Faculty

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Austin K Mircheff, PhD
Professor of Physiology & Biophysics
Physiology and Biophysics
BMT 11-A 1333 San Pablo Street Health Sciences Campus Los Angeles
+1 323 442 1242

Publications

Sriprasert I, Warren DW, Mircheff AK, Stanczyk FZ. Dry eye in postmenopausal women: a hormonal disorder. Menopause. 2016 Mar; 23(3):343-51. View in: PubMed

Mircheff AK, Wang Y, Ding C, Warren DW, Schechter JE. Potentially pathogenic immune cells and networks in apparently healthy lacrimal glands. Ocul Surf. 2015 Jan; 13(1):47-81. View in: PubMed

Selvam S, Mircheff AK, Yiu SC. Diverse mediators modulate the chloride ion fluxes that drive lacrimal fluid production. Invest Ophthalmol Vis Sci. 2013 Apr; 54(4):2927-33. View in: PubMed

Wei RH, Thomas PB, Samant DM, Schechter JE, Mircheff AK, Trousdale MD. Autoimmune dacryoadenitis and sialadenitis induced in rabbits by intravenous injection of autologous lymphocytes activated ex vivo against lacrimal antigens. Cornea. 2012 Jun; 31(6):693-701. View in: PubMed

Xu S, Edman M, Kothawala MS, Sun G, Chiang L, Mircheff A, Zhu L, Okamoto C, Hamm-Alvarez S. A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland. J Cell Sci. 2011 Oct 15; 124(Pt 20):3503-14. View in: PubMed

Mircheff AK, Wang Y, Thomas PB, Nakamura T, Samant D, Trousdale MD, Warren DW, Ding C, Schechter JE. Systematic variations in immune response-related gene transcript abundance suggest new questions about environmental influences on lacrimal gland immunoregulation. Curr Eye Res. 2011 Apr; 36(4):285-94. View in: PubMed

Thomas PB, Samant DM, Selvam S, Wei RH, Wang Y, Stevenson D, Schechter JE, Apparailly F, Mircheff AK, Trousdale MD. Adeno-associated virus-mediated IL-10 gene transfer suppresses lacrimal gland immunopathology in a rabbit model of autoimmune dacryoadenitis. Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5137-44. View in: PubMed

Thomas PB, Samant DM, Wang Y, Selvam S, Stevenson D, Gray JD, Schechter JE, Mircheff AK, Trousdale MD. Distinct dacryoadenitides autoadoptively transferred to rabbits by different subpopulations of lymphocytes activated ex vivo. Cornea. 2010 Oct; 29(10):1153-62. View in: PubMed

Schechter JE, Warren DW, Mircheff AK. A lacrimal gland is a lacrimal gland, but rodent's and rabbit's are not human. Ocul Surf. 2010 Jul; 8(3):111-34. View in: PubMed

Selvam S, Chang WV, Nakamura T, Samant DM, Thomas PB, Trousdale MD, Mircheff AK, Schechter JE, Yiu SC. Microporous poly(L-lactic acid) membranes fabricated by polyethylene glycol solvent-cast/particulate leaching technique. Tissue Eng Part C Methods. 2009 Sep; 15(3):463-74. View in: PubMed

McDonald ML, Wang Y, Selvam S, Nakamura T, Chow RH, Schechter JE, Yiu SC, Mircheff AK. Cytopathology and exocrine dysfunction induced in ex vivo rabbit lacrimal gland acinar cell models by chronic exposure to histamine or serotonin. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3164-75. View in: PubMed

Thomas PB, Samant DM, Zhu Z, Selvam S, Stevenson D, Wang Y, Song SW, Mircheff AK, Schechter JE, Yiu SC, Trousdale MD. Long-term topical cyclosporine treatment improves tear production and reduces keratoconjunctivitis in rabbits with induced autoimmune dacryoadenitis. J Ocul Pharmacol Ther. 2009 Jun; 25(3):285-92. View in: PubMed

Schrader S, Mircheff AK, Geerling G. Animal models of dry eye. Dev Ophthalmol. 2008; 41:298-312. View in: PubMed

Wang Y, Chiu CT, Nakamura T, Walker AM, Petridou B, Trousdale MD, Hamm-Alvarez SF, Mircheff AK, Schechter JE. Traffic of endogenous, transduced, and endocytosed prolactin in rabbit lacrimal acinar cells. Exp Eye Res. 2007 Dec; 85(6):749-61. View in: PubMed

