Faculty

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David R. Hinton, MD
Exam Committee Facilitator
Professor of Pathology
Gavin S. Herbert Professorship in Vision Research
Associate Dean For Vision Science
Vice Chair of Pathology
Director, Dean's Research Scholars Program
Pathology
NRT 7503 Off Campus Los Angeles
+1 323 442 6617

Overview

Dr Hinton investigates the pathogenesis of blinding retinal diseases including age related macular degeneration (AMD) and proliferative vitreoretinopathy(PVR). In particular, he is interested in how alterations in the retinal microenvironment can promote the development of intraocular fibrosis, proliferative membranes and neovascular choroidal responses. His work has established the central role of the retinal pigment epithelial (RPE) cell in these disorders, and has demonstrated novel mechanisms for growth factor activation of the RPE with resulting alterations in migration, proliferation and gene expression. He has developed and validated several in vitro and in vivo models of PVR and choroidal neovascularization and has used these models to elucidate basic mechanisms of disease and to evaluate novel therapeutic approaches to the disorders. He is especially interested in therapeutic approaches involving manipulation of growth factor receptors and their intracellular signaling pathways. He has now extended this work into investigating genetic polymorphisms that result in susceptibility to these disorders in human populations. Most recently, Dr Hinton’s lab has been evaluating endogenous neuroprotectants (eg pigment epithelial derived factor) and chaperones (alpha B crystallin) for their therapeutic potential. He has also developed methods for differentiating RPE cells from human embryonic stem cells and is evaluating these cells for their potential for cellular therapy for patients with AMD. In a collaborative Program Project with investigators at the Cleveland Clinic, Dr Hinton investigates the immunopathogenesis of demyelinating diseases of the brain and spinal cord in animal models.

Publications

Huang AS, Saraswathy S, Dastiridou A, Begian A, Mohindroo C, Tan JC, Francis BA, Hinton DR, Weinreb RN. Aqueous Angiography-Mediated Guidance of Trabecular Bypass Improves Angiographic Outflow in Human Enucleated Eyes. Invest Ophthalmol Vis Sci. 2016 Sep 1; 57(11):4558-65. View in: PubMed

Koss MJ, Falabella P, Stefanini FR, Pfister M, Thomas BB, Kashani AH, Brant R, Zhu D, Clegg DO, Hinton DR, Humayun MS. Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs. Graefes Arch Clin Exp Ophthalmol. 2016 Aug; 254(8):1553-65. View in: PubMed

Thomas BB, Zhu D, Zhang L, Thomas PB, Hu Y, Nazari H, Stefanini F, Falabella P, Clegg DO, Hinton DR, Humayun MS. Survival and Functionality of hESC-Derived Retinal Pigment Epithelium Cells Cultured as a Monolayer on Polymer Substrates Transplanted in RCS Rats. Invest Ophthalmol Vis Sci. 2016 May 1; 57(6):2877-87. View in: PubMed

Ishikawa K, Sreekumar PG, Spee C, Nazari H, Zhu D, Kannan R, Hinton DR. aB-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition. Am J Pathol. 2016 Apr; 186(4):859-73. View in: PubMed

Brant Fernandes RA, Koss MJ, Falabella P, Stefanini FR, Maia M, Diniz B, Ribeiro R, Hu Y, Hinton D, Clegg DO, Chader G, Humayun MS. An Innovative Surgical Technique for Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigmented Epithelium in Yucatan Mini Pigs: Preliminary Results. Ophthalmic Surg Lasers Imaging Retina. 2016 Apr 1; 47(4):342-51. View in: PubMed

Sreekumar PG, Ishikawa K, Spee C, Mehta HH, Wan J, Yen K, Cohen P, Kannan R, Hinton DR. The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. Invest Ophthalmol Vis Sci. 2016 Mar 1; 57(3):1238-53. View in: PubMed

Valentin-Torres A, Savarin C, Hinton DR, Phares TW, Bergmann CC, Stohlman SA. Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis. J Neuroinflammation. 2016; 13(1):46. View in: PubMed

Ishikawa K, Kannan R, Hinton DR. Molecular mechanisms of subretinal fibrosis in age-related macular degeneration. Exp Eye Res. 2016 Jan; 142:19-25. View in: PubMed

Saraswathy S, Tan JC, Yu F, Francis BA, Hinton DR, Weinreb RN, Huang AS. Aqueous Angiography: Real-Time and Physiologic Aqueous Humor Outflow Imaging. PLoS One. 2016; 11(1):e0147176. View in: PubMed

Kannan R, Sreekumar PG, Hinton DR. Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration. Biochim Biophys Acta. 2016 Jan; 1860(1 Pt B):258-68. View in: PubMed

Kochounian H, Zhang Z, Spee C, Hinton DR, Fong HK. Targeting of exon VI-skipping human RGR-opsin to the plasma membrane of pigment epithelium and co-localization with terminal complement complex C5b-9. Mol Vis. 2016; 22:213-23. View in: PubMed

Zhang H, He S, Spee C, Ishikawa K, Hinton DR. SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization. Cytokine. 2015 Dec; 76(2):549-52. View in: PubMed

Butchi N, Kapil P, Puntambekar S, Stohlman SA, Hinton DR, Bergmann CC. Myd88 Initiates Early Innate Immune Responses and Promotes CD4 T Cells during Coronavirus Encephalomyelitis. J Virol. 2015 Sep 15; 89(18):9299-312. View in: PubMed

