Faculty

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Daniel Oscar Stram, PhD
Professor of Preventive Medicine
Preventive Medicine
SSB 202D 2001 N. Soto Street Health Sciences Campus Los Angeles
+1 323 442 1817

Overview

My research is on general biostatistical issues in epidemiology, and I am a long time collaborator on a number of important prospective (cohort) studies of cancer and other diseases. These include the Atomic Bomb Survivors Study, the Multiethnic Cohort Study, and the Children's Health Study. I participate in many other projects in the Preventive Medicine Department at USC. I have particular interest in measurement error issues in dosimetry for radiation epidemiology and in dietary assessment for nutritional epidemiology. I have recently begun working on association-based testing for the influence upon cancer risk of genomic variation in candidate genes using nested case-control studies within the MEC, with special emphasis on haplotype-based risk estimation and haplotype-tagging SNP selection. See the publications and software development list below, for further information.

Publications

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Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry. Cancer Epidemiol Biomarkers Prev. 2017 Apr 04. View in: PubMed

Genetic Determinants of 1,3-Butadiene Metabolism and Detoxification in Three Populations of Smokers with Different Risks of Lung Cancer. Cancer Epidemiol Biomarkers Prev. 2017 Mar 14. View in: PubMed

Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans. Int J Cancer. 2017 Mar 13. View in: PubMed

Coffee Drinking and Alcoholic and Nonalcoholic Fatty Liver Diseases and Viral Hepatitis in the Multiethnic Cohort. Clin Gastroenterol Hepatol. 2017 Mar 11. View in: PubMed

BRCA2 hypomorphic missense variants confer moderate risks of breast cancer. Cancer Res. 2017 Mar 10. View in: PubMed

THE GROWTH OF BIOSTATISTICS AND ESTIMATION OF CANCER RISK ESTIMATES: PAST, CURRENT, AND FUTURE CHALLENGES. Radiat Prot Dosimetry. 2017 Mar 02; 1-4. View in: PubMed

Correction of confidence intervals in excess relative risk models using Monte Carlo dosimetry systems with shared errors. PLoS One. 2017; 12(4):e0174641. View in: PubMed

Isotope dilution nanoLC/ESI+-HRMS3 quantitation of urinary N7-(1-hydroxy-3-buten-2-yl) guanine adducts in humans and their use as biomarkers of exposure to 1, 3-butadiene. Chem Res Toxicol. 2016 Dec 20. View in: PubMed

A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer. Int J Cancer. 2016 Dec 15; 139(12):2646-2654. View in: PubMed

Estimates of Radiation Effects on Cancer Risks in the Mayak Worker, Techa River and Atomic Bomb Survivor Studies. Radiat Prot Dosimetry. 2016 Nov 24. View in: PubMed

Risk Prediction for Epithelial Ovarian Cancer in 11 United States-Based Case-Control Studies: Incorporation of Epidemiologic Risk Factors and 17 Confirmed Genetic Loci. Am J Epidemiol. 2016 Oct 15; 184(8):579-589. View in: PubMed

Replication of associations between genetic polymorphisms and chronic graft-versus-host disease. Blood. 2016 Oct 6. View in: PubMed

Novel Association of Genetic Markers Affecting CYP2A6 Activity and Lung Cancer Risk. Cancer Res. 2016 Oct 1; 76(19):5768-5776. View in: PubMed

Breast Cancer Risk From Modifiable and Nonmodifiable Risk Factors Among White Women in the United States. JAMA Oncol. 2016 Oct 1; 2(10):1295-1302. View in: PubMed

Mortality from solid cancers other than lung, liver, and bone in relation to external dose among plutonium and non-plutonium workers in the Mayak Worker Cohort. Radiat Environ Biophys. 2016 Sep 30. View in: PubMed

A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci. Cancer Epidemiol Biomarkers Prev. 2016 Sep 1. View in: PubMed

Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types. Cancer Discov. 2016 Sep; 6(9):1052-67. View in: PubMed

