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Anatoly V Grishin, PhD
Associate Professor of Research Surgery
CHL Mail Stop 65 Health Sciences Campus Los Angeles
+1 323 669 2104


Anatoly V. Grishin, PhD, a researcher with the Division of Pediatrics at Childrens Hospital Los Angeles and assistant professor of surgery at the Keck School of Medicine, received a two-year grant totaling $400,000 to fund a pilot study about how intestinal epithelial cells establish and maintain tolerance to Toll-like receptor (TLR) ligands of bacteria that populate the gastrointestinal tract.

The study will define roles of A20 and CYLD, the two key negative regulators of innate immune responses in intestinal tolerance to different TLR ligands.

Because intestinal inflammatory disorders such as necrotizing enterocolitis and IBD can be regarded as failure to establish and/or maintain tolerance to luminal microbiota, dissecting the mechanisms of intestinal tolerance to TLR ligands will lead to better understanding of these ailments, and, ultimately, better therapies.


Experimental Anti-Inflammatory Drug Semapimod Inhibits TLR Signaling by Targeting the TLR Chaperone gp96. J Immunol. 2016 Jun 15; 196(12):5130-7. View in: PubMed

Toll-like receptor 3 mediates PROMININ-1 expressing cell expansion in biliary atresia via Transforming Growth Factor-Beta. J Pediatr Surg. 2016 Jun; 51(6):917-22. View in: PubMed

Roles of nitric oxide and intestinal microbiota in the pathogenesis of necrotizing enterocolitis. J Pediatr Surg. 2016 Jan; 51(1):13-7. View in: PubMed

Low doses of Celecoxib attenuate gut barrier failure during experimental peritonitis. Lab Invest. 2013 Dec; 93(12):1265-75. View in: PubMed

The role of the intestinal microbiota in the pathogenesis of necrotizing enterocolitis. Semin Pediatr Surg. 2013 May; 22(2):69-75. View in: PubMed

The human milk oligosaccharide disialyllacto-N-tetraose prevents necrotising enterocolitis in neonatal rats. Gut. 2012 Oct; 61(10):1417-25. View in: PubMed

Role of interleukin-10 in the pathogenesis of necrotizing enterocolitis. Am J Surg. 2012 Apr; 203(4):428-35. View in: PubMed

Transactivation of EGFR by LPS Induces COX-2 Expression in Enterocytes. PLoS One. 2012; 7(5):e38373. View in: PubMed

P-glycoprotein induction by breast milk attenuates intestinal inflammation in experimental necrotizing enterocolitis. Lab Invest. 2011 Nov; 91(11):1668-79. View in: PubMed

NF-kappaB-mediated expression of MAPK phosphatase-1 is an early step in desensitization to TLR ligands in enterocytes. Mucosal Immunol. 2010 Sep; 3(5):523-34. View in: PubMed

Ubiquitin-editing enzyme A20 promotes tolerance to lipopolysaccharide in enterocytes. J Immunol. 2009 Jul 15; 183(2):1384-92. View in: PubMed

Peroxynitrite-induced p38 MAPK pro-apoptotic signaling in enterocytes. Biochem Biophys Res Commun. 2009 Jun 26; 384(2):221-5. View in: PubMed

Current concepts regarding the pathogenesis of necrotizing enterocolitis. Pediatr Surg Int. 2009 Apr; 25(4):309-18. View in: PubMed

Induction of fibroblast growth factor 10 (FGF10) in the ileal crypt epithelium after massive small bowel resection suggests a role for FGF10 in gut adaptation. Dev Dyn. 2009 Feb; 238(2):294-301. View in: PubMed

Enterobacter sakazakii enhances epithelial cell injury by inducing apoptosis in a rat model of necrotizing enterocolitis. J Infect Dis. 2008 Aug 15; 198(4):586-93. View in: PubMed

The role of nitric oxide in intestinal epithelial injury and restitution in neonatal necrotizing enterocolitis. Semin Perinatol. 2008 Apr; 32(2):92-9. View in: PubMed

Molecular signaling in necrotizing enterocolitis: regulation of intestinal COX-2 expression. J Pediatr Surg. 2007 Jul; 42(7):1165-71. View in: PubMed

Lipopolysaccharide induces cyclooxygenase-2 in intestinal epithelium via a noncanonical p38 MAPK pathway. J Immunol. 2006 Jan 1; 176(1):580-8. View in: PubMed

Attenuation of apoptosis in enterocytes by blockade of potassium channels. Am J Physiol Gastrointest Liver Physiol. 2005 Nov; 289(5):G815-21. View in: PubMed

Mechanisms of nitric oxide-mediated intestinal barrier failure in necrotizing enterocolitis. Semin Pediatr Surg. 2005 Aug; 14(3):159-66. View in: PubMed

Increased expression and function of integrins in enterocytes by endotoxin impairs epithelial restitution. Gastroenterology. 2005 Apr; 128(4):1012-22. View in: PubMed

Disordered enterocyte signaling and intestinal barrier dysfunction in the pathogenesis of necrotizing enterocolitis. Semin Pediatr Surg. 2005 Feb; 14(1):49-57. View in: PubMed

p38 MAP kinase mediates endotoxin-induced expression of cyclooxygenase-2 in enterocytes. Surgery. 2004 Aug; 136(2):329-35. View in: PubMed

Peroxynitrite inhibits enterocyte proliferation and modulates Src kinase activity in vitro. Am J Physiol Gastrointest Liver Physiol. 2003 Nov; 285(5):G861-9. View in: PubMed

Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms. Biochem Biophys Res Commun. 2002 May 24; 293(5):1426-30. View in: PubMed

Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10172-7. View in: PubMed

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