Nazari H, Zhang L, Zhu D, Chader GJ, Falabella P, Stefanini F, Rowland T, Clegg DO, Kashani AH, Hinton DR, Humayun MS. Stem cell based therapies for age-related macular degeneration: The promises and the challenges. Prog Retin Eye Res. 2015 Sep; 48:1-39. View in: PubMed

He S, Barron E, Ishikawa K, Nazari Khanamiri H, Spee C, Zhou P, Kase S, Wang Z, Dustin LD, Hinton DR. Inhibition of DNA Methylation and Methyl-CpG-Binding Protein 2 Suppresses RPE Transdifferentiation: Relevance to Proliferative Vitreoretinopathy. Invest Ophthalmol Vis Sci. 2015 Aug 1; 56(9):5579-89. View in: PubMed

Hirsch L, Nazari H, Sreekumar PG, Kannan R, Dustin L, Zhu D, Barron E, Hinton DR. TGF-ß2 secretion from RPE decreases with polarization and becomes apically oriented. Cytokine. 2015 Feb; 71(2):394-6. View in: PubMed

Hsiung J, Zhu D, Hinton DR. Polarized human embryonic stem cell-derived retinal pigment epithelial cell monolayers have higher resistance to oxidative stress-induced cell death than nonpolarized cultures. Stem Cells Transl Med. 2015 Jan; 4(1):10-20. View in: PubMed

Savarin C, Hinton DR, Valentin-Torres A, Chen Z, Trapp BD, Bergmann CC, Stohlman SA. Astrocyte response to IFN-? limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis. J Neuroinflammation. 2015; 12(1):79. View in: PubMed

Ishikawa K, He S, Terasaki H, Nazari H, Zhang H, Spee C, Kannan R, Hinton DR. Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy. Sci Rep. 2015; 5:16386. View in: PubMed

Chan N, He S, Spee CK, Ishikawa K, Hinton DR. Attenuation of choroidal neovascularization by histone deacetylase inhibitor. PLoS One. 2015; 10(3):e0120587. View in: PubMed

Hirano Y, Yasuma T, Mizutani T, Fowler BJ, Tarallo V, Yasuma R, Kim Y, Bastos-Carvalho A, Kerur N, Gelfand BD, Bogdanovich S, He S, Zhang X, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Nagai H, Haro I, Núñez G, Ambati BK, Hinton DR, Ambati J. IL-18 is not therapeutic for neovascular age-related macular degeneration. Nat Med. 2014 Dec 4; 20(12):1372-5. View in: PubMed

Kannan R, Hinton DR. Sodium iodate induced retinal degeneration: new insights from an old model. Neural Regen Res. 2014 Dec 1; 9(23):2044-5. View in: PubMed

Sur A, Kesaraju S, Prentice H, Ayyanathan K, Baronas-Lowell D, Zhu D, Hinton DR, Blanks J, Weissbach H. Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-a. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16754-9. View in: PubMed

Fowler BJ, Gelfand BD, Kim Y, Kerur N, Tarallo V, Hirano Y, Amarnath S, Fowler DH, Radwan M, Young MT, Pittman K, Kubes P, Agarwal HK, Parang K, Hinton DR, Bastos-Carvalho A, Li S, Yasuma T, Mizutani T, Yasuma R, Wright C, Ambati J. Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. Science. 2014 Nov 21; 346(6212):1000-3. View in: PubMed

Kim Y, Tarallo V, Kerur N, Yasuma T, Gelfand BD, Bastos-Carvalho A, Hirano Y, Yasuma R, Mizutani T, Fowler BJ, Li S, Kaneko H, Bogdanovich S, Ambati BK, Hinton DR, Hauswirth WW, Hakem R, Wright C, Ambati J. DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):16082-7. View in: PubMed

Wang W, Sreekumar PG, Valluripalli V, Shi P, Wang J, Lin YA, Cui H, Kannan R, Hinton DR, MacKay JA. Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells. J Control Release. 2014 Oct 10; 191:4-14. View in: PubMed

Sonoda S, Nagineni CN, Kitamura M, Spee C, Kannan R, Hinton DR. Ceramide inhibits connective tissue growth factor expression by human retinal pigment epithelial cells. Cytokine. 2014 Aug; 68(2):137-40. View in: PubMed

de Aquino MT, Kapil P, Hinton DR, Phares TW, Puntambekar SS, Savarin C, Bergmann CC, Stohlman SA. IL-27 Limits Central Nervous System Viral Clearance by Promoting IL-10 and Enhances Demyelination. J Immunol. 2014 Jul 1; 193(1):285-94. View in: PubMed

Kapil P, Stohlman SA, Hinton DR, Bergmann CC. PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis. J Neuroimmunol. 2014 May 15; 270(1-2):1-12. View in: PubMed

Zhou P, Kannan R, Spee C, Sreekumar PG, Dou G, Hinton DR. Protection of Retina by aB Crystallin in Sodium Iodate Induced Retinal Degeneration. PLoS One. 2014; 9(5):e98275. View in: PubMed

Butchi NB, Hinton DR, Stohlman SA, Kapil P, Fensterl V, Sen GC, Bergmann CC. Ifit2 Deficiency Results in Uncontrolled Neurotropic Coronavirus Replication and Enhanced Encephalitis via Impaired Alpha/Beta Interferon Induction in Macrophages. J Virol. 2014 Jan; 88(2):1051-64. View in: PubMed

de Aquino MT, Puntambekar SS, Savarin C, Bergmann CC, Phares TW, Hinton DR, Stohlman SA. Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system. Virology. 2013 Dec; 447(1-2):112-20. View in: PubMed

