Faculty

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D. Brent Polk, MD
Chair and Professor of Pediatrics
Vice Dean For Clinical Affairs (CHLA)
Director, The Saban Research Institute
Vice President, Academic Affairs, CHLA
Pediatrics
CHL Mail Stop 71 Off Campus Los Angeles
+1 323 361 2278

Publications

Dubé PE, Yan F, Punit S, Girish N, McElroy SJ, Washington MK, Polk DB. Epidermal growth factor receptor inhibits colitis-associated cancer in mice. J Clin Invest. 2012 Aug 1; 122(8):2780-92. View in: PubMed

Zhang Y, Dubé PE, Washington MK, Yan F, Polk DB. ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival. Lab Invest. 2012 Mar; 92(3):437-50. View in: PubMed

Yan F, Wang L, Shi Y, Cao H, Liu L, Washington MK, Chaturvedi R, Israel DA, Cao H, Wang B, Peek RM, Wilson KT, Polk DB. Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. Am J Physiol Gastrointest Liver Physiol. 2012 Mar; 302(5):G504-14. View in: PubMed

Weitkamp JH, Koyama T, Rock MT, Correa H, Goettel JA, Matta P, Oswald-Richter K, Rosen MJ, Engelhardt BG, Moore DJ, Polk DB. Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios. Gut. 2012 Jan 20. View in: PubMed

Wang L, Liu L, Shi Y, Cao H, Chaturvedi R, Calcutt MW, Hu T, Ren X, Wilson KT, Polk DB, Yan F. Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor. PLoS One. 2012; 7(5):e36418. View in: PubMed

McElroy SJ, Hobbs S, Kallen M, Tejera N, Rosen MJ, Grishin A, Matta P, Schneider C, Upperman J, Ford H, Polk DB, Weitkamp JH. Transactivation of EGFR by LPS Induces COX-2 Expression in Enterocytes. PLoS One. 2012; 7(5):e38373. View in: PubMed

Yan F, Polk DB. Characterization of a probiotic-derived soluble protein which reveals a mechanism of preventive and treatment effects of probiotics on intestinal inflammatory diseases. Gut Microbes. 2012 Jan 1; 3(1):25-8. View in: PubMed

Chaturvedi R, Asim M, Romero-Gallo J, Barry DP, Hoge S, de Sablet T, Delgado AG, Wroblewski LE, Piazuelo MB, Yan F, Israel DA, Casero RA, Correa P, Gobert AP, Polk DB, Peek RM, Wilson KT. Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology. 2011 Nov; 141(5):1696-708. e1-2. View in: PubMed

Rosen MJ, Frey MR, Washington MK, Chaturvedi R, Kuhnhein LA, Matta P, Revetta FL, Wilson KT, Polk DB. STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction. Inflamm Bowel Dis. 2011 Nov; 17(11):2224-34. View in: PubMed

Yan F, Polk DB. Probiotics and immune health. Curr Opin Gastroenterol. 2011 Oct; 27(6):496-501. View in: PubMed

Ueno PM, Oriá RB, Maier EA, Guedes M, de Azevedo OG, Wu D, Willson T, Hogan SP, Lima AA, Guerrant RL, Polk DB, Denson LA, Moore SR. Alanyl-glutamine promotes intestinal epithelial cell homeostasis in vitro and in a murine model of weanling undernutrition. Am J Physiol Gastrointest Liver Physiol. 2011 Oct; 301(4):G612-22. View in: PubMed

McElroy SJ, Prince LS, Weitkamp JH, Reese J, Slaughter JC, Polk DB. Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2011 Oct; 301(4):G656-66. View in: PubMed

Yamaoka T, Frey MR, Dise RS, Bernard JK, Polk DB. Specific epidermal growth factor receptor autophosphorylation sites promote mouse colon epithelial cell chemotaxis and restitution. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G368-76. View in: PubMed

Hilliard VC, Frey MR, Dempsey PJ, Peek RM, Polk DB. TNF-a converting enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survival. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G338-46. View in: PubMed

Hobbs SS, Goettel JA, Liang D, Yan F, Edelblum KL, Frey MR, Mullane MT, Polk DB. TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G220-9. View in: PubMed

Yan F, Cao H, Cover TL, Washington MK, Shi Y, Liu L, Chaturvedi R, Peek RM, Wilson KT, Polk DB. Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J Clin Invest. 2011 Jun 1; 121(6):2242-53. View in: PubMed

