Faculty

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Brad Spellberg, MD
Professor of Clinical Medicine
Associate Dean For Clinical Affairs (LAC+USC)
Medicine
KEK 1500 San Pablo St Health Sciences Campus Los Angeles

Overview

Dr. Spellberg is Chief Medical Officer at the Los Angeles County-University of Southern California (LAC+USC) Medical Center. He is also a Professor of Clinical Medicine and Associate Dean for Clinical Affairs at the Keck School of Medicine at USC. He received his BA in Molecular Cell Biology-Immunology from UC Berkeley. He then attended medical school at UCLA, where he received numerous academic honors, including serving as the UCLA AOA Chapter Co-President, and winning the prestigious Stafford Warren Award for the topic academic performance in his graduating class. Dr. Spellberg completed his Residency in Internal Medicine and subspecialty fellowship in Infectious Diseases at Harbor-UCLA Medical Center.

Dr. Spellberg has extensive administrative, patient care, and teaching activities. His NIH-funded research interests are diverse, ranging from basic immunology and vaccinology, to pure clinical and outcomes research, to process improvement work related to delivery of care, focusing on safety net hospitals. His laboratory research has focused on developing a vaccine that targets the bacterium Staphylococcus aureus and the fungus Candida; the vaccine is undergoing clinical development. Dr. Spellberg is currently working on the immunology, vaccinology, and host defense against highly resistant Gram negative bacilli, including Acinetobacter and carbapenem-resistant Enterobacteriaceae infections.

Dr. Spellberg has worked extensively with the Infectious Diseases Society of America (IDSA) to attempt to bring attention to the problems of increasing drug resistance and decreasing new antibiotics. His research regarding new drug development was a cornerstone of the IDSA’s white paper, Bad Bugs, No Drugs, and has been cited extensively in medical literature and on Capitol Hill. He first-authored numerous societal position papers and review articles relating to public policy of antibiotic resistance and antibiotic development. Dr. Spellberg is the author of Rising Plague, which he wrote to inform and educate the public about the crisis in antibiotic resistant infections and lack of antibiotic development. He has appeared on TV programs including Dr. Oz, The Doctors, Katie Couric, and has given numerous radio and news interviews.

Outside of medicine, he enjoys intergalactic hyperspace travel, dinosaur cloning, and going after bad guys while dressed up in a Kevlar suit with a cool utility belt. He has also been known to split an atom or two from time to time when bored. Sometimes, he reads non-medical textbooks and lifts weights.

Awards

Choice Magazine: Outstanding Academic Title Award for Rising Plague, 2010

UCLA School of Medicine: First STAR Summer Fellowship Award, 1996

UCLA Alpha Omega Alpha: Chapter Co-President, 1998-1999

Alpha Omega Alpha: Elected Member, 1998

Department of Medicine, UCLA: Kouichi R. Tanaka Distinguished Faculty Teaching Award, 2011

UCLA Department of Medicine: Faculty Award for Outstanding Junior Medicine Clerk, 1999

University of California, Berkeley: Summa Cum Laude, 1994

American College of Physicians: Outstanding Student in Internal Medicine at UCLA, 1999

Harbor-UCLA Medical Center: Subspecialty Fellow of the Year, 2004

Phi Beta Kappa: Elected Member, 1994

LA Biomedical Research Institute : Liu Young Investigator's Award, 2007

University of California, Berkeley: Dean's List, 1991-1994

UCLA School of Medicine: Stafford Warren Award, 1999

LA BioMed Research Institute: Richard E. Weitzman Memorial Prize for Meritorious Research, 2013

Publications

Spellberg B. The New Antibiotic Mantra-"Shorter Is Better". JAMA Intern Med. 2016 Sep 1; 176(9):1254-5. View in: PubMed

Spellberg B, Brass E. The VITAL study: case control studies are hypothesis-generating. Lancet Infect Dis. 2016 Aug; 16(8):886. View in: PubMed

Spellberg B. Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Abscess. N Engl J Med. 2016 Jul 21; 375(3):284-6. View in: PubMed

Spellberg B, Srinivasan A, Chambers HF. New Societal Approaches to Empowering Antibiotic Stewardship. JAMA. 2016 Mar 22-29; 315(12):1229-30. View in: PubMed

Russo TA, Spellberg B, Johnson JR. Important Complexities of the Antivirulence Target Paradigm: A Novel Ostensibly Resistance-Avoiding Approach for Treating Infections. J Infect Dis. 2016 Mar 15; 213(6):901-3. View in: PubMed

Spellberg B, Brass EP. Noninferiority Doesn't Mean Not Inferior. Clin Infect Dis. 2016 Feb 15; 62(4):525-6. View in: PubMed

