: start date, 2017

House of Commons: Medicine, 2005

American Physiology Society: Medicine, 2014

British Council: Medicine, 2017

American Thoracic Society: Medicine, 2017

House of Commons: Keck School of Medicine of USC, 2005

American Thoracic Society: Keck School of Medicine of USC, 2017

British Council: Keck School of Medicine of USC, 2017

American Heart Association : Keck School of Medicine of USC, 2009

American Physiology Society: Keck School of Medicine of USC, 2014

American Heart Association : Agent, 2009

British Council: Agent, 2017

American Thoracic Society: Agent, 2017

House of Commons: Agent, 2005

American Physiology Society: Agent, 2014

American Physiology Society: Featured Publications, 2014

American Heart Association : Featured Publications, 2009

House of Commons: Featured Publications, 2005

American Thoracic Society: Featured Publications, 2017

British Council: Featured Publications, 2017

American Physiology Society: Faculty Rank, 2014

American Heart Association : HR job title, 2009

American Physiology Society: HR job title, 2014

British Council: HR job title, 2017

American Thoracic Society: HR job title, 2017

American Physiology Society: Organization, 2014

American Thoracic Society: ATS Assembly on Respiratory Cell and Molecular Biology Carol Basbaum Award , 2017

American Physiology Society: first name, 2014

House of Commons: first name, 2005

American Heart Association : first name, 2009

British Council: first name, 2017

House of Commons: has faculty rank, 2005

Publications

. View in: PubMed

The selective serotonin reuptake inhibitor dapoxetine inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells. Clin Exp Pharmacol Physiol. 2017 Jan 06. View in: PubMed

Selective serotonin reuptake inhibitor sertraline inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells. J Biosci. 2016 Dec; 41(4):659-666. View in: PubMed

The anti-diabetic drug repaglinide induces vasorelaxation via activation of PKA and PKG in aortic smooth muscle. Vascul Pharmacol. 2016 Sep; 84:38-46. View in: PubMed

Alterations of voltage-dependent K(+) channels in the mesenteric artery during the early and chronic phases of diabetes. Clin Exp Pharmacol Physiol. 2016 Sep; 43(9):808-17. View in: PubMed

The class III anti-arrhythmic agent, amiodarone, inhibits voltage-dependent K(+) channels in rabbit coronary arterial smooth muscle cells. Naunyn Schmiedebergs Arch Pharmacol. 2016 Jul; 389(7):713-21. View in: PubMed

Y-27632, a Rho-Associated Protein Kinase Inhibitor, Inhibits Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells. Pharmacology. 2016; 98(5-6):220-227. View in: PubMed

Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs. Cell Rep. 2015 Sep 1; 12(9):1385-90. View in: PubMed

Lymphoid Regeneration from Gene-Corrected SCID-X1 Subject-Derived iPSCs. Cell Stem Cell. 2015 Apr 2; 16(4):367-72. View in: PubMed

W-7 inhibits voltage-dependent K(+) channels independent of calmodulin activity in rabbit coronary arterial smooth muscle cells. Eur J Pharmacol. 2015 Mar 5; 750C:14-9. View in: PubMed

The Effects of the Selective Serotonin Reuptake Inhibitor Fluvoxamine on Voltage-Dependent K(+) Channels in Rabbit Coronary Arterial Smooth Muscle Cells. Biol Pharm Bull. 2015; 38(8):1208-13. View in: PubMed

Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):E1723-30. View in: PubMed

Side-effects of protein kinase inhibitors on ion channels. J Biosci. 2013 Dec; 38(5):937-49. View in: PubMed

Thrombin-mediated activation of Akt signaling contributes to pulmonary vascular remodeling in pulmonary hypertension. Physiol Rep. 2013 Dec 1; 1(7):e00190. View in: PubMed

Human models for smooth muscle cell differentiation. Focus on "A novel in vitro model system for smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells". Am J Physiol Cell Physiol. 2013 Feb 15; 304(4):C287-8. View in: PubMed

Regulation of ca(2+) signaling in pulmonary hypertension. Korean J Physiol Pharmacol. 2013 Feb; 17(1):1-8. View in: PubMed