Goettel JA, Liang D, Hilliard VC, Edelblum KL, Broadus MR, Gould KL, Hanks SK, Polk DB. KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1. Exp Cell Res. 2011 Feb 15; 317(4):452-63. View in: PubMed

Goettel JA, Scott Algood HM, Olivares-Villagómez D, Washington MK, Chaturvedi R, Wilson KT, Van Kaer L, Polk DB. KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-? production. Gastroenterology. 2011 Jan; 140(1):265-74. View in: PubMed

Frey MR, Carraro G, Batra RK, Polk DB, Warburton D. Sprouty keeps bowel kinases regular in colon cancer, while miR-21 targets Sprouty. Cancer Biol Ther. 2011 Jan 1; 11(1):122-4. View in: PubMed

Frey MR, Hilliard VC, Mullane MT, Polk DB. ErbB4 promotes cyclooxygenase-2 expression and cell survival in colon epithelial cells. Lab Invest. 2010 Oct; 90(10):1415-24. View in: PubMed

Yan F, Polk DB. Disruption of NF-kappaB signalling by ancient microbial molecules: novel therapies of the future? Gut. 2010 Apr; 59(4):421-6. View in: PubMed

Yan F, Polk DB. Probiotics: progress toward novel therapies for intestinal diseases. Curr Opin Gastroenterol. 2010 Mar; 26(2):95-101. View in: PubMed

Rosen MJ, Moulton DE, Koyama T, Morgan WM, Morrow SE, Herline AJ, Muldoon RL, Wise PE, Polk DB, Schwartz DA. Endoscopic ultrasound to guide the combined medical and surgical management of pediatric perianal Crohn's disease. Inflamm Bowel Dis. 2010 Mar; 16(3):461-8. View in: PubMed

Bäuerl C, Pérez-Martínez G, Yan F, Polk DB, Monedero V. Functional analysis of the p40 and p75 proteins from Lactobacillus casei BL23. J Mol Microbiol Biotechnol. 2010; 19(4):231-41. View in: PubMed

Weitkamp JH, Rudzinski E, Koyama T, Correa H, Matta P, Alberty B, Polk DB. Ontogeny of FOXP3(+) regulatory T cells in the postnatal human small intestinal and large intestinal lamina propria. Pediatr Dev Pathol. 2009 Nov-Dec; 12(6):443-9. View in: PubMed

Yan F, Cao H, Chaturvedi R, Krishna U, Hobbs SS, Dempsey PJ, Peek RM, Cover TL, Washington MK, Wilson KT, Polk DB. Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology. 2009 Apr; 136(4):1297-1307, e1-3. View in: PubMed

Nagy TA, Frey MR, Yan F, Israel DA, Polk DB, Peek RM. Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling. J Infect Dis. 2009 Mar 1; 199(5):641-51. View in: PubMed

Li B, Vincent A, Cates J, Brantley-Sieders DM, Polk DB, Young PP. Low levels of tumor necrosis factor alpha increase tumor growth by inducing an endothelial phenotype of monocytes recruited to the tumor site. Cancer Res. 2009 Jan 1; 69(1):338-48. View in: PubMed

Frey MR, Edelblum KL, Mullane MT, Liang D, Polk DB. The ErbB4 growth factor receptor is required for colon epithelial cell survival in the presence of TNF. Gastroenterology. 2009 Jan; 136(1):217-26. View in: PubMed

Vanderpool C, Yan F, Polk DB. Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases. Inflamm Bowel Dis. 2008 Nov; 14(11):1585-96. View in: PubMed

Edelblum KL, Goettel JA, Koyama T, McElroy SJ, Yan F, Polk DB. TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB. J Biol Chem. 2008 Oct 24; 283(43):29485-94. View in: PubMed

Yamaoka T, Yan F, Cao H, Hobbs SS, Dise RS, Tong W, Polk DB. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11772-7. View in: PubMed

Edelblum KL, Washington MK, Koyama T, Robine S, Baccarini M, Polk DB. Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB. Gastroenterology. 2008 Aug; 135(2):539-51. View in: PubMed

McElroy SJ, Frey MR, Yan F, Edelblum KL, Goettel JA, John S, Polk DB. Tumor necrosis factor inhibits ligand-stimulated EGF receptor activation through a TNF receptor 1-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2008 Aug; 295(2):G285-93. View in: PubMed

Seth A, Yan F, Polk DB, Rao RK. Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2008 Apr; 294(4):G1060-9. View in: PubMed

Dise RS, Frey MR, Whitehead RH, Polk DB. Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G276-85. View in: PubMed

