Faculty

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Beiyun Zhou, PhD
Associate Professor of Medicine
Medicine
IRD 720 2020 Zonal Avenue Health Sciences Campus Los Angeles
+1 323 442 1088

Overview

Dr. Zhou's major areas of research interest are transcriptional and epigenetic regulation of pulmonary alveolar epithelial cell (AEC) differentiation and plasticity; role of ER stress and chaperone protein GRP78 in epithelial abnormalities during development in idiopathic pulmonary fibrosis, among others. Her current research includes the role of endoplasmic reticulum (ER) stress in mediating EMT/pulmonary fibrosis, mechanisms underlying ER stress-mediated and transforming growth factor ß1 (TGF-ß1)-induced EMT/fibrosis and related signaling pathways.

Dr. Zhou earned her Master's in Microbiology from the Institute of Plant Physiology and Ecology, Chinese Academy of Sciences. She then went on to complete her PhD in Molecular Pharmacology and Toxicology at USC.

Awards

American Thoracic Society International Conference: Award for Best Scientific Abstract, 2015

Epithelial-Mesenchymal Transition International Association: Travel Bursary, 2013

Phi Kappa Phi: Elected Member, 2008

SuperArray Bioscience Corporation: SuperArray Travel Grant Award, 2008

Chinese Academy of Sciences: Visiting Scholar Fellowship, 1998-1999

Publications

Pleiotropic Analysis of Lung Cancer and Blood Triglycerides. J Natl Cancer Inst. 2016 Dec; 108(12). View in: PubMed

The importance of detailed epigenomic profiling of different cell types within organs. Epigenomics. 2016 Jun; 8(6):817-29. View in: PubMed

p300/ß-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC). J Biol Chem. 2016 Mar 18; 291(12):6569-82. View in: PubMed

GRP78 Regulates ER Homeostasis and Distal Epithelial Cell Survival During Lung Development. Am J Respir Cell Mol Biol. 2016 Jan 27. View in: PubMed

Combinations of differentiation markers distinguish subpopulations of alveolar epithelial cells in adult lung. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 15; 310(2):L114-20. View in: PubMed

Transforming Growth Factor-ß1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E. Sci Rep. 2015; 5:18233. View in: PubMed

Transcriptomic Profiling of Primary Alveolar Epithelial Cell Differentiation in Human and Rat. Genom Data. 2014 Dec 1; 2:105-109. View in: PubMed

TRIM72 is required for effective repair of alveolar epithelial cell wounding. Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15; 307(6):L449-59. View in: PubMed

Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):210-22. View in: PubMed

Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue. Nat Commun. 2014; 5:3365. View in: PubMed

Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation. PLoS Genet. 2013 Jun; 9(6):e1003513. View in: PubMed

Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2. PLoS One. 2013; 8(1):e53342. View in: PubMed

GRP78/BiP is a novel downstream target of IGF-1 receptor mediated signaling. J Cell Physiol. 2012 Dec; 227(12):3803-11. View in: PubMed

Interactions Between ß-Catenin and Transforming Growth Factor-ß Signaling Pathways Mediate Epithelial-Mesenchymal Transition and Are Dependent on the Transcriptional Co-activator cAMP-response Element-binding Protein (CREB)-binding Protein (CBP). J Biol Chem. 2012 Mar 2; 287(10):7026-38. View in: PubMed

Ligand-independent transforming growth factor-ß type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition. J Pathol. 2012 Mar; 226(4):633-44. View in: PubMed

Ligand-independent transforming growth factor-ß type I receptor signalling mediates type A collagen-induced epithelial-mesenchymal transition. J Pathol. 2012 Mar; 226(4)2633-44. View in: PubMed

Troglitazone Attenuates TGF-ß1-Induced EMT in Alveolar Epithelial Cells via a PPAR?-Independent Mechanism. Troglitazone Attenuates TGF-ß1-Induced EMT in Alveolar Epithelial Cells via a PPAR? -Independent Mechanism. PLoS One. 2012; 7(6):e38827. View in: PubMed

Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):498-509. View in: PubMed

Epithelium-specific deletion of TGF-ß receptor type II protects mice from bleomycin-induced pulmonary fibrosis. J Clin Invest. 2011 Jan 4; 121(1):277-87. View in: PubMed

Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14309-14. View in: PubMed

Directed expression of Cre in alveolar epithelial type 1 cells. Am J Respir Cell Mol Biol. 2010 Aug; 43(2):173-8. View in: PubMed

Rat aquaporin-5 4. 3-kb 5'-flanking region differentially regulates expression in salivary gland and lung in vivo. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C111-20. View in: PubMed

Foxp2 inhibits Nkx2. 1-mediated transcription of SP-C via interactions with the Nkx2. 1 homeodomain. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):750-8. View in: PubMed

Conserved elements within first intron of aquaporin-5 (Aqp5) function as transcriptional enhancers. Biochem Biophys Res Commun. 2007 Apr 27; 356(1):26-31. View in: PubMed

Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1280-90. View in: PubMed

Transcriptional regulation by targeted expression of architectural transcription factor high mobility group A2 in salivary glands of transgenic mice. Eur J Oral Sci. 2007 Feb; 115(1):30-9. View in: PubMed

Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells. J Appl Physiol. 2005 Jan; 98(1):322-8. View in: PubMed

Alveolar epithelial type I cells express beta2-adrenergic receptors and G-protein receptor kinase 2. J Histochem Cytochem. 2004 Jun; 52(6):759-67. View in: PubMed

Subunit-specific coordinate upregulation of sodium pump activity in alveolar epithelial cells by lentivirus-mediated gene transfer. Hum Gene Ther. 2004 May; 15(5):457-68. View in: PubMed

Identification of three genes of known function expressed by alveolar epithelial type I cells. Am J Respir Cell Mol Biol. 2003 Jul; 29(1):98-105. View in: PubMed

Na transport proteins are expressed by rat alveolar epithelial type I cells. Am J Physiol Lung Cell Mol Physiol. 2002 Apr; 282(4):L599-608. View in: PubMed

Region-specific role for Pten in maintenance of epithelial phenotype and integrity. Am J Physiol Lung Cell Mol Physiol. 2016 Nov 18; ajplung. 00005. 2015. View in: PubMed

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