Faculty

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David Warburton, MD
Professor of Pediatrics
Pediatrics
CHLA 4650 W. Sunset Blvd. Off Campus Los Angeles
+1 323 361 5422

Overview

Professor David Warburton is a world leader in child health and regenerative medicine. Born and medically educated in London, at Harvard and Brown, he has made a broad translational impact in pediatrics. His major contributions range from clinical studies establishing management practices of extreme prematurity, to infants of diabetics, to basic mechanisms of organ morphogenesis, repair and regeneration. He is thus a seminal figure in neonatal- perinatal medicine, developmental biology, stem cell biology and regenerative medicine. His most highly cited work established and leads the field of molecular embryology of the lung, showing how growth factors and matrix molecules direct formation and repair of the gas exchange surface. Active UK collaborations include Liverpool, Cardiff and London, supported by UK Foreign and Commonwealth Office, MRC, BBSRC and build on his NIH and CIRM funded programs. He mentors UK Doctoral and Postdoctoral Fellows (Basic Science and Clinical), supported by funders ranging from MRC and Wellcome Trust to Royal College of Surgeons of England. An elected Fellow of the Royal Colleges of Surgeons, Physicians as well as Paediatrics and Child Health, he regularly gives keynotes at major US and world scientific meetings as well as teaching in Liverpool, Cardiff, Birmingham and London. In Los Angeles, he hosts UK and other foreign scientific delegations including the Ministers of Science, Heads of Welsh and Scottish Parliaments, Lords Mayor of Manchester and London and HRH Prince Andrew. His personal contribution and enthusiastic support for UK/US Science collaboration has been recognized by several awards including, in 2009, the Order of the British Empire. His commitment to the development of science for human benefit is evident from his many scientific and clinical discoveries, his personal mentoring through to his public advising.

Publications

Jakubzick CV, Warburton D. Can Alveolar Macrophages Made from Stem Cells Achieve Functional Rescue of Lung Diseases? Am J Respir Crit Care Med. 2016 Jun 1; 193(11):1187-8. View in: PubMed

Krainock M, Toubat O, Danopoulos S, Beckham A, Warburton D, Kim R. Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease. J Clin Med. 2016; 5(2). View in: PubMed

George UZ, Bokka KK, Warburton D, Lubkin SR. Quantifying stretch and secretion in the embryonic lung: Implications for morphogenesis. Mech Dev. 2015 Nov; 138 Pt 3:356-63. View in: PubMed

Buckley S, Shi W, Xu W, Frey MR, Moats R, Pardo A, Selman M, Warburton D. Increased alveolar soluble annexin V promotes lung inflammation and fibrosis. Eur Respir J. 2015 Nov; 46(5):1417-29. View in: PubMed

Bokka KK, Jesudason EC, Warburton D, Lubkin SR. Morphogenetic implications of peristaltic fluid-tissue dynamics in the embryonic lung. J Theor Biol. 2015 Oct 7; 382:378-85. View in: PubMed

Luo Y, Xu W, Chen H, Warburton D, Dong R, Qian B, Selman M, Gauldie J, Kolb M, Shi W. A novel profibrotic mechanism mediated by TGFß-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells. J Pathol. 2015 Jul; 236(3):384-94. View in: PubMed

Walentin K, Hinze C, Werth M, Haase N, Varma S, Morell R, Aue A, Pötschke E, Warburton D, Qiu A, Barasch J, Purfürst B, Dieterich C, Popova E, Bader M, Dechend R, Staff AC, Yurtdas ZY, Kilic E, Schmidt-Ott KM. A Grhl2-dependent gene network controls trophoblast branching morphogenesis. Development. 2015 Mar 15; 142(6):1125-36. View in: PubMed

Darehzereshki A, Rubin N, Gamba L, Kim J, Fraser J, Huang Y, Billings J, Mohammadzadeh R, Wood J, Warburton D, Kaartinen V, Lien CL. Differential regenerative capacity of neonatal mouse hearts after cryoinjury. Dev Biol. 2015 Mar 1; 399(1):91-9. View in: PubMed