Chen X, Abair TD, Ibanez MR, Su Y, Frey MR, Dise RS, Polk DB, Singh AB, Harris RC, Zent R, Pozzi A. Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol. 2007 May; 27(9):3313-26. View in: PubMed

Yan F, Cao H, Cover TL, Whitehead R, Washington MK, Polk DB. Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology. 2007 Feb; 132(2):562-75. View in: PubMed

Frey MR, Dise RS, Edelblum KL, Polk DB. p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration. EMBO J. 2006 Dec 13; 25(24):5683-92. View in: PubMed

Yan F, Polk DB. Probiotics as functional food in the treatment of diarrhea. Curr Opin Clin Nutr Metab Care. 2006 Nov; 9(6):717-21. View in: PubMed

Ho SB, Dvorak LA, Moor RE, Jacobson AC, Frey MR, Corredor J, Polk DB, Shekels LL. Cysteine-rich domains of muc3 intestinal mucin promote cell migration, inhibit apoptosis, and accelerate wound healing. Gastroenterology. 2006 Nov; 131(5):1501-17. View in: PubMed

Batts LE, Polk DB, Dubois RN, Kulessa H. Bmp signaling is required for intestinal growth and morphogenesis. Dev Dyn. 2006 Jun; 235(6):1563-70. View in: PubMed

O'Brien DP, Israel DA, Krishna U, Romero-Gallo J, Nedrud J, Medof ME, Lin F, Redline R, Lublin DM, Nowicki BJ, Franco AT, Ogden S, Williams AD, Polk DB, Peek RM. The role of decay-accelerating factor as a receptor for Helicobacter pylori and a mediator of gastric inflammation. J Biol Chem. 2006 May 12; 281(19):13317-23. View in: PubMed

Edelblum KL, Yan F, Yamaoka T, Polk DB. Regulation of apoptosis during homeostasis and disease in the intestinal epithelium. Inflamm Bowel Dis. 2006 May; 12(5):413-24. View in: PubMed

Abbott DW, Polk DB. NODing off and Ramping up. Inflamm Bowel Dis. 2005 Sep; 11(9):860-1. View in: PubMed

Yan F, John SK, Wilson G, Jones DS, Washington MK, Polk DB. Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation. J Clin Invest. 2004 Nov; 114(9):1272-80. View in: PubMed

Yan F, Polk DB. Commensal bacteria in the gut: learning who our friends are. Curr Opin Gastroenterol. 2004 Nov; 20(6):565-71. View in: PubMed

Frey MR, Golovin A, Polk DB. Epidermal growth factor-stimulated intestinal epithelial cell migration requires Src family kinase-dependent p38 MAPK signaling. J Biol Chem. 2004 Oct 22; 279(43):44513-21. View in: PubMed

Walker LS, Lipani TA, Greene JW, Caines K, Stutts J, Polk DB, Caplan A, Rasquin-Weber A. Recurrent abdominal pain: symptom subtypes based on the Rome II Criteria for pediatric functional gastrointestinal disorders. J Pediatr Gastroenterol Nutr. 2004 Feb; 38(2):187-91. View in: PubMed

Corredor J, Yan F, Shen CC, Tong W, John SK, Wilson G, Whitehead R, Polk DB. Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms. Am J Physiol Cell Physiol. 2003 Apr; 284(4):C953-61. View in: PubMed

Yan F, Polk DB. Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. J Biol Chem. 2002 Dec 27; 277(52):50959-65. View in: PubMed

Washington K, Greenson JK, Montgomery E, Shyr Y, Crissinger KD, Polk DB, Barnard J, Lauwers GY. Histopathology of ulcerative colitis in initial rectal biopsy in children. Am J Surg Pathol. 2002 Nov; 26(11):1441-9. View in: PubMed

Montgomery R, Ghishan FK, Moyer MS, Polk DB, Thompson JF. Research agenda for pediatric gastroenterology, hepatology and nutrition: developmental physiology and pathophysiology. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundation. J Pediatr Gastroenterol Nutr. 2002; 35 Suppl 3:S242-5. View in: PubMed

Yan F, John SK, Polk DB. Kinase suppressor of Ras determines survival of intestinal epithelial cells exposed to tumor necrosis factor. Cancer Res. 2001 Dec 15; 61(24):8668-75. View in: PubMed

Hernanz-Schulman M, Lowe LH, Johnson J, Neblett WW, Polk DB, Perez R, Scheker LE, Stein SM, Heller RM, Cywes R. In vivo visualization of pyloric mucosal hypertrophy in infants with hypertrophic pyloric stenosis: is there an etiologic role? AJR Am J Roentgenol. 2001 Oct; 177(4):843-8. View in: PubMed