Sartelli M, Weber DG, Ruppé E, Bassetti M, Wright BJ, Ansaloni L, Catena F, Coccolini F, Abu-Zidan FM, Coimbra R, Moore EE, Moore FA, Maier RV, De Waele JJ, Kirkpatrick AW, Griffiths EA, Eckmann C, Brink AJ, Mazuski JE, May AK, Sawyer RG, Mertz D, Montravers P, Kumar A, Roberts JA, Vincent JL, Watkins RR, Lowman W, Spellberg B, Abbott IJ, Adesunkanmi AK, Al-Dahir S, Al-Hasan MN, Agresta F, Althani AA, Ansari S, Ansumana R, Augustin G, Bala M, Balogh ZJ, Baraket O, Bhangu A, Beltrán MA, Bernhard M, Biffl WL, Boermeester MA, Brecher SM, Cherry-Bukowiec JR, Buyne OR, Cainzos MA, Cairns KA, Camacho-Ortiz A, Chandy SJ, Che Jusoh A, Chichom-Mefire A, Colijn C, Corcione F, Cui Y, Curcio D, Delibegovic S, Demetrashvili Z, De Simone B, Dhingra S, Diaz JJ, Di Carlo I, Dillip A, Di Saverio S, Doyle MP, Dorj G, Dogjani A, Dupont H, Eachempati SR, Enani MA, Egiev VN, Elmangory MM, Ferrada P, Fitchett JR, Fraga GP, Guessennd N, Giamarellou H, Ghnnam W, Gkiokas G, Goldberg SR, Gomes CA, Gomi H, Guzmán-Blanco M, Haque M, Hansen S, Hecker A, Heizmann WR, Herzog T, Hodonou AM, Hong SK, Kafka-Ritsch R, Kaplan LJ, Kapoor G, Karamarkovic A, Kees MG, Kenig J, Kiguba R, Kim PK, Kluger Y, Khokha V, Koike K, Kok KY, Kong V, Knox MC, Inaba K, Isik A, Iskandar K, Ivatury RR, Labbate M, Labricciosa FM, Laterre PF, Latifi R, Lee JG, Lee YR, Leone M, Leppaniemi A, Li Y, Liang SY, Loho T, Maegele M, Malama S, Marei HE, Martin-Loeches I, Marwah S, Massele A, McFarlane M, Melo RB, Negoi I, Nicolau DP, Nord CE, Ofori-Asenso R, Omari AH, Ordonez CA, Ouadii M, Pereira Júnior GA, Piazza D, Pupelis G, Rawson TM, Rems M, Rizoli S, Rocha C, Sakakhushev B, Sanchez-Garcia M, Sato N, Segovia Lohse HA, Sganga G, Siribumrungwong B, Shelat VG, Soreide K, Soto R, Talving P, Tilsed JV, Timsit JF, Trueba G, Trung NT, Ulrych J, van Goor H, Vereczkei A, Vohra RS, Wani I, Uhl W, Xiao Y, Yuan KC, Zachariah SK, Zahar JR, Zakrison TL, Corcione A, Melotti RM, Viscoli C, Viale P. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA). World J Emerg Surg. 2016; 11:33. View in: PubMed

Bruhn KW, Dekitani K, Nielsen TB, Pantapalangkoor P, Spellberg B. Ly6G-mediated depletion of neutrophils is dependent on macrophages. Results Immunol. 2016; 6:5-7. View in: PubMed

Rojas LJ, Taracila MA, Papp-Wallace KM, Bethel CR, Caselli E, Romagnoli C, Winkler ML, Spellberg B, Prati F, Bonomo RA. Boronic Acid Transition State Inhibitors Active against KPC and Other Class A ß-Lactamases: Structure-Activity Relationships as a Guide to Inhibitor Design. Antimicrob Agents Chemother. 2016; 60(3):1751-9. View in: PubMed

Sartelli M, Weber DG, Ruppé E, Bassetti M, Wright BJ, Ansaloni L, Catena F, Coccolini F, Abu-Zidan FM, Coimbra R, Moore EE, Moore FA, Maier RV, De Waele JJ, Kirkpatrick AW, Griffiths EA, Eckmann C, Brink AJ, Mazuski JE, May AK, Sawyer RG, Mertz D, Montravers P, Kumar A, Roberts JA, Vincent JL, Watkins RR, Lowman W, Spellberg B, Abbott IJ, Adesunkanmi AK, Al-Dahir S, Al-Hasan MN, Agresta F, Althani AA, Ansari S, Ansumana R, Augustin G, Bala M, Balogh ZJ, Baraket O, Bhangu A, Beltrán MA, Bernhard M, Biffl WL, Boermeester MA, Brecher SM, Cherry-Bukowiec JR, Buyne OR, Cainzos MA, Cairns KA, Camacho-Ortiz A, Chandy SJ, Che Jusoh A, Chichom-Mefire A, Colijn C, Corcione F, Cui Y, Curcio D, Delibegovic S, Demetrashvili Z, De Simone B, Dhingra S, Diaz JJ, Di Carlo I, Dillip A, Di Saverio S, Doyle MP, Dorj G, Dogjani A, Dupont H, Eachempati SR, Enani MA, Egiev VN, Elmangory MM, Ferrada P, Fitchett JR, Fraga GP, Guessennd N, Giamarellou H, Ghnnam W, Gkiokas G, Goldberg SR, Gomes CA, Gomi H, Guzmán-Blanco M, Haque M, Hansen S, Hecker A, Heizmann WR, Herzog T, Hodonou AM, Hong SK, Kafka-Ritsch R, Kaplan LJ, Kapoor G, Karamarkovic A, Kees MG, Kenig J, Kiguba R, Kim PK, Kluger Y, Khokha V, Koike K, Kok KY, Kong V, Knox MC, Inaba K, Isik A, Iskandar K, Ivatury RR, Labbate M, Labricciosa FM, Laterre PF, Latifi R, Lee JG, Lee YR, Leone M, Leppaniemi A, Li Y, Liang SY, Loho T, Maegele M, Malama S, Marei HE, Martin-Loeches I, Marwah S, Massele A, McFarlane M, Melo RB, Negoi I, Nicolau DP, Nord CE, Ofori-Asenso R, Omari AH, Ordonez CA, Ouadii M, Pereira Júnior GA, Piazza D, Pupelis G, Rawson TM, Rems M, Rizoli S, Rocha C, Sakakhushev B, Sanchez-Garcia M, Sato N, Segovia Lohse HA, Sganga G, Siribumrungwong B, Shelat VG, Soreide K, Soto R, Talving P, Tilsed JV, Timsit JF, Trueba G, Trung NT, Ulrych J, van Goor H, Vereczkei A, Vohra RS, Wani I, Uhl W, Xiao Y, Yuan KC, Zachariah SK, Zahar JR, Zakrison TL, Corcione A, Melotti RM, Viscoli C, Viale P. Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA). World J Emerg Surg. 2016; 11:33. View in: PubMed

Spellberg B, Doi Y. The Rise of Fluoroquinolone-Resistant Escherichia coli in the Community: Scarier Than We Thought. J Infect Dis. 2015 Dec 15; 212(12):1853-5. View in: PubMed

Bruhn KW, Spellberg B. Transferrin-mediated iron sequestration as a novel therapy for bacterial and fungal infections. Curr Opin Microbiol. 2015 Oct; 27:57-61. View in: PubMed

Spellberg B, Bonomo RA. Combination Therapy for Extreme Drug-Resistant Acinetobacter baumannii: Ready for Prime Time? Crit Care Med. 2015 Jun; 43(6):1332-4. View in: PubMed