Phares TW, DiSano KD, Hinton DR, Hwang M, Zajac AJ, Stohlman SA, Bergmann CC. IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis. J Neuroimmunol. 2013 Oct 15; 263(1-2):43-54. View in: PubMed

Diniz B, Thomas P, Thomas B, Ribeiro R, Hu Y, Brant R, Ahuja A, Zhu D, Liu L, Koss M, Maia M, Chader G, Hinton DR, Humayun MS. Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer. Invest Ophthalmol Vis Sci. 2013 Jul; 54(7):5087-96. View in: PubMed

Ribeiro RM, Oregon A, Diniz B, Fernandes RB, Koss MJ, Charafeddin W, Hu Y, Thomas P, Thomas BB, Maia M, Chader GJ, Hinton DR, Humayun MS. In vivo detection of hESC-RPE cells via confocal near-infrared fundus reflectance. Ophthalmic Surg Lasers Imaging Retina. 2013 Jul-Aug; 44(4):380-4. View in: PubMed

Sreekumar PG, Chothe P, Sharma KK, Baid R, Kompella U, Spee C, Kannan N, Manh C, Ryan SJ, Ganapathy V, Kannan R, Hinton DR. Antiapoptotic properties of a-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells. Invest Ophthalmol Vis Sci. 2013 Apr; 54(4):2787-98. View in: PubMed

Phares TW, Stohlman SA, Hinton DR, Bergmann CC. Astrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis. J Virol. 2013 Mar; 87(6):3382-92. View in: PubMed

Zhu G, Ye R, Jung DY, Barron E, Friedline RH, Benoit VM, Hinton DR, Kim JK, Lee AS. GRP78 plays an essential role in adipogenesis and postnatal growth in mice. FASEB J. 2013 Mar; 27(3):955-64. View in: PubMed

He S, Li X, Chan N, Hinton DR. Review: Epigenetic mechanisms in ocular disease. Mol Vis. 2013; 19:665-74. View in: PubMed

Savarin C, Bergmann CC, Hinton DR, Stohlman SA. MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitis. ASN Neuro. 2013; 5(5). View in: PubMed

Kerur N, Hirano Y, Tarallo V, Fowler BJ, Bastos-Carvalho A, Yasuma T, Yasuma R, Kim Y, Hinton DR, Kirschning CJ, Gelfand BD, Ambati J. TLR-Independent and P2X7-Dependent Signaling Mediate Alu RNA-Induced NLRP3 Inflammasome Activation in Geographic Atrophy. Invest Ophthalmol Vis Sci. 2013; 54(12):7395-401. View in: PubMed

Kannan R, Sreekumar PG, Hinton DR. Novel roles for a-crystallins in retinal function and disease. Prog Retin Eye Res. 2012 Nov; 31(6):576-604. View in: PubMed

Gundimeda U, McNeill TH, Elhiani AA, Schiffman JE, Hinton DR, Gopalakrishna R. Green Tea Polyphenols Precondition against Cell Death Induced by Oxygen-Glucose Deprivation via Stimulation of Laminin Receptor, Generation of Reactive Oxygen Species, and Activation of Protein Kinase C{epsilon}. J Biol Chem. 2012 Oct 5; 287(41):34694-708. View in: PubMed

Dou G, Sreekumar PG, Spee C, He S, Ryan SJ, Kannan R, Hinton DR. Deficiency of aB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction. Free Radic Biol Med. 2012 Sep 1; 53(5):1111-22. View in: PubMed

Sohn EH, He S, Kim LA, Salehi-Had H, Javaheri M, Spee C, Dustin L, Hinton DR, Eliott D. Angiofibrotic response to vascular endothelial growth factor inhibition in diabetic retinal detachment: report no. 1. Arch Ophthalmol. 2012 Sep 1; 130(9):1127-34. View in: PubMed

Dridi S, Hirano Y, Tarallo V, Kim Y, Fowler BJ, Ambati BK, Bogdanovich S, Chiodo VA, Hauswirth WW, Kugel JF, Goodrich JA, Ponicsan SL, Hinton DR, Kleinman ME, Baffi JZ, Gelfand BD, Ambati J. ERK1/2 activation is a therapeutic target in age-related macular degeneration. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13781-6. View in: PubMed

Lu B, Zhu D, Hinton D, Humayun MS, Tai YC. Mesh-supported submicron parylene-C membranes for culturing retinal pigment epithelial cells. Biomed Microdevices. 2012 Aug; 14(4):659-67. View in: PubMed

Xu J, Zhu D, Sonoda S, He S, Spee C, Ryan SJ, Hinton DR. Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9. Angiogenesis. 2012 Jun; 15(2):213-27. View in: PubMed

Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H, Fowler BJ, Bogdanovich S, Albuquerque RJ, Hauswirth WW, Chiodo VA, Kugel JF, Goodrich JA, Ponicsan SL, Chaudhuri G, Murphy MP, Dunaief JL, Ambati BK, Ogura Y, Yoo JW, Lee DK, Provost P, Hinton DR, Núñez G, Baffi JZ, Kleinman ME, Ambati J. DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88. Cell. 2012 May 11; 149(4):847-59. View in: PubMed