Gupta RA, Polk DB, Krishna U, Israel DA, Yan F, DuBois RN, Peek RM. Activation of peroxisome proliferator-activated receptor gamma suppresses nuclear factor kappa B-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells. J Biol Chem. 2001 Aug 17; 276(33):31059-66. View in: PubMed

Yan F, Polk DB. Kinase suppressor of ras is necessary for tumor necrosis factor alpha activation of extracellular signal-regulated kinase/mitogen-activated protein kinase in intestinal epithelial cells. Cancer Res. 2001 Feb 1; 61(3):963-9. View in: PubMed

Yan F, Polk DB. Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells. J Biol Chem. 1999 Dec 17; 274(51):36631-6. View in: PubMed

Polk DB, Tong W. Epidermal and hepatocyte growth factors stimulate chemotaxis in an intestinal epithelial cell line. Am J Physiol. 1999 Dec; 277(6 Pt 1):C1149-59. View in: PubMed

Kaiser GC, Yan F, Polk DB. Conversion of TNF alpha from antiproliferative to proliferative ligand in mouse intestinal epithelial cells by regulating mitogen-activated protein kinase. Exp Cell Res. 1999 Jun 15; 249(2):349-58. View in: PubMed

Kaiser GC, Yan F, Polk DB. Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor kappaB activation in mouse colonocytes. Gastroenterology. 1999 Mar; 116(3):602-9. View in: PubMed

Hernanz-Schulman M, Neblett WW, Polk DB, Johnson JE. Hypertrophied pyloric mucosa in patients with hypertrophic pyloric stenosis. Pediatr Radiol. 1998 Nov; 28(11):901. View in: PubMed

Polk DB. Epidermal growth factor receptor-stimulated intestinal epithelial cell migration requires phospholipase C activity. Gastroenterology. 1998 Mar; 114(3):493-502. View in: PubMed

Kaiser GC, Polk DB. Tumor necrosis factor alpha regulates proliferation in a mouse intestinal cell line. Gastroenterology. 1997 Apr; 112(4):1231-40. View in: PubMed

Taufiq S, Hernanz-Schulman M, Wheeler AV, Morgan WM, Teague MD, Polk DB. Recurrent necrotizing jejunitis in a child. J Pediatr. 1996 Feb; 128(2):246-9. View in: PubMed

Polk DB. Shc is a substrate of the rat intestinal epidermal growth factor receptor tyrosine kinase. Gastroenterology. 1995 Dec; 109(6):1845-51. View in: PubMed

Molrine DC, Polk DB, Ciamarra A, Phillips N, Ambrosino DM. Impaired human responses to tetanus toxoid in vitamin A-deficient SCID mice reconstituted with human peripheral blood lymphocytes. Infect Immun. 1995 Aug; 63(8):2867-72. View in: PubMed

Hernanz-Schulman M, Dinauer P, Ambrosino MM, Polk DB, Neblett WW. The antral nipple sign of pyloric mucosal prolapse: endoscopic correlation of a new sonographic observation in patients with pyloric stenosis. J Ultrasound Med. 1995 Apr; 14(4):283-7. View in: PubMed

Polk DB, McCollum GW, Carpenter G. Cell density-dependent regulation of PLC gamma 1 tyrosine phosphorylation and catalytic activity in an intestinal cell line (IEC-6). J Cell Physiol. 1995 Mar; 162(3):427-33. View in: PubMed

Polk DB. Ontogenic regulation of phospholipase C-gamma 1 activity and expression in the rat small intestine. Gastroenterology. 1994 Jul; 107(1):109-16. View in: PubMed

Sacks AI, Acra SA, Dykes W, Polk DB, Barnard JA, Pietsch J, Ghishan FK. Intestinal Na+/H+ exchanger activity is up-regulated by bowel resection in the weanling rat. Pediatr Res. 1993 Mar; 33(3):215-20. View in: PubMed

Polk DB, Hattner JA, Kerner JA. Improved growth and disease activity after intermittent administration of a defined formula diet in children with Crohn's disease. JPEN J Parenter Enteral Nutr. 1992 Nov-Dec; 16(6):499-504. View in: PubMed

Polk DB, Steele RW. Bacterial meningitis presenting with normal cerebrospinal fluid. Pediatr Infect Dis J. 1987 Nov; 6(11):1040-2. View in: PubMed

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