Selvam S, Thomas PB, Gukasyan HJ, Yu AS, Stevenson D, Trousdale MD, Mircheff AK, Schechter JE, Smith RE, Yiu SC. Transepithelial bioelectrical properties of rabbit acinar cell monolayers on polyester membrane scaffolds. Am J Physiol Cell Physiol. 2007 Oct; 293(4):C1412-9. View in: PubMed

Wang Y, Chiu CT, Nakamura T, Walker AM, Petridou B, Trousdale MD, Hamm-Alvarez SF, Schechter JE, Mircheff AK. Elevated prolactin redirects secretory vesicle traffic in rabbit lacrimal acinar cells. Am J Physiol Endocrinol Metab. 2007 Apr; 292(4):E1122-34. View in: PubMed

Pyrko P, Kardosh A, Liu YT, Soriano N, Xiong W, Chow RH, Uddin J, Petasis NA, Mircheff AK, Farley RA, Louie SG, Chen TC, Schönthal AH. Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib. Mol Cancer Ther. 2007 Apr; 6(4):1262-75. View in: PubMed

Selvam S, Thomas PB, Trousdale MD, Stevenson D, Schechter JE, Mircheff AK, Jacob JT, Smith RE, Yiu SC. Tissue-engineered tear secretory system: functional lacrimal gland acinar cells cultured on matrix protein-coated substrata. J Biomed Mater Res B Appl Biomater. 2007 Jan; 80(1):192-200. View in: PubMed

Selvam S, Thomas PB, Hamm-Alvarez SF, Schechter JE, Stevenson D, Mircheff AK, Trousdale MD. Current status of gene delivery and gene therapy in lacrimal gland using viral vectors. Adv Drug Deliv Rev. 2006 Nov 15; 58(11):1243-57. View in: PubMed

Andersson SV, Edman MC, Bekmezian A, Holmberg J, Mircheff AK, Gierow JP. Characterization of beta-hexosaminidase secretion in rabbit lacrimal gland. Exp Eye Res. 2006 Nov; 83(5):1081-8. View in: PubMed

Ding C, Chang N, Fong YC, Wang Y, Trousdale MD, Mircheff AK, Schechter JE. Interacting influences of pregnancy and corneal injury on rabbit lacrimal gland immunoarchitecture and function. Invest Ophthalmol Vis Sci. 2006 Apr; 47(4):1368-75. View in: PubMed

Mircheff AK, Wang Y, Jean Mde S, Ding C, Trousdale MD, Hamm-Alvarez SF, Schechter JE. Mucosal immunity and self-tolerance in the ocular surface system. Ocul Surf. 2005 Oct; 3(4):182-92. View in: PubMed

Trousdale MD, Zhu Z, Stevenson D, Schechter JE, Ritter T, Mircheff AK. Expression of TNF inhibitor gene in the lacrimal gland promotes recovery of tear production and tear stability and reduced immunopathology in rabbits with induced autoimmune dacryoadenitis. J Autoimmune Dis. 2005 Jun 28; 2:6. View in: PubMed

Qian L, Xie J, Rose CM, Sou E, Zeng H, Hamm-Alvarez SF, Mircheff AK. Altered traffic to the lysosome in an ex vivo lacrimal acinar cell model for chronic muscarinic receptor stimulation. Exp Eye Res. 2004 Nov; 79(5):665-75. View in: PubMed

Xie J, Qian L, Wang Y, Hamm-Alvarez SF, Mircheff AK. Role of the microtubule cytoskeleton in traffic of EGF through the lacrimal acinar cell endomembrane network. Exp Eye Res. 2004 Jun; 78(6):1093-106. View in: PubMed

Zhu Z, Stevenson D, Schechter JE, Mircheff AK, Ritter T, Labree L, Trousdale MD. Prophylactic effect of IL-10 gene transfer on induced autoimmune dacryoadenitis. Invest Ophthalmol Vis Sci. 2004 May; 45(5):1375-81. View in: PubMed

Xie J, Qian L, Wang Y, Rose CM, Yang T, Nakamura T, Hamm-Alvarez SF, Mircheff AK. Novel biphasic traffic of endocytosed EGF to recycling and degradative compartments in lacrimal gland acinar cells. J Cell Physiol. 2004 Apr; 199(1):108-25. View in: PubMed

Da Costa SR, Sou E, Xie J, Yarber FA, Okamoto CT, Pidgeon M, Kessels MM, Mircheff AK, Schechter JE, Qualmann B, Hamm-Alvarez SF. Impairing actin filament or syndapin functions promotes accumulation of clathrin-coated vesicles at the apical plasma membrane of acinar epithelial cells. Mol Biol Cell. 2003 Nov; 14(11):4397-413. View in: PubMed