Prostate Cancer Susceptibility in Men of African Ancestry at 8q24. J Natl Cancer Inst. 2016 Jul; 108(7). View in: PubMed

Prevalence of chronic liver disease and cirrhosis by underlying cause in understudied ethnic groups: The multiethnic cohort. Hepatology. 2016 Jun 15. View in: PubMed

No Association between the Mitochondrial Genome and Prostate Cancer Risk: The Multiethnic Cohort. Cancer Epidemiol Biomarkers Prev. 2016 Jun; 25(6):1001-3. View in: PubMed

Association Between Menopausal Estrogen-Only Therapy and Ovarian Carcinoma Risk. Obstet Gynecol. 2016 May; 127(5):828-36. View in: PubMed

Genetic determinants of CYP2A6 activity across racial/ethnic groups with different risks of lung cancer and effect on their smoking intensity. Carcinogenesis. 2016 Mar; 37(3):269-79. View in: PubMed

Whole-exome sequencing of over 4100 men of African ancestry and prostate cancer risk. Hum Mol Genet. 2016 Jan 15; 25(2):371-81. View in: PubMed

Benzene Uptake and Glutathione S-transferase T1 Status as Determinants of S-Phenylmercapturic Acid in Cigarette Smokers in the Multiethnic Cohort. PLoS One. 2016; 11(3):e0150641. View in: PubMed

The contribution of rare variation to prostate cancer heritability. Nat Genet. 2016 Jan; 48(1):30-5. View in: PubMed

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome. Nat Commun. 2016; 7:11843. View in: PubMed

Meta-Analysis of Rare Variant Association Tests in Multiethnic Populations. Genet Epidemiol. 2016 Jan; 40(1):57-65. View in: PubMed

Metabolites of the Polycyclic Aromatic Hydrocarbon Phenanthrene in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. PLoS One. 2016; 11(6):e0156203. View in: PubMed

Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs). Sci Rep. 2016; 6:32512. View in: PubMed

Corrigendum: Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet. 2015 Dec 29; 48(1):101. View in: PubMed

Associations Between Genetic Ancestries and Nicotine Metabolism Biomarkers in the Multiethnic Cohort Study. Am J Epidemiol. 2015 Dec 1; 182(11):945-51. View in: PubMed

Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium. Clin Cancer Res. 2015 Dec 1; 21(23):5264-76. View in: PubMed

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat Genet. 2015 Nov; 47(11):1282-93. View in: PubMed

Pleiotropic Analysis of Cancer Risk Loci on Esophageal Adenocarcinoma Risk. Cancer Epidemiol Biomarkers Prev. 2015 Nov; 24(11):1801-3. View in: PubMed

ABO blood group alleles and prostate cancer risk: Results from the breast and prostate cancer cohort consortium (BPC3). Prostate. 2015 Nov; 75(15):1677-81. View in: PubMed

Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions. Hum Mol Genet. 2015 Oct 1; 24(19):5603-18. View in: PubMed

Atopic allergic conditions and colorectal cancer risk in the multiethnic cohort study. Am J Epidemiol. 2015 Jun 1; 181(11):889-97. View in: PubMed

Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31. 2. Hum Mol Genet. 2015 May 15; 24(10):2966-84. View in: PubMed

Population distribution of lifetime risk of ovarian cancer in the United States. Cancer Epidemiol Biomarkers Prev. 2015 Apr; 24(4):671-6. View in: PubMed

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. Nat Genet. 2015 Apr; 47(4):373-80. View in: PubMed

Characterization of large structural genetic mosaicism in human autosomes. Am J Hum Genet. 2015 Mar 5; 96(3):487-97. View in: PubMed

Generalizability of established prostate cancer risk variants in men of African ancestry. Int J Cancer. 2015 Mar 1; 136(5):1210-7. View in: PubMed

Vitamin D-Associated Genetic Variation and Risk of Breast Cancer in the Breast and Prostate Cancer Cohort Consortium (BPC3). Cancer Epidemiol Biomarkers Prev. 2015 Mar; 24(3):627-30. View in: PubMed

