Faculty

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Darryl Shibata, MD
Professor of Pathology
Pathology
NOR 1441 Eastlake Ave Health Sciences Campus Los Angeles
+1 323 865 3298

Overview

After attending UCLA for his undergraduate degree, Dr. Shibata obtained his medical degree from the Keck School of Medicine of USC. After completing his internship training in pediatrics from UC San Diego, Dr. Shibata returned to USC for his residency and fellowship at LAC+USC Medical Center. Currently, Dr. Shibata has clinical appointments at both LAC+USC Medical Center and USC/Norris Comprehensive Cancer Center. In addition to his wide array of responsibilities in the research, education and practitioner capacities, Dr. Shibata sits on the editorial board of the BMC Cancer Journal and the American Journal of Pathology.

Publications

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Classifying the evolutionary and ecological features of neoplasms. Nat Rev Cancer. 2017 Sep 15. View in: PubMed

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Between-region genetic divergence reflects the mode and tempo of tumor evolution. Nat Genet. 2017 Jul; 49(7):1015-1024. View in: PubMed

Early mutation bursts in colorectal tumors. PLoS One. 2017; 12(3):e0172516. View in: PubMed

Single cell lineage tracing reveals a role for TgfßR2 in intestinal stem cell dynamics and differentiation. Proc Natl Acad Sci U S A. 2016 Oct 25; 113(43):12192-12197. View in: PubMed

At least two well-spaced samples are needed to genotype a solid tumor. BMC Cancer. 2016 Mar 25; 16:250. View in: PubMed

HistoMosaic Detecting KRAS G12V Mutation Across Colorectal Cancer Tissue Slices through in Situ PCR. Anal Chem. 2016 Mar 01; 88(5):2792-8. View in: PubMed

Many private mutations originate from the first few divisions of a human colorectal adenoma. J Pathol. 2015 Nov; 237(3):355-62. View in: PubMed

Derivation of induced pluripotent stem cells from orangutan skin fibroblasts. BMC Res Notes. 2015 Oct 16; 8:577. View in: PubMed

Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities. Stem Cell Res Ther. 2015 Aug 29; 6:158. View in: PubMed

Can oncology recapitulate paleontology? Lessons from species extinctions. Nat Rev Clin Oncol. 2015 May; 12(5):273-85. View in: PubMed

A Big Bang model of human colorectal tumor growth. Nat Genet. 2015 Mar; 47(3):209-16. View in: PubMed

Diffuse large B-cell lymphoma of germinal center and nongerminal center phenotypes presenting concurrently at the same anatomic site: intratumoral heterogeneity or composite lymphoma? Appl Immunohistochem Mol Morphol. Diffuse large B-cell lymphoma of germinal center and nongerminal center phenotypes presenting concurrently at the same anatomic site: intratumoral heterogeneity or composite lymphoma? Appl Immunohistochem Mol Morphol. 2015 Jan; 23(1):78-80. View in: PubMed

Ancestral inference in tumors: how much can we know? J Theor Biol. Ancestral inference in tumors: how much can we know? J Theor Biol. 2014 Oct 21; 359:136-45. View in: PubMed

Deep sequencing reveals lack of a clonal relationship between a metachronous classical hodgkin and diffuse large B-cell lymphoma. Clin Lymphoma Myeloma Leuk. 2014 Jun; 14(3):e87-93. View in: PubMed

Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention. Carcinogenesis. 2014 Jan; 35(1):237-46. View in: PubMed

Direct measurements of human colon crypt stem cell niche genetic fidelity: the role of chance in non-darwinian mutation selection. Front Oncol. 2013 Oct 14; 3:264. View in: PubMed

Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. Science. 2013 Feb 01; 339(6119):543-8. View in: PubMed

Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization. Cancer Res. 2013 Jan 01; 73(1):41-9. View in: PubMed

The gene expression profiles of induced pluripotent stem cells from individuals with childhood cerebral adrenoleukodystrophy are consistent with proposed mechanisms of pathogenesis. Stem Cell Res Ther. 2012 Oct 04; 3(5):39. View in: PubMed

Heterogeneity and randomness of DNA methylation patterns in human embryonic stem cells. DNA Cell Biol. 2012 Jun; 31(6):893-907. View in: PubMed

The role of theorem proving in systems biology. J Theor Biol. 2012 May 7; 300:57-61. View in: PubMed

The role of theorem proving in systems biology. J Theor Biol. 2012 May 07; 300:57-61. View in: PubMed

Cancer. Heterogeneity and tumor history. Science. 2012 Apr 20; 336(6079):304-5. View in: PubMed

Molecular tumor clocks to study the evolution of drug resistance. Mol Pharm. 2011 Dec 5; 8(6):2050-4. View in: PubMed

Molecular tumor clocks to study the evolution of drug resistance. Mol Pharm. 2011 Dec 05; 8(6):2050-4. View in: PubMed

Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice. Carcinogenesis. 2011 Jun; 32(6):829-35. View in: PubMed

Mutation and epigenetic molecular clocks in cancer. Carcinogenesis. 2011 Feb; 32(2):123-8. View in: PubMed

A stem cell niche dominance theorem. BMC Syst Biol. 2011 Jan 08; 5:4. View in: PubMed

Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors. PLoS One. 2011; 6(10):e25985. View in: PubMed

High DNA methylation pattern intratumoral diversity implies weak selection in many human colorectal cancers. PLoS One. 2011; 6(6):e21657. View in: PubMed

Using DNA methylation patterns to infer tumor ancestry. PLoS One. 2010 Aug 09; 5(8):e12002. View in: PubMed

Is there any genetic instability in human cancer? DNA Repair (Amst). Is there any genetic instability in human cancer? DNA Repair (Amst). 2010 Aug 5; 9(8):858; discussion 859-60. View in: PubMed

Is there any genetic instability in human cancer? DNA Repair (Amst). Is there any genetic instability in human cancer? DNA Repair (Amst). 2010 Aug 05; 9(8):858; discussion 859-60. View in: PubMed

Hormone therapy, DNA methylation and colon cancer. Carcinogenesis. 2010 Jun; 31(6):1060-7. View in: PubMed

Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations. J Cell Biochem. 2010 Mar 01; 109(4):818-27. View in: PubMed

A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates. BMC Cancer. 2010 Jan 05; 10:3. View in: PubMed

A simple algebraic cancer equation: calculating how cancers may arise with normal mutation rates. BMC Cancer. 2010; 10:3. View in: PubMed

Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Res. 2010 Jan 01; 70(1):12-3. View in: PubMed

Many colorectal cancers are "flat" clonal expansions. Cell Cycle. 2009 Jul 15; 8(14):2187-93. View in: PubMed

Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4828-33. View in: PubMed

Older individuals appear to acquire mitotically older colorectal cancers. J Pathol. 2009 Mar; 217(4):483-8. View in: PubMed

Water intake and bladder cancer risk in Los Angeles County. Int J Cancer. 2008 Oct 01; 123(7):1649-56. View in: PubMed

Inferring relative numbers of human leucocyte genome replications. Br J Haematol. 2008 Jun; 141(6):862-71. View in: PubMed

Multilineage hematopoietic recovery with concomitant antitumor effects using low dose Interleukin-12 in myelosuppressed tumor-bearing mice. J Transl Med. 2008 May 19; 6:26. View in: PubMed

Unregulated smooth-muscle myosin in human intestinal neoplasia. Proc Natl Acad Sci U S A. 2008 Apr 08; 105(14):5513-8. View in: PubMed

Tractable Cre-lox system for stochastic alteration of genes in mice. Nat Methods. 2008 Mar; 5(3):227-9. View in: PubMed

Mistakes make history: visualizing intestinal tectonics. Gastroenterology. 2008 Feb; 134(2):628-31. View in: PubMed

Ancestral trees for modeling stem cell lineages genetically rather than functionally: understanding mutation accumulation and distinguishing the restrictive cancer stem cell propagation theory and the unrestricted cell propagation theory of human tumorigenesis. Breast Dis. 2008; 29:15-25. View in: PubMed

Stem cells as common ancestors in a colorectal cancer ancestral tree. Curr Opin Gastroenterol. 2008 Jan; 24(1):59-63. View in: PubMed

Modeling DNA methylation in a population of cancer cells. Stat Appl Genet Mol Biol. 2008; 7(1):Article 18. View in: PubMed

Multilineage hematopoietic recovery with concomitant antitumor effects using low dose Interleukin-12 in myelosuppressed tumor-bearing mice. J Transl Med. 2008; 6:26. View in: PubMed

The fuzzy math of solid tumor stem cells: a perspective. Cancer Res. 2007 Oct 1; 67(19):8985-8. View in: PubMed

The fuzzy math of solid tumor stem cells: a perspective. Cancer Res. 2007 Oct 01; 67(19):8985-8. View in: PubMed

Lack of increases in methylation at three CpG-rich genomic loci in non-mitotic adult tissues during aging. BMC Med Genet. 2007 Jul 31; 8:50. View in: PubMed

The stem cell population of the human colon crypt: analysis via methylation patterns. PLoS Comput Biol. 2007 Mar 02; 3(3):e28. View in: PubMed

The stem cell population of the human colon crypt: analysis via methylation patterns. PLoS Comput Biol. 2007 Mar 2; 3(3):e28. View in: PubMed

IL-12 facilitates both the recovery of endogenous hematopoiesis and the engraftment of stem cells after ionizing radiation. Exp Hematol. 2007 Feb; 35(2):203-13. View in: PubMed