Bruhn KW, Pantapalangkoor P, Nielsen T, Tan B, Junus J, Hujer KM, Wright MS, Bonomo RA, Adams MD, Chen W, Spellberg B. Host Fate is Rapidly Determined by Innate Effector-Microbial Interactions During Acinetobacter baumannii Bacteremia. J Infect Dis. 2015 Apr 15; 211(8):1296-305. View in: PubMed

Broglio KR, Daar ES, Quintana M, Yuan Y, Kalsekar A, Spellberg B, Lewis RJ, Akker DV, Detry MA, Le T, Berry SM. A meta-analysis platform methodology for determining the comparative effectiveness of antihepatitis C virus regimens. J Comp Eff Res. 2015 Mar; 4(2):101-14. View in: PubMed

Fleischman RJ, Kaji AH, Diaz VM, McKenzie K, Soltero P, Van Natta TL, Spellberg B. A simple intervention to improve hospital flow from emergency department to inpatient units. JAMA Intern Med. 2015 Feb 1; 175(2):289-90. View in: PubMed

Spellberg B, Bartlett J, Wunderink R, Gilbert DN. Novel Approaches Are Needed to Develop Tomorrow's Antibacterial Therapies. Am J Respir Crit Care Med. 2015 Jan 15; 191(2):135-40. View in: PubMed

Nielsen TB, Bruhn KW, Pantapalangkoor P, Junus JL, Spellberg B. Cryopreservation of virulent Acinetobacter baumannii to reduce variability of in vivo studies. BMC Microbiol. 2015; 15(1):252. View in: PubMed

Chang DW, Huynh R, Sandoval E, Han N, Coil CJ, Spellberg BJ. Volume of fluids administered during resuscitation for severe sepsis and septic shock and the development of the acute respiratory distress syndrome. J Crit Care. 2014 Dec; 29(6):1011-5. View in: PubMed

David MZ, Daum RS, Bayer AS, Chambers HF, Fowler VG, Miller LG, Ostrowsky B, Baesa A, Boyle-Vavra S, Eells SJ, Garcia-Houchins S, Gialanella P, Macias-Gil R, Rude TH, Ruffin F, Sieth JJ, Volinski J, Spellberg B. Staphylococcus aureus Bacteremia at 5 US Academic Medical Centers, 2008-2011: Significant Geographic Variation in Community-Onset Infections. Clin Infect Dis. 2014 Sep 15; 59(6):798-807. View in: PubMed

Spellberg B, Gilbert DN. The future of antibiotics and resistance: a tribute to a career of leadership by john bartlett. Clin Infect Dis. 2014 Sep 15; 59 Suppl 2:S71-5. View in: PubMed

Spellberg B, Shlaes D. Prioritized current unmet needs for antibacterial therapies. Clin Pharmacol Ther. 2014 Aug; 96(2):151-3. View in: PubMed

Lin L, Pantapalangkoor P, Tan B, Bruhn KW, Ho T, Nielsen T, Skaar EP, Zhang Y, Bai R, Wang A, Doherty TM, Spellberg B. Transferrin iron starvation therapy for lethal bacterial and fungal infections. J Infect Dis. 2014 Jul 15; 210(2):254-64. View in: PubMed

Park H, Solis NV, Louie JS, Spellberg B, Rodriguez N, Filler SG. Different tumor necrosis factor a antagonists have different effects on host susceptibility to disseminated and oropharyngeal candidiasis in mice. Virulence. 2014 Jul 1; 5(5):625-9. View in: PubMed

Chambers HF, Bartlett JG, Bonomo RA, Chiou C, Cosgrove SE, Cross HR, Daum RS, Downing M, Evans SR, Knisely J, Kreiswirth BN, Lautenbach E, Mickley BS, Patel R, Pettigrew MM, Rodvold KA, Spellberg B, Fowler VG. Antibacterial resistance leadership group: open for business. Clin Infect Dis. 2014 Jun; 58(11):1571-6. View in: PubMed

Spellberg B. Community-acquired pneumonia. N Engl J Med. 2014 May 8; 370(19):1861-2. View in: PubMed

Luo G, Spellberg B, Gebremariam T, Lee H, Xiong YQ, French SW, Bayer A, Ibrahim AS. Combination therapy with iron chelation and vancomycin in treating murine staphylococcemia. Eur J Clin Microbiol Infect Dis. 2014 May; 33(5):845-51. View in: PubMed

Spellberg B, Bonomo RA. The Deadly Impact of Extreme Drug Resistance in Acinetobacter baumannii*. Crit Care Med. 2014 May; 42(5):1289-91. View in: PubMed

Spellberg B. Antibiotic judo: working gently with prescriber psychology to overcome inappropriate use. JAMA Intern Med. 2014 Mar 1; 174(3):432-3. View in: PubMed

Mendez CM, Harrington DW, Christenson P, Spellberg B. Impact of hospital variables on case mix index as a marker of disease severity. Popul Health Manag. 2014 Feb; 17(1):28-34. View in: PubMed

Mendez CM, Harrington DW, Christenson P, Spellberg B. Impact of hospital variables on case mix index as a marker of disease severity. Popul Health Manag. 2014 Feb; 17(1):28-34. View in: PubMed

Shimizu E, Glaspy K, Witt MD, Poon K, Black S, Schwartz S, Bholat T, Diaz N, Kuo A, Spellberg B. Readmissions at a public safety net hospital. PLoS One. 2014; 9(3):e91244. View in: PubMed

Spellberg B. The future of antibiotics. Crit Care. 2014; 18(3):228. View in: PubMed

Spellberg B, Rex JH. The value of single-pathogen antibacterial agents. Nat Rev Drug Discov. 2013 Dec; 12(12):963. View in: PubMed

Shlaes DM, Sahm D, Opiela C, Spellberg B. The FDA reboot of antibiotic development. Antimicrob Agents Chemother. 2013 Oct; 57(10):4605-7. View in: PubMed

Spellberg B, Harrington D, Black S, Sue D, Stringer W, Witt M. Capturing the diagnosis: an internal medicine education program to improve documentation. Am J Med. 2013 Aug; 126(8):739-743. e1. View in: PubMed

Spellberg B, Harrington D, Black S, Sue D, Stringer W, Witt M. Capturing the diagnosis: an internal medicine education program to improve documentation. Am J Med. 2013 Aug; 126(8):739-743. e1. View in: PubMed