Mircheff AK. Sjogrens syndrome as failed local immunohomeostasis: prospects for cell-based therapy. Ocul Surf. 2003 Oct; 1(4):160-79. View in: PubMed

Wang Y, Jerdeva G, Yarber FA, da Costa SR, Xie J, Qian L, Rose CM, Mazurek C, Kasahara N, Mircheff AK, Hamm-Alvarez SF. Cytoplasmic dynein participates in apically targeted stimulated secretory traffic in primary rabbit lacrimal acinar epithelial cells. J Cell Sci. 2003 May 15; 116(Pt 10):2051-65. View in: PubMed

Zhu Z, Stevenson D, Schechter JE, Mircheff AK, Crow RW, Atkinson R, Ritter T, Bose S, Trousdale MD. Tumor necrosis factor inhibitor gene expression suppresses lacrimal gland immunopathology in a rabbit model of autoimmune dacryoadenitis. Cornea. 2003 May; 22(4):343-51. View in: PubMed

Zhu Z, Stevenson D, Schechter JE, Mircheff AK, Atkinson R, Trousdale MD. Lacrimal histopathology and ocular surface disease in a rabbit model of autoimmune dacryoadenitis. Cornea. 2003 Jan; 22(1):25-32. View in: PubMed

Mircheff AK. The Ocular Surface Center at the University of Southern California. Ocul Surf. 2003 Jan; 1(1):41-5. View in: PubMed

Mircheff AK, Xie J, Qian L, Hamm-Alvarez SF. Diverse perturbations may alter the lacrimal acinar cell autoantigenic spectra. DNA Cell Biol. 2002 May-Jun; 21(5-6):435-42. View in: PubMed

Schechter J, Stevenson D, Chang D, Chang N, Pidgeon M, Nakamura T, Okamoto CT, Trousdale MD, Mircheff AK. Growth of purified lacrimal acinar cells in Matrigel raft cultures. Exp Eye Res. 2002 Mar; 74(3):349-60. View in: PubMed

Zhu Z, Stevenson D, Ritter T, Schechter JE, Mircheff AK, Kaslow HR, Trousdale MD. Expression of IL-10 and TNF-inhibitor genes in lacrimal gland epithelial cells suppresses their ability to activate lymphocytes. Cornea. 2002 Mar; 21(2):210-4. View in: PubMed

Xie J, Qian L, Hamm-Alvarez SF, Mircheff AK. Epidermal growth factor traffic in lacrimal acinar cells. Adv Exp Med Biol. 2002; 506(Pt A):213-7. View in: PubMed

Stevenson D, Schechter JE, Nakamuro T, Chang D, Chang NY, Pidgeon M, Zeng H, Mircheff AK, Trousdale MD. A new model system for studying lacrimal physiology using cultured lacrimal gland acinar cells on Matrigel rafts. Adv Exp Med Biol. 2002; 506(Pt A):159-63. View in: PubMed

Qian L, Yang T, Chen H, Xie J, Zeng H, Warren DW, MacVeigh M, Meneray MA, Hamm-Alvarez SF, Mircheff AK. Heterotrimeric GTP-binding proteins in the lacrimal acinar cell endomembrane system. Exp Eye Res. 2002 Jan; 74(1):7-22. View in: PubMed

Mircheff AK, Qian L, Xie J, Wang Y, Hamm-Alvarez SF. M3 receptor autoimmunity: losing tolerance to a familiar protein. Adv Exp Med Biol. 2002; 506(Pt A):51-8. View in: PubMed

Trousdale MD, Stevenson D, Zhu Z, Kaslow HR, Schechter JE, Warren DW, Azzarolo AM, Ritter T, Mircheff AK. Effect of anti-inflammatory cytokines on the activation of lymphocytes by lacrimal gland acinar cells in an autologous mixed cell reaction. Adv Exp Med Biol. 2002; 506(Pt B):789-94. View in: PubMed

Zhang Y, Xie J, Qian L, Schechter JE, Mircheff AK. IL-2 immunoreactive proteins in lacrimal acinar cells. Adv Exp Med Biol. 2002; 506(Pt B):795-9. View in: PubMed

Qian L, Xie J, Mircheff AK. Glycolipid-rich membrane microdomains in lacrimal acinar cell endomembrane compartments. Adv Exp Med Biol. 2002; 506(Pt A):207-11. View in: PubMed

Casbon AJ, Warren DW, Mircheff AK. Prolactin inhibits carbachol-dependent secretion by lacrimal acinar cells in vitro. Adv Exp Med Biol. 2002; 506(Pt A):231-5. View in: PubMed

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