Faculty

Back to Index
Charalampos Zalavras, MD
Professor of Clinical Orthopaedic Surgery
Orthopaedic Surgery
GNH 3900 1200 N. State Street Off Campus Los Angeles
+1 323 226 8010

Overview

Dr. Charalampos Zalavras is a specialist in the field of orthopaedic trauma at the Los Angeles County & University of Southern California Medical Center. Dr. Zalavras joined the Department of Orthopaedic Surgery at the Keck School of Medicine of USC as faculty in 2001 and is currently Professor of Clinical Orthopaedics and Director of Orthopaedic Resident Research. He has a particular interest in trauma and reconstruction of the upper extremity and in musculoskeletal infection. Dr. Zalavras has published approximately 90 peer-reviewed manuscripts and 20 book chapters focusing in the topics of trauma and infection and his work has been extensively cited with approximately 3,000 citations. Dr. Zalavras has been invited to deliver more than 80 scientific lectures in conferences in the US and all over the world. Dr. Zalavras has received numerous distinguished awards. He was the recipient of the Marshall R. Urist Young Investigator Award by the Association of Bone and Joint Surgeons and the Scholar Award by the Musculoskeletal Infection Society and the Association of Bone and Joint Surgeons. His research work resulted in Award for Best Resident/Fellow Paper in the Annual Meeting of the Arthroscopy Association of North America and in nomination for the Charles S. Neer II Award by the American Shoulder and Elbow Surgeons. He was recipient of a Traveling Fellowship Award by the Japanese Orthopaedic Association in 2013. Dr. Zalavras currently serves in the Editorial Board of Clinical Orthopaedics and Related Research (Deputy Editor for Infection) and Journal of Orthopaedic Trauma (Section Editor for Infection). Dr. Zalavras has served as president of the Musculoskeletal Infection Society and as member of its executive board. He is member of the Association of Bone and Joint Surgeons, the American Academy of Orthopaedic Surgery, the American College of Surgeons, and the European Bone and Joint Infection Society.

Publications

Zalavras CG. CORR Insights(®): Cathodic Voltage-controlled Electrical Stimulation Plus Prolonged Vancomycin Reduce Bacterial Burden of a Titanium Implant-associated Infection in a Rodent Model. Clin Orthop Relat Res. 2016 Jul; 474(7):1676-8. View in: PubMed

Zalavras CG, Schmitt SK. Editorial Comment: Proceedings of the 2015 Musculoskeletal Infection Society. Clin Orthop Relat Res. 2016 Jul; 474(7):1581-2. View in: PubMed

Zalavras CG. CORR Insights(®): Regional Intraosseous Administration of Prophylactic Antibiotics is More Effective Than Systemic Administration in a Mouse Model of TKA. Clin Orthop Relat Res. 2015 Nov; 473(11):3585-7. View in: PubMed

Zalavras CG. Invited Commentary. J Orthop Trauma. 2015 Oct; 29(10):e395. View in: PubMed

Zalavras C, Marculescu C. Editorial Comment: Symposium: 2014 Musculoskeletal Infection Society. Clin Orthop Relat Res. 2015 Jul; 473(7):2227-8. View in: PubMed

van der Jagt D, Mokete L, Pietrzak J, Zalavras CG, Lieberman JR. Osteonecrosis of the femoral head: evaluation and treatment. J Am Acad Orthop Surg. 2015 Feb; 23(2):69-70. View in: PubMed

Mavrodontidis A, Lykissas M, Koulouvaris P, Pafilas D, Kontogeorgakos V, Zalavras C. Percutaneous repair of acute Achilles tendon rupture: a functional evaluation study with a minimum 10-year follow-up. Acta Orthop Traumatol Turc. 2015; 49(6):661-7. View in: PubMed

Zalavras CG. Editorial comment: 2013 musculoskeletal infection society meeting. Clin Orthop Relat Res. 2014 Nov; 472(11):3273-4. View in: PubMed

Zalavras CG, Lieberman JR. Osteonecrosis of the femoral head: evaluation and treatment. J Am Acad Orthop Surg. 2014 Jul; 22(7):455-64. View in: PubMed