Phares TW, Stohlman SA, Hwang M, Min B, Hinton DR, Bergmann CC. CD4 T Cells Promote CD8 T Cell Immunity at the Priming and Effector Site during Viral Encephalitis. J Virol. 2012 Mar; 86(5):2416-27. View in: PubMed

Sreekumar PG, Spee C, Ryan SJ, Cole SP, Kannan R, Hinton DR. Mechanism of RPE Cell Death in a-Crystallin Deficient Mice: A Novel and Critical Role for MRP1-Mediated GSH Efflux. PLoS One. 2012; 7(3):e33420. View in: PubMed

Phares TW, Stohlman SA, Hinton DR, Bergmann CC. Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis. J Neuroinflammation. 2012; 9:269. View in: PubMed

Hindinger C, Bergmann CC, Hinton DR, Phares TW, Parra GI, Hussain S, Savarin C, Atkinson RD, Stohlman SA. IFN-? Signaling to Astrocytes Protects from Autoimmune Mediated Neurological Disability. PLoS One. 2012; 7(7):e42088. View in: PubMed

Savarin C, Stohlman SA, Hinton DR, Ransohoff RM, Cua DJ, Bergmann CC. IFN-? protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils. J Neuroinflammation. 2012; 9:104. View in: PubMed

Hu Y, Liu L, Lu B, Zhu D, Ribeiro R, Diniz B, Thomas PB, Ahuja AK, Hinton DR, Tai YC, Hikita ST, Johnson LV, Clegg DO, Thomas BB, Humayun MS. A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer. Ophthalmic Res. 2012; 48(4):186-91. View in: PubMed

Amin EM, Oltean S, Hua J, Gammons MV, Hamdollah-Zadeh M, Welsh GI, Cheung MK, Ni L, Kase S, Rennel ES, Symonds KE, Nowak DG, Royer-Pokora B, Saleem MA, Hagiwara M, Schumacher VA, Harper SJ, Hinton DR, Bates DO, Ladomery MR. WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing. Cancer Cell. 2011 Dec 13; 20(6):768-80. View in: PubMed

Couldwell WT, Surnock AA, Tobia AJ, Cabana BE, Stillerman CB, Forsyth PA, Appley AJ, Spence AM, Hinton DR, Chen TC. A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas. Cancer. 2011 Nov 1; 117(21):4905-15. View in: PubMed

Sreekumar PG, Hinton DR, Kannan R. Methionine sulfoxide reductase A: Structure, function and role in ocular pathology. World J Biol Chem. 2011 Aug 26; 2(8):184-92. View in: PubMed

Puntambekar SS, Bergmann CC, Savarin C, Karp CL, Phares TW, Parra GI, Hinton DR, Stohlman SA. Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis. J Virol. 2011 Jul; 85(13):6702-13. View in: PubMed

Xu J, Zhu D, He S, Spee C, Ryan SJ, Hinton DR. Transcriptional regulation of bone morphogenetic protein 4 by tumor necrosis factor and its relationship with age-related macular degeneration. FASEB J. 2011 Jul; 25(7):2221-33. View in: PubMed

Marques CP, Kapil P, Hinton DR, Hindinger C, Nutt SL, Ransohoff RM, Phares TW, Stohlman SA, Bergmann CC. CXCR3-dependent plasma blast migration to the central nervous system during viral encephalomyelitis. J Virol. 2011 Jul; 85(13):6136-47. View in: PubMed

Khankan R, Oliver N, He S, Ryan SJ, Hinton DR. Regulation of fibronectin-EDA through CTGF domain-specific interactions with TGFß2 and its receptor TGFßRII. Invest Ophthalmol Vis Sci. 2011 Jul; 52(8):5068-78. View in: PubMed

Lee NG, Berry JL, Lee TC, Wang AT, Honowitz S, Murphree AL, Varshney N, Hinton DR, Fawzi AA. Sonoporation enhances chemotherapeutic efficacy in retinoblastoma cells in vitro. Invest Ophthalmol Vis Sci. 2011 May; 52(6):3868-73. View in: PubMed

Sadler TR, Nguyen PT, Yang J, Givrad TK, Mayer EA, Maarek JM, Hinton DR, Holschneider DP. Antenatal maternal stress alters functional brain responses in adult offspring during conditioned fear. Brain Res. 2011 Apr 18; 1385:163-74. View in: PubMed

Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karikó K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature. 2011 Mar 17; 471(7338):325-30. View in: PubMed

Zhu D, Deng X, Spee C, Sonoda S, Hsieh CL, Barron E, Pera M, Hinton DR. Polarized secretion of PEDF from human embryonic stem cell-derived RPE promotes retinal progenitor cell survival. Invest Ophthalmol Vis Sci. 2011 Mar; 52(3):1573-85. View in: PubMed

Phares TW, Marques CP, Stohlman SA, Hinton DR, Bergmann CC. Factors supporting intrathecal humoral responses following viral encephalomyelitis. J Virol. 2011 Mar; 85(6):2589-98. View in: PubMed

Chothe PP, Gnana-Prakasam JP, Ananth S, Martin PM, Kannan R, Hinton DR, Smith SB, Ganapathy V. Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis. Biochem Biophys Res Commun. 2011 Feb 11; 405(2):244-9. View in: PubMed

Abdallah W, Ameri H, Barron E, Chader GJ, Greenbaum E, Hinton DR, Humayun MS. Vitreal oxygenation in retinal ischemia reperfusion. Invest Ophthalmol Vis Sci. 2011 Feb; 52(2):1035-42. View in: PubMed

