Faculty

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Chengyu Liang, MD, PhD
Associate Professor of Molecular Microbiology & Immunology
Molecular Microbiology and Immunology
NRT 5507 1450 Biggy Street Health Sciences Campus Los Angeles
+1 323 442 7840

Overview

Research in my lab is centered on understanding the basic principle of cellular processes including apoptosis and autophagy, cell cycle regulation and genomic stability, as well as intracellular trafficking matrix in the development of cancer and infectious disease. Being a lysosome-dependent quality control mechanism and house-cleaning activity of the cessll, autophagy (Greek for self-eating) has been increasing recognized being essential for cells to maintain homeostasis and also protect the organism against diverse pathogens and cancerous cells.

Publications

Yang Y, Quach C, Liang C. Autophagy modulator plays a part in UV protection. Autophagy. 2016 Sep; 12(9):1677-8. View in: PubMed

Yang Y, He S, Wang Q, Li F, Kwak MJ, Chen S, O'Connell D, Zhang T, Pirooz SD, Jeon Y, Chimge NO, Frenkel B, Choi Y, Aldrovandi GM, Oh BH, Yuan Z, Liang C. Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase. Mol Cell. 2016 May 19; 62(4):507-19. View in: PubMed

O'Connell D, Liang C. Autophagy interaction with herpes simplex virus type-1 infection. Autophagy. 2016 Mar 3; 12(3):451-9. View in: PubMed

Chimge NO, Little GH, Baniwal SK, Adisetiyo H, Xie Y, Zhang T, O'Laughlin A, Liu ZY, Ulrich P, Martin A, Mhawech-Fauceglia P, Ellis MJ, Tripathy D, Groshen S, Liang C, Li Z, Schones DE, Frenkel B. RUNX1 prevents oestrogen-mediated AXIN1 suppression and ß-catenin activation in ER-positive breast cancer. Nat Commun. 2016; 7:10751. View in: PubMed

Minassian A, Zhang J, He S, Zhao J, Zandi E, Saito T, Liang C, Feng P. An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction. PLoS Pathog. 2015 Jul; 11(7):e1005060. View in: PubMed

Liang Q, Chang B, Lee P, Brulois KF, Ge J, Shi M, Rodgers MA, Feng P, Oh BH, Liang C, Jung JU. Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication. J Virol. 2015 May 15; 89(10):5308-17. View in: PubMed

He S, Zhao J, Song S, He X, Minassian A, Zhou Y, Zhang J, Brulois K, Wang Y, Cabo J, Zandi E, Liang C, Jung JU, Zhang X, Feng P. Viral Pseudo-Enzymes Activate RIG-I via Deamidation to Evade Cytokine Production. Mol Cell. 2015 Apr 2; 58(1):134-46. View in: PubMed

Yang Y, Liang C. MicroRNAs: an emerging player in autophagy. ScienceOpen Res. 2015; 2015. View in: PubMed

Liang C, Oh BH, Jung JU. Novel functions of viral anti-apoptotic factors. Nat Rev Microbiol. 2015 Jan; 13(1):7-12. View in: PubMed

Pirooz S, He S, O'Connell D, Khalilzadeh P, Yang Y, Liang C. Viruses customize autophagy protein for efficient viral entry. Autophagy. 2014 Jul; 10(7):1355-6. View in: PubMed

Pirooz SD, He S, Zhang T, Zhang X, Zhao Z, Oh S, O'Connell D, Khalilzadeh P, Amini-Bavil-Olyaee S, Farzan M, Liang C. UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2716-21. View in: PubMed

He S, O'Connell D, Zhang X, Yang Y, Liang C. The intersection of Golgi-ER retrograde and autophagic trafficking. Autophagy. 2014 Jan; 10(1):180-1. View in: PubMed

