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Chih-Lin Hsieh, PhD
Professor of Urology
Catherine and Joseph Aresty Chair in Urologic Research
NOR 5420 Health Sciences Campus Los Angeles
+1 323 865 0567


Lu Z, Lieber MR, Tsai AG, Pardo CE, Müschen M, Kladde MP, Hsieh CL. Human lymphoid translocation fragile zones are hypomethylated and have accessible chromatin. Mol Cell Biol. 2015 Apr 1; 35(7):1209-22. View in: PubMed

Zhang ZZ, Pannunzio NR, Han L, Hsieh CL, Yu K, Lieber MR. The Strength of an Ig Switch Region Is Determined by Its Ability to Drive R Loop Formation and Its Number of WGCW Sites. Cell Rep. 2014 Jul 24; 8(2):557-69. View in: PubMed

Hong EE, Okitsu CY, Smith AD, Hsieh CL. Regionally specific and genome-wide analyses conclusively demonstrate the absence of CpG methylation in human mitochondrial DNA. Mol Cell Biol. 2013 Jul; 33(14):2683-90. View in: PubMed

Hsieh JC, Van Den Berg D, Kang H, Hsieh CL, Lieber MR. Large chromosome deletions, duplications, and gene conversion events accumulate with age in normal human colon crypts. Aging Cell. 2013 Apr; 12(2):269-79. View in: PubMed

Cui X, Lu Z, Kurosawa A, Klemm L, Bagshaw AT, Tsai AG, Gemmell N, Müschen M, Adachi N, Hsieh CL, Lieber MR. Both CpG methylation and activation-induced deaminase are required for the fragility of the human bcl-2 major breakpoint region: implications for the timing of the breaks in the t(14;18) translocation. Mol Cell Biol. 2013 Mar; 33(5):947-57. View in: PubMed

Tsai AG, Chen DM, Lin M, Hsieh JC, Okitsu CY, Taghva A, Shibata D, Hsieh CL. Heterogeneity and randomness of DNA methylation patterns in human embryonic stem cells. DNA Cell Biol. 2012 Jun; 31(6):893-907. View in: PubMed

Ayazi S, DeMeester SR, Hsieh CC, Zehetner J, Sharma G, Grant KS, Oh DS, Lipham JC, Hagen JA, DeMeester TR. Thoraco-abdominal pressure gradients during the phases of respiration contribute to gastroesophageal reflux disease. Dig Dis Sci. 2011 Jun; 56(6):1718-22. View in: PubMed

Zhu D, Deng X, Spee C, Sonoda S, Hsieh CL, Barron E, Pera M, Hinton DR. Polarized secretion of PEDF from human embryonic stem cell-derived RPE promotes retinal progenitor cell survival. Invest Ophthalmol Vis Sci. 2011 Mar; 52(3):1573-85. View in: PubMed

Irvine RA, Okitsu C, Hsieh CL. Q-PCR in combination with ChIP assays to detect changes in chromatin acetylation. Methods Mol Biol. 2011; 791:213-23. View in: PubMed

Okitsu CY, Hsieh JC, Hsieh CL. Transcriptional activity affects the H3K4me3 level and distribution in the coding region. Mol Cell Biol. 2010 Jun; 30(12):2933-46. View in: PubMed

Roy D, Zhang Z, Lu Z, Hsieh CL, Lieber MR. Competition between the RNA transcript and the nontemplate DNA strand during R-loop formation in vitro: a nick can serve as a strong R-loop initiation site. Mol Cell Biol. 2010 Jan; 30(1):146-59. View in: PubMed

Chiu PW, Ayazi S, Hagen JA, Lipham JC, Zehetner J, Abate E, Oezcelik A, Hsieh CC, DeMeester SR, Banki F, Chandrasoma P, DeMeester TR. Esophageal pH exposure and epithelial cell differentiation. Dis Esophagus. 2009; 22(7):596-9. View in: PubMed

Li P, Tong C, Mehrian-Shai R, Jia L, Wu N, Yan Y, Maxson RE, Schulze EN, Song H, Hsieh CL, Pera MF, Ying QL. Germline competent embryonic stem cells derived from rat blastocysts. Cell. 2008 Dec 26; 135(7):1299-310. View in: PubMed

Tsai AG, Lu H, Raghavan SC, Muschen M, Hsieh CL, Lieber MR. Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity. Cell. 2008 Dec 12; 135(6):1130-42. View in: PubMed