Kannan R, Sreekumar PG, Hinton DR. VEGF and PEDF Secretion in ARPE-19 and fhRPE Cells. Invest Ophthalmol Vis Sci. 2011; 52(12):9047. View in: PubMed

Gundimeda U, McNeill TH, Schiffman JE, Hinton DR, Gopalakrishna R. Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species. J Neurosci Res. 2010 Dec; 88(16):3644-55. View in: PubMed

Ye R, Mareninova OA, Barron E, Wang M, Hinton DR, Pandol SJ, Lee AS. Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis. Am J Pathol. 2010 Dec; 177(6):2827-36. View in: PubMed

Phares TW, Stohlman SA, Hinton DR, Atkinson R, Bergmann CC. Enhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis. J Immunol. 2010 Nov 1; 185(9):5607-18. View in: PubMed

Lim JI, Spee C, Hinton DR. A comparison of hypoxia-inducible factor-a in surgically excised neovascular membranes of patients with diabetes compared with idiopathic epiretinal membranes in nondiabetic patients. Retina. 2010 Oct; 30(9):1472-8. View in: PubMed

Hua J, Spee C, Kase S, Rennel ES, Magnussen AL, Qiu Y, Varey A, Dhayade S, Churchill AJ, Harper SJ, Bates DO, Hinton DR. Recombinant human VEGF165b inhibits experimental choroidal neovascularization. Invest Ophthalmol Vis Sci. 2010 Aug; 51(8):4282-8. View in: PubMed

Tran ND, Kim S, Vincent HK, Rodriguez A, Hinton DR, Bullock MR, Young HF. Aquaporin-1-mediated cerebral edema following traumatic brain injury: effects of acidosis and corticosteroid administration. J Neurosurg. 2010 May; 112(5):1095-104. View in: PubMed

Kase S, He S, Sonoda S, Kitamura M, Spee C, Wawrousek E, Ryan SJ, Kannan R, Hinton DR. alphaB-crystallin regulation of angiogenesis by modulation of VEGF. Blood. 2010 Apr 22; 115(16):3398-406. View in: PubMed

Zhu D, Sreekumar PG, Hinton DR, Kannan R. Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration. Vision Res. 2010 Mar 31; 50(7):643-51. View in: PubMed

Parra GI, Bergmann CC, Phares TW, Hinton DR, Atkinson R, Stohlman SA. Gamma interferon signaling in oligodendrocytes is critical for protection from neurotropic coronavirus infection. J Virol. 2010 Mar; 84(6):3111-5. View in: PubMed

He S, Kumar SR, Zhou P, Krasnoperov V, Ryan SJ, Gill PS, Hinton DR. Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro. Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):543-52. View in: PubMed

Zhou J, He S, Zhang N, Spee C, Zhou P, Ryan SJ, Kannan R, Hinton DR. Neutrophils compromise retinal pigment epithelial barrier integrity. J Biomed Biotechnol. 2010; 2010:289360. View in: PubMed

Chothe PP, Thakkar SV, Gnana-Prakasam JP, Ananth S, Hinton DR, Kannan R, Smith SB, Martin PM, Ganapathy V. Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):413-20. View in: PubMed

Sreekumar PG, Kannan R, Kitamura M, Spee C, Barron E, Ryan SJ, Hinton DR. aB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells. PLoS One. 2010; 5(10):e12578. View in: PubMed

Sonoda S, Sreekumar PG, Kase S, Spee C, Ryan SJ, Kannan R, Hinton DR. Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: relevance to age-related macular degeneration. Aging (Albany NY). 2010; 2(1):28-42. View in: PubMed

Ireland DD, Stohlman SA, Hinton DR, Kapil P, Silverman RH, Atkinson RA, Bergmann CC. RNase L mediated protection from virus induced demyelination. PLoS Pathog. 2009 Oct; 5(10):e1000602. View in: PubMed

Zhu D, Deng X, Xu J, Hinton DR. What determines the switch between atrophic and neovascular forms of age related macular degeneration? - the role of BMP4 induced senescence. Aging (Albany NY). 2009 Aug; 1(8):740-5. View in: PubMed

Kim YH, He S, Kase S, Kitamura M, Ryan SJ, Hinton DR. Regulated secretion of complement factor H by RPE and its role in RPE migration. Graefes Arch Clin Exp Ophthalmol. 2009 May; 247(5):651-9. View in: PubMed

Zhu D, Wu J, Spee C, Ryan SJ, Hinton DR. BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration. J Biol Chem. 2009 Apr 3; 284(14):9529-39. View in: PubMed

Sreekumar PG, Ding Y, Ryan SJ, Kannan R, Hinton DR. Regulation of thioredoxin by ceramide in retinal pigment epithelial cells. Exp Eye Res. 2009 Mar; 88(3):410-7. View in: PubMed

Sadler TR, Khodavirdi AC, Hinton DR, Holschneider DP. Snap-frozen brain tissue sections stored with desiccant at ambient laboratory conditions without chemical fixation are resistant to degradation for a minimum of 6 months. Appl Immunohistochem Mol Morphol. 2009 Mar; 17(2):165-71. View in: PubMed

Ray A, Colodetti L, Weiland JD, Hinton DR, Humayun MS, Lee EJ. Immunocytochemical analysis of retinal neurons under electrical stimulation. Brain Res. 2009 Feb 19; 1255:89-97. View in: PubMed