Evaluating the ovarian cancer gonadotropin hypothesis: A candidate gene study. Gynecol Oncol. 2015 Mar; 136(3):542-8. View in: PubMed

Variation in Levels of the Lung Carcinogen NNAL and Its Glucuronides in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. Cancer Epidemiol Biomarkers Prev. 2015 Mar; 24(3):561-9. View in: PubMed

Dose reconstruction for the million worker study: status and guidelines. Health Phys. 2015 Feb; 108(2):206-20. View in: PubMed

Fine-Scale Mapping of the 5q11. 2 Breast Cancer Locus Reveals at Least Three Independent Risk Variants Regulating MAP3K1. Am J Hum Genet. 2015 Jan 8; 96(1):5-20. View in: PubMed

Methodological Considerations in Estimation of Phenotype Heritability Using Genome-Wide SNP Data, Illustrated by an Analysis of the Heritability of Height in a Large Sample of African Ancestry Adults. PLoS One. 2015; 10(6):e0131106. View in: PubMed

Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. PLoS One. 2015; 10(6):e0124841. View in: PubMed

Association of Genes, Pathways, and Haplogroups of the Mitochondrial Genome with the Risk of Colorectal Cancer: The Multiethnic Cohort. PLoS One. 2015; 10(9):e0136796. View in: PubMed

Shared dosimetry error in epidemiological dose-response analyses. PLoS One. 2015; 10(3):e0119418. View in: PubMed

Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk. Hum Mol Genet. 2015 Jan 1; 24(1):285-98. View in: PubMed

The contribution of common genetic variation to nicotine and cotinine glucuronidation in multiple ethnic/racial populations. Cancer Epidemiol Biomarkers Prev. 2015 Jan; 24(1):119-27. View in: PubMed

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15. 33. Hum Mol Genet. 2014 Dec 15; 23(24):6616-33. View in: PubMed

Leveraging population admixture to characterize the heritability of complex traits. Nat Genet. 2014 Dec; 46(12):1356-62. View in: PubMed

High Calorie Intake Is Associated With Worsening Insulin Resistance and ß-Cell Function in Hispanic Women After Gestational Diabetes Mellitus. Diabetes Care. 2014 Dec; 37(12):3294-300. View in: PubMed

Diabetes and racial/ethnic differences in hepatocellular carcinoma risk: the multiethnic cohort. J Natl Cancer Inst. 2014 Dec; 106(12). View in: PubMed

Additive interactions between susceptibility single-nucleotide polymorphisms identified in genome-wide association studies and breast cancer risk factors in the breast and prostate cancer cohort consortium. Am J Epidemiol. 2014 Nov 15; 180(10):1018-27. View in: PubMed

Common non-synonymous SNPs associated with breast cancer susceptibility: findings from the Breast Cancer Association Consortium. Hum Mol Genet. 2014 Nov 15; 23(22):6096-111. View in: PubMed

Nicotine N-glucuronidation relative to N-oxidation and C-oxidation and UGT2B10 genotype in five ethnic/racial groups. Carcinogenesis. 2014 Nov; 35(11):2526-33. View in: PubMed

A comprehensive examination of breast cancer risk loci in African American women. Hum Mol Genet. 2014 Oct 15; 23(20):5518-26. View in: PubMed

Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk. Mol Nutr Food Res. 2014 Oct; 58(10):2023-35. View in: PubMed

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. Nat Genet. 2014 Oct; 46(10):1103-9. View in: PubMed

Fine-Mapping IGF1 and Prostate Cancer Risk in African Americans: The Multiethnic Cohort Study. Cancer Epidemiol Biomarkers Prev. 2014 Sep; 23(9):1928-32. View in: PubMed

The role of local ancestry adjustment in association studies using admixed populations. Genet Epidemiol. 2014 Sep; 38(6):502-15. View in: PubMed

Multiple nonglycemic genomic Loci are newly associated with blood level of glycated hemoglobin in East asians. Diabetes. 2014 Jul; 63(7):2551-62. View in: PubMed