Wang LC, Okitsu CY, Kochounian H, Rodriguez A, Hsieh CL, Zandi E. A simple and inexpensive on-column frit fabrication method for fused-silica capillaries for increased capacity and versatility in LC-MS/MS applications. Proteomics. 2008 May; 8(9):1758-61. View in: PubMed

Huang FT, Yu K, Balter BB, Selsing E, Oruc Z, Khamlichi AA, Hsieh CL, Lieber MR. Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch region. Mol Cell Biol. 2007 Aug; 27(16):5921-32. View in: PubMed

Higashimoto T, Panopoulos A, Hsieh CL, Zandi E. TNFalpha induces chromosomal abnormalities independent of ROS through IKK, JNK, p38 and caspase pathways. Cytokine. 2006 Apr; 34(1-2):39-50. View in: PubMed

Huang FT, Yu K, Hsieh CL, Lieber MR. Downstream boundary of chromosomal R-loops at murine switch regions: implications for the mechanism of class switch recombination. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):5030-5. View in: PubMed

Raghavan SC, Tsai A, Hsieh CL, Lieber MR. Analysis of non-B DNA structure at chromosomal sites in the mammalian genome. Methods Enzymol. 2006; 409:301-16. View in: PubMed

Raghavan SC, Hsieh CL, Lieber MR. Both V(D)J coding ends but neither signal end can recombine at the bcl-2 major breakpoint region, and the rejoining is ligase IV dependent. Mol Cell Biol. 2005 Aug; 25(15):6475-84. View in: PubMed

Raghavan SC, Chastain P, Lee JS, Hegde BG, Houston S, Langen R, Hsieh CL, Haworth IS, Lieber MR. Evidence for a triplex DNA conformation at the bcl-2 major breakpoint region of the t(14;18) translocation. J Biol Chem. 2005 Jun 17; 280(24):22749-60. View in: PubMed

Portale G, Peters JH, Hagen JA, Demeester SR, Gandamihardja TA, Tharavej C, Hsieh CC, Demeester TR. Comparison of the clinical and histological characteristics and survival of distal esophageal-gastroesophageal junction adenocarcinoma in patients with and without barrett mucosa. Arch Surg. 2005 Jun; 140(6):570-4; discussion 574-5. View in: PubMed

Hsieh CL. The de novo methylation activity of Dnmt3a is distinctly different than that of Dnmt1. BMC Biochem. 2005; 6:6. View in: PubMed

Ma Y, Lu H, Tippin B, Goodman MF, Shimazaki N, Koiwai O, Hsieh CL, Schwarz K, Lieber MR. A biochemically defined system for mammalian nonhomologous DNA end joining. Mol Cell. 2004 Dec 3; 16(5):701-13. View in: PubMed

Tamhankar AP, Peters JH, Portale G, Hsieh CC, Hagen JA, Bremner CG, DeMeester TR. Omeprazole does not reduce gastroesophageal reflux: new insights using multichannel intraluminal impedance technology. J Gastrointest Surg. 2004 Nov; 8(7):890-7; discussion 897-8. View in: PubMed

Veal N, Hsieh CL, Xiong S, Mato JM, Lu S, Tsukamoto H. Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine. Am J Physiol Gastrointest Liver Physiol. 2004 Aug; 287(2):G352-62. View in: PubMed

Irvine RA, Hsieh CL. Q-PCR in combination with ChIP assays to detect changes in chromatin acetylation. Methods Mol Biol. 2004; 287:45-52. View in: PubMed

Karanjawala ZE, Hinton DR, Oh E, Hsieh CL, Lieber MR. Developmental retinal apoptosis in Ku86-/- mice. DNA Repair (Amst). 2003 Dec 9; 2(12):1429-34. View in: PubMed

Yu K, Chedin F, Hsieh CL, Wilson TE, Lieber MR. R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells. Nat Immunol. 2003 May; 4(5):442-51. View in: PubMed

Chedin F, Lieber MR, Hsieh CL. The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16916-21. View in: PubMed

Irvine RA, Lin IG, Hsieh CL. DNA methylation has a local effect on transcription and histone acetylation. Mol Cell Biol. 2002 Oct; 22(19):6689-96. View in: PubMed

Karanjawala ZE, Murphy N, Hinton DR, Hsieh CL, Lieber MR. Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants. Curr Biol. 2002 Mar 5; 12(5):397-402. View in: PubMed

Lin IG, Han L, Taghva A, O'Brien LE, Hsieh CL. Murine de novo methyltransferase Dnmt3a demonstrates strand asymmetry and site preference in the methylation of DNA in vitro. Mol Cell Biol. 2002 Feb; 22(3):704-23. View in: PubMed

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