He S, Ni D, Ma B, Lee JH, Zhang T, Ghozalli I, Pirooz SD, Zhao Z, Bharatham N, Li B, Oh S, Lee WH, Takahashi Y, Wang HG, Minassian A, Feng P, Deretic V, Pepperkok R, Tagaya M, Yoon HS, Liang C. PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex. Nat Cell Biol. 2013 Oct; 15(10):1206-19. View in: PubMed

Kim HJ, Zhong Q, Sheng ZH, Yoshimori T, Liang C, Jung JU. Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking. J Cell Sci. 2012 Oct 15; 125(Pt 20):4740-50. View in: PubMed

Zhao Z, Ni D, Ghozalli I, Pirooz SD, Ma B, Liang C. UVRAG: At the crossroad of autophagy and genomic stability. Autophagy. 2012 Sep 1; 8(9):1392-3. View in: PubMed

Zhao Z, Oh S, Li D, Ni D, Pirooz SD, Lee JH, Yang S, Lee JY, Ghozalli I, Costanzo V, Stark JM, Liang C. A Dual Role for UVRAG in Maintaining Chromosomal Stability Independent of Autophagy. Dev Cell. 2012 May 15; 22(5):1001-16. View in: PubMed

Yang CS, Lee JS, Rodgers M, Min CK, Lee JY, Kim HJ, Lee KH, Kim CJ, Oh B, Zandi E, Yue Z, Kramnik I, Liang C, Jung JU. Autophagy Protein Rubicon Mediates Phagocytic NADPH Oxidase Activation in Response to Microbial Infection or TLR Stimulation. Cell Host Microbe. 2012 Mar 15; 11(3):264-76. View in: PubMed

Liang C. Viral FLIPping Autophagy for Longevity. Cell Host Microbe. 2012 Feb 16; 11(2):101-3. View in: PubMed

Oh S, Pirooz SD, Ni D, Zhao Z, Liang C. Anti-autophagic Bcl-2: Not just an innocent bystander. Autophagy. 2011 Feb; 7(2):231-2. View in: PubMed

Pirooz SD, Lee JH, Zhao Z, Ni D, Oh S, Liang C. Measurement of γHV68 Infection in Mice. J Vis Exp. 2011; (57). View in: PubMed

Liang C, Jung JU. Autophagy genes as tumor suppressors. Curr Opin Cell Biol. 2010 Apr; 22(2):226-33. View in: PubMed

Oh S, E X, Hwang S, Liang C. Autophagy evasion in herpesviral latency. Autophagy. 2010 Jan; 6(1):151-2. View in: PubMed

Lee JS, Li Q, Lee JY, Lee SH, Jeong JH, Lee HR, Chang H, Zhou FC, Gao SJ, Liang C, Jung JU. FLIP-mediated autophagy regulation in cell death control. Nat Cell Biol. 2009 Nov; 11(11):1355-62. View in: PubMed

Lee HR, Kim MH, Lee JS, Liang C, Jung JU. Viral interferon regulatory factors. J Interferon Cytokine Res. 2009 Sep; 29(9):621-7. View in: PubMed

Liang C, Lee JS, Jung JU. Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis. Semin Cancer Biol. 2008 Dec; 18(6):423-36. View in: PubMed

Gack MU, Kirchhofer A, Shin YC, Inn KS, Liang C, Cui S, Myong S, Ha T, Hopfner KP, Jung JU. Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16743-8. View in: PubMed

Sir D, Liang C, Chen WL, Jung JU, Ou JH. Perturbation of autophagic pathway by hepatitis C virus. Autophagy. 2008 Aug; 4(6):830-1. View in: PubMed

Liang C, Sir D, Lee S, Ou JH, Jung JU. Beyond autophagy: the role of UVRAG in membrane trafficking. Autophagy. 2008 Aug; 4(6):817-20. View in: PubMed

Liang C, Lee JS, Inn KS, Gack MU, Li Q, Roberts EA, Vergne I, Deretic V, Feng P, Akazawa C, Jung JU. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol. 2008 Jul; 10(7):776-87. View in: PubMed

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