Faculty

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Cheng-Ming Chuong, MD, PhD
Professor of Pathology
Director of Graduate Programs
Pathology
HMR 313B Health Sciences Campus Los Angeles
+1 323 442 1296

Publications

The GCaMP-R Family of Genetically Encoded Ratiometric Calcium Indicators. ACS Chem Biol. 2017 Feb 14. View in: PubMed

Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme. Nat Commun. 2017 Jan 20; 8:ncomms14139. View in: PubMed

The "tao" of integuments. Science. 2016 Dec 23; 354(6319):1533-1534. View in: PubMed

Corrigendum: Assembling Composite Dermal Papilla Spheres with Adipose-derived Stem Cells to Enhance Hair Follicle Induction. Sci Rep. 2016 Nov 14; 6:31257. View in: PubMed

Quorum sensing and other collective regenerative behavior in organ populations. Curr Opin Genet Dev. 2016 Oct; 40:138-143. View in: PubMed

Regulatory Differences in Natal Down Development between Altricial Zebra Finch and Precocial Chicken. Mol Biol Evol. 2016 Aug; 33(8):2030-43. View in: PubMed

The Modulatable Stem Cell Niche: Tissue Interactions during Hair and Feather Follicle Regeneration. J Mol Biol. 2016 Apr 10; 428(7):1423-40. View in: PubMed

STEM CELLS. Aging, alopecia, and stem cells. Science. 2016 Feb 5; 351(6273):559-60. View in: PubMed

Assembling Composite Dermal Papilla Spheres with Adipose-derived Stem Cells to Enhance Hair Follicle Induction. Sci Rep. 2016; 6:26436. View in: PubMed

Topographical mapping of a- and ß-keratins on developing chicken skin integuments: Functional interaction and evolutionary perspectives. Proc Natl Acad Sci U S A. 2015 Dec 8; 112(49):E6770-9. View in: PubMed

Proper BMP Signaling Levels Are Essential for 3D Assembly of Hepatic Cords from Hepatoblasts and Mesenchymal Cells. Dig Dis Sci. 2015 Dec; 60(12):3669-80. View in: PubMed

Roles of GasderminA3 in Catagen-Telogen Transition During Hair Cycling. J Invest Dermatol. 2015 Sep; 135(9):2162-72. View in: PubMed

Prolonged overexpression of Wnt10b induces epidermal keratinocyte transformation through activating EGF pathway. Histochem Cell Biol. 2015 Sep; 144(3):209-21. View in: PubMed

Deciphering principles of morphogenesis from temporal and spatial patterns on the integument. Dev Dyn. 2015 Aug; 244(8):905-20. View in: PubMed

Feather on the Cap of Medicine. J Invest Dermatol. 2015 Jul; 135(7):1719-21. View in: PubMed

Organ-level quorum sensing directs regeneration in hair stem cell populations. Cell. 2015 Apr 9; 161(2):277-90. View in: PubMed

Perivascular-derived stem cells with neural crest characteristics are involved in tendon repair. Stem Cells Dev. 2015 Apr 1; 24(7):857-68. View in: PubMed

Development, regeneration, and evolution of feathers. Annu Rev Anim Biosci. 2015 Feb 16; 3:169-95. View in: PubMed

Emergence of differentially regulated pathways associated with the development of regional specificity in chicken skin. BMC Genomics. 2015; 16(1):22. View in: PubMed

Transcriptomic analyses of regenerating adult feathers in chicken. BMC Genomics. 2015; 16(1):756. View in: PubMed

Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis. Nat Commun. 2015; 6:6798. View in: PubMed

An integrative approach to understanding bird origins. Science. 2014 Dec 12; 346(6215):1253293. View in: PubMed

Bifunctional ectodermal stem cells around the nail display dual fate homeostasis and adaptive wounding response toward nail regeneration. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15114-9. View in: PubMed

Defining dermal adipose tissue. Exp Dermatol. 2014 Sep; 23(9):629-31. View in: PubMed

SnapShot: Branching Morphogenesis. Cell. 2014 Aug 28; 158(5):1212-1212. e1. View in: PubMed

Regenerative hair waves in aging mice and extra-follicular modulators follistatin, dkk1, and sfrp4. J Invest Dermatol. 2014 Aug; 134(8):2086-96. View in: PubMed

Ultrastructural characteristics of 5BrdU labeling retention cells including stem cells of regenerating feathers in chicken. J Morphol. 2014 Jul; 275(7):768-74. View in: PubMed

