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Anisa Shaker, MD
Assistant Professor of Medicine
HMR 810 Health Sciences Campus Los Angeles


Dr. Shaker is a physician-scientist with a clinical and research interest in esophageal disorders. Her research program is focused on understanding the mechanisms of esophageal injury, repair, and inflammation. Her work is supported by both federal and private funding. Dr. Shaker has authored several articles in peer-reviewed journals and serves as a mentor to physicians in training interested in gastrointestinal research.

Dr. Shaker earned her medical degree from Medical College of Wisconsin. She then performed her internship and residency at Brown University- Rhode Island Hospital, followed by a Gastroenterology Fellowship at Washington University School of Medicine- Barnes Jewish Hospital.


Association of American Medical Colleges: Early Career Women Faculty Professional Development Seminar, 2011

American Gastroenterology Association: Women's Leadership Conference, 2015


Hoff DA, Brock C, Farmer AD, Dickman R, Ruffle JK, Shaker A, Drewes AM. Pharmacological and other treatment modalities for esophageal pain. Ann N Y Acad Sci. 2016 Sep; 1380(1):58-66. View in: PubMed

Niu C, Chauhan U, Gargus M, Shaker A. Generation and Characterization of an Immortalized Human Esophageal Myofibroblast Line. PLoS One. 2016; 11(4):e0153185. View in: PubMed

Gargus M, Niu C, Vallone JG, Binkley J, Rubin DC, Shaker A. Human esophageal myofibroblasts secrete proinflammatory cytokines in response to acid and Toll-like receptor 4 ligands. Am J Physiol Gastrointest Liver Physiol. 2015 Jun 1; 308(11):G904-23. View in: PubMed

Gargus M, Niu C, Shaker A. Isolation of myofibroblasts from mouse and human esophagus. J Vis Exp. 2015; (95). View in: PubMed

Shaker A, Gargus M, Fink J, Binkley J, Darwech I, Swietlicki E, Levin MS, Rubin DC. Epimorphin(-/-) mice are protected, in part, from acute colitis via decreased interleukin 6 signaling. Transl Res. 2014 Mar 25. View in: PubMed

Shaker A, Stoikes N, Drapekin J, Kushnir V, Brunt LM, Gyawali CP. Multiple rapid swallow responses during esophageal high-resolution manometry reflect esophageal body peristaltic reserve. Am J Gastroenterol. 2013 Nov; 108(11):1706-12. View in: PubMed

Swietlicki EA, Bala S, Lu J, Shaker A, Kularatna G, Levin MS, Rubin DC. Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 15; 305(8):G564-72. View in: PubMed

Shaker A, Binkley J, Darwech I, Swietlicki E, McDonald K, Newberry R, Rubin DC. Stromal cells participate in the murine esophageal mucosal injury response. Am J Physiol Gastrointest Liver Physiol. 2013 Apr 1; 304(7):G662-72. View in: PubMed

Stoikes N, Drapekin J, Kushnir V, Shaker A, Brunt LM, Gyawali CP. The value of multiple rapid swallows during preoperative esophageal manometry before laparoscopic antireflux surgery. Surg Endosc. 2012 Dec; 26(12):3401-7. View in: PubMed

Shaker A, Rubin DC. Stem cells: One step closer to gut repair. Nature. 2012 May 10; 485(7397):181-2. View in: PubMed

Thaker AI, Shaker A, Rao MS, Ciorba MA. Modeling colitis-associated cancer with azoxymethane (AOM) and dextran sulfate sodium (DSS). J Vis Exp. 2012; (67). View in: PubMed

Rubin DC, Shaker A, Levin MS. Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer. Front Immunol. 2012; 3:107. View in: PubMed

Shaker A, Rubin DC. Intestinal stem cells and epithelial-mesenchymal interactions in the crypt and stem cell niche. Transl Res. 2010 Sep; 156(3):180-7. View in: PubMed

Shaker A, Swietlicki EA, Wang L, Jiang S, Onal B, Bala S, DeSchryver K, Newberry R, Levin MS, Rubin DC. Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion. J Clin Invest. 2010 Jun; 120(6):2081-93. View in: PubMed

Shaker A, Snyder JE. Miriam Hospital morbidity and mortality conference, a case of chronic headaches. Med Health R I. 2004 Sep; 87(9):280-3. View in: PubMed

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