Li Y, Trivedi V, Truong TV, Koos DS, Lansford R, Chuong CM, Warburton D, Moats RA, Fraser SE. Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis. Nat Commun. 2015; 6:6798. View in: PubMed

Luo Y, El Agha E, Turcatel G, Chen H, Chiu J, Warburton D, Bellusci S, Qian BP, Menke DB, Shi W. Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development. BMC Biol. 2015; 13:42. View in: PubMed

Bokka KK, Jesudason EC, Lozoya OA, Guilak F, Warburton D, Lubkin SR. Morphogenetic Implications of Peristalsis-Driven Fluid Flow in the Embryonic Lung. PLoS One. 2015; 10(7):e0132015. View in: PubMed

Varma S, Mahavadi P, Sasikumar S, Cushing L, Hyland T, Rosser AE, Riccardi D, Lu J, Kalin TV, Kalinichenko VV, Guenther A, Ramirez MI, Pardo A, Selman M, Warburton D. Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2014 Mar; 306(5):L405-19. View in: PubMed

Guo Y, Chen TH, Zeng X, Warburton D, Boström KI, Ho CM, Zhao X, Garfinkel A. Branching patterns emerge in a mathematical model of the dynamics of lung development. J Physiol. 2014 Jan 15; 592(Pt 2):313-24. View in: PubMed

Bower DV, Lee HK, Lansford R, Zinn K, Warburton D, Fraser SE, Jesudason EC. Airway branching has conserved needs for local parasympathetic innervation but not neurotransmission. BMC Biol. 2014; 12(1):92. View in: PubMed

Enkhmaa D, Warburton N, Javzandulam B, Uyanga J, Khishigsuren Y, Lodoysamba S, Enkhtur S, Warburton D. Seasonal ambient air pollution correlates strongly with spontaneous abortion in Mongolia. BMC Pregnancy Childbirth. 2014; 14(1):146. View in: PubMed

Moodley Y, Thompson P, Warburton D. Stem cells: a recapitulation of development. Respirology. 2013 Nov; 18(8):1167-76. View in: PubMed

Lu K, Reddy R, Berika M, Warburton D, El-Hashash AH. Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling. Dev Biol. 2013 Oct 1; 382(1):110-23. View in: PubMed

Wang Y, Huang Z, Nayak PS, Matthews BD, Warburton D, Shi W, Sanchez-Esteban J. Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin a6ß1-ADAM17/tumor necrosis factor-a-converting enzyme (TACE) signaling pathway. J Biol Chem. 2013 Aug 30; 288(35):25646-57. View in: PubMed

Al Alam D, Warburton D. Wingless: developmentally important genes that respond adversely to smoking. Thorax. 2013 Aug; 68(8):703-4. View in: PubMed

Warburton D, Gilliland F, Dashdendev B. Environmental pollution in Mongolia: effects across the lifespan. Environ Res. 2013 Jul; 124:65-6. View in: PubMed

Choi IS, Yu K, Kim J, De Guzman E, Weisenberger DJ, Oghamian S, Kim HJ, Lee KH, Carroll C, Trinh BN, Kim M, Houshdaran S, Laird PW, Jones PA, Warburton D, Liang G, Koh CJ. Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse model. Urology. 2013 Jul; 82(1):253. e9-15. View in: PubMed

Warburton D, Shi W, Xu B. TGF-ß-Smad3 signaling in emphysema and pulmonary fibrosis: an epigenetic aberration of normal development? Am J Physiol Lung Cell Mol Physiol. 2013 Jan 15; 304(2):L83-5. View in: PubMed

Garcia O, Carraro G, Turcatel G, Hall M, Sedrakyan S, Roche T, Buckley S, Driscoll B, Perin L, Warburton D. Amniotic fluid stem cells inhibit the progression of bleomycin-induced pulmonary fibrosis via CCL2 modulation in bronchoalveolar lavage. PLoS One. 2013; 8(8):e71679. View in: PubMed