Modulating hair follicle size with Wnt10b/DKK1 during hair regeneration. Exp Dermatol. 2014 Jun; 23(6):407-13. View in: PubMed

Dkk2/Frzb in the dermal papillae regulates feather regeneration. Dev Biol. 2014 Mar 15; 387(2):167-78. View in: PubMed

Regeneration of reptilian scales after wounding: neogenesis, regional difference, and molecular modules. Regeneration (Oxf). 2014 Feb 1; 1(1):15-26. View in: PubMed

Genomic Organization, Transcriptomic Analysis, and Functional Characterization of Avian a- and ß-Keratins in Diverse Feather Forms. Genome Biol Evol. 2014; 6(9):2258-73. View in: PubMed

Macroenvironmental regulation of hair cycling and collective regenerative behavior. Cold Spring Harb Perspect Med. 2014; 4(1). View in: PubMed

Disrupted ectodermal organ morphogenesis in mice with a conditional histone deacetylase 1, 2 deletion in the epidermis. J Invest Dermatol. 2014 Jan; 134(1):24-32. View in: PubMed

Environmental reprogramming and molecular profiling in reconstitution of human hair follicles. Proc Natl Acad Sci U S A. 2013 Dec 3; 110(49):19658-9. View in: PubMed

Nuclear topology, epigenetics, and keratinocyte differentiation. J Invest Dermatol. 2013 Sep; 133(9):2130-3. View in: PubMed

Local circadian clock gates cell cycle progression of transient amplifying cells during regenerative hair cycling. Proc Natl Acad Sci U S A. 2013 Jun 4; 110(23):E2106-15. View in: PubMed

Many paths to alopecia via compromised regeneration of hair follicle stem cells. J Invest Dermatol. 2013 Jun; 133(6):1450-2. View in: PubMed

Specialized stem cell niche enables repetitive renewal of alligator teeth. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):E2009-18. View in: PubMed

Shaping organs by a wingless-int/Notch/nonmuscle myosin module which orients feather bud elongation. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):E1452-61. View in: PubMed

Sox2 marks epithelial competence to generate teeth in mammals and reptiles. Development. 2013 Apr; 140(7):1424-32. View in: PubMed

Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering. Expert Opin Biol Ther. 2013 Mar; 13(3):377-91. View in: PubMed

Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation. Proc Natl Acad Sci U S A. 2013 Jan 22; 110(4):1351-6. View in: PubMed

Tuning Wnt signals for more or fewer hairs. J Invest Dermatol. 2013 Jan; 133(1):7-9. View in: PubMed

Feather regeneration as a model for organogenesis. Dev Growth Differ. 2013 Jan; 55(1):139-48. View in: PubMed

Module-based complexity formation: periodic patterning in feathers and hairs. Wiley Interdiscip Rev Dev Biol. 2013 Jan-Feb; 2(1):97-112. View in: PubMed

Sprouty/FGF signaling regulates the proximal-distal feather morphology and the size of dermal papillae. Dev Biol. 2012 Dec 1; 372(1):45-54. View in: PubMed

Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1. J Invest Dermatol. 2012 Dec; 132(12):2681-90. View in: PubMed

Homology and Potential Cellular and Molecular Mechanisms for the Development of Unique Feather Morphologies in Early Birds. Geosciences (Basel). 2012 Sep 14; 2(3):157-177. View in: PubMed

The Chicken Frizzle Feather Is Due to an a-Keratin (KRT75) Mutation That Causes a Defective Rachis. PLoS Genet. 2012 Jul; 8(7):e1002748. View in: PubMed

Multi-layered environmental regulation on the homeostasis of stem cells: The saga of hair growth and alopecia. J Dermatol Sci. 2012 Apr; 66(1):3-11. View in: PubMed

Physiological regeneration of skin appendages and implications for regenerative medicine. Physiology (Bethesda). 2012 Apr; 27(2):61-72. View in: PubMed

Patterning skin by planar cell polarity: the multi-talented hair designer. Exp Dermatol. 2012 Feb; 21(2):81-5. View in: PubMed

Modelling hair follicle growth dynamics as an excitable medium. PLoS Comput Biol. 2012; 8(12):e1002804. View in: PubMed

Roles of EphB3/ephrin-B1 in feather morphogenesis. Int J Dev Biol. 2012; 56(9):719-28. View in: PubMed

