Faculty

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Amytis Towfighi, MD
Associate Professor of Neurology (Clinical Scholar)
Neurology
Rancho Los Amigos Health Sciences Campus Downey
+1 323 442 5710

Overview

Dr. Towfighi, Associate Professor of Neurology (Clinical Scholar), is Director of Neurological Services and Innovation for Los Angeles County Department of Health Services and Associate Chief Medical Officer and Chair of the Neurology Department at Rancho Los Amigos National Rehabilitation Center. She received her bachelor degree from MIT, MD from Johns Hopkins, completed internship at Massachusetts General Hospital (MGH), Neurology Residency at the Harvard Partners Neurology Program (MGH and Brigham and Women's Hospital), and Neurovascular Fellowship at UCLA.

She has published extensively on sex, race/ethnic, and socioeconomic disparities in stroke, and is currently testing two interventions designed to address disparities in post-stroke care. She received the prestigious Robert G. Siekert New Investigator in Stroke Award from the American Heart Association and Michael S. Pessin Stroke Leadership Prize from the American Academy of Neurology.

She has been involved in three randomized controlled trials (RCTs) of secondary stroke prevention interventions in the Los Angeles County – Department of Health Services (LAC-DHS) public safety-net system: (1) she was the site principal investigator for an American Heart Association-funded multi-center RCT of a chronic-care model based intervention for blood pressure control, SUSTAIN (Systematic Use of STroke Averting Interventions) (Overall PI: Vickrey, UCLA); (2) she is the principal investigator in an American Heart Association-funded RCT of a lifestyle intervention, HEALS (Healthy Eating And Lifestyle after Stroke) (Mentor: Vickrey); and (3) she is the principal investigator (Multiple PI: Towfighi/Vickrey) of an NINDS-funded RCT of a care manager/community health worker team intervention for improving risk factor control after stroke, the “Secondary stroke prevention by Uniting Community and Chronic care model teams Early to End Disparities (SUCCEED)” trial. The SUCCEED intervention is a culturally-tailored, community-based intervention to improve secondary stroke prevention efforts in underserved, socioeconomically disadvantaged communities (primary outcome – blood pressure control). They are enrolling a broad patient population including individuals with transient ischemic attack (TIA), ischemic and hemorrhagic stroke who speak English, Spanish, Cantonese, Mandarin and Korean.

Awards

American Academy of Neurology: Michael S. Pessin Stroke Leadership Prize, 2013

American Heart Association: Robert G. Siekert New Investigator Award in Stroke, 2012

Princeton Stroke Conference: Junior Investigator, 2012

California Association of Public Hospitals & Health Systems/California Health Care Safety Net Inst: Kaiser Permanente Clinical Systems Development Award, 2011

American Neurological Association: Junior Academic Neurologist, 2011

Massachusetts General Hospital: Massachusetts General Hospital Clinical Research Day Neurology Award, 2006

Publications

Foraker RE, Greiner M, Sims M, Tucker KL, Towfighi A, Bidulescu A, Shoben AB, Smith S, Talegawkar S, Blackshear C, Wang W, Hardy NC, O'Brien E. Comparison of risk scores for the prediction of stroke in African Americans: Findings from the Jackson Heart Study. Am Heart J. 2016 Jul; 177:25-32. View in: PubMed

Hirata S, Ovbiagele B, Markovic D, Towfighi A. Key Factors Associated with Major Depression in a National Sample of Stroke Survivors. J Stroke Cerebrovasc Dis. 2016 May; 25(5):1090-5. View in: PubMed

Lin MP, Towfighi A. Stroke Literature Synopses: Clinical Science. Stroke. 2016 May; 47(5):e77-8. View in: PubMed

Razmara A, Ovbiagele B, Markovic D, Towfighi A. Patterns and Predictors of Blood Pressure Treatment, Control, and Outcomes among Stroke Survivors in the United States. J Stroke Cerebrovasc Dis. 2016 Apr; 25(4):857-65. View in: PubMed

Park JH, Saposnik G, Ovbiagele B, Markovic D, Towfighi A. Effect of B-vitamins on stroke risk among individuals with vascular disease who are not on antiplatelets: A meta-analysis. Int J Stroke. 2016 Feb; 11(2):206-11. View in: PubMed

Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, Das SR, de Ferranti S, Després JP, Fullerton HJ, Howard VJ, Huffman MD, Isasi CR, Jiménez MC, Judd SE, Kissela BM, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Magid DJ, McGuire DK, Mohler ER, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Rosamond W, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Woo D, Yeh RW, Turner MB. Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation. 2016 Jan 26; 133(4):e38-e360. View in: PubMed

Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, Das SR, de Ferranti S, Després JP, Fullerton HJ, Howard VJ, Huffman MD, Isasi CR, Jiménez MC, Judd SE, Kissela BM, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Magid DJ, McGuire DK, Mohler ER, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Rosamond W, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Woo D, Yeh RW, Turner MB. Executive Summary: Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation. 2016 Jan 26; 133(4):447-54. View in: PubMed

Lin MP, Towfighi A. Stroke Literature Synopses: Clinical Science. Stroke. 2016 Jan; 47(1):e4-5. View in: PubMed

Ramirez L, Kim-Tenser MA, Sanossian N, Cen S, Wen G, He S, Mack WJ, Towfighi A. Trends in Acute Ischemic Stroke Hospitalizations in the United States. J Am Heart Assoc. 2016; 5(5). View in: PubMed

Lin MP, Towfighi A. Stroke Literature Synopses: Clinical Science. Stroke. 2015 Nov; 46(11):e232-3. View in: PubMed

McManus M, Ovbiagele B, Markovic D, Towfighi A. Association of Insurance Status with Stroke-Related Mortality and Long-term Survival after Stroke. J Stroke Cerebrovasc Dis. 2015 Aug; 24(8):1924-30. View in: PubMed

Lin MP, Ovbiagele B, Markovic D, Towfighi A. Systolic blood pressure and mortality after stroke: too low, no go? Stroke. 2015 May; 46(5):1307-13. View in: PubMed

Arshi B, Ovbiagele B, Markovic D, Saposnik G, Towfighi A. Differential effect of B-vitamin therapy by antiplatelet use on risk of recurrent vascular events after stroke. Stroke. 2015 Mar; 46(3):870-3. View in: PubMed

Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, de Ferranti S, Després JP, Fullerton HJ, Howard VJ, Huffman MD, Judd SE, Kissela BM, Lackland DT, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Matchar DB, McGuire DK, Mohler ER, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Willey JZ, Woo D, Yeh RW, Turner MB. Heart disease and stroke statistics-2015 update: a report from the american heart association. Circulation. 2015 Jan 27; 131(4):e29-e322. View in: PubMed

Lin MP, Ovbiagele B, Markovic D, Towfighi A. "Life's Simple 7" and Long-Term Mortality After Stroke. J Am Heart Assoc. 2015; 4(11). View in: PubMed

Bushnell C, McCullough LD, Awad IA, Chireau MV, Fedder WN, Furie KL, Howard VJ, Lichtman JH, Lisabeth LD, Piña IL, Reeves MJ, Rexrode KM, Saposnik G, Singh V, Towfighi A, Vaccarino V, Walters MR. Guidelines for the prevention of stroke in women: a statement for healthcare professionals from the american heart association/american stroke association. Stroke. 2014 May; 45(5):1545-88. View in: PubMed

Towfighi A, Markovic D, Ovbiagele B. Consistency of blood pressure control after ischemic stroke: prevalence and prognosis. Stroke. 2014 May; 45(5):1313-7. View in: PubMed

Mochari-Greenberger H, Towfighi A, Mosca L. National Women's Knowledge of Stroke Warning Signs, Overall and by Race/Ethnic Group. Stroke. 2014 Apr; 45(4):1180-2. View in: PubMed

Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Judd SE, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Mackey RH, Magid DJ, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER, Moy CS, Mussolino ME, Neumar RW, Nichol G, Pandey DK, Paynter NP, Reeves MJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Wong ND, Woo D, Turner MB. Executive summary: heart disease and stroke statistics--2014 update: a report from the american heart association. Circulation. 2014 Jan 21; 129(3):399-410. View in: PubMed

Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Huffman MD, Judd SE, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Mackey RH, Magid DJ, Marcus GM, Marelli A, Matchar DB, McGuire DK, Mohler ER, Moy CS, Mussolino ME, Neumar RW, Nichol G, Pandey DK, Paynter NP, Reeves MJ, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Wong ND, Woo D, Turner MB. Heart disease and stroke statistics--2014 update: a report from the american heart association. Circulation. 2014 Jan 21; 129(3):e28-e292. View in: PubMed