Zhang W, Menke DB, Jiang M, Chen H, Warburton D, Turcatel G, Lu CH, Xu W, Luo Y, Shi W. Spatial-temporal targeting of lung-specific mesenchyme by a Tbx4 enhancer. BMC Biol. 2013; 11:111. View in: PubMed

Turcatel G, Rubin N, Menke DB, Martin G, Shi W, Warburton D. Lung mesenchymal expression of Sox9 plays a critical role in tracheal development. BMC Biol. 2013; 11:117. View in: PubMed

Warburton D, Garcia O. New ideas in lung regeneration: a personal view from Estoril. Expert Rev Respir Med. 2012 Nov; 6(5):507-8. View in: PubMed

Varma S, Cao Y, Tagne JB, Lakshminarayanan M, Li J, Friedman TB, Morell RJ, Warburton D, Kotton DN, Ramirez MI. The Transcription Factors Grainyhead-like 2 and NK2-Homeobox 1 Form a Regulatory Loop That Coordinates Lung Epithelial Cell Morphogenesis and Differentiation. J Biol Chem. 2012 Oct 26; 287(44):37282-95. View in: PubMed

Al Alam D, Sala FG, Baptista S, Galzote R, Danopoulos S, Tiozzo C, Gage P, Grikscheit T, Warburton D, Frey MR, Bellusci S. FGF9-Pitx2-FGF10 signaling controls cecal formation in mice. Dev Biol. 2012 Sep 15; 369(2):340-8. View in: PubMed

El-Hashash AH, Warburton D. Numb Expression and Asymmetric versus Symmetric Cell Division in Distal Embryonic Lung Epithelium. J Histochem Cytochem. 2012 Sep; 60(9):675-82. View in: PubMed

El-Hashash AH, Turcatel G, Varma S, Berika M, Al Alam D, Warburton D. Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J Cell Sci. 2012 Sep 1; 125(Pt 17):4036-48. View in: PubMed

Lee YS, Wysocki A, Warburton D, Tuan TL. Wound healing in development. Birth Defects Res C Embryo Today. 2012 Sep; 96(3):213-22. View in: PubMed

Garcia O, Buckley S, Navarro S, Driscoll B, Warburton D. Modulating the alveolar milieu to enhance resolution of fibrotic lung injury. Proc Am Thorac Soc. 2012 Jul; 9(3):117-9. View in: PubMed

Xu B, Chen H, Xu W, Zhang W, Buckley S, Zheng SG, Warburton D, Kolb M, Gauldie J, Shi W. Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2012 Jul; 303(2):L89-96. View in: PubMed

Sedrakyan S, Da Sacco S, Milanesi A, Shiri L, Petrosyan A, Varimezova R, Warburton D, Lemley KV, De Filippo RE, Perin L. Injection of amniotic fluid stem cells delays progression of renal fibrosis. J Am Soc Nephrol. 2012 Apr; 23(4):661-73. View in: PubMed

Tiozzo C, Danopoulos S, Lavarreda-Pearce M, Baptista S, Varimezova R, Al Alam D, Warburton D, Virender R, De Langhe S, Di Cristofano A, Bellusci S, Minoo P. Embryonic epithelial Pten deletion through Nkx2. 1-cre leads to thyroid tumorigenesis in a strain-dependent manner. Endocr Relat Cancer. 2012 Apr; 19(2):111-22. View in: PubMed

Warburton D. Developmental responses to lung injury: repair or fibrosis. Fibrogenesis Tissue Repair. 2012; 5(Suppl 1):S2. View in: PubMed

Xu W, Lan Q, Chen M, Chen H, Zhu N, Zhou X, Wang J, Fan H, Yan CS, Kuang JL, Warburton D, Togbe D, Ryffel B, Zheng SG, Shi W. Adoptive transfer of induced-treg cells effectively attenuates murine airway allergic inflammation. PLoS One. 2012; 7(7):e40314. View in: PubMed

