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David V. Conti, PhD
Professor of Preventive Medicine
Preventive Medicine
SSB 202 2001 N. Soto Street Health Sciences Campus Los Angeles
+1 323 442 3140


My research is aimed at elucidating the genetic contribution of complex diseases from population-based samples, and is comprised of both applied genetic epidemiologic studies and development of statistical methods. Presently, my applied work focuses on elucidating the genetic contribution of candidate genes within the dopamine and serotonin pathways and their role in smoking initation, progression, and cessation. My research in statistical methodology concentrates on the use of hierarchical modeling and Bayes model averaging as a general framework for the analysis of multiple genetic polymorphisms in genes involved in numerous pathways impacting disease.


Novel colon cancer susceptibility variants identified from a genome-wide association study in African Americans. Int J Cancer. 2017 Mar 13. View in: PubMed

The OncoArray Consortium: a Network for Understanding the Genetic Architecture of Common Cancers. Cancer Epidemiol Biomarkers Prev. 2016 Oct 3. View in: PubMed

Common variants in the obesity-associated genes FTO and MC4R are not associated with risk of colorectal cancer. Cancer Epidemiol. 2016 Oct; 44:1-4. View in: PubMed

Prostate Cancer Susceptibility in Men of African Ancestry at 8q24. J Natl Cancer Inst. 2016 Jul; 108(7). View in: PubMed

Detecting Gene-Environment Interactions for a Quantitative Trait in a Genome-Wide Association Study. Genet Epidemiol. 2016 Jul; 40(5):394-403. View in: PubMed

Genome-wide association study of colorectal cancer in Hispanics. Carcinogenesis. 2016 Jun; 37(6):547-56. View in: PubMed

JAM: A Scalable Bayesian Framework for Joint Analysis of Marginal SNP Effects. Genet Epidemiol. 2016 Apr; 40(3):188-201. View in: PubMed

Reducing GWAS Complexity. Cell Cycle. 2016 Jan 2; 15(1):22-4. View in: PubMed

The contribution of rare variation to prostate cancer heritability. Nat Genet. 2016 Jan; 48(1):30-5. View in: PubMed

Smokescreen: a targeted genotyping array for addiction research. BMC Genomics. 2016; 17(1):145. View in: PubMed

Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer. J Natl Cancer Inst. 2015 Nov; 107(11). View in: PubMed

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans. Hum Mol Genet. 2015 Oct 1; 24(19):5589-602. View in: PubMed

Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population. J Clin Oncol. 2015 Sep 10; 33(26):2901-7. View in: PubMed

Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer. Carcinogenesis. 2015 Sep; 36(9):999-1007. View in: PubMed

Identification of a Novel Mucin Gene HCG22 Associated with Steroid-Induced Ocular Hypertension. Invest Ophthalmol Vis Sci. 2015 Mar 26. View in: PubMed

Generalizability of established prostate cancer risk variants in men of African ancestry. Int J Cancer. 2015 Mar 1; 136(5):1210-7. View in: PubMed

Enlight: web-based integration of GWAS results with biological annotations. Bioinformatics. 2015 Jan 15; 31(2):275-6. View in: PubMed

Genetic ancestry influences asthma susceptibility and lung function among Latinos. J Allergy Clin Immunol. 2015 Jan; 135(1):228-35. View in: PubMed

Corrigendum: Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Nat Commun. 2015; 6:8739. View in: PubMed

Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption. PLoS One. 2015; 10(7):e0126113. View in: PubMed

Place of birth,age of immigration,and disability in Hispanics with multiple sclerosis. Mult Scler Relat Disord. 2015 Jan; 4(1):25-30. View in: PubMed

UGT1A and UGT2B Genetic Variation Alters Nicotine and Nitrosamine Glucuronidation in European and African American Smokers. Cancer Epidemiol Biomarkers Prev. 2015 Jan; 24(1):94-104. View in: PubMed

Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD. Am J Psychiatry. 2015 Jan 1; 172(1):82-93. View in: PubMed