Spellberg B, Bonomo RA. "Airborne assault": a new dimension in Acinetobacter baumannii transmission*. Crit Care Med. 2013 Aug; 41(8):2042-4. View in: PubMed

Spellberg B. End points in trials of treatments for skin infections. JAMA. 2013 May 22; 309(20):2091-2. View in: PubMed

Bartlett JG, Gilbert DN, Spellberg B. Seven ways to preserve the miracle of antibiotics. Clin Infect Dis. 2013 May; 56(10):1445-50. View in: PubMed

Spellberg B, Sue D, Chang D, Witt M. Change in intern calls at night after a work hour restriction process change. JAMA Intern Med. 2013 Apr 22; 173(8):707-9; discussion 663. View in: PubMed

Russo TA, Beanan JM, Olson R, MacDonald U, Cox AD, St Michael F, Vinogradov EV, Spellberg B, Luke-Marshall NR, Campagnari AA. The K1 capsular polysaccharide from Acinetobacter baumannii is a potential therapeutic target via passive immunization. Infect Immun. 2013 Mar; 81(3):915-22. View in: PubMed

Spellberg B, Bartlett JG, Gilbert DN. The future of antibiotics and resistance. N Engl J Med. 2013 Jan 24; 368(4):299-302. View in: PubMed

Lin L, Tan B, Pantapalangkoor P, Ho T, Hujer AM, Taracila MA, Bonomo RA, Spellberg B. Acinetobacter baumannii rOmpA vaccine dose alters immune polarization and immunodominant epitopes. Vaccine. 2013 Jan 2; 31(2):313-8. View in: PubMed

Montgomery CP, Daniels MD, Zhao F, Spellberg B, Chong AS, Daum RS. Local inflammation exacerbates the severity of Staphylococcus aureus skin infection. PLoS One. 2013; 8(7):e69508. View in: PubMed

Spellberg B, Taylor-Blake B. On the exoneration of Dr. William H. Stewart: debunking an urban legend. Infect Dis Poverty. 2013; 2(1):3. View in: PubMed

Thompson G, Wang S, Bercovitch R, Bolaris M, Van Den Akker D, Taylor S, Lopez R, Catanzaro A, Cadena J, Chin-Hong P, Spellberg B. Routine CSF analysis in coccidioidomycosis is not required. PLoS One. 2013; 8(5):e64249. View in: PubMed

Shlaes DM, Spellberg B. Overcoming the challenges to developing new antibiotics. Curr Opin Pharmacol. 2012 Oct; 12(5):522-6. View in: PubMed

Spellberg B, Kontoyiannis DP, Fredricks D, Morris MI, Perfect JR, Chin-Hong PV, Ibrahim AS, Brass EP. Risk factors for mortality in patients with mucormycosis. Med Mycol. 2012 Aug; 50(6):611-8. View in: PubMed

Luo G, Spellberg B, Gebremariam T, Bolaris M, Lee H, Fu Y, French SW, Ibrahim AS. Diabetic murine models for Acinetobacter baumannii infection. J Antimicrob Chemother. 2012 Jun; 67(6):1439-45. View in: PubMed

Baquir B, Lemaire S, Van Bambeke F, Tulkens PM, Lin L, Spellberg B. Macrophage killing of bacterial and fungal pathogens is not inhibited by intense intracellular accumulation of the lipoglycopeptide antibiotic oritavancin. Clin Infect Dis. 2012 Apr; 54 Suppl 3:S229-32. View in: PubMed

Spellberg B, Ibrahim AS, Chin-Hong PV, Kontoyiannis DP, Morris MI, Perfect JR, Fredricks D, Brass EP. The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial. J Antimicrob Chemother. 2012 Mar; 67(3):715-22. View in: PubMed

Spellberg B, Daum R. Development of a vaccine against Staphylococcus aureus. Semin Immunopathol. 2012 Mar; 34(2):335-48. View in: PubMed

Daum RS, Spellberg B. Progress toward a Staphylococcus aureus vaccine. Clin Infect Dis. 2012 Feb 15; 54(4):560-7. View in: PubMed

Spellberg B, Sharma P, Rex JH. The critical impact of time discounting on economic incentives to overcome the antibiotic market failure. Nat Rev Drug Discov. 2012 Feb; 11(2):168. View in: PubMed

Spellberg B, Lipsky BA. Systemic antibiotic therapy for chronic osteomyelitis in adults. Clin Infect Dis. 2012 Feb 1; 54(3):393-407. View in: PubMed

Spellberg B. Gastrointestinal mucormycosis: an evolving disease. Gastroenterol Hepatol (N Y). 2012 Feb; 8(2):140-2. View in: PubMed

Ibrahim AS, Spellberg B, Walsh TJ, Kontoyiannis DP. Pathogenesis of mucormycosis. Clin Infect Dis. 2012 Feb; 54 Suppl 1:S16-22. View in: PubMed

Kontoyiannis DP, Lewis RE, Lortholary O, Lotholary O, Spellberg B, Petrikkos G, Roillides E, Ibrahim A, Walsh TJ. Future directions in mucormycosis research. Clin Infect Dis. 2012 Feb; 54 Suppl 1:S79-85. View in: PubMed

Spellberg B, Ibrahim A, Roilides E, Lewis RE, Lortholary O, Petrikkos G, Kontoyiannis DP, Walsh TJ. Combination therapy for mucormycosis: why, what, and how? Clin Infect Dis. 2012 Feb; 54 Suppl 1:S73-8. View in: PubMed

Lewis RE, Lortholary O, Spellberg B, Roilides E, Kontoyiannis DP, Walsh TJ. How does antifungal pharmacology differ for mucormycosis versus aspergillosis? Clin Infect Dis. 2012 Feb; 54 Suppl 1:S67-72. View in: PubMed

Lin L, Ibrahim AS, Baquir B, Palosaari A, Spellberg B. Luminescent-activated transfected killer cells to monitor leukocyte trafficking during systemic bacterial and fungal infection. J Infect Dis. 2012 Jan 15; 205(2):337-47. View in: PubMed