Driscoll B, Kikuchi A, Lau AN, Lee J, Reddy R, Jesudason E, Kim CF, Warburton D. Isolation and characterization of distal lung progenitor cells. Methods Mol Biol. 2012; 879:109-22. View in: PubMed

Matthews JA, Sala FG, Speer AL, Li Y, Warburton D, Grikscheit TC. Mesenchymal-specific inhibition of vascular endothelial growth factor (VEGF) attenuates growth in neonatal mice. J Surg Res. 2012 Jan; 172(1):40-7. View in: PubMed

Sanchez-Lara PA, Zhao H, Bajpai R, Abdelhamid AI, Warburton D. Impact of stem cells in craniofacial regenerative medicine. Front Physiol. 2012; 3:188. View in: PubMed

Garcia O, Carraro G, Navarro S, Bertoncello I, McQualter J, Driscoll B, Jesudason E, Warburton D. Cell-based therapies for lung disease. Br Med Bull. 2012; 101:147-61. View in: PubMed

Turcatel G, Rubin N, El-Hashash A, Warburton D. MIR-99a and MIR-99b Modulate TGF-ß Induced Epithelial to Mesenchymal Plasticity in Normal Murine Mammary Gland Cells. PLoS One. 2012; 7(1):e31032. View in: PubMed

Buckley S, Shi W, Carraro G, Sedrakyan S, Da Sacco S, Driscoll BA, Perin L, De Filippo RE, Warburton D. The milieu of damaged alveolar epithelial type 2 cells stimulates alveolar wound repair by endogenous and exogenous progenitors. Am J Respir Cell Mol Biol. 2011 Dec; 45(6):1212-21. View in: PubMed

Farkas L, Farkas D, Warburton D, Gauldie J, Shi W, Stampfli MR, Voelkel NF, Kolb M. Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis in Smad3 knockout mice. Am J Physiol Lung Cell Mol Physiol. 2011 Oct; 301(4):L391-401. View in: PubMed

Matthews JA, Sala FG, Speer AL, Warburton D, Grikscheit TC. VEGF optimizes the formation of tissue-engineered small intestine. Regen Med. 2011 Sep; 6(5):559-67. View in: PubMed

Farkas L, Farkas D, Gauldie J, Warburton D, Shi W, Kolb M. Transient overexpression of Gremlin results in epithelial activation and reversible fibrosis in rat lungs. Am J Respir Cell Mol Biol. 2011 Jun; 44(6):870-8. View in: PubMed

Lazarus A, Del-Moral PM, Ilovich O, Mishani E, Warburton D, Keshet E. A perfusion-independent role of blood vessels in determining branching stereotypy of lung airways. Development. 2011 Jun; 138(11):2359-68. View in: PubMed

Weiss DJ, Bertoncello I, Borok Z, Kim C, Panoskaltsis-Mortari A, Reynolds S, Rojas M, Stripp B, Warburton D, Prockop DJ. Stem cells and cell therapies in lung biology and lung diseases. Proc Am Thorac Soc. 2011 Jun; 8(3):223-72. View in: PubMed

Jackson SR, Lee J, Reddy R, Williams GN, Kikuchi A, Freiberg Y, Warburton D, Driscoll B. Partial pneumonectomy of telomerase null mice carrying shortened telomeres initiates cell growth arrest resulting in a limited compensatory growth response. Am J Physiol Lung Cell Mol Physiol. 2011 Jun; 300(6):L898-909. View in: PubMed

El-Hashash AH, Al Alam D, Turcatel G, Rogers O, Li X, Bellusci S, Warburton D. Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 May 15; 353(2):242-58. View in: PubMed

Dashdendev B, Fukushima LK, Woo MS, Ganbaatar E, Warburton D. Carbon monoxide pollution and lung function in urban compared with rural Mongolian children. Respirology. 2011 May; 16(4):653-8. View in: PubMed

El-Hashash AH, Turcatel G, Al Alam D, Buckley S, Tokumitsu H, Bellusci S, Warburton D. Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development. 2011 Apr; 138(7):1395-407. View in: PubMed