Sonoda S, Spee C, Barron E, Ryan SJ, Kannan R, Hinton DR. A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells. Nat Protoc. 2009; 4(5):662-73. View in: PubMed

Savarin C, Bergmann CC, Hinton DR, Ransohoff RM, Stohlman SA. Memory CD4+ T-cell-mediated protection from lethal coronavirus encephalomyelitis. J Virol. 2008 Dec; 82(24):12432-40. View in: PubMed

Yang Z, Stratton C, Francis PJ, Kleinman ME, Tan PL, Gibbs D, Tong Z, Chen H, Constantine R, Yang X, Chen Y, Zeng J, Davey L, Ma X, Hau VS, Wang C, Harmon J, Buehler J, Pearson E, Patel S, Kaminoh Y, Watkins S, Luo L, Zabriskie NA, Bernstein PS, Cho W, Schwager A, Hinton DR, Klein ML, Hamon SC, Simmons E, Yu B, Campochiaro B, Sunness JS, Campochiaro P, Jorde L, Parmigiani G, Zack DJ, Katsanis N, Ambati J, Zhang K. Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med. 2008 Oct 2; 359(14):1456-63. View in: PubMed

He S, Chen Y, Khankan R, Barron E, Burton R, Zhu D, Ryan SJ, Oliver N, Hinton DR. Connective tissue growth factor as a mediator of intraocular fibrosis. Invest Ophthalmol Vis Sci. 2008 Sep; 49(9):4078-88. View in: PubMed

Lundberg P, Ramakrishna C, Brown J, Tyszka JM, Hamamura M, Hinton DR, Kovats S, Nalcioglu O, Weinberg K, Openshaw H, Cantin EM. The immune response to herpes simplex virus type 1 infection in susceptible mice is a major cause of central nervous system pathology resulting in fatal encephalitis. J Virol. 2008 Jul; 82(14):7078-88. View in: PubMed

He S, Yaung J, Kim YH, Barron E, Ryan SJ, Hinton DR. Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol. 2008 May; 246(5):677-83. View in: PubMed

Sreekumar PG, Zhou J, Sohn J, Spee C, Ryan SJ, Maurer BJ, Kannan R, Hinton DR. N-(4-hydroxyphenyl) retinamide augments laser-induced choroidal neovascularization in mice. Invest Ophthalmol Vis Sci. 2008 Mar; 49(3):1210-20. View in: PubMed

Stohlman SA, Hinton DR, Parra B, Atkinson R, Bergmann CC. CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus. J Virol. 2008 Mar; 82(5):2130-9. View in: PubMed

Yaung J, Kannan R, Wawrousek EF, Spee C, Sreekumar PG, Hinton DR. Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia. Exp Eye Res. 2008 Feb; 86(2):355-65. View in: PubMed

Ireland DD, Stohlman SA, Hinton DR, Atkinson R, Bergmann CC. Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells. J Virol. 2008 Jan; 82(1):300-10. View in: PubMed

Tedeschi-Blok N, Buckley J, Varma R, Triche TJ, Hinton DR. Population-based study of early age-related macular degeneration: role of the complement factor H Y402H polymorphism in bilateral but not unilateral disease. Ophthalmology. 2007 Jan; 114(1):99-103. View in: PubMed

Yaung J, Jin M, Barron E, Spee C, Wawrousek EF, Kannan R, Hinton DR. alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. Mol Vis. 2007; 13:566-77. View in: PubMed

Agrawal RN, He S, Spee C, Cui JZ, Ryan SJ, Hinton DR. In vivo models of proliferative vitreoretinopathy. Nat Protoc. 2007; 2(1):67-77. View in: PubMed

He S, Incardona F, Jin M, Ryan SJ, Hinton DR. Thrombospondin-1 expression in RPE and choroidal neovascular membranes. Yan Ke Xue Bao. 2006 Dec; 22(4):265-74. View in: PubMed

Hindinger C, Hinton DR, Kirwin SJ, Atkinson RD, Burnett ME, Bergmann CC, Stohlman SA. Liver X receptor activation decreases the severity of experimental autoimmune encephalomyelitis. J Neurosci Res. 2006 Nov 1; 84(6):1225-34. View in: PubMed

Kirwin SJ, Dowdell KC, Hindinger C, Feng N, Bergmann CC, Hinton DR, Stohlman SA. Altered neuroantigen-specific cytokine secretion in a Th2 environment reduces experimental autoimmune encephalomyelitis. J Neuroimmunol. 2006 Sep; 178(1-2):30-9. View in: PubMed

Sreekumar PG, Kannan R, de Silva AT, Burton R, Ryan SJ, Hinton DR. Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells. Biochem Biophys Res Commun. 2006 Aug 11; 346(4):1200-6. View in: PubMed

Gamulescu MA, Chen Y, He S, Spee C, Jin M, Ryan SJ, Hinton DR. Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor. Exp Eye Res. 2006 Jul; 83(1):212-22. View in: PubMed

Zuo J, Stohlman SA, Hoskin JB, Hinton DR, Atkinson R, Bergmann CC. Mouse hepatitis virus pathogenesis in the central nervous system is independent of IL-15 and natural killer cells. Virology. 2006 Jun 20; 350(1):206-15. View in: PubMed

Kramerov AA, Saghizadeh M, Pan H, Kabosova A, Montenarh M, Ahmed K, Penn JS, Chan CK, Hinton DR, Grant MB, Ljubimov AV. Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Am J Pathol. 2006 May; 168(5):1722-36. View in: PubMed