Spellberg B, Lewis RJ, Sue D, Chavoshan B, Vintch J, Munekata M, Kim C, Lanks C, Witt MD, Stringer W, Harrington D. A controlled investigation of optimal internal medicine ward team structure at a teaching hospital. PLoS One. 2012; 7(4):e35576. View in: PubMed

Spellberg B, Lewis RJ, Sue D, Chavoshan B, Vintch J, Munekata M, Kim C, Lanks C, Witt MD, Stringer W, Harrington D. A controlled investigation of optimal internal medicine ward team structure at a teaching hospital. PLoS One. 2012; 7(4):e35576. View in: PubMed

Lin L, Tan B, Pantapalangkoor P, Ho T, Baquir B, Tomaras A, Montgomery JI, Reilly U, Barbacci EG, Hujer K, Bonomo RA, Fernandez L, Hancock RE, Adams MD, French SW, Buslon VS, Spellberg B. Inhibition of LpxC protects mice from resistant Acinetobacter baumannii by modulating inflammation and enhancing phagocytosis. MBio. 2012; 3(5). View in: PubMed

Luo G, Lin L, Ibrahim AS, Baquir B, Pantapalangkoor P, Bonomo RA, Doi Y, Adams MD, Russo TA, Spellberg B. Active and passive immunization protects against lethal, extreme drug resistant-Acinetobacter baumannii infection. PLoS One. 2012; 7(1):e29446. View in: PubMed

Spellberg B. Acute bacterial skin and skin structure infection trials: the bad is the enemy of the good. Clin Infect Dis. 2011 Dec; 53(12):1308-9; author reply 1309-10. View in: PubMed

Adams-Haduch JM, Onuoha EO, Bogdanovich T, Tian GB, Marschall J, Urban CM, Spellberg BJ, Rhee D, Halstead DC, Pasculle AW, Doi Y. Molecular epidemiology of carbapenem-nonsusceptible Acinetobacter baumannii in the United States. J Clin Microbiol. 2011 Nov; 49(11):3849-54. View in: PubMed

Spellberg B. The antibiotic crisis: can we reverse 65 years of failed stewardship? Arch Intern Med. 2011 Jun 27; 171(12):1080-1. View in: PubMed

Combating antimicrobial resistance: policy recommendations to save lives. Clin Infect Dis. 2011 May; 52 Suppl 5:S397-428. View in: PubMed

Ibrahim AS, Gebremariam T, Luo G, Fu Y, French SW, Edwards JE, Spellberg B. Combination therapy of murine mucormycosis or aspergillosis with iron chelation, polyenes, and echinocandins. Antimicrob Agents Chemother. 2011 Apr; 55(4):1768-70. View in: PubMed

Miller LG, McKinnell JA, Vollmer ME, Spellberg B. Impact of methicillin-resistant Staphylococcus aureus prevalence among S. aureus isolates on surgical site infection risk after coronary artery bypass surgery. Infect Control Hosp Epidemiol. 2011 Apr; 32(4):342-50. View in: PubMed

Spellberg B, Boucher H, Bradley J, Das A, Talbot G. To treat or not to treat: adjunctive antibiotics for uncomplicated abscesses. Ann Emerg Med. 2011 Feb; 57(2):183-5. View in: PubMed

Spellberg B. Vaccines for invasive fungal infections. F1000 Med Rep. 2011; 3:13. View in: PubMed

Spellberg B, Ibrahim AS. Recent advances in the treatment of mucormycosis. Curr Infect Dis Rep. 2010 Nov; 12(6):423-9. View in: PubMed

Spellberg B. Geographic differences in Medicare spending. N Engl J Med. 2010 Oct 21; 363(17):1678; author reply 1678-9. View in: PubMed

Spellberg B. Skin and soft-tissue infections: modern evolution of an ancient problem. Clin Infect Dis. 2010 Oct 15; 51(8):904-6. View in: PubMed

Spellberg B, Daum R. A new view on development of a Staphylococcus aureus vaccine: insights from mice and men. Hum Vaccin. 2010 Oct; 6(10):857-9. View in: PubMed

Ibrahim AS, Gebremariam T, Lin L, Luo G, Husseiny MI, Skory CD, Fu Y, French SW, Edwards JE, Spellberg B. The high affinity iron permease is a key virulence factor required for Rhizopus oryzae pathogenesis. Mol Microbiol. 2010 Aug; 77(3):587-604. View in: PubMed

Recommended design features of future clinical trials of antibacterial agents for hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia. Clin Infect Dis. 2010 Aug 1; 51 Suppl 1:S150-70. View in: PubMed

Luo G, Ibrahim AS, Spellberg B, Nobile CJ, Mitchell AP, Fu Y. Candida albicans Hyr1p confers resistance to neutrophil killing and is a potential vaccine target. J Infect Dis. 2010 Jun 1; 201(11):1718-28. View in: PubMed

Lin L, Ibrahim AS, Baquir B, Fu Y, Applebaum D, Schwartz J, Wang A, Avanesian V, Spellberg B. Safety and efficacy of activated transfected killer cells for neutropenic fungal infections. J Infect Dis. 2010 Jun 1; 201(11):1708-17. View in: PubMed

Liu M, Spellberg B, Phan QT, Fu Y, Fu Y, Lee AS, Edwards JE, Filler SG, Ibrahim AS. The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice. J Clin Invest. 2010 Jun 1; 120(6):1914-24. View in: PubMed

Quan C, Spellberg B. Mucormycosis, pseudallescheriasis, and other uncommon mold infections. Proc Am Thorac Soc. 2010 May; 7(3):210-5. View in: PubMed

Ibrahim AS, Gebremariam T, French SW, Edwards JE, Spellberg B. The iron chelator deferasirox enhances liposomal amphotericin B efficacy in treating murine invasive pulmonary aspergillosis. J Antimicrob Chemother. 2010 Feb; 65(2):289-92. View in: PubMed

Baquir B, Lin L, Ibrahim AS, Fu Y, Avanesian V, Tu A, Edwards J, Spellberg B. Immunological reactivity of blood from healthy humans to the rAls3p-N vaccine protein. J Infect Dis. 2010 Feb 1; 201(3):473-7. View in: PubMed

Lin L, Ibrahim AS, Xu X, Farber JM, Avanesian V, Baquir B, Fu Y, French SW, Edwards JE, Spellberg B. Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice. PLoS Pathog. 2009 Dec; 5(12):e1000703. View in: PubMed