El-Hashash AH, Warburton D. Cell polarity and spindle orientation in the distal epithelium of embryonic lung. Dev Dyn. 2011 Feb; 240(2):441-5. View in: PubMed

El-Hashash AH, Al Alam D, Turcatel G, Bellusci S, Warburton D. Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 Feb 1; 350(1):112-26. View in: PubMed

Jackson SR, Williams GN, Lee J, Baer JF, Warburton D, Driscoll B. A modified technique for partial pneumonectomy in the mouse. J Invest Surg. 2011; 24(2):81-6. View in: PubMed

Al Alam D, Green M, Tabatabai Irani R, Parsa S, Danopoulos S, Sala FG, Branch J, El Agha E, Tiozzo C, Voswinckel R, Jesudason EC, Warburton D, Bellusci S. Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair. PLoS One. 2011; 6(8):e23139. View in: PubMed

Frey MR, Carraro G, Batra RK, Polk DB, Warburton D. Sprouty keeps bowel kinases regular in colon cancer, while miR-21 targets Sprouty. Cancer Biol Ther. 2011 Jan 1; 11(1):122-4. View in: PubMed

Sala FG, Del Moral PM, Tiozzo C, Alam DA, Warburton D, Grikscheit T, Veltmaat JM, Bellusci S. FGF10 controls the patterning of the tracheal cartilage rings via Shh. Development. 2011 Jan; 138(2):273-82. View in: PubMed

Jesudason EC, Keshet E, Warburton D. Entrained pulmonary clocks: epithelium and vasculature keeping pace. Am J Physiol Lung Cell Mol Physiol. 2010 Oct; 299(4):L453-4. View in: PubMed

Batra RK, Warburton D. On the derivation and clinical implications of "driver" mutations in lung cancer. Am J Respir Crit Care Med. 2010 Jul 1; 182(1):4-5. View in: PubMed

Da Sacco S, Sedrakyan S, Boldrin F, Giuliani S, Parnigotto P, Habibian R, Warburton D, De Filippo RE, Perin L. Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications. J Urol. 2010 Mar; 183(3):1193-200. View in: PubMed

Sharma S, Tantisira K, Carey V, Murphy AJ, Lasky-Su J, Celedón JC, Lazarus R, Klanderman B, Rogers A, Soto-Quirós M, Avila L, Mariani T, Gaedigk R, Leeder S, Torday J, Warburton D, Raby B, Weiss ST. A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. Am J Respir Crit Care Med. 2010 Feb 15; 181(4):328-36. View in: PubMed

Carraro G, del Moral PM, Warburton D. Mouse embryonic lung culture, a system to evaluate the molecular mechanisms of branching. J Vis Exp. 2010; (40). View in: PubMed

Del Moral PM, Warburton D. Explant culture of mouse embryonic whole lung, isolated epithelium, or mesenchyme under chemically defined conditions as a system to evaluate the molecular mechanism of branching morphogenesis and cellular differentiation. Methods Mol Biol. 2010; 633:71-9. View in: PubMed

El-Hashash AH, Warburton D, Kimber SJ. Genes and signals regulating murine trophoblast cell development. Mech Dev. 2010 Jan-Feb; 127(1-2):1-20. View in: PubMed

Chung S, Kang DO, Yamzon J, Warburton D, Koh CJ. O-GlcNAc mediated glycosylation down-regulation in mice with cyclophosphamide induced cystitis. J Urol. 2010 Jan; 183(1):351-6. View in: PubMed

Perin L, Sedrakyan S, Giuliani S, Da Sacco S, Carraro G, Shiri L, Lemley KV, Rosol M, Wu S, Atala A, Warburton D, De Filippo RE. Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis. PLoS One. 2010; 5(2):e9357. View in: PubMed

Warburton D, El-Hashash A, Carraro G, Tiozzo C, Sala F, Rogers O, De Langhe S, Kemp PJ, Riccardi D, Torday J, Bellusci S, Shi W, Lubkin SR, Jesudason E. Lung organogenesis. Curr