Lackland DT, Roccella EJ, Deutsch AF, Fornage M, George MG, Howard G, Kissela BM, Kittner SJ, Lichtman JH, Lisabeth LD, Schwamm LH, Smith EE, Towfighi A. Factors influencing the decline in stroke mortality: a statement from the american heart association/american stroke association. Stroke. 2014 Jan; 45(1):315-53. View in: PubMed

Towfighi A, Arshi B, Markovic D, Ovbiagele B. Homocysteine-Lowering Therapy and Risk of Recurrent Stroke, Myocardial Infarction and Death: The Impact of Age in the VISP Trial. Cerebrovasc Dis. 2014; 37(4):263-7. View in: PubMed

Towfighi A, Markovic D, Ovbiagele B. Sex differences in revascularization interventions after acute ischemic stroke. J Stroke Cerebrovasc Dis. 2013 Nov; 22(8):e347-53. View in: PubMed

Mosca L, Hammond G, Mochari-Greenberger H, Towfighi A, Albert MA. Fifteen-year trends in awareness of heart disease in women: results of a 2012 American Heart Association national survey. Circulation. 2013 Mar 19; 127(11):1254-63, e1-29. View in: PubMed

Towfighi A, Markovic D, Ovbiagele B. Utility of framingham coronary heart disease risk score for predicting cardiac risk after stroke. Stroke. 2012 Nov; 43(11):2942-7. View in: PubMed

Towfighi A, Markovic D, Ovbiagele B. Temporal trends in risk of future cardiac events among stroke survivors in the United States. Int J Stroke. 2012 Apr; 7(3):207-12. View in: PubMed

Towfighi A, Markovic D, Ovbiagele B. Impact of a healthy lifestyle on all-cause and cardiovascular mortality after stroke in the USA. J Neurol Neurosurg Psychiatry. 2012 Feb; 83(2):146-51. View in: PubMed

Towfighi A, Markovic D, Ovbiagele B. Current National Patterns of Comorbid Diabetes among Acute Ischemic Stroke Patients. Cerebrovasc Dis. 2012; 33(5):411-8. View in: PubMed

Towfighi A. Insulin resistance, obesity, metabolic syndrome, and lifestyle modification. Continuum (Minneapolis Minn). 2011 Dec; 17(6 2ndary Stroke Prevention):1293-303. View in: PubMed

Towfighi A, Markovic D, Ovbiagele B. Recent patterns of sex-specific midlife stroke hospitalization rates in the United States. Stroke. 2011 Nov; 42(11):3029-33. View in: PubMed

Cornier MA, Després JP, Davis N, Grossniklaus DA, Klein S, Lamarche B, Lopez-Jimenez F, Rao G, St-Onge MP, Towfighi A, Poirier P. Assessing adiposity: a scientific statement from the american heart association. Circulation. 2011 Nov 1; 124(18):1996-2019. View in: PubMed

Towfighi A, Markovic D, Ovbiagele B. National gender-specific trends in myocardial infarction hospitalization rates among patients aged 35 to 64 years. Am J Cardiol. 2011 Oct 15; 108(8):1102-7. View in: PubMed

Towfighi A, Kelley G. The (pre)hypertension limbo: is it time to lower the treatment bar? Neurology. 2011 Oct 4; 77(14):1322-3. View in: PubMed

Ovbiagele B, Markovic D, Towfighi A. Recent age- and gender-specific trends in mortality during stroke hospitalization in the United States. Int J Stroke. 2011 Oct; 6(5):379-87. View in: PubMed

Towfighi A, Tai W, Markovic D, Ovbiagele B. Sex-specific temporal trends in in-hospital mortality after stroke among middle-age individuals in the United States. Stroke. 2011 Oct; 42(10):2740-5. View in: PubMed

Lee M, Saver JL, Towfighi A, Chow J, Ovbiagele B. Efficacy of fibrates for cardiovascular risk reduction in persons with atherogenic dyslipidemia: a meta-analysis. Atherosclerosis. 2011 Aug; 217(2):492-8. View in: PubMed

Towfighi A, Saver JL. Stroke declines from third to fourth leading cause of death in the United States: historical perspective and challenges ahead. Stroke. 2011 Aug; 42(8):2351-5. View in: PubMed

Antillon D, Towfighi A. No time to 'weight': the link between obesity and stroke in women. Womens Health (Lond Engl). 2011 Jul; 7(4):453-63. View in: PubMed