Organic cation transporter variation and response to smoking cessation therapies. Nicotine Tob Res. 2014 Dec; 16(12):1638-46. View in: PubMed

A novel colorectal cancer risk locus at 4q32. 2 identified from an international genome-wide association study. Carcinogenesis. 2014 Nov; 35(11):2512-9. View in: PubMed

A comprehensive examination of breast cancer risk loci in African American women. Hum Mol Genet. 2014 Oct 15; 23(20):5518-26. View in: PubMed

The 19q12 Bladder Cancer GWAS Signal: Association with Cyclin E Function and Aggressive Disease. Cancer Res. 2014 Oct 15; 74(20):5808-18. View in: PubMed

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. Nat Genet. 2014 Oct; 46(10):1103-9. View in: PubMed

Genome-wide interaction study of smoking and bladder cancer risk. Carcinogenesis. 2014 Aug; 35(8):1737-44. View in: PubMed

Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai. Int J Cancer. 2014 Jul 15; 135(2):335-47. View in: PubMed

Nicotine dependence as a moderator of genetic influences on smoking cessation treatment outcome. Drug Alcohol Depend. 2014 May 1; 138:109-17. View in: PubMed

Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia. Gut. 2014 May; 63(5):800-7. View in: PubMed

Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q23. 1. Hum Mol Genet. 2014 Apr 15; 23(8):2198-209. View in: PubMed

A Genome-wide Association Study of Early-Onset Breast Cancer Identifies PFKM as a Novel Breast Cancer Gene and Supports a Common Genetic Spectrum for Breast Cancer at Any Age. Cancer Epidemiol Biomarkers Prev. 2014 Apr; 23(4):658-69. View in: PubMed

Deciphering the genetic architecture of low-penetrance susceptibility to colorectal cancer. Hum Mol Genet. 2013 Dec 15; 22(24):5075-82. View in: PubMed

Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion. Addiction. 2013 Dec; 108(12):2202-11. View in: PubMed

Sneaker "jack" males outcompete dominant "hooknose" males under sperm competition in Chinook salmon (Oncorhynchus tshawytscha). Ecol Evol. 2013 Dec; 3(15):4987-97. View in: PubMed

Genetic predictors of circulating 25-hydroxyvitamin d and risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2013 Nov; 22(11):2037-46. View in: PubMed

Partitioning the heritability of tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet. 2013 Oct; 9(10):e1003864. View in: PubMed

The DRD4 exon III VNTR, bupropion, and associations with prospective abstinence. Nicotine Tob Res. 2013 Jul; 15(7):1190-200. View in: PubMed

Efficient two-step testing of gene-gene interactions in genome-wide association studies. Genet Epidemiol. 2013 Jul; 37(5):440-51. View in: PubMed

Next generation sequencing and a new era of medicine. Gut. 2013 Jun; 62(6):920-32. View in: PubMed

Elevated 4-aminobiphenyl and 2,6-dimethylaniline hemoglobin adducts and increased risk of bladder cancer among lifelong nonsmokers--The Shanghai Bladder Cancer Study. Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):937-45. View in: PubMed

Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Gastroenterology. 2013 Apr; 144(4):799-807. e24. View in: PubMed

Confounding and heterogeneity in genetic association studies with admixed populations. Am J Epidemiol. 2013 Feb 15; 177(4):351-60. View in: PubMed

Nicotinic acetylcholine receptor variation and response to smoking cessation therapies. Pharmacogenet Genomics. 2013 Feb; 23(2):94-103. View in: PubMed

Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry. PLoS One. 2013; 8(4):e60464. View in: PubMed

A scalable, knowledge-based analysis framework for genetic association studies. BMC Bioinformatics. 2013; 14:312. View in: PubMed

Analysis and optimal design for association studies using next-generation sequencing with case-control pools. Genet Epidemiol. 2012 Dec; 36(8):870-81. View in: PubMed

Vitamin D levels in Hispanics with multiple sclerosis. J Neurol. 2012 Dec; 259(12):2565-70. View in: PubMed