Analysis of cancer risks in populations near nuclear facilities: phase I. A report by the national academies nuclear and radiation studies board. Health Phys. 2014 Feb; 106(2):305-6. View in: PubMed

Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A. Nat Commun. 2014; 5:4613. View in: PubMed

Insulin-like Growth Factor Pathway Genetic Polymorphisms, Circulating IGF1 and IGFBP3, and Prostate Cancer Survival. J Natl Cancer Inst. 2014; 106(6). View in: PubMed

Joint effects of known type 2 diabetes susceptibility Loci in genome-wide association study of singapore chinese: the singapore chinese health study. PLoS One. 2014; 9(2):e87762. View in: PubMed

Pleiotropy of Cancer Susceptibility Variants on the Risk of Non-Hodgkin Lymphoma: The PAGE Consortium. PLoS One. 2014; 9(3):e89791. View in: PubMed

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation. Nat Commun. 2014; 4:4999. View in: PubMed

Fine-mapping of genome-wide association study-identified risk loci for colorectal cancer in African Americans. Hum Mol Genet. 2013 Dec 15; 22(24):5048-55. View in: PubMed

Fine-Scale Mapping of the FGFR2 Breast Cancer Risk Locus: Putative Functional Variants Differentially Bind FOXA1 and E2F1. Am J Hum Genet. 2013 Dec 5; 93(6):1046-60. View in: PubMed

Dietary patterns and breast cancer risk in the California Teachers Study cohort. Am J Clin Nutr. 2013 Dec; 98(6):1524-32. View in: PubMed

Genetic variation in the inflammation and innate immunity pathways and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2013 Nov; 22(11):2094-101. View in: PubMed

Role of aldehydes in the toxic and mutagenic effects of nitrosamines. Chem Res Toxicol. 2013 Oct 21; 26(10):1464-73. View in: PubMed

Late health effects of radiation exposure: new statistical, epidemiological, and biological approaches. Int J Radiat Biol. 2013 Aug; 89(8):673-83. View in: PubMed

Workshop report on atomic bomb dosimetry-residual radiation exposure: recent research and suggestions for future studies. Health Phys. 2013 Aug; 105(2):140-9. View in: PubMed

Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls. Hum Mol Genet. 2013 Jun 15; 22(12):2539-50. View in: PubMed

Combined and interactive effects of environmental and GWAS-identified risk factors in ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):880-90. View in: PubMed

Hormone metabolism genes and mammographic density in Singapore Chinese women. Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):984-6. View in: PubMed

Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet. 2013 Apr 4; 92(4):489-503. View in: PubMed

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet. 2013 Apr; 45(4):371-84, 384e1-2. View in: PubMed

Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet. 2013 Apr; 45(4):353-61, 361e1-2. View in: PubMed

Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet. 2013 Apr; 45(4):392-8, 398e1-2. View in: PubMed

Genetic variation in transforming growth factor beta 1 and mammographic density in Singapore Chinese women. Cancer Res. 2013 Mar 15; 73(6):1876-82. View in: PubMed

Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population. PLoS Genet. 2013 Mar; 9(3):e1003419. View in: PubMed

Levels of beta-microseminoprotein in blood and risk of prostate cancer in multiple populations. J Natl Cancer Inst. 2013 Feb 6; 105(3):237-43. View in: PubMed

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun. 2013; 4:1628. View in: PubMed

A genome-wide association study of breast cancer in women of African ancestry. Hum Genet. 2013 Jan; 132(1):39-48. View in: PubMed

A genome-wide scan for breast cancer risk haplotypes among African American women. PLoS One. 2013; 8(2):e57298. View in: PubMed

Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21. 31. Nat Commun. 2013; 4:1627. View in: PubMed

A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. Hum Mol Genet. 2012 Dec 15; 21(24):5373-84. View in: PubMed

Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium. Am J Epidemiol. 2012 Dec 15; 176(12):1121-9. View in: PubMed

Evaluating genetic risk for prostate cancer among Japanese and Latinos. Cancer Epidemiol Biomarkers Prev. 2012 Nov; 21(11):2048-58. View in: PubMed