Spellberg B, Talbot GH, Boucher HW, Bradley JS, Gilbert D, Scheld WM, Edwards J, Bartlett JG. Antimicrobial agents for complicated skin and skin-structure infections: justification of noninferiority margins in the absence of placebo-controlled trials. Clin Infect Dis. 2009 Aug 1; 49(3):383-91. View in: PubMed

Spellberg B, Andes D, Perez M, Anglim A, Bonilla H, Mathisen GE, Walsh TJ, Ibrahim AS. Safety and outcomes of open-label deferasirox iron chelation therapy for mucormycosis. Antimicrob Agents Chemother. 2009 Jul; 53(7):3122-5. View in: PubMed

Spellberg B, Walsh TJ, Kontoyiannis DP, Edwards J, Ibrahim AS. Recent advances in the management of mucormycosis: from bench to bedside. Clin Infect Dis. 2009 Jun 15; 48(12):1743-51. View in: PubMed

Freifeld A, Proia L, Andes D, Baddour LM, Blair J, Spellberg B, Arnold S, Lentnek A, Wheat LJ. Voriconazole use for endemic fungal infections. Antimicrob Agents Chemother. 2009 Apr; 53(4):1648-51. View in: PubMed

Lin L, Ibrahim AS, Baquir B, Avanesian V, Fu Y, Spellberg B. Immunological surrogate marker of rAls3p-N vaccine-induced protection against Staphylococcus aureus. FEMS Immunol Med Microbiol. 2009 Apr; 55(3):293-5. View in: PubMed

Ibrahim AS, Gebremariam T, Schwartz JA, Edwards JE, Spellberg B. Posaconazole mono- or combination therapy for treatment of murine zygomycosis. Antimicrob Agents Chemother. 2009 Feb; 53(2):772-5. View in: PubMed

Ibrahim AS, Edwards JE, Bryant R, Spellberg B. Economic burden of mucormycosis in the United States: can a vaccine be cost-effective? Med Mycol. 2009; 47(6):592-600. View in: PubMed

Boucher HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice LB, Scheld M, Spellberg B, Bartlett J. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis. 2009 Jan 1; 48(1):1-12. View in: PubMed

Spellberg B, Talbot GH, Brass EP, Bradley JS, Boucher HW, Gilbert DN. Position paper: recommended design features of future clinical trials of antibacterial agents for community-acquired pneumonia. Clin Infect Dis. 2008 Dec 1; 47 Suppl 3:S249-65. View in: PubMed

Ibrahim AS, Spellberg B, Edwards J. Iron acquisition: a novel perspective on mucormycosis pathogenesis and treatment. Curr Opin Infect Dis. 2008 Dec; 21(6):620-5. View in: PubMed

Spellberg B, Fleming TR, Gilbert DN. Executive summary: workshop on issues in the design and conduct of clinical trials of antibacterial drugs in the treatment of community-acquired pneumonia. Clin Infect Dis. 2008 Dec 1; 47 Suppl 3:S105-7. View in: PubMed

Spellberg B, Ibrahim AS, Yeaman MR, Lin L, Fu Y, Avanesian V, Bayer AS, Filler SG, Lipke P, Otoo H, Edwards JE. The antifungal vaccine derived from the recombinant N terminus of Als3p protects mice against the bacterium Staphylococcus aureus. Infect Immun. 2008 Oct; 76(10):4574-80. View in: PubMed

Ibrahim AS, Gebremariam T, Liu M, Chamilos G, Kontoyiannis D, Mink R, Kwon-Chung KJ, Fu Y, Skory CD, Edwards JE, Spellberg B. Bacterial endosymbiosis is widely present among zygomycetes but does not contribute to the pathogenesis of mucormycosis. J Infect Dis. 2008 Oct 1; 198(7):1083-90. View in: PubMed

Reed C, Bryant R, Ibrahim AS, Edwards J, Filler SG, Goldberg R, Spellberg B. Combination polyene-caspofungin treatment of rhino-orbital-cerebral mucormycosis. Clin Infect Dis. 2008 Aug 1; 47(3):364-71. View in: PubMed

Spellberg B. Stewart: mistaken or maligned? Clin Infect Dis. 2008 Jul 15; 47(2):294. View in: PubMed

Spellberg B. Antibiotic resistance and antibiotic development. Lancet Infect Dis. 2008 Apr; 8(4):211-2; author reply 212-4. View in: PubMed

Spellberg B, Ibrahim AS, Lin L, Avanesian V, Fu Y, Lipke P, Otoo H, Ho T, Edwards JE. Antibody titer threshold predicts anti-candidal vaccine efficacy even though the mechanism of protection is induction of cell-mediated immunity. J Infect Dis. 2008 Apr 1; 197(7):967-71. View in: PubMed

Ibrahim AS, Gebremariam T, Husseiny MI, Stevens DA, Fu Y, Edwards JE, Spellberg B. Comparison of lipid amphotericin B preparations in treating murine zygomycosis. Antimicrob Agents Chemother. 2008 Apr; 52(4):1573-6. View in: PubMed

Spellberg B. Antibiotic resistance and antibiotic development. Lancet Infect Dis. 2008 Apr; 8(4):211-2; author reply 212-4. View in: PubMed

Ibrahim AS, Gebremariam T, Fu Y, Edwards JE, Spellberg B. Combination echinocandin-polyene treatment of murine mucormycosis. Antimicrob Agents Chemother. 2008 Apr; 52(4):1556-8. View in: PubMed

Fu Y, Luo G, Spellberg BJ, Edwards JE, Ibrahim AS. Gene overexpression/suppression analysis of candidate virulence factors of Candida albicans. Eukaryot Cell. 2008 Mar; 7(3):483-92. View in: PubMed

Lin L, Ibrahim AS, Avanesian V, Edwards JE, Fu Y, Baquir B, Taub R, Spellberg B. Considerable differences in vaccine immunogenicities and efficacies related to the diluent used for aluminum hydroxide adjuvant. Clin Vaccine Immunol. 2008 Mar; 15(3):582-4. View in: PubMed