Underlying genetic structure impacts the association between CYP2B6 polymorphisms and response to efavirenz and nevirapine. AIDS. 2012 Oct 23; 26(16):2097-106. View in: PubMed

DRD1 associations with smoking abstinence across slow and normal nicotine metabolizers. Pharmacogenet Genomics. 2012 Jul; 22(7):551-4. View in: PubMed

Cigarette smoking and subtypes of bladder cancer. Int J Cancer. 2012 Feb 15; 130(4):896-901. View in: PubMed

Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials. Neuropsychopharmacology. 2012 Feb; 37(3):641-50. View in: PubMed

Meta-analysis of new genome-wide association studies of colorectal cancer risk. Hum Genet. 2012 Feb; 131(2):217-34. View in: PubMed

A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21. 32. Blood. 2012 Jan 12; 119(2):469-75. View in: PubMed

Incorporating prior biologic information for high-dimensional rare variant association studies. Hum Hered. 2012; 74(3-4):184-95. View in: PubMed

Genome-wide search for gene-gene interactions in colorectal cancer. PLoS One. 2012; 7(12):e52535. View in: PubMed

Joint analysis for integrating two related studies of different data types and different study designs using hierarchical modeling approaches. Hum Hered. 2012; 74(2):83-96. View in: PubMed

Incorporating model uncertainty in detecting rare variants: the Bayesian risk index. Genet Epidemiol. 2011 Nov; 35(7):638-49. View in: PubMed

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet. 2011 Sep; 43(9):887-92. View in: PubMed

Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma. Nat Med. 2011 Aug; 17(8):941-3. View in: PubMed

The impact of change in visual field on health-related quality of life the los angeles latino eye study. Ophthalmology. 2011 Jul; 118(7):1310-7. View in: PubMed

Genetic contribution of the leukotriene pathway to coronary artery disease. Hum Genet. 2011 Jun; 129(6):617-27. View in: PubMed

Risk of contralateral breast cancer associated with common variants in BRCA1 and BRCA2: potential modifying effect of BRCA1/BRCA2 mutation carrier status. Breast Cancer Res Treat. 2011 Jun; 127(3):819-29. View in: PubMed

Genetic variation in insulin-like growth factor 2 may play a role in ovarian cancer risk. Hum Mol Genet. 2011 Jun 1; 20(11):2263-72. View in: PubMed

Lower risk in parous women suggests that hormonal factors are important in bladder cancer etiology. Cancer Epidemiol Biomarkers Prev. 2011 Jun; 20(6):1156-70. View in: PubMed

Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California. Am J Epidemiol. 2011 May 1; 173(9):1039-48. View in: PubMed

Relationships between IGF-1 and IGFBP-1 and adiposity in obese African-American and Latino adolescents. Obesity (Silver Spring). 2011 May; 19(5):933-8. View in: PubMed

Genotype-environment interactions in microsatellite stable/microsatellite instability-low colorectal cancer: results from a genome-wide association study. Cancer Epidemiol Biomarkers Prev. 2011 May; 20(5):758-66. View in: PubMed

Sample size requirements to detect gene-environment interactions in genome-wide association studies. Genet Epidemiol. 2011 Apr; 35(3):201-10. View in: PubMed

Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control study. Cancer Causes Control. 2011 Apr; 22(4):541-52. View in: PubMed

Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. Carcinogenesis. 2011 Feb; 32(2):197-202. View in: PubMed

Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development. BMC Med Genet. 2011; 12:156. View in: PubMed

Risk of urinary bladder cancer is associated with 8q24 variant rs9642880[T] in multiple racial/ethnic groups: results from the Los Angeles-Shanghai case-control study. Cancer Epidemiol Biomarkers Prev. 2010 Dec; 19(12):3150-6. View in: PubMed

Hypertension, diuretics and antihypertensives in relation to bladder cancer. Carcinogenesis. 2010 Nov; 31(11):1964-71. View in: PubMed

Discovery of complex pathways from observational data. Stat Med. 2010 Aug 30; 29(19):1998-2011. View in: PubMed

