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Andre J Ouellette, PhD
Professor of Pathology
NRT 7505 Health Sciences Campus Los Angeles
+1 323 442 7959


Rattusin, an intestinal a-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities. Antimicrob Agents Chemother. 2013 Apr; 57(4):1823-31. View in: PubMed

Immunology. HD6 defensin nanonets. Science. 2012 Jul 27; 337(6093):420-1. View in: PubMed

A novel role for lipid droplets in the organismal antibacterial response. Elife. 2012; 1:e00003. View in: PubMed

Biosynthesis and antimicrobial evaluation of backbone-cyclized a-defensins. Biochemistry. 2011 Dec 6; 50(48):10508-19. View in: PubMed

Paneth cell a-defensins in enteric innate immunity. Cell Mol Life Sci. 2011 Jul; 68(13):2215-29. View in: PubMed

Paneth cells and innate mucosal immunity. Curr Opin Gastroenterol. 2010 Nov; 26(6):547-53. View in: PubMed

Mechanisms of alpha-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue. Biochemistry. 2008 Nov 25; 47(47):12626-34. View in: PubMed

Combination of ellipsometry, laser scanning microscopy and Z-scan fluorescence correlation spectroscopy elucidating interaction of cryptdin-4 with supported phospholipid bilayers. J Pept Sci. 2008 Apr; 14(4):503-9. View in: PubMed

Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins. Antimicrob Agents Chemother. 2008 Mar; 52(3):944-53. View in: PubMed

A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion. J Immunol. 2007 Jul 15; 179(2):1245-53. View in: PubMed

Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity. J Biol Chem. 2006 Sep 29; 281(39):28932-42. View in: PubMed

Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4. J Biol Chem. 2006 Sep 22; 281(38):28068-78. View in: PubMed

Paneth cell alpha-defensins: peptide mediators of innate immunity in the small intestine. Springer Semin Immunopathol. 2005 Sep; 27(2):133-46. View in: PubMed

Mammalian defensins in the antimicrobial immune response. Nat Immunol. 2005 Jun; 6(6):551-7. View in: PubMed

The alternative sigma factor sigma is required for resistance of Salmonella enterica serovar Typhimurium to anti-microbial peptides. Mol Microbiol. 2005 May; 56(3):789-99. View in: PubMed

Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria. Infect Immun. 2005 Apr; 73(4):2312-20. View in: PubMed

Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin. Biochemistry. 2004 Dec 21; 43(50):15759-66. View in: PubMed

Differential effects on human immunodeficiency virus type 1 replication by alpha-defensins with comparable bactericidal activities. J Virol. 2004 Nov; 78(21):11622-31. View in: PubMed

Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. J Biol Chem. 2004 Oct 15; 279(42):44188-96. View in: PubMed

Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice. Am J Physiol Gastrointest Liver Physiol. 2004 Jun; 286(6):G1050-8. View in: PubMed

Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response. J Biol Chem. 2004 May 7; 279(19):19902-7. View in: PubMed

Defensin-mediated innate immunity in the small intestine. Best Pract Res Clin Gastroenterol. 2004 Apr; 18(2):405-19. View in: PubMed

Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions. J Biol Chem. 2004 Mar 19; 279(12):11976-83. View in: PubMed

Paneth cell alpha-defensins from rhesus macaque small intestine. Infect Immun. 2004 Mar; 72(3):1470-8. View in: PubMed

Quantitative interactions between cryptdin-4 amino terminal variants and membranes. Peptides. 2003 Nov; 24(11):1795-805. View in: PubMed

Interactions of mouse Paneth cell alpha-defensins and alpha-defensin precursors with membranes. Prosegment inhibition of peptide association with biomimetic membranes. J Biol Chem. 2003 Apr 18; 278(16):13838-46. View in: PubMed

Structural determinants of procryptdin recognition and cleavage by matrix metalloproteinase-7. J Biol Chem. 2003 Mar 7; 278(10):7910-9. View in: PubMed

Activation of Paneth cell alpha-defensins in mouse small intestine. J Biol Chem. 2002 Feb 15; 277(7):5219-28. View in: PubMed

Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem. 2002 Feb 1; 277(5):3793-800. View in: PubMed

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