Susceptibility variants for obesity and colorectal cancer risk: The multiethnic cohort and PAGE studies. Int J Cancer. 2012 Sep 15; 131(6):E1038-43. View in: PubMed

Prediction of breast cancer risk by genetic risk factors, overall and by hormone receptor status. J Med Genet. 2012 Sep; 49(9):601-8. View in: PubMed

Genetic variation in peroxisome proliferator-activated receptor gamma, soy, and mammographic density in singapore chinese women. Cancer Epidemiol Biomarkers Prev. 2012 Apr; 21(4):635-44. View in: PubMed

Common Genetic Variants in Prostate Cancer Risk Prediction--Results from the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). Cancer Epidemiol Biomarkers Prev. 2012 Mar; 21(3):437-44. View in: PubMed

Regression calibration when foods (measured with error) are the variables of interest: markedly non-gaussian data with many zeroes. Am J Epidemiol. 2012 Feb 15; 175(4):325-31. View in: PubMed

Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet. 2012; 44(6):651-8. View in: PubMed

Population genetic structure and origins of Native Hawaiians in the multiethnic cohort study. PLoS One. 2012; 7(11):e47881. View in: PubMed

Multi-SNP Haplotype Analysis Methods for Association Analysis. Methods Mol Biol. 2012; 850:423-52. View in: PubMed

Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies. Gut. 2011 Dec; 60(12):1703-11. View in: PubMed

A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nat Genet. 2011 Dec; 43(12):1210-4. View in: PubMed

Fine-mapping of breast cancer susceptibility loci characterizes genetic risk in African Americans. Hum Mol Genet. 2011 Nov 15; 20(22):4491-503. View in: PubMed

Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. PLoS Genet. 2011 Oct; 7(10):e1002298. View in: PubMed

Genome-wide association study identifies new prostate cancer susceptibility loci. Hum Mol Genet. 2011 Oct 1; 20(19):3867-75. View in: PubMed

No association of type 2 diabetes risk variants and prostate cancer risk: the multiethnic cohort and PAGE. Cancer Epidemiol Biomarkers Prev. 2011 Sep; 20(9):1979-81. View in: PubMed

Interactions between genetic variants and breast cancer risk factors in the breast and prostate cancer cohort consortium. J Natl Cancer Inst. 2011 Aug 17; 103(16):1252-63. View in: PubMed

Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. Nat Genet. 2011 Jun; 43(6):570-3. View in: PubMed

Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk. Hum Mol Genet. 2011 Jun 1; 20(11):2263-72. View in: PubMed

The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing. Clin Cancer Res. 2011 Jun 1; 17(11):3742-50. View in: PubMed

Prostate cancer susceptibility polymorphism rs2660753 is not associated with invasive ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2011 May; 20(5):1028-31. View in: PubMed

No association of risk variants for diabetes and obesity with breast cancer: the Multiethnic Cohort and PAGE studies. Cancer Epidemiol Biomarkers Prev. 2011 May; 20(5):1039-42. View in: PubMed

Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans. PLoS Genet. 2011 May; 7(5):e1001387. View in: PubMed

Age-specific effects of hormone therapy use on overall mortality and ischemic heart disease mortality among women in the California Teachers Study. Menopause. 2011 Mar; 18(3):253-61. View in: PubMed

Caution in generalizing known genetic risk markers for breast cancer across all ethnic/racial populations. Eur J Hum Genet. 2011 Feb; 19(2):243-5. View in: PubMed

Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3. PLoS One. 2011; 6(2):e17142. View in: PubMed

Improved imputation of common and uncommon SNPs with a new reference set. Nat Genet. 2011; 44(1):6-7. View in: PubMed

Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations. Cancer Epidemiol Biomarkers Prev. 2011 Jan; 20(1):70-81. View in: PubMed

Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. Cancer Epidemiol Biomarkers Prev. 2010 Nov; 19(11):2877-87. View in: PubMed

Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. Hum Mol Genet. 2010 Oct 1; 19(19):3873-84. View in: PubMed