Toward the isolation and culture of melanocyte stem cells. J Invest Dermatol. 2011 Dec; 131(12):2341-3. View in: PubMed

PI3K, Erk signaling in BMP7-induced epithelial-mesenchymal transition (EMT) of PC-3 prostate cancer cells in 2- and 3-dimensional cultures. Horm Cancer. 2011 Oct; 2(5):298-309. View in: PubMed

From buds to follicles: matrix metalloproteinases in developmental tissue remodeling during feather morphogenesis. Differentiation. 2011 Jun; 81(5):307-14. View in: PubMed

Self-organizing and stochastic behaviors during the regeneration of hair stem cells. Science. 2011 Apr 29; 332(6029):586-9. View in: PubMed

A simplified procedure to reconstitute hair-producing skin. Tissue Eng Part C Methods. 2011 Apr; 17(4):391-400. View in: PubMed

In search of the Golden Fleece: unraveling principles of morphogenesis by studying the integrative biology of skin appendages. Integr Biol (Camb). 2011 Apr; 3(4):388-407. View in: PubMed

The cycling hair follicle as an ideal systems biology research model. Exp Dermatol. 2010 Aug; 19(8):707-13. View in: PubMed

Spots and stripes: pleomorphic patterning of stem cells via p-ERK-dependent cell chemotaxis shown by feather morphogenesis and mathematical simulation. Dev Biol. 2009 Oct 15; 334(2):369-82. View in: PubMed

Accelerated closure of skin wounds in mice deficient in the homeobox gene Msx2. Wound Repair Regen. 2009 Sep-Oct; 17(5):639-48. View in: PubMed

Building complex tissues: high-throughput screening for molecules required in hair engineering. J Invest Dermatol. 2009 Apr; 129(4):815-7. View in: PubMed

The river of stem cells. Cell Stem Cell. 2009 Feb 6; 4(2):100-2. View in: PubMed

Preface to pattern formation special issue. Int J Dev Biol. 2009; 53(5-6):651. View in: PubMed

Reptile scale paradigm: Evo-Devo, pattern formation and regeneration. Int J Dev Biol. 2009; 53(5-6):813-26. View in: PubMed

Pattern formation today. Int J Dev Biol. 2009; 53(5-6):653-8. View in: PubMed

Analyses of regenerative wave patterns in adult hair follicle populations reveal macro-environmental regulation of stem cell activity. Int J Dev Biol. 2009; 53(5-6):857-68. View in: PubMed

Regenerative patterning in Swarm Robots: mutual benefits of research in robotics and stem cell biology. Int J Dev Biol. 2009; 53(5-6):869-81. View in: PubMed

Conversion of the nipple to hair-bearing epithelia by lowering bone morphogenetic protein pathway activity at the dermal-epidermal interface. Am J Pathol. 2008 Nov; 173(5):1339-48. View in: PubMed

Complex hair cycle domain patterns and regenerative hair waves in living rodents. J Invest Dermatol. 2008 May; 128(5):1071-80. View in: PubMed

Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature. 2008 Jan 17; 451(7176):340-4. View in: PubMed

Defining hair follicles in the age of stem cell bioengineering. J Invest Dermatol. 2007 Sep; 127(9):2098-100. View in: PubMed

An integrated gene regulatory network controls stem cell proliferation in teeth. PLoS Biol. 2007 Jun; 5(6):e159. View in: PubMed

Regenerative biology: new hair from healing wounds. Nature. 2007 May 17; 447(7142):265-6. View in: PubMed

The Edar subfamily in feather placode formation. Dev Biol. 2007 May 1; 305(1):232-45. View in: PubMed

Mammary glands and feathers: comparing two skin appendages which help define novel classes during vertebrate evolution. Semin Cell Dev Biol. 2007 Apr; 18(2):255-66. View in: PubMed

Molecular signaling in feather morphogenesis. Curr Opin Cell Biol. 2006 Dec; 18(6):730-41. View in: PubMed

Developmental biology. The Turing model comes of molecular age. Science. 2006 Dec 1; 314(5804):1397-8. View in: PubMed

Distinct mechanisms underlie pattern formation in the skin and skin appendages. Birth Defects Res C Embryo Today. 2006 Sep; 78(3):280-91. View in: PubMed

Morphoregulation of avian beaks: comparative mapping of growth zone activities and morphological evolution. Dev Dyn. 2006 May; 235(5):1400-12. View in: PubMed