Hoffmann S, He S, Ehren M, Ryan SJ, Wiedemann P, Hinton DR. MMP-2 and MMP-9 secretion by rpe is stimulated by angiogenic molecules found in choroidal neovascular membranes. Retina. 2006 Apr; 26(4):454-61. View in: PubMed

Tschen SI, Stohlman SA, Ramakrishna C, Hinton DR, Atkinson RD, Bergmann CC. CNS viral infection diverts homing of antibody-secreting cells from lymphoid organs to the CNS. Eur J Immunol. 2006 Mar; 36(3):603-12. View in: PubMed

González JM, Bergmann CC, Ramakrishna C, Hinton DR, Atkinson R, Hoskin J, Macklin WB, Stohlman SA. Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination. Am J Pathol. 2006 Mar; 168(3):796-804. View in: PubMed

Hangai M, He S, Hoffmann S, Lim JI, Ryan SJ, Hinton DR. Sequential induction of angiogenic growth factors by TNF-alpha in choroidal endothelial cells. J Neuroimmunol. 2006 Feb; 171(1-2):45-56. View in: PubMed

Kannan R, Zhang N, Sreekumar PG, Spee CK, Rodriguez A, Barron E, Hinton DR. Stimulation of apical and basolateral VEGF-A and VEGF-C secretion by oxidative stress in polarized retinal pigment epithelial cells. Mol Vis. 2006; 12:1649-59. View in: PubMed

Zhang N, Kannan R, Okamoto CT, Ryan SJ, Lee VH, Hinton DR. Characterization of brimonidine transport in retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):287-94. View in: PubMed

Lutty GA, Chan-Ling T, Phelps DL, Adamis AP, Berns KI, Chan CK, Cole CH, D'Amore PA, Das A, Deng WT, Dobson V, Flynn JT, Friedlander M, Fulton A, Good WV, Grant MB, Hansen R, Hauswirth WW, Hardy RJ, Hinton DR, Hughes S, McLeod DS, Palmer EA, Patz A, Penn JS, Raisler BJ, Repka MX, Saint-Geniez M, Shaw LC, Shima DT, Smith BT, Smith LE, Tahija SG, Tasman W, Trese MT. Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Mol Vis. 2006; 12:532-80. View in: PubMed

He S, Ding Y, Zhou J, Krasnoperov V, Zozulya S, Kumar SR, Ryan SJ, Gill PS, Hinton DR. Soluble EphB4 regulates choroidal endothelial cell function and inhibits laser-induced choroidal neovascularization. Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4772-9. View in: PubMed

Lim JI, Spee C, Hangai M, Rocha J, Ying HS, Ryan SJ, Hinton DR. Neuropilin-1 expression by endothelial cells and retinal pigment epithelial cells in choroidal neovascular membranes. Am J Ophthalmol. 2005 Dec; 140(6):1044-1050. View in: PubMed

Jin M, Yaung J, Kannan R, He S, Ryan SJ, Hinton DR. Hepatocyte growth factor protects RPE cells from apoptosis induced by glutathione depletion. Invest Ophthalmol Vis Sci. 2005 Nov; 46(11):4311-9. View in: PubMed

Pan J, Al-Dubaib M, Liao CP, Fujino Y, Hinton DR, Hayes KA, Mathes LE, Roy-Burman P. In vivo expression of GFP transgene delivered via a replicating feline leukemia virus. Vet Microbiol. 2005 Oct 31; 110(3-4):181-95. View in: PubMed

Hindinger C, Gonzalez JM, Bergmann CC, Fuss B, Hinton DR, Atkinson RD, Macklin WB, Stohlman SA. Astrocyte expression of a dominant-negative interferon-gamma receptor. J Neurosci Res. 2005 Oct 1; 82(1):20-31. View in: PubMed

Sreekumar PG, Kannan R, Yaung J, Spee CK, Ryan SJ, Hinton DR. Protection from oxidative stress by methionine sulfoxide reductases in RPE cells. Biochem Biophys Res Commun. 2005 Aug 19; 334(1):245-53. View in: PubMed

González JM, Bergmann CC, Fuss B, Hinton DR, Kangas C, Macklin WB, Stohlman SA. Expression of a dominant negative IFN-gammareceptor on mouse oligodendrocytes. Glia. 2005 Jul; 51(1):22-34. View in: PubMed

Chan CK, Pham LN, Zhou J, Spee C, Ryan SJ, Hinton DR. Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization. Lab Invest. 2005 Jun; 85(6):721-33. View in: PubMed

Zhou J, Marten NW, Bergmann CC, Macklin WB, Hinton DR, Stohlman SA. Expression of matrix metalloproteinases and their tissue inhibitor during viral encephalitis. J Virol. 2005 Apr; 79(8):4764-73. View in: PubMed

Güven D, Weiland JD, Fujii G, Mech BV, Mahadevappa M, Greenberg R, Roizenblatt R, Qiu G, Labree L, Wang X, Hinton D, Humayun MS. Long-term stimulation by active epiretinal implants in normal and RCD1 dogs. J Neural Eng. 2005 Mar; 2(1):S65-73. View in: PubMed