A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations. Cancer Epidemiol Biomarkers Prev. 2010 Oct; 19(10):2639-46. View in: PubMed

Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet. 2010 Oct; 42(10):880-4. View in: PubMed

A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat Genet. 2010 Oct; 42(10):874-9. View in: PubMed

Outcome after reduced chemotherapy for intermediate-risk neuroblastoma. N Engl J Med. 2010 Sep 30; 363(14):1313-23. View in: PubMed

The potential for enhancing the power of genetic association studies in African Americans through the reuse of existing genotype data. PLoS Genet. 2010 Sep; 6(9). View in: PubMed

A large study of androgen receptor germline variants and their relation to sex hormone levels and prostate cancer risk. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. J Clin Endocrinol Metab. 2010 Sep; 95(9):E121-7. View in: PubMed

A comprehensive analysis of common IGF1, IGFBP1 and IGFBP3 genetic variation with prospective IGF-I and IGFBP-3 blood levels and prostate cancer risk among Caucasians. Hum Mol Genet. 2010 Aug 1; 19(15):3089-101. View in: PubMed

Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups. PLoS Genet. 2010 Aug; 6(8). View in: PubMed

Self-reported ethnicity, genetic structure and the impact of population stratification in a multiethnic study. Hum Genet. 2010 Aug; 128(2):165-77. View in: PubMed

Fine mapping of the association with obesity at the FTO locus in African-derived populations. Hum Mol Genet. 2010 Jul 15; 19(14):2907-16. View in: PubMed

Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". PLoS Genet. 2010 Jul; 6(7):e1001016. View in: PubMed

Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev. 2010 Jul; 19(7):1822-30. View in: PubMed

Review and evaluation of updated research on the health effects associated with low-dose ionising radiation. Radiat Prot Dosimetry. 2010 Jul; 140(2):103-36. View in: PubMed

Meat consumption, nonsteroidal anti-inflammatory drug use, and mortality among colorectal cancer patients in the California Teachers Study. Cancer Prev Res (Phila). 2010 Jul; 3(7):865-75. View in: PubMed

Exploring genetic susceptibility to cancer in diverse populations. Curr Opin Genet Dev. 2010 Jun; 20(3):330-5. View in: PubMed

Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer. Cancer Res. 2010 Mar 15; 70(6):2389-96. View in: PubMed

PTGS2 and IL6 genetic variation and risk of breast and prostate cancer: results from the Breast and Prostate Cancer Cohort Consortium (BPC3). Carcinogenesis. 2010 Mar; 31(3):455-61. View in: PubMed

Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev. 2010 Feb; 19(2):600-4. View in: PubMed

Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs. J Exp Clin Cancer Res. 2010; 29:57. View in: PubMed

Recent breast cancer incidence trends according to hormone therapy use: the California Teachers Study cohort. Breast Cancer Res. 2010; 12(1):R4. View in: PubMed

Nonsteroidal anti-inflammatory drugs: effects on mortality after colorectal cancer diagnosis. Cancer. 2009 Dec 15; 115(24):5662-71. View in: PubMed

Methodological Issues in Multistage Genome-wide Association Studies. Stat Sci. 2009 Nov 1; 24(4):414-429. View in: PubMed

Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3). Hum Mol Genet. 2009 Oct 1; 18(19):3749-57. View in: PubMed

CYP19A1 genetic variation in relation to prostate cancer risk and circulating sex hormone concentrations in men from the Breast and Prostate Cancer Cohort Consortium. Cancer Epidemiol Biomarkers Prev. 2009 Oct; 18(10):2734-44. View in: PubMed

A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22. 2. Nat Genet. 2009 Sep; 41(9):996-1000. View in: PubMed

Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study. Hum Mol Genet. 2009 Jun 15; 18(12):2297-304. View in: PubMed

IGF2R missense single-nucleotide polymorphisms and breast cancer risk: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev. 2009 Jun; 18(6):1922-4. View in: PubMed

Association of diabetes with prostate cancer risk in the multiethnic cohort. Am J Epidemiol. 2009 Apr 15; 169(8):937-45. View in: PubMed