Wnt3a gradient converts radial to bilateral feather symmetry via topological arrangement of epithelia. Proc Natl Acad Sci U S A. 2006 Jan 24; 103(4):951-5. View in: PubMed

PubFocus: semantic MEDLINE/PubMed citations analytics through integration of controlled biomedical dictionaries and ranking algorithm. BMC Bioinformatics. 2006; 7:424. View in: PubMed

Engineering stem cells into organs: topobiological transformations demonstrated by beak, feather, and other ectodermal organ morphogenesis. Curr Top Dev Biol. 2006; 72:237-74. View in: PubMed

Mapping stem cell activities in the feather follicle. Nature. 2005 Dec 15; 438(7070):1026-9. View in: PubMed

Morphoregulation of teeth: modulating the number, size, shape and differentiation by tuning Bmp activity. Evol Dev. 2005 Sep-Oct; 7(5):440-57. View in: PubMed

Rooster feathering, androgenic alopecia, and hormone-dependent tumor growth: what is in common? Differentiation. Rooster feathering, androgenic alopecia, and hormone-dependent tumor growth: what is in common? Differentiation. 2004 Dec; 72(9-10):474-88. View in: PubMed

Molecular shaping of the beak. Science. 2004 Sep 3; 305(5689):1465-6. View in: PubMed

Sculpting skin appendages out of epidermal layers via temporally and spatially regulated apoptotic events. J Invest Dermatol. 2004 Jun; 122(6):1348-55. View in: PubMed

Making waves with hairs. J Invest Dermatol. 2004 Apr; 122(4):vii-ix. View in: PubMed

Morpho-regulation of ectodermal organs: integument pathology and phenotypic variations in K14-Noggin engineered mice through modulation of bone morphogenic protein pathway. Am J Pathol. 2004 Mar; 164(3):1099-114. View in: PubMed

Distinct Wnt members regulate the hierarchical morphogenesis of skin regions (spinal tract) and individual feathers. Mech Dev. 2004 Feb; 121(2):157-71. View in: PubMed

Morphogenesis of chicken liver: identification of localized growth zones and the role of beta-catenin/Wnt in size regulation. Dev Biol. 2004 Feb 1; 266(1):109-22. View in: PubMed

Integument pattern formation involves genetic and epigenetic controls: feather arrays simulated by digital hormone models. Int J Dev Biol. 2004; 48(2-3):117-35. View in: PubMed

New Early Cretaceous fossil from China documents a novel trophic specialization for Mesozoic birds. Naturwissenschaften. 2004 Jan; 91(1):22-5. View in: PubMed

The biology of feather follicles. Int J Dev Biol. 2004; 48(2-3):181-91. View in: PubMed

Evo-Devo of amniote integuments and appendages. Int J Dev Biol. 2004; 48(2-3):249-70. View in: PubMed

A mouthful of epithelial-mesenchymal interactions. J Invest Dermatol. 2003 Dec; 121(6):vii-viii. View in: PubMed

Development and evolution of the amniote integument: current landscape and future horizon. J Exp Zool B Mol Dev Evol. 2003 Aug 15; 298(1):1-11. View in: PubMed

Molecular biology of feather morphogenesis: a testable model for evo-devo research. J Exp Zool B Mol Dev Evol. 2003 Aug 15; 298(1):109-22. View in: PubMed

Adaptation to the sky: Defining the feather with integument fossils from mesozoic China and experimental evidence from molecular laboratories. J Exp Zool B Mol Dev Evol. 2003 Aug 15; 298(1):42-56. View in: PubMed

Homeobox genes, fetal wound healing, and skin regional specificity. J Invest Dermatol. 2003 Jan; 120(1):9-11. View in: PubMed

'Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation. Development. 2003 Jan; 130(2):379-89. View in: PubMed

Shift of localized growth zones contributes to skin appendage morphogenesis: role of the Wnt/beta-catenin pathway. J Invest Dermatol. 2003 Jan; 120(1):20-6. View in: PubMed

The morphogenesis of feathers. Nature. 2002 Nov 21; 420(6913):308-12. View in: PubMed

Synergistic coactivator function by coactivator-associated arginine methyltransferase (CARM) 1 and beta-catenin with two different classes of DNA-binding transcriptional activators. J Biol Chem. 2002 Jul 19; 277(29):26031-5. View in: PubMed

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