Genetic variation in the retinoid X receptor and calcium-sensing receptor and risk of colorectal cancer in the Colon Cancer Family Registry. Carcinogenesis. 2010 Aug; 31(8):1412-6. View in: PubMed

A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2010 Jul; 19(7):1812-21. View in: PubMed

A polytomous conditional likelihood approach for combining matched and unmatched case-control studies. Stat Med. 2010 Apr 30; 29(9):1004-13. View in: PubMed

Genes involved with folate uptake and distribution and their association with colorectal cancer risk. Cancer Causes Control. 2010 Apr; 21(4):597-608. View in: PubMed

Genetic polymorphisms in vitamin D receptor VDR/RXRA influence the likelihood of colon adenoma recurrence. Cancer Res. 2010 Feb 15; 70(4):1496-504. View in: PubMed

Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence. Thorax. 2010 Feb; 65(2):139-45. View in: PubMed

Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family Registry. Cancer Epidemiol Biomarkers Prev. 2010 Feb; 19(2):525-36. View in: PubMed

Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry. Cancer Epidemiol Biomarkers Prev. 2010 Jan; 19(1):89-100. View in: PubMed

Complex system approaches to genetic analysis Bayesian approaches. Adv Genet. 2010; 72:47-71. View in: PubMed

Sequence variant on 3q28 and urinary bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. Cancer Epidemiol Biomarkers Prev. 2009 Nov; 18(11):3057-61. View in: PubMed

Methodological Issues in Multistage Genome-wide Association Studies. Stat Sci. 2009 Nov 1; 24(4):414-429. View in: PubMed

Use of pathway information in molecular epidemiology. Hum Genomics. 2009 Oct; 4(1):21-42. View in: PubMed

Dopamine genes and nicotine dependence in treatment-seeking and community smokers. Neuropsychopharmacology. 2009 Sep; 34(10):2252-64. View in: PubMed

Effect of tidal volume in children with acute hypoxemic respiratory failure. Intensive Care Med. 2009 Aug; 35(8):1428-37. View in: PubMed

A systems biology network model for genetic association studies of nicotine addiction and treatment. Pharmacogenet Genomics. 2009 Jul; 19(7):538-51. View in: PubMed

Polymorphic variation in NFKB1 and other aspirin-related genes and risk of Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev. 2009 Mar; 18(3):976-86. View in: PubMed

Detecting gene-environment interactions using a combined case-only and case-control approach. Am J Epidemiol. 2009 Feb 15; 169(4):497-504. View in: PubMed

Variation in genetic admixture and population structure among Latinos: the Los Angeles Latino eye study (LALES). BMC Genet. 2009; 10:71. View in: PubMed

Water intake and bladder cancer risk in Los Angeles County. Int J Cancer. 2008 Oct 1; 123(7):1649-56. View in: PubMed

Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. Hum Mol Genet. 2008 Sep 15; 17(18):2834-48. View in: PubMed

Glutathione S-transferase P1, maternal smoking, and asthma in children: a haplotype-based analysis. Environ Health Perspect. 2008 Mar; 116(3):409-15. View in: PubMed

Comprehensive evaluation of ESR2 variation and ovarian cancer risk. Cancer Epidemiol Biomarkers Prev. 2008 Feb; 17(2):393-6. View in: PubMed

Prevalence of common disease-associated variants in Asian Indians. BMC Genet. 2008; 9:13. View in: PubMed

Snagger: a user-friendly program for incorporating additional information for tagSNP selection. BMC Bioinformatics. 2008; 9:174. View in: PubMed

Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry. Cancer Res. 2007 Dec 1; 67(23):11128-32. View in: PubMed

Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation. Genet Epidemiol. 2007 Dec; 31(8):871-82. View in: PubMed

DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study. Cancer Epidemiol Biomarkers Prev. 2007 Nov; 16(11):2363-72. View in: PubMed

The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics. Chest. 2007 Sep; 132(3):868-74. View in: PubMed

Alcohol consumption and risk of bladder cancer in Los Angeles County. Int J Cancer. 2007 Aug 15; 121(4):839-45. View in: PubMed

