Faculty

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Carrie Breton, ScD
Associate Professor of Preventive Medicine
Environmental Health
SSB 2nd floor 2001 N. Soto Street Health Sciences Campus Los Angeles
+1 323 442 7383

Overview

The overarching goals of my research program are to understand how environmental exposures early in life contribute to the increased risk of disease later in life, as well as the role genetic and epigenetic mechanisms play in driving observed associations.

Despite evidence from animal models supporting a developmental origins of adult disease hypothesis (DOHad), which proposes that adverse events during early life program an increased risk for numerous adult diseases, human studies of in utero or childhood environmental exposures have not been a primary focus until recently. My work in evaluating prenatal air pollution and prenatal tobacco smoke exposures provides evidence that early life exposures are important risk factors for cardio-respiratory health in children and young adults.

Publications

Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure. Environ Health Perspect. 2017 Jan; 125(1):104-110. View in: PubMed

Prenatal Air Pollution Exposures, DNA Methyl Transferase Genotypes, and Associations with Newborn LINE1 and Alu Methylation and Childhood Blood Pressure and Carotid Intima-Media Thickness in the Children's Health Study. Environ Health Perspect. 2016 Dec; 124(12):1905-1912. View in: PubMed

Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation. J Am Heart Assoc. 2016 Aug; 5(8). View in: PubMed

cit: hypothesis testing software for mediation analysis in genomic applications. Bioinformatics. 2016 Aug 1; 32(15):2364-5. View in: PubMed

DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. Am J Hum Genet. 2016 Apr 7; 98(4):680-96. View in: PubMed

Prenatal Air Pollution Exposure and Early Cardiovascular Phenotypes in Young Adults. PLoS One. 2016; 11(3):e0150825. View in: PubMed

Chronic effects of air pollution on respiratory health in Southern California children: findings from the Southern California Children's Health Study. J Thorac Dis. 2015 Jan; 7(1):46-58. View in: PubMed

NOS1 Methylation and Carotid Artery Intima-Media Thickness in Children. Circ Cardiovasc Genet. 2014 Apr 1; 7(2):116-22. View in: PubMed

HDL anti-oxidant function associates with LDL level in young adults. Atherosclerosis. 2014 Jan; 232(1):165-70. View in: PubMed

Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation. PLoS One. 2014; 9(6):e99716. View in: PubMed

Response to letter regarding article, “Childhood air pollutant exposure and carotid artery intima–media thickness in young adults”. Circulation. 2013 Jun 4; 127(22):e659. View in: PubMed

Birth weight and carotid artery intima-media thickness. J Pediatr. 2013 May; 162(5):906-11. e1-2. View in: PubMed

Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Hum Genet. 2012 Oct; 131(10):1565-89. View in: PubMed

Childhood air pollutant exposure and carotid artery intima-media thickness in young adults. Circulation. 2012 Sep 25; 126(13):1614-20. View in: PubMed

Particulate matter, DNA methylation in nitric oxide synthase, and childhood respiratory disease. Environ Health Perspect. 2012 Sep; 120(9):1320-6. View in: PubMed

Air pollution and health: emerging information on susceptible populations. Air Qual Atmos Health. 2012 Jun 01; 5(2):189-201. View in: PubMed

Genetic and epigenetic variations in inducible nitric oxide synthase promoter, particulate pollution, and exhaled nitric oxide levels in children. J Allergy Clin Immunol. 2012 Jan; 129(1):232-239. e7. View in: PubMed

Carotid artery intima-media thickness in college students: race/ethnicity matters. Atherosclerosis. 2011 Aug; 217(2):441-6. View in: PubMed

DNA methylation in the arginase-nitric oxide synthase pathway is associated with exhaled nitric oxide in children with asthma. Am J Respir Crit Care Med. 2011 Jul 15; 184(2):191-7. View in: PubMed

Heritability and role for the environment in DNA methylation in AXL receptor tyrosine kinase. Epigenetics. 2011 Jul; 6(7):895-8. View in: PubMed

A pathway-based analysis of urinary arsenic metabolites and skin lesions. Am J Epidemiol. 2011 Apr 1; 173(7):778-86. View in: PubMed

Investigating air pollution and atherosclerosis in humans: concepts and outlook. Prog Cardiovasc Dis. 2011 Mar-Apr; 53(5):334-43. View in: PubMed

Genetic variation in the glutathione synthesis pathway, air pollution, and children's lung function growth. Am J Respir Crit Care Med. 2011 Jan 15; 183(2):243-8. View in: PubMed

Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence. Thorax. 2010 Feb; 65(2):139-45. View in: PubMed

Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation. Am J Respir Crit Care Med. 2009 Sep 1; 180(5):462-7. View in: PubMed

Variation in the GST mu locus and tobacco smoke exposure as determinants of childhood lung function. Am J Respir Crit Care Med. 2009 Apr 1; 179(7):601-7. View in: PubMed

Association between total ingested arsenic and toenail arsenic concentrations. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2007 Oct; 42(12):1827-34. View in: PubMed

Maternal arsenic exposure associated with low birth weight in Bangladesh. J Occup Environ Med. 2007 Oct; 49(10):1097-104. View in: PubMed

Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genes. Carcinogenesis. 2007 Jul; 28(7):1520-5. View in: PubMed

Dietary arsenic exposure in bangladesh. Environ Health Perspect. 2007 Jun; 115(6):889-93. View in: PubMed

GSTM1 and APE1 genotypes affect arsenic-induced oxidative stress: a repeated measures study. Environ Health. 2007; 6:39. View in: PubMed

Characteristics of work related asthma: results from a population based survey. Occup Environ Med. 2006 Jun; 63(6):411-5. View in: PubMed

Gender-specific protective effect of hemoglobin on arsenic-induced skin lesions. Cancer Epidemiol Biomarkers Prev. 2006 May; 15(5):902-7. View in: PubMed

[Epidemiological profile of patients with myocardial infarction and normal coronary arteriography]. Arch Mal Coeur Vaiss. 1979 Jan; 72(1):26-31. View in: PubMed

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