Zalavras CG. CORR Insights(®): Sonication of Antibiotic Spacers Predicts Failure during Two-stage Revision for Prosthetic Knee and Hip Infections. Clin Orthop Relat Res. 2014 Jul; 472(7):2215-6. View in: PubMed

Neuhaus V, Bot AG, Guitton TG, Ring DC. Scapula fractures: interobserver reliability of classification and treatment. J Orthop Trauma. 2014 Mar; 28(3):124-9. View in: PubMed

Alijanipour P, Karam J, Llinás A, Vince KG, Zalavras C, Austin M, Garrigues G, Heller S, Huddleston J, Klatt B, Krebs V, Lohmann C, McPherson EJ, Molloy R, Oliashirazi A, Schwaber M, Sheehan E, Smith E, Sterling R, Stocks G, Vaidya S. Operative environment. J Arthroplasty. 2014 Feb; 29(2 Suppl):49-64. View in: PubMed

Alijanipour P, Karam J, Llinás A, Vince KG, Zalavras C, Austin M, Garrigues G, Heller S, Huddleston J, Klatt B, Krebs V, Lohmann C, McPherson EJ, Molloy R, Oliashirazi A, Schwaber M, Sheehan E, Smith E, Sterling R, Stocks G, Vaidya S. Operative environment. J Orthop Res. 2014 Jan; 32 Suppl 1:S60-80. View in: PubMed

Papasoulis E, Patzakis MJ, Zalavras CG. Antibiotics in the Treatment of Low-velocity Gunshot-induced Fractures: A Systematic Literature Review. Clin Orthop Relat Res. 2013 Dec; 471(12):3937-44. View in: PubMed

Parvizi J, Zmistowski B, Berbari EF, Bauer TW, Springer BD, Della Valle CJ, Garvin KL, Mont MA, Wongworawat MD, Zalavras CG. New definition for periprosthetic joint infection: from the Workgroup of the Musculoskeletal Infection Society. Clin Orthop Relat Res. 2011 Nov; 469(11):2992-4. View in: PubMed

Zalavras CG, Wongworawat MD. Papers presented at the 2010 [corrected] meeting of the Musculoskeletal Infection Society: editorial comment. Clin Orthop Relat Res. 2011 Nov; 469(11):2989-90. View in: PubMed

Zalavras CG, Vercillo MT, Jun BJ, Otarodifard K, Itamura JM, Lee TQ. Biomechanical evaluation of parallel versus orthogonal plate fixation of intra-articular distal humerus fractures. J Shoulder Elbow Surg. 2011 Jan; 20(1):12-20. View in: PubMed

Zalavras CG, Sirkin M. Treatment of long bone intramedullary infection using the RIA for removal of infected tissue: indications, method and clinical results. Injury. 2010 Nov; 41 Suppl 2:S43-7. View in: PubMed

Allison DC, Holtom PD, Patzakis MJ, Zalavras CG. Microbiology of bone and joint infections in injecting drug abusers. Clin Orthop Relat Res. 2010 Aug; 468(8):2107-12. View in: PubMed

Stine IA, Lee B, Zalavras CG, Hatch G, Itamura JM. Management of chronic shoulder infections utilizing a fixed articulating antibiotic-loaded spacer. J Shoulder Elbow Surg. 2010 Jul; 19(5):739-48. View in: PubMed

Zionts LE, Woodson CJ, Manjra N, Zalavras C. Time of return of elbow motion after percutaneous pinning of pediatric supracondylar humerus fractures. Clin Orthop Relat Res. 2009 Aug; 467(8):2007-10. View in: PubMed

Zalavras CG, Rigopoulos N, Ahlmann E, Patzakis MJ. Hip disarticulation for severe lower extremity infections. Clin Orthop Relat Res. 2009 Jul; 467(7):1721-6. View in: PubMed

Zalavras CG, Rigopoulos N, Lee J, Learch T, Patzakis MJ. Magnetic resonance imaging findings in hematogenous osteomyelitis of the hip in adults. Clin Orthop Relat Res. 2009 Jul; 467(7):1688-92. View in: PubMed

Zalavras CG, Christensen T, Rigopoulos N, Holtom P, Patzakis MJ. Infection following operative treatment of ankle fractures. Clin Orthop Relat Res. 2009 Jul; 467(7):1715-20. View in: PubMed