Generalizability of associations from prostate cancer genome-wide association studies in multiple populations. Cancer Epidemiol Biomarkers Prev. 2009 Apr; 18(4):1285-9. View in: PubMed

Vitamin D receptor polymorphisms and breast cancer risk: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. Cancer Epidemiol Biomarkers Prev. 2009 Jan; 18(1):297-305. View in: PubMed

Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3). BMC Cancer. 2009; 9:257. View in: PubMed

A kinship-based modification of the armitage trend test to address hidden population structure and small differential genotyping errors. PLoS One. 2009; 4(6):e5825. View in: PubMed

Dietary assessment in the California Teachers Study: reproducibility and validity. Cancer Causes Control. 2008 Aug; 19(6):595-603. View in: PubMed

Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet. 2008 Apr; 4(4):e1000054. View in: PubMed

Comprehensive association testing of common genetic variation in DNA repair pathway genes in relationship with breast cancer risk in multiple populations. Hum Mol Genet. 2008 Mar 15; 17(6):825-34. View in: PubMed

Comprehensive evaluation of ESR2 variation and ovarian cancer risk. Cancer Epidemiol Biomarkers Prev. 2008 Feb; 17(2):393-6. View in: PubMed

Haplotypes of the estrogen receptor beta gene and breast cancer risk. Int J Cancer. 2008 Jan 15; 122(2):387-92. View in: PubMed

Relationship of serological subtype, basic core promoter and precore mutations to genotypes/subgenotypes of hepatitis B virus. J Med Virol. 2008 Jan; 80(1):27-46. View in: PubMed

IGF-1, IGFBP-1, and IGFBP-3 polymorphisms predict circulating IGF levels but not breast cancer risk: findings from the Breast and Prostate Cancer Cohort Consortium (BPC3). PLoS One. 2008; 3(7):e2578. View in: PubMed

Utilizing HapMap and tagging SNPs. Methods Mol Med. 2008; 141:37-54. View in: PubMed

Dietary patterns and risk of ovarian cancer in the California Teachers Study cohort. Nutr Cancer. 2008; 60(3):285-91. View in: PubMed

Calcium, vitamin D, and dairy product intake and prostate cancer risk: the Multiethnic Cohort Study. Am J Epidemiol. 2007 Dec 1; 166(11):1259-69. View in: PubMed

A Monte Carlo maximum likelihood method for estimating uncertainty arising from shared errors in exposures in epidemiological studies of nuclear workers. Radiat Res. 2007 Dec; 168(6):757-63. View in: PubMed

CYP17 genetic variation and risk of breast and prostate cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3). Cancer Epidemiol Biomarkers Prev. 2007 Nov; 16(11):2237-46. View in: PubMed

Risk factors for renal cell cancer: the multiethnic cohort. Am J Epidemiol. 2007 Oct 15; 166(8):932-40. View in: PubMed

Re: the use of inferred haplotypes in downstream analysis. Am J Hum Genet. 2007 Oct; 81(4):863-5; author reply 865-6. View in: PubMed

Hypothesis testing, statistical power, and confidence limits in the presence of epistemic uncertainty. Health Phys. 2007 Oct; 93(4):326-7; author reply 327-8. View in: PubMed

Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. Cancer Epidemiol Biomarkers Prev. 2007 Oct; 16(10):1973-81. View in: PubMed

Dietary fiber and colorectal cancer risk: the multiethnic cohort study. Cancer Causes Control. 2007 Sep; 18(7):753-64. View in: PubMed

A common genetic risk factor for colorectal and prostate cancer. Nat Genet. 2007 Aug; 39(8):954-6. View in: PubMed

Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet. 2007 May; 39(5):638-44. View in: PubMed

Diet and risk of ovarian cancer in the California Teachers Study cohort. Am J Epidemiol. 2007 Apr 1; 165(7):802-13. View in: PubMed

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An utter refutation of the "Fundamental Theorem of the HapMap" by Terwilliger and Hiekkalinna. Eur J Hum Genet. 2006 Dec; 14(12):1238-9. View in: PubMed