Spellberg B. Novel insights into disseminated candidiasis: pathogenesis research and clinical experience converge. PLoS Pathog. 2008 Feb 8; 4(2):e38. View in: PubMed

Spellberg B, Guidos R, Gilbert D, Bradley J, Boucher HW, Scheld WM, Bartlett JG, Edwards J. The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America. Clin Infect Dis. 2008 Jan 15; 46(2):155-64. View in: PubMed

Spellberg B. Prospects for and barriers to a fungal vaccine. Expert Opin Biol Ther. 2007 Dec; 7(12):1785-8. View in: PubMed

Ibrahim AS, Gebermariam T, Fu Y, Lin L, Husseiny MI, French SW, Schwartz J, Skory CD, Edwards JE, Spellberg BJ. The iron chelator deferasirox protects mice from mucormycosis through iron starvation. J Clin Invest. 2007 Sep; 117(9):2649-57. View in: PubMed

Perlroth J, Choi B, Spellberg B. Nosocomial fungal infections: epidemiology, diagnosis, and treatment. Med Mycol. 2007 Jun; 45(4):321-46. View in: PubMed

Spellberg B, Miller LG, Kuo MN, Bradley J, Scheld WM, Edwards JE. Societal costs versus savings from wild-card patent extension legislation to spur critically needed antibiotic development. Infection. 2007 Jun; 35(3):167-74. View in: PubMed

Spellberg BJ, Collins M, Avanesian V, Gomez M, Edwards JE, Cogle C, Applebaum D, Fu Y, Ibrahim AS. Optimization of a myeloid cell transfusion strategy for infected neutropenic hosts. J Leukoc Biol. 2007 Mar; 81(3):632-41. View in: PubMed

Miller LG, Perdreau-Remington F, Bayer AS, Diep B, Tan N, Bharadwa K, Tsui J, Perlroth J, Shay A, Tagudar G, Ibebuogu U, Spellberg B. Clinical and epidemiologic characteristics cannot distinguish community-associated methicillin-resistant Staphylococcus aureus infection from methicillin-susceptible S. aureus infection: a prospective investigation. Clin Infect Dis. 2007 Feb 15; 44(4):471-82. View in: PubMed

Ibrahim AS, Edwards JE, Fu Y, Spellberg B. Deferiprone iron chelation as a novel therapy for experimental mucormycosis. J Antimicrob Chemother. 2006 Nov; 58(5):1070-3. View in: PubMed

Spellberg B, Schwartz J, Fu Y, Avanesian V, Adler-Moore J, Edwards JE, Ibrahim AS. Comparison of antifungal treatments for murine fusariosis. J Antimicrob Chemother. 2006 Nov; 58(5):973-9. View in: PubMed

Reed C, Ibrahim A, Edwards JE, Walot I, Spellberg B. Deferasirox, an iron-chelating agent, as salvage therapy for rhinocerebral mucormycosis. Antimicrob Agents Chemother. 2006 Nov; 50(11):3968-9. View in: PubMed

Rieg G, Spellberg B, Schwartz J, Fu Y, Edwards JE, Sheppard DC, Ibrahim AS. Antifungal prophylaxis is effective against murine invasive pulmonary aspergillosis. Antimicrob Agents Chemother. 2006 Aug; 50(8):2895-6. View in: PubMed

Spellberg BJ, Ibrahim AS, Avanesian V, Fu Y, Myers C, Phan QT, Filler SG, Yeaman MR, Edwards JE. Efficacy of the anti-Candida rAls3p-N or rAls1p-N vaccines against disseminated and mucosal candidiasis. J Infect Dis. 2006 Jul 15; 194(2):256-60. View in: PubMed

Ibrahim AS, Spellberg BJ, Avanesian V, Fu Y, Edwards JE. The anti-Candida vaccine based on the recombinant N-terminal domain of Als1p is broadly active against disseminated candidiasis. Infect Immun. 2006 May; 74(5):3039-41. View in: PubMed

Spellberg B. Immunoglobulin G2 antibodies and HIV-infected long-term nonprogressors: what is the mechanism? J Infect Dis. 2006 Apr 1; 193(7):1047; author reply 1047-8. View in: PubMed

Spellberg BJ, Filler SG, Edwards JE. Current treatment strategies for disseminated candidiasis. Clin Infect Dis. 2006 Jan 15; 42(2):244-51. View in: PubMed

Spellberg BJ, Ibrahim AS, Avenissian V, Filler SG, Myers CL, Fu Y, Edwards JE. The anti-Candida albicans vaccine composed of the recombinant N terminus of Als1p reduces fungal burden and improves survival in both immunocompetent and immunocompromised mice. Infect Immun. 2005 Sep; 73(9):6191-3. View in: PubMed

Spellberg BJ, Collins M, French SW, Edwards JE, Fu Y, Ibrahim AS. A phagocytic cell line markedly improves survival of infected neutropenic mice. J Leukoc Biol. 2005 Aug; 78(2):338-44. View in: PubMed

Spellberg B, Ibrahim AS, Edwards JE, Filler SG. Mice with disseminated candidiasis die of progressive sepsis. J Infect Dis. 2005 Jul 15; 192(2):336-43. View in: PubMed

Spellberg B, Edwards J, Ibrahim A. Novel perspectives on mucormycosis: pathophysiology, presentation, and management. Clin Microbiol Rev. 2005 Jul; 18(3):556-69. View in: PubMed

Spellberg B. Carl von Clausewitz (1780-1831) and cholera: the cause of World War II? J Med Biogr. 2005 May; 13(2):108-12. View in: PubMed

Miller LG, Perdreau-Remington F, Rieg G, Mehdi S, Perlroth J, Bayer AS, Tang AW, Phung TO, Spellberg B. Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. N Engl J Med. 2005 Apr 7; 352(14):1445-53. View in: PubMed

Spellberg B. Is computed tomography of the head useful before lumbar puncture? Clin Infect Dis. 2005 Apr 1; 40(7):1061; author reply 1062-3. View in: PubMed

Ibrahim AS, Spellberg BJ, Avenissian V, Fu Y, Filler SG, Edwards JE. Vaccination with recombinant N-terminal domain of Als1p improves survival during murine disseminated candidiasis by enhancing cell-mediated, not humoral, immunity. Infect Immun. 2005 Feb; 73(2):999-1005. View in: PubMed