Dinh P, Hutchinson BK, Zalavras C, Stevanovic MV. Reconstruction of osteomyelitis defects. Semin Plast Surg. 2009 May; 23(2):108-18. View in: PubMed

Zalavras CG, Rigopoulos N, Poultsides L, Patzakis MJ. Increased oxacillin resistance in thigh pyomyositis in diabetic patients. Clin Orthop Relat Res. 2008 Jun; 466(6):1405-9. View in: PubMed

Holtom PD, Borges L, Zalavras CG. Hematogenous septic ankle arthritis. Clin Orthop Relat Res. 2008 Jun; 466(6):1388-91. View in: PubMed

Itamura JM, Roidis NT, Chong AK, Vaishnav S, Papadakis SA, Zalavras C. Computed tomography study of radial head morphology. J Shoulder Elbow Surg. 2008 Mar-Apr; 17(2):347-54. View in: PubMed

Zalavras CG, Marcus RE, Levin LS, Patzakis MJ. Management of open fractures and subsequent complications. Instr Course Lect. 2008; 57:51-63. View in: PubMed

Papadakis SA, Zalavras C, Mirzayan R, Shepherd L. Undetected iatrogenic lesions of the anterior femoral shaft during intramedullary nailing: a cadaveric study. J Orthop Surg Res. 2008; 3:30. View in: PubMed

Zalavras CG, McAllister ET, Singh A, Itamura JM. Operative treatment of intra-articular distal humerus fractures. Am J Orthop (Belle Mead NJ). 2007 Dec; 36(12 Suppl 2):8-12. View in: PubMed

Themistocleous G, Zalavras C, Stine I, Zachos V, Itamura J. Prolonged implantation of an antibiotic cement spacer for management of shoulder sepsis in compromised patients. J Shoulder Elbow Surg. 2007 Nov-Dec; 16(6):701-5. View in: PubMed

Ogawa BK, Thordarson DB, Zalavras C. Peroneal tendon subluxation repair with an indirect fibular groove deepening technique. Foot Ankle Int. 2007 Nov; 28(11):1194-7. View in: PubMed

Zalavras CG, Femino D, Triche R, Zionts L, Stevanovic M. Reconstruction of large skeletal defects due to osteomyelitis with the vascularized fibular graft in children. J Bone Joint Surg Am. 2007 Oct; 89(10):2233-40. View in: PubMed

Vercillo M, Patzakis MJ, Holtom P, Zalavras CG. Linezolid in the treatment of implant-related chronic osteomyelitis. Clin Orthop Relat Res. 2007 Aug; 461:40-3. View in: PubMed

Zalavras CG, Singh A, Patzakis MJ. Novel technique for medullary canal débridement in tibia and femur osteomyelitis. Clin Orthop Relat Res. 2007 Aug; 461:31-4. View in: PubMed

Holtom PD, Zalavras CG, Lamp KC, Park N, Friedrich LV. Clinical experience with daptomycin treatment of foot or ankle osteomyelitis: a preliminary study. Clin Orthop Relat Res. 2007 Aug; 461:35-9. View in: PubMed

Allison DC, Miller T, Holtom P, Patzakis MJ, Zalavras CG. Microbiology of upper extremity soft tissue abscesses in injecting drug abusers. Clin Orthop Relat Res. 2007 Aug; 461:9-13. View in: PubMed

Lee JA, Papadakis SA, Moon C, Zalavras CG. Tibial plateau fractures treated with the less invasive stabilisation system. Int Orthop. 2007 Jun; 31(3):415-8. View in: PubMed

Zalavras C, Thordarson D. Ankle syndesmotic injury. J Am Acad Orthop Surg. 2007 Jun; 15(6):330-9. View in: PubMed

Malizos KN, Zachos V, Dailiana ZH, Zalavras C, Varitimidis S, Hantes M, Karantanas A. Scaphoid nonunions: management with vascularized bone grafts from the distal radius: a clinical and functional outcome study. Plast Reconstr Surg. 2007 Apr 15; 119(5):1513-25. View in: PubMed