Liebeskind DS, Sanossian N, Yong WH, Starkman S, Tsang MP, Moya AL, Zheng DD, Abolian AM, Kim D, Ali LK, Shah SH, Towfighi A, Ovbiagele B, Kidwell CS, Tateshima S, Jahan R, Duckwiler GR, Viñuela F, Salamon N, Villablanca JP, Vinters HV, Marder VJ, Saver JL. CT and MRI early vessel signs reflect clot composition in acute stroke. Stroke. 2011 May; 42(5):1237-43. View in: PubMed

Cheng EM, Cunningham WE, Towfighi A, Sanossian N, Bryg RJ, Anderson TL, Guterman JJ, Gross-Schulman SG, Beanes S, Jones AS, Liu H, Ettner SL, Saver JL, Vickrey BG. Randomized, controlled trial of an intervention to enable stroke survivors throughout the Los Angeles County safety net to "stay with the guidelines". Circ Cardiovasc Qual Outcomes. 2011 Mar; 4(2):229-34. View in: PubMed

Towfighi A, Markovic D, Ovbiagele B. Persistent sex disparity in midlife stroke prevalence in the United States. Cerebrovasc Dis. 2011; 31(4):322-8. View in: PubMed

Loh Y, Liebeskind DS, Towfighi A, Vespa P, Starkman S, Saver JL, Gonzalez NR, Tateshima S, Jahan R, Shi ZS, Viñuela F, Duckwiler GR. Preprocedural basal ganglionic infarction increases the risk of hemorrhagic transformation but not worse outcome following successful recanalization of acute middle cerebral artery occlusions. World Neurosurg. 2010 Dec; 74(6):636-40. View in: PubMed

Towfighi A, Markovic D, Ovbiagele B. Pronounced association of elevated serum homocysteine with stroke in subgroups of individuals: a nationwide study. J Neurol Sci. 2010 Nov 15; 298(1-2):153-7. View in: PubMed

Biffi A, Halpin A, Towfighi A, Gilson A, Busl K, Rost N, Smith EE, Greenberg MS, Rosand J, Viswanathan A. Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy. Neurology. 2010 Aug 24; 75(8):693-8. View in: PubMed

Towfighi A, Zheng L, Ovbiagele B. Weight of the obesity epidemic: rising stroke rates among middle-aged women in the United States. Stroke. 2010 Jul; 41(7):1371-5. View in: PubMed

Towfighi A, Ovbiagele B, Saver JL. Therapeutic milestone: stroke declines from the second to the third leading organ- and disease-specific cause of death in the United States. Stroke. 2010 Mar; 41(3):499-503. View in: PubMed

Towfighi A, Zheng L, Ovbiagele B. Sex-specific trends in midlife coronary heart disease risk and prevalence. Arch Intern Med. 2009 Oct 26; 169(19):1762-6. View in: PubMed

Loh Y, Towfighi A, Liebeskind DS, MacArthur DL, Vespa P, Gonzalez NR, Tateshima S, Starkman S, Saver JL, Shi ZS, Jahan R, Viñuela F, Duckwiler GR. Basal ganglionic infarction before mechanical thrombectomy predicts poor outcome. Stroke. 2009 Oct; 40(10):3315-20. View in: PubMed

Towfighi A, Ovbiagele B. The impact of body mass index on mortality after stroke. Stroke. 2009 Aug; 40(8):2704-8. View in: PubMed

Towfighi A, Saver JL, Engelhardt R, Ovbiagele B. Factors associated with the steep increase in late-midlife stroke occurrence among US men. J Stroke Cerebrovasc Dis. 2008 Jul-Aug; 17(4):165-8. View in: PubMed

Towfighi A, Ovbiagele B. Metabolic syndrome and stroke. Curr Diab Rep. 2008 Feb; 8(1):37-41. View in: PubMed

Towfighi A, Ovbiagele B. Partial peroxisome proliferator-activated receptor agonist angiotensin receptor blockers. Potential multipronged strategy in stroke prevention. Cerebrovasc Dis. 2008; 26(2):106-12. View in: PubMed

Towfighi A, Saver JL, Engelhardt R, Ovbiagele B. A midlife stroke surge among women in the United States. Neurology. 2007 Nov 13; 69(20):1898-904. View in: PubMed

Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG. A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke. 2007 Nov; 38(11):2979-84. View in: PubMed

Towfighi A, Greenberg SM, Rosand J. Treatment and prevention of primary intracerebral hemorrhage. Semin Neurol. 2005 Dec; 25(4):445-52. View in: PubMed

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