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Asparagine depletion after pegylated E. coli asparaginase treatment and induction outcome in children with acute lymphoblastic leukemia in first bone marrow relapse: a Children's Oncology Group study (CCG-1941). Pediatr Blood Cancer. 2006 Aug; 47(2):141-6. View in: PubMed

Bone marrow transplantation versus prolonged intensive chemotherapy for children with acute lymphoblastic leukemia and an initial bone marrow relapse within 12 months of the completion of primary therapy: Children's Oncology Group study CCG-1941. J Clin Oncol. 2006 Jul 1; 24(19):3150-6. View in: PubMed

Common genetic variation at PTEN and risk of sporadic breast and prostate cancer. Cancer Epidemiol Biomarkers Prev. 2006 May; 15(5):1021-5. View in: PubMed

Optimal two-stage genotyping designs for genome-wide association scans. Genet Epidemiol. 2006 May; 30(4):356-68. View in: PubMed

Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohort studies. Cancer Res. 2006 Feb 15; 66(4):2468-75. View in: PubMed

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A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3). Breast Cancer Res. 2006; 8(5):R54. View in: PubMed

Igf-I genetic variation and breast cancer: the multiethnic cohort. Cancer Epidemiol Biomarkers Prev. 2006 Jan; 15(1):172-4. View in: PubMed

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Comparison of prostate-specific antigen and hormone levels among men in Singapore and the United States. Cancer Epidemiol Biomarkers Prev. 2005 Jul; 14(7):1692-6. View in: PubMed

Nonsteroidal anti-inflammatory drug use and breast cancer risk by stage and hormone receptor status. J Natl Cancer Inst. 2005 Jun 1; 97(11):805-12. View in: PubMed

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BRCA1 variants in a family study of African-American and Latina women. Hum Genet. 2005 May; 116(6):497-506. View in: PubMed

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Tag SNP selection for association studies. Genet Epidemiol. 2004 Dec; 27(4):365-74. View in: PubMed

Common variation in BRCA2 and breast cancer risk: a haplotype-based analysis in the Multiethnic Cohort. Hum Mol Genet. 2004 Oct 15; 13(20):2431-41. View in: PubMed

Revision of the International Neuroblastoma Pathology Classification: confirmation of favorable and unfavorable prognostic subsets in ganglioneuroblastoma, nodular. Cancer. 2003 Nov 15; 98(10):2274-81. View in: PubMed

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Power and uncertainty analysis of epidemiological studies of radiation-related disease risk in which dose estimates are based on a complex dosimetry system: some observations. Radiat Res. 2003 Oct; 160(4):408-17. View in: PubMed

Dietary cryptoxanthin and reduced risk of lung cancer: the Singapore Chinese Health Study. Cancer Epidemiol Biomarkers Prev. 2003 Sep; 12(9):890-8. View in: PubMed

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Haplotype tagging single nucleotide polymorphisms and association studies. Hum Hered. 2003; 56(1-3):48-55. View in: PubMed

Bayesian spatial modeling of haplotype associations. Hum Hered. 2003; 56(1-3):32-40. View in: PubMed

Modeling and E-M estimation of haplotype-specific relative risks from genotype data for a case-control study of unrelated individuals. Hum Hered. 2003; 55(4):179-90. View in: PubMed

Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study. Hum Hered. 2003; 55(1):27-36. View in: PubMed

Breast cancer in a multiethnic cohort in Hawaii and Los Angeles: risk factor-adjusted incidence in Japanese equals and in Hawaiians exceeds that in whites. Cancer Epidemiol Biomarkers Prev. 2002 Sep; 11(9):795-800. View in: PubMed

Association between air pollution and lung function growth in southern California children: results from a second cohort. Am J Respir Crit Care Med. 2002 Jul 1; 166(1):76-84. View in: PubMed

Breast-feeding and neuroblastoma, USA and Canada. Cancer Causes Control. 2002 Jun; 13(5):401-5. View in: PubMed

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