Zalavras CG, Marcus RE, Levin LS, Patzakis MJ. Management of open fractures and subsequent complications. J Bone Joint Surg Am. 2007 Apr; 89(4):884-95. View in: PubMed

Mehta P, Schnall SB, Zalavras CG. Septic arthritis of the shoulder, elbow, and wrist. Clin Orthop Relat Res. 2006 Oct; 451:42-5. View in: PubMed

Zalavras CG, Dellamaggiora R, Patzakis MJ, Zachos V, Holtom PD. Recalcitrant septic knee arthritis due to adjacent osteomyelitis in adults. Clin Orthop Relat Res. 2006 Oct; 451:38-41. View in: PubMed

Zalavras CG, Dellamaggiora R, Patzakis MJ, Bava E, Holtom PD. Septic arthritis in patients with human immunodeficiency virus. Clin Orthop Relat Res. 2006 Oct; 451:46-9. View in: PubMed

Themistocleous GS, Zalavras CG, Zachos VC, Itamura JM. Biologic resurfacing of the glenoid using a meniscal allograft. Tech Hand Up Extrem Surg. 2006 Sep; 10(3):145-9. View in: PubMed

Johnson KW, Zalavras C, Thordarson DB. Surgical management of insertional calcific achilles tendinosis with a central tendon splitting approach. Foot Ankle Int. 2006 Apr; 27(4):245-50. View in: PubMed

Zalavras CG, Gardocki R, Huang E, Stevanovic M, Hedman T, Tibone J. Reconstruction of large rotator cuff tendon defects with porcine small intestinal submucosa in an animal model. J Shoulder Elbow Surg. 2006 Mar-Apr; 15(2):224-31. View in: PubMed

Zalavras CG, Patzakis MJ, Holtom PD, Sherman R. Management of open fractures. Infect Dis Clin North Am. 2005 Dec; 19(4):915-29. View in: PubMed

Zalavras CG, Patzakis MJ, Tibone J, Weisman N, Holtom P. Treatment of persistent infection after anterior cruciate ligament surgery. Clin Orthop Relat Res. 2005 Oct; 439:52-5. View in: PubMed

Zalavras CG, Gupta N, Patzakis MJ, Holtom PD. Microbiology of osteomyelitis in patients infected with the human immunodeficiency virus. Clin Orthop Relat Res. 2005 Oct; 439:97-100. View in: PubMed

Patzakis MJ, Zalavras CG. Chronic posttraumatic osteomyelitis and infected nonunion of the tibia: current management concepts. J Am Acad Orthop Surg. 2005 Oct; 13(6):417-27. View in: PubMed

Savage K, Holtom PD, Zalavras CG. Spinal epidural abscess: early clinical outcome in patients treated medically. Clin Orthop Relat Res. 2005 Oct; 439:56-60. View in: PubMed

Zionts LE, Zalavras CG, Gerhardt MB. Closed treatment of displaced diaphyseal both-bone forearm fractures in older children and adolescents. J Pediatr Orthop. 2005 Jul-Aug; 25(4):507-12. View in: PubMed

Zalavras C, Velmahos GC, Chan L, Demetriades D, Patzakis MJ. Risk factors for respiratory failure following femoral fractures: the role of multiple intramedullary nailing. Injury. 2005 Jun; 36(6):751-7. View in: PubMed

Zalavras C, Nikolopoulou G, Essin D, Manjra N, Zionts LE. Pediatric fractures during skateboarding, roller skating, and scooter riding. Am J Sports Med. 2005 Apr; 33(4):568-73. View in: PubMed

Mavrodontidis AN, Zalavras CG, Papadonikolakis A, Soucacos PN. Bilateral absence of the patella in nail-patella syndrome: delayed presentation with anterior knee instability. Arthroscopy. 2004 Oct; 20(8):e89-93. View in: PubMed

Zalavras CG, Patzakis MJ, Holtom P. Local antibiotic therapy in the treatment of open fractures and osteomyelitis. Clin Orthop Relat Res. 2004 Oct; (427):86-93. View in: PubMed

Zalavras CG, Patzakis MJ, Thordarson DB, Shah S, Sherman R, Holtom P. Infected fractures of the distal tibial metaphysis and plafond: achievement of limb salvage with free muscle flaps, bone grafting, and ankle fusion. Clin Orthop Relat Res. 2004 Oct; (427):57-62. View in: PubMed

