Dr. Lund received an honors degree in Biochemistry from the University of Dundee, Scotland in 1990 and a Ph.D. in Veterinary Immunology and Pathology from the Royal “Dick” Veterinary College at the University of Edinburgh, Scotland in 1994. He trained with world-renowned immunologists during his post-doctoral fellowship in viral immunology from 1994-1997 at the BBSRC Institute for Animal Health. Dr. Lund was recruited to the USC Department of Neurology as a senior research fellow in 1997 to the study efficacy of a novel vaccine for the treatment of multiple sclerosis. In 1999 Dr. Lund was appointed to the faculty in the Department of Neurology at USC as a visiting Assistant Professor and was subsequently appointed as Assistant Professor in 2004.
Dr. Lund’s research primarily focuses on the role of the immune system, not only in the pathogenesis and accrual of pathology in the central nervous system, but also in tissue repair and neuroplasticity. His work is conducted both in animal models of disease and in MS patients. Current research includes assessing the potential role of the renin-angiotensin system on disease progression in MS and animal models, and in collaboration with faculty in the school of pharmacy and the school of medicine assessing the capacity of therapeutic intervention by manipulating the protective arm of this critical biological system. Dr. Lund is also assessing the effect of exercise in disease prevention and recovery, testing the possibility that exercise alters immune status to be more neuroprotective and less damaging. Dr. Lund is also actively involved in numerous clinical trials and studies with colleagues at USC, assessing possible modes of action of new and approved MS therapies, and studying the effects of MS drugs on the immune system in MS patients.
The National Multiple Sclerosis Society, US Department of Defense, USC-CTSI, numerous pharmaceutical companies and private foundations have supported Dr. Lund’s research. He is a member of the British Society for Immunology, the Society for General Microbiology and the Federation of Clinical Immunology Societies and serves as a member of the University of Southern California, Radiation Safety Committee and the Institutional Animal Care and Use Committee.
Goeden N, Velasquez J, Arnold KA, Chan Y, Lund BT, Anderson GM, Bonnin A. Maternal Inflammation Disrupts Fetal Neurodevelopment via Increased Placental Output of Serotonin to the Fetal Brain. J Neurosci. 2016 Jun 1; 36(22):6041-9. View in: PubMed
Kelland EE, Gilmore W, Hayardeny L, Weiner LP, Lund BT. In vitro assessment of the direct effect of laquinimod on basic functions of human neural stem cells and oligodendrocyte progenitor cells. J Neurol Sci. 2014 Nov 15; 346(1-2):66-74. View in: PubMed
Lund BT, Kelland EE, Hayardeny L, Barilan O, Gilmore W, Weiner LP. Assessment of changes in immune measures of multiple sclerosis patients treated with laquinimod. J Neuroimmunol. 2013 Oct 15; 263(1-2):108-15. View in: PubMed
Brück W, Gold R, Lund BT, Oreja-Guevara C, Prat A, Spencer CM, Steinman L, Tintoré M, Vollmer TL, Weber MS, Weiner LP, Ziemssen T, Zamvil SS. Therapeutic decisions in multiple sclerosis: moving beyond efficacy. JAMA Neurol. 2013 Oct; 70(10):1315-24. View in: PubMed
Kelland EE, Gilmore W, Weiner LP, Lund BT. The dual role of CXCL8 in human CNS stem cell function: Multipotent neural stem cell death and oligodendrocyte progenitor cell chemotaxis. Glia. 2011 Dec; 59(12):1864-78. View in: PubMed
Dietlin TA, Cua DJ, Burke KA, Lund BT, van der Veen RC. Role of IL-23 in mobilization of immunoregulatory nitric oxide- or superoxide-producing Gr-1+ cells from bone marrow. Free Radic Biol Med. 2009 Aug 15; 47(4):357-63. View in: PubMed
Lund BT, Kelland EE. Measuring apoptosis in neural stem cells. Methods Mol Biol. 2008; 438:227-41. View in: PubMed
Dietlin TA, Hofman FM, Lund BT, Gilmore W, Stohlman SA, van der Veen RC. Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion. J Leukoc Biol. 2007 May; 81(5):1205-12. View in: PubMed
Zhong JF, Song Y, Du J, Gamache C, Burke KA, Lund BT, Weiner LP. Gene regulation networks related to neural differentiation of hESC. Gene Expr. 2007; 14(1):23-34. View in: PubMed
Lund BT, Chakryan Y, Ashikian N, Mnatsakanyan L, Bevan CJ, Aguilera R, Gallaher T, Jakowec MW. Association of MBP peptides with Hsp70 in normal appearing human white matter. J Neurol Sci. 2006 Nov 15; 249(2):122-34. View in: PubMed
Lund BT, Ashikian N, Ta HQ, Chakryan Y, Manoukian K, Groshen S, Gilmore W, Cheema GS, Stohl W, Burnett ME, Ko D, Kachuck NJ, Weiner LP. Increased CXCL8 (IL-8) expression in Multiple Sclerosis. J Neuroimmunol. 2004 Oct; 155(1-2):161-71. View in: PubMed