Hoffmann S, He S, Jin M, Ehren M, Wiedemann P, Ryan SJ, Hinton DR. A selective cyclic integrin antagonist blocks the integrin receptors alphavbeta3 and alphavbeta5 and inhibits retinal pigment epithelium cell attachment, migration and invasion. BMC Ophthalmol. 2005; 5:16. View in: PubMed

Zhou J, Hinton DR, Stohlman SA, Liu CP, Zhong L, Marten NW. Maintenance of CD8+ T cells during acute viral infection of the central nervous system requires CD4+ T cells but not interleukin-2. Viral Immunol. 2005; 18(1):162-9. View in: PubMed

Zhou J, Pham L, Zhang N, He S, Gamulescu MA, Spee C, Ryan SJ, Hinton DR. Neutrophils promote experimental choroidal neovascularization. Mol Vis. 2005; 11:414-24. View in: PubMed

Ramakrishna C, Stohlman SA, Atkinson RA, Hinton DR, Bergmann CC. Differential regulation of primary and secondary CD8+ T cells in the central nervous system. J Immunol. 2004 Nov 15; 173(10):6265-73. View in: PubMed

Kannan R, Jin M, Gamulescu MA, Hinton DR. Ceramide-induced apoptosis: role of catalase and hepatocyte growth factor. Free Radic Biol Med. 2004 Jul 15; 37(2):166-75. View in: PubMed

Weiner LP, Louie KA, Atalla LR, Kochounian HH, Du J, Wei W, Hinton DR, Gordon EM, Anderson WF, McMillan M. Gene therapy in a murine model for clinical application to multiple sclerosis. Ann Neurol. 2004 Mar; 55(3):390-9. View in: PubMed

Hinton DR, Spee C, He S, Weitz S, Usinger W, LaBree L, Oliver N, Lim JI. Accumulation of NH2-terminal fragment of connective tissue growth factor in the vitreous of patients with proliferative diabetic retinopathy. Diabetes Care. 2004 Mar; 27(3):758-64. View in: PubMed

Bergmann CC, Parra B, Hinton DR, Ramakrishna C, Dowdell KC, Stohlman SA. Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cells. J Virol. 2004 Feb; 78(4):1739-50. View in: PubMed

Chan CK, Pham LN, Chinn C, Spee C, Ryan SJ, Akhurst RJ, Hinton DR. Mouse strain-dependent heterogeneity of resting limbal vasculature. Invest Ophthalmol Vis Sci. 2004 Feb; 45(2):441-7. View in: PubMed

Jin M, Chen Y, He S, Ryan SJ, Hinton DR. Hepatocyte growth factor and its role in the pathogenesis of retinal detachment. Invest Ophthalmol Vis Sci. 2004 Jan; 45(1):323-9. View in: PubMed

Karanjawala ZE, Hinton DR, Oh E, Hsieh CL, Lieber MR. Developmental retinal apoptosis in Ku86-/- mice. DNA Repair (Amst). 2003 Dec 9; 2(12):1429-34. View in: PubMed

He S, Jin ML, Worpel V, Hinton DR. A role for connective tissue growth factor in the pathogenesis of choroidal neovascularization. Arch Ophthalmol. 2003 Sep; 121(9):1283-8. View in: PubMed

Wu LY, Li M, Hinton DR, Guo L, Jiang S, Wang JT, Zeng A, Xie JB, Snead M, Shuler C, Maxson RE, Liu YH. Microphthalmia resulting from MSX2-induced apoptosis in the optic vesicle. Invest Ophthalmol Vis Sci. 2003 Jun; 44(6):2404-12. View in: PubMed

Bergmann CC, Parra B, Hinton DR, Chandran R, Morrison M, Stohlman SA. Perforin-mediated effector function within the central nervous system requires IFN-gamma-mediated MHC up-regulation. J Immunol. 2003 Mar 15; 170(6):3204-13. View in: PubMed

Zhou J, Stohlman SA, Hinton DR, Marten NW. Neutrophils promote mononuclear cell infiltration during viral-induced encephalitis. J Immunol. 2003 Mar 15; 170(6):3331-6. View in: PubMed

Stohlman SA, Ramakrishna C, Tschen SI, Hinton DR, Bergmann CC. The art of survival during viral persistence. J Neurovirol. 2002 Dec; 8 Suppl 2:53-8. View in: PubMed

Simard M, Zhang W, Hinton DR, Chen TC, Weiss MH, Su YZ, Gopalakrishna R, Law RE, Couldwell WT. Tamoxifen-induced growth arrest and apoptosis in pituitary tumor cells in vitro via a protein kinase C-independent pathway. Cancer Lett. 2002 Nov 28; 185(2):131-8. View in: PubMed

Zhou J, Stohlman SA, Atkinson R, Hinton DR, Marten NW. Matrix metalloproteinase expression correlates with virulence following neurotropic mouse hepatitis virus infection. J Virol. 2002 Aug; 76(15):7374-84. View in: PubMed

Jin M, Barron E, He S, Ryan SJ, Hinton DR. Regulation of RPE intercellular junction integrity and function by hepatocyte growth factor. Invest Ophthalmol Vis Sci. 2002 Aug; 43(8):2782-90. View in: PubMed

Karanjawala ZE, Murphy N, Hinton DR, Hsieh CL, Lieber MR. Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants. Curr Biol. 2002 Mar 5; 12(5):397-402. View in: PubMed

Ryan SJ, Hinton DR, Ogden TE, Rao N. Translational research in ophthalmology. Arch Ophthalmol. 2002 Mar; 120(3):389-90. View in: PubMed

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