Hurvitz G, Zalavras C, Thordarson DB. Débridement and primary closure of nonhealing foot wounds. Am J Orthop (Belle Mead NJ). 2004 Oct; 33(10):507-9. View in: PubMed

Hantes ME, Mavrodontidis AN, Zalavras CG, Karantanas AH, Karachalios T, Malizos KN. Low-intensity transosseous ultrasound accelerates osteotomy healing in a sheep fracture model. J Bone Joint Surg Am. 2004 Oct; 86-A(10):2275-82. View in: PubMed

Malizos KN, Zalavras CG, Soucacos PN, Beris AE, Urbaniak JR. Free vascularized fibular grafts for reconstruction of skeletal defects. J Am Acad Orthop Surg. 2004 Sep-Oct; 12(5):360-9. View in: PubMed

Chow JC, Hantes ME, Houle JB, Zalavras CG. Arthroscopic autogenous osteochondral transplantation for treating knee cartilage defects: a 2- to 5-year follow-up study. Arthroscopy. 2004 Sep; 20(7):681-90. View in: PubMed

Zalavras CG, Vartholomatos G, Dokou E, Malizos KN. Genetic background of osteonecrosis: associated with thrombophilic mutations? Clin Orthop Relat Res. 2004 May; (422):251-5. View in: PubMed

Darlis NA, Kotsovolos ES, Zalavras CG, Mavrodondidis AN. Ipsilateral radial shaft, head, and medial epicondyle fractures. J Orthop Trauma. 2004 Apr; 18(4):238-40. View in: PubMed

Papadonikolakis A, Mavrodontidis AN, Zalavras C, Hantes M, Soucacos PN. Transscaphoid volar lunate dislocation. A case report. J Bone Joint Surg Am. 2003 Sep; 85-A(9):1805-8. View in: PubMed

Zalavras CG, Patzakis MJ. Open fractures: evaluation and management. J Am Acad Orthop Surg. 2003 May-Jun; 11(3):212-9. View in: PubMed

Shepherd LE, Zalavras CG, Jaki K, Shean C, Patzakis MJ. Gunshot femoral shaft fractures: is the current classification system reliable? Clin Orthop Relat Res. 2003 Mar; (408):101-9. View in: PubMed

Zalavras ChG, Giotopoulou S, Dokou E, Mitsis M, Ioannou HV, Tsaousi C, Tzolou A, Kolaitis N, Vartholomatos G. Prevalence of the G20210A prothrombin gene mutation in Northwestern Greece and association with venous thromboembolism. Int Angiol. 2003 Mar; 22(1):55-7. View in: PubMed

Zalavras C, Shah S, Birnbaum MJ, Frenkel B. Role of apoptosis in glucocorticoid-induced osteoporosis and osteonecrosis. Crit Rev Eukaryot Gene Expr. 2003; 13(2-4):221-35. View in: PubMed

Mora S, Zalavras CG, Wang L, Thordarson DB. The role of pulsatile cold compression in edema resolution following ankle fractures: a randomized clinical trial. Foot Ankle Int. 2002 Nov; 23(11):999-1002. View in: PubMed

Zalavras ChG, Giotopoulou S, Dokou E, Mitsis M, Ioannou HV, Tzolou A, Kolaitis N, Vartholomatos G. Lack of association between the C677T mutation in the 5,10-methylenetetrahydrofolate reductase gene and venous thromboembolism in Northwestern Greece. Int Angiol. 2002 Sep; 21(3):268-71. View in: PubMed

Zalavras CG, Vartholomatos G, Dokou E, Malizos KN. Factor V Leiden and prothrombin gene mutations in femoral head osteonecrosis. Thromb Haemost. 2002 Jun; 87(6):1079-80. View in: PubMed

Zalavras CG, Malizos KN, Dokou E, Vartholomatos G. The 677C-->T mutation of the methylene-tetrahydrofolate reductase gene in the pathogenesis of osteonecrosis of the femoral head. Haematologica. 2002 Jan; 87(1):111-2. View in: PubMed

Powered bySC CTSI