Animal models of pulmonary hypertension: Rho kinase inhibition. Prog Biophys Mol Biol. 2012 Aug; 109(3):67-75. View in: PubMed

"Ether-à-go-go" proliferation of iPSC-derived mesenchymal stem cells. Focus on "Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-à-go-go 1 (hEAG1) potassium channel". Am J Physiol Cell Physiol. 2012 Jul 15; 303(2):C113-4. View in: PubMed

PDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol. 2012 Jan 15; 302(2):C405-11. View in: PubMed

Identification of functional progenitor cells in the pulmonary vasculature. Pulm Circ. 2012 Jan-Mar; 2(1):84-100. View in: PubMed

Direct effect of protein kinase C inhibitors on cardiovascular ion channels. BMB Rep. 2011 Sep; 44(9):559-65. View in: PubMed

Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines. Stem Cells. 2011 Jul; 29(7):1158-64. View in: PubMed

Endothelial and smooth muscle cell ion channels in pulmonary vasoconstriction and vascular remodeling. Compr Physiol. 2011 Jul; 1(3):1555-602. View in: PubMed

Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant. Mol Pharmacol. 2011 Mar; 79(3):381-8. View in: PubMed

Functional ion channels in human pulmonary artery smooth muscle cells: Voltage-dependent cation channels. Pulm Circ. 2011 Jan 1; 1(1):48-71. View in: PubMed

Increased sensitivity of serotonin on the voltage-dependent K+ channels in mesenteric arterial smooth muscle cells of OLETF rats. Prog Biophys Mol Biol. 2010 Sep; 103(1):88-94. View in: PubMed

Pathophysiology of voltage-gated K+ channels in vascular smooth muscle cells: modulation by protein kinases. Prog Biophys Mol Biol. 2010 Sep; 103(1):95-101. View in: PubMed

Multipotent mesenchymal progenitor cells are present in endarterectomized tissues from patients with chronic thromboembolic pulmonary hypertension. Am J Physiol Cell Physiol. 2010 May; 298(5):C1217-25. View in: PubMed

Idiopathic pulmonary arterial hypertension. Dis Model Mech. 2010 May-Jun; 3(5-6):268-73. View in: PubMed

Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2010 Apr; 298(4):L548-57. View in: PubMed

Patho-, physiological roles of voltage-dependent K+ channels in pulmonary arterial smooth muscle cells. J Smooth Muscle Res. 2010; 46(2):89-105. View in: PubMed

Hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells. Ann N Y Acad Sci. 2009 Oct; 1177:101-11. View in: PubMed

Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L666-76. View in: PubMed

Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L979-86. View in: PubMed

Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L870-8. View in: PubMed

Cellular localization of mitochondria contributes to Kv channel-mediated regulation of cellular excitability in pulmonary but not mesenteric circulation. Am J Physiol Lung Cell Mol Physiol. 2009 Mar; 296(3):L347-60. View in: PubMed

Fine tuning I(CRAC): the interactions of STIM-1 and Orai. J Physiol. 2009 Jan 15; 587(Pt 1):15-6. View in: PubMed

Bringing down the ROS: a new therapeutic approach for PPHN. Am J Physiol Lung Cell Mol Physiol. 2008 Dec; 295(6):L976-8. View in: PubMed

Thrombin-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2008 Dec; 295(6):L1048-55. View in: PubMed

Prednisolone inhibits PDGF-induced nuclear translocation of NF-kappaB in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2008 Oct; 295(4):L648-57. View in: PubMed

Mitochondria-dependent regulation of Kv currents in rat pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2008 Jul; 295(1):L61-70. View in: PubMed

Regulation of pulmonary vasoconstriction by agonists and caveolae. Exp Lung Res. 2008 May; 34(4):195-208. View in: PubMed

Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling. Circulation. 2008 Jan 1; 117(1):61-9. View in: PubMed

Hypoxia divergently regulates production of reactive oxygen species in human pulmonary and coronary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2007 Oct; 293(4):L952-9. View in: PubMed

Functional characterization of voltage-gated K+ channels in mouse pulmonary artery smooth muscle cells. Am J Physiol Cell Physiol. 2007 Sep; 293(3):C928-37. View in: PubMed

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