Ibrahim AS, Bowman JC, Avanessian V, Brown K, Spellberg B, Edwards JE, Douglas CM. Caspofungin inhibits Rhizopus oryzae 1,3-beta-D-glucan synthase, lowers burden in brain measured by quantitative PCR, and improves survival at a low but not a high dose during murine disseminated zygomycosis. Antimicrob Agents Chemother. 2005 Feb; 49(2):721-7. View in: PubMed

Ibrahim AS, Spellberg B, Avanessian V, Fu Y, Edwards JE. Rhizopus oryzae adheres to, is phagocytosed by, and damages endothelial cells in vitro. Infect Immun. 2005 Feb; 73(2):778-83. View in: PubMed

Spellberg B, Fu Y, Edwards JE, Ibrahim AS. Combination therapy with amphotericin B lipid complex and caspofungin acetate of disseminated zygomycosis in diabetic ketoacidotic mice. Antimicrob Agents Chemother. 2005 Feb; 49(2):830-2. View in: PubMed

Spellberg B, Yoo T, Bayer AS. Reversal of linezolid-associated cytopenias, but not peripheral neuropathy, by administration of vitamin B6. J Antimicrob Chemother. 2004 Oct; 54(4):832-5. View in: PubMed

Miller LG, Spellberg B. Treatment of community-associated methicillin-resistant Staphylococcus aureus skin and soft tissue infections with drainage but no antibiotic therapy. Pediatr Infect Dis J. 2004 Aug; 23(8):795; author reply 795-6. View in: PubMed

Fu Y, Lee H, Collins M, Tsai HF, Spellberg B, Edwards JE, Kwon-Chung KJ, Ibrahim AS. Cloning and functional characterization of the Rhizopus oryzae high affinity iron permease (rFTR1) gene. FEMS Microbiol Lett. 2004 Jun 1; 235(1):169-76. View in: PubMed

Spellberg B, Powers JH, Brass EP, Miller LG, Edwards JE. Trends in antimicrobial drug development: implications for the future. Clin Infect Dis. 2004 May 1; 38(9):1279-86. View in: PubMed

Spellberg B, Witt MD, Beck CK. Amphotericin B: is a lipid-formulation gold standard feasible? Clin Infect Dis. 2004 Jan 15; 38(2):304-5; author reply 306-7. View in: PubMed

Miller LG, Spellberg B. Spider bites and infections caused by community-associated methicillin-resistant Staphylococcus aureus. Surg Infect (Larchmt). 2004; 5(3):321-2; author reply 322. View in: PubMed

Ibrahim AS, Avanessian V, Spellberg B, Edwards JE. Liposomal amphotericin B, and not amphotericin B deoxycholate, improves survival of diabetic mice infected with Rhizopus oryzae. Antimicrob Agents Chemother. 2003 Oct; 47(10):3343-4. View in: PubMed

Spellberg B, Johnston D, Phan QT, Edwards JE, French SW, Ibrahim AS, Filler SG. Parenchymal organ, and not splenic, immunity correlates with host survival during disseminated candidiasis. Infect Immun. 2003 Oct; 71(10):5756-64. View in: PubMed

Spellberg B, Rieg G, Bayer A, Edwards JE. Lack of cross-hepatotoxicity between fluconazole and voriconazole. Clin Infect Dis. 2003 Apr 15; 36(8):1091-3. View in: PubMed

Spellberg B, Carroll RM, Robinson E, Brass E. mtDNA disease in the primary care setting. Arch Intern Med. 2001 Nov 12; 161(20):2497-500. View in: PubMed

Spellberg B, Edwards JE. Type 1/Type 2 immunity in infectious diseases. Clin Infect Dis. 2001 Jan; 32(1):76-102. View in: PubMed

Spellberg B. The cutaneous citadel: a holistic view of skin and immunity. Life Sci. 2000 Jun 23; 67(5):477-502. View in: PubMed

Spellberg B. The cutaneous citadel: a holistic view of skin and immunity. Life Sci. 2000 Jun 23; 67(5):477-502. View in: PubMed

Spellberg B, Schiller GJ. Autologous bone marrow transplantation in acute leukemia. Hematol Oncol Clin North Am. 1999 Oct; 13(5):919-38. View in: PubMed

Wirshing DA, Spellberg BJ, Erhart SM, Marder SR, Wirshing WC. Novel antipsychotics and new onset diabetes. Biol Psychiatry. 1998 Oct 15; 44(8):778-83. View in: PubMed

Fu Y, Filler SG, Spellberg BJ, Fonzi W, Ibrahim AS, Kanbe T, Ghannoum MA, Edwards JE. Cloning and characterization of CAD1/AAF1, a gene from Candida albicans that induces adherence to endothelial cells after expression in Saccharomyces cerevisiae. Infect Immun. 1998 May; 66(5):2078-84. View in: PubMed

Libraty DH, Airan LE, Uyemura K, Jullien D, Spellberg B, Rea TH, Modlin RL. Interferon-gamma differentially regulates interleukin-12 and interleukin-10 production in leprosy. J Clin Invest. 1997 Jan 15; 99(2):336-41. View in: PubMed

Filler SG, Pfunder AS, Spellberg BJ, Spellberg JP, Edwards JE. Candida albicans stimulates cytokine production and leukocyte adhesion molecule expression by endothelial cells. Infect Immun. 1996 Jul; 64(7):2609-17. View in: PubMed

Ghannoum MA, Spellberg B, Saporito-Irwin SM, Fonzi WA. Reduced virulence of Candida albicans PHR1 mutants. Infect Immun. 1995 Nov; 63(11):4528-30. View in: PubMed

Kim D, Spellberg B. Does real-time feedback to residents with or without attendings improve medical documentation? Hosp Pract (1995). 2014 Aug; 42(3):123-30. View in: PubMed

Ghannoum MA, Spellberg BJ, Ibrahim AS, Ritchie JA, Currie B, Spitzer ED, Edwards JE, Casadevall A. Sterol composition of Cryptococcus neoformans in the presence and absence of fluconazole. Antimicrob Agents Chemother. 1994 Sep; 38(9):2029-33. View in: PubMed

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