Faculty

Back to Index
Brian Michael Luna, PhD
Instructor of Research Medicine
Medicine
HCT 1520 San Pablo St Health Sciences Campus Los Angeles
+1 323 865 3737

Overview

In the United States there has been a rapid increase in the disease burden caused by antibiotic resistant members of the ESKAPE pathogens: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species. More than 2,000,000 illnesses and 23,000 deaths were attributed to antibiotic resistant infections in the US in 2013, with an added $20 billion dollar cost to the healthcare system. Continued research is needed to understand antibiotic tolerance mechanisms for the purpose of developing the next generation of therapeutics that can subvert these mechanisms.

I am interested in the study of antibiotic tolerance mechanisms by bacterial pathogens; including both antibiotic resistance and antibiotic persister cell formation. Better understanding of antibiotic tolerance mechanisms will guide improved therapeutic strategies for combating these infections. We use multiple research strategies including synthetic biology, microbial genetics, next-generation sequencing, and preclinical mouse models in our work.

Publications

Kubler A, Larsson C, Luna B, Andrade BB, Amaral EP, Urbanowski M, Orandle M, Bock K, Ammerman NC, Cheung LS, Winglee K, Halushka M, Park JK, Sher A, Friedland JS, Elkington PT, Bishai WR. Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis. J Infect Dis. 2016 Feb 15; 213(4):618-27. View in: PubMed

Xu Z, Bagci U, Mansoor A, Kramer-Marek G, Luna B, Kubler A, Dey B, Foster B, Papadakis GZ, Camp JV, Jonsson CB, Bishai WR, Jain S, Udupa JK, Mollura DJ. Computer-aided pulmonary image analysis in small animal models. Med Phys. 2015 Jul; 42(7):3896-910. View in: PubMed

Luna B, Kubler A, Larsson C, Foster B, Bagci U, Mollura DJ, Jain SK, Bishai WR. In vivo prediction of tuberculosis-associated cavity formation in rabbits. J Infect Dis. 2015 Feb 1; 211(3):481-5. View in: PubMed

Kübler A, Luna B, Larsson C, Ammerman NC, Andrade BB, Orandle M, Bock KW, Xu Z, Bagci U, Mollura DJ, Marshall J, Burns J, Winglee K, Ahidjo BA, Cheung LS, Klunk M, Jain SK, Kumar NP, Babu S, Sher A, Friedland JS, Elkington PT, Bishai WR. Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation. J Pathol. 2015 Feb; 235(3):431-44. View in: PubMed

Foster B, Bagci U. Segmentation of PET images for computer-aided functional quantification of tuberculosis in small animal models. IEEE Trans Biomed Eng. 2014 Mar; 61(3):711-24. View in: PubMed

Foster B, Bagci U. Segmentation of PET images for computer-aided functional quantification of tuberculosis in small animal models. IEEE Trans Biomed Eng. 2014 Mar; 61(3):711-24. View in: PubMed

Xu Z, Bagci U, Kubler A, Luna B, Jain S, Bishai WR, Mollura DJ. Computer-aided detection and quantification of cavitary tuberculosis from CT scans. Med Phys. 2013 Nov; 40(11):113701. View in: PubMed

Bagci U, Foster B, Miller-Jaster K, Luna B, Dey B, Bishai WR, Jonsson CB, Jain S, Mollura DJ. A computational pipeline for quantification of pulmonary infections in small animal models using serial PET-CT imaging. EJNMMI Res. 2013; 3(1):55. View in: PubMed

Bagci U, Foster B, Miller-Jaster K, Luna B, Dey B, Bishai WR, Jonsson CB, Jain S, Mollura DJ. A computational pipeline for quantification of pulmonary infections in small animal models using serial PET-CT imaging. EJNMMI Res. 2013; 3(1):55. View in: PubMed

Larsson C, Luna B, Ammerman NC, Maiga M, Agarwal N, Bishai WR. Gene expression of Mycobacterium tuberculosis putative transcription factors whiB1-7 in redox environments. PLoS One. 2012; 7(7):e37516. View in: PubMed

Luna BM, Juhn J, James AA. Injection of dsRNA into female A. aegypti mosquitos. J Vis Exp. 2007; (5):215. View in: PubMed

Powered bySC CTSI