Testing association between disease and multiple SNPs in a candidate gene. Genet Epidemiol. 2007 Jul; 31(5):383-95. View in: PubMed

XRCC1, XRCC3, and XPD polymorphisms as modifiers of the effect of smoking and alcohol on colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev. 2006 Dec; 15(12):2384-90. View in: PubMed

Interleukin-6-related genotypes, body mass index, and risk of multiple myeloma and plasmacytoma. Cancer Epidemiol Biomarkers Prev. 2006 Nov; 15(11):2285-91. View in: PubMed

Age-related smoking progression among adolescents in China. J Adolesc Health. 2006 Nov; 39(5):686-93. View in: PubMed

A testing framework for identifying susceptibility genes in the presence of epistasis. Am J Hum Genet. 2006 Jan; 78(1):15-27. View in: PubMed

Testing association and linkage using affected-sib-parent study designs. Genet Epidemiol. 2005 Nov; 29(3):225-33. View in: PubMed

Intercellular adhesion molecule-1 and childhood asthma. Hum Genet. 2005 Sep; 117(5):476-84. View in: PubMed

Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating shbg levels among postmenopausal women: the Multiethnic Cohort. J Clin Endocrinol Metab. 2005 Apr; 90(4):2198-204. View in: PubMed

Identifying susceptibility genes by using joint tests of association and linkage and accounting for epistasis. BMC Genet. 2005; 6 Suppl 1:S147. View in: PubMed

SNPs, haplotypes, and model selection in a candidate gene region: the SIMPle analysis for multilocus data. Genet Epidemiol. 2004 Dec; 27(4):429-41. View in: PubMed

Relationship between methylenetetrahydrofolate reductase C677T and A1298C genotypes and haplotypes and prostate cancer risk and aggressiveness. Cancer Epidemiol Biomarkers Prev. 2004 Aug; 13(8):1331-6. View in: PubMed

A survey of current Bayesian gene mapping methods. Hum Genomics. 2004 Aug; 1(5):371-4. View in: PubMed

Genetic dissection of complex traits with chromosome substitution strains of mice. Science. 2004 Apr 16; 304(5669):445-8. View in: PubMed

Comprehensive evaluation of the association between prostate cancer and genotypes/haplotypes in CYP17A1, CYP3A4, and SRD5A2. Eur J Hum Genet. 2004 Apr; 12(4):321-32. View in: PubMed

Association of prostate cancer risk and aggressiveness to androgen pathway genes: SRD5A2, CYP17, and the AR. Prostate. 2004 Apr 1; 59(1):69-76. View in: PubMed

Commentary: the concept of 'Mendelian Randomization'. Int J Epidemiol. 2004 Feb; 33(1):21-5. View in: PubMed

DNA repair gene XRCC1 and XPD polymorphisms and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2004 Jan; 13(1):23-9. View in: PubMed

CYP3A4 and CYP3A5 genotypes, haplotypes, and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2003 Sep; 12(9):928-32. View in: PubMed

Prostate cancer aggressiveness locus on chromosome segment 19q12-q13. 1 identified by linkage and allelic imbalance studies. Genes Chromosomes Cancer. 2003 Apr; 36(4):332-9. View in: PubMed

Hierarchical modeling of linkage disequilibrium: genetic structure and spatial relations. Am J Hum Genet. 2003 Feb; 72(2):351-63. View in: PubMed

Comparison of missing data approaches in linkage analysis. BMC Genet. 2003; 4 Suppl 1:S44. View in: PubMed

Bayesian spatial modeling of haplotype associations. Hum Hered. 2003; 56(1-3):32-40. View in: PubMed

Bayesian modeling of complex metabolic pathways. Hum Hered. 2003; 56(1-3):83-93. View in: PubMed

Prostate cancer aggressiveness locus on chromosome 7q32-q33 identified by linkage and allelic imbalance studies. Neoplasia. 2002 Sep-Oct; 4(5):424-31. View in: PubMed

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