Stem cell chronicles: autobiographies within genomes. Stem Cell Rev. 2007 Jan; 3(1):94-103. View in: PubMed

Lack of increases in methylation at three CpG-rich genomic loci in non-mitotic adult tissues during aging. BMC Med Genet. 2007; 8:50. View in: PubMed

Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice. Cancer Res. 2006 Sep 01; 66(17):8430-8. View in: PubMed

Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice. Cancer Res. 2006 Sep 1; 66(17):8430-8. View in: PubMed

Clonal diversity in tumor progression. Nat Genet. 2006 Apr; 38(4):402-3. View in: PubMed

Counting divisions in a human somatic cell tree: how, what and why? Cell Cycle. Counting divisions in a human somatic cell tree: how, what and why? Cell Cycle. 2006 Mar; 5(6):610-4. View in: PubMed

Human hair genealogies and stem cell latency. BMC Biol. 2006 Feb 03; 4:2. View in: PubMed

When does MMR loss occur during HNPCC progression? Cancer Biomark. When does MMR loss occur during HNPCC progression? Cancer Biomark. 2006; 2(1-2):29-35. View in: PubMed

Counting human somatic cell replications: methylation mirrors endometrial stem cell divisions. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17739-44. View in: PubMed

Numbers of mutations to different types of colorectal cancer. BMC Cancer. 2005 Oct 03; 5:126. View in: PubMed

Diethylstilbestrol effects and lymphomagenesis in Mlh1-deficient mice. Int J Cancer. 2005 Jul 1; 115(4):666-9. View in: PubMed

Diethylstilbestrol effects and lymphomagenesis in Mlh1-deficient mice. Int J Cancer. 2005 Jul 01; 115(4):666-9. View in: PubMed

Age-related human small intestine methylation: evidence for stem cell niches. BMC Med. 2005 Jun 23; 3:10. View in: PubMed

Stability of colon stem cell methylation after neo-adjuvant therapy in a patient with attenuated familial adenomatous polyposis. BMC Gastroenterol. 2005 Jun 07; 5:19. View in: PubMed

Generation and characterization of endonuclease G null mice. Mol Cell Biol. 2005 Jan; 25(1):294-302. View in: PubMed

Stability of colon stem cell methylation after neo-adjuvant therapy in a patient with attenuated familial adenomatous polyposis. BMC Gastroenterol. 2005; 5:19. View in: PubMed

Age-related human small intestine methylation: evidence for stem cell niches. BMC Med. 2005; 3:10. View in: PubMed

Numbers of mutations to different types of colorectal cancer. BMC Cancer. 2005; 5:126. View in: PubMed

Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors. Cancer Res. 2004 May 1; 64(9):3096-102. View in: PubMed

Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors. Cancer Res. 2004 May 01; 64(9):3096-102. View in: PubMed

Pretumor progression: clonal evolution of human stem cell populations. Am J Pathol. 2004 Apr; 164(4):1337-46. View in: PubMed

Tracing ancestry with methylation patterns: most crypts appear distantly related in normal adult human colon. BMC Gastroenterol. 2004 Apr 01; 4:8. View in: PubMed

Tracing ancestry with methylation patterns: most crypts appear distantly related in normal adult human colon. BMC Gastroenterol. 2004 Apr 1; 4:8. View in: PubMed

Colorectal pretumor progression before and after loss of DNA mismatch repair. Am J Pathol. 2004 Apr; 164(4):1447-53. View in: PubMed

Enhanced stem cell survival in familial adenomatous polyposis. Am J Pathol. 2004 Apr; 164(4):1369-77. View in: PubMed

In vitro mutation artifacts after formalin fixation and error prone translesion synthesis during PCR. BMC Clin Pathol. 2004 Feb 12; 4(1):1. View in: PubMed

The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants. DNA Repair (Amst). 2002 Dec 5; 1(12):1017-26. View in: PubMed

The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants. DNA Repair (Amst). 2002 Dec 05; 1(12):1017-26. View in: PubMed

Molecular tumour clocks and colorectal cancer: seeing the unseen. Pathology. 2002 Dec; 34(6):534-40. View in: PubMed

Diet, cancer and aging in DNA mismatch repair deficient mice. Carcinogenesis. 2002 Nov; 23(11):1807-10. View in: PubMed

Methylation reveals a niche: stem cell succession in human colon crypts. Oncogene. 2002 Aug 12; 21(35):5441-9. View in: PubMed

DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair. Mol Cell Biol. 2002 May; 22(9):2906-17. View in: PubMed

PolyA deletions in hereditary nonpolyposis colorectal cancer: mutations before a gatekeeper. Am J Pathol. 2002 Apr; 160(4):1503-6. View in: PubMed

Low-level microsatellite instability in most colorectal carcinomas. Cancer Res. 2002 Feb 15; 62(4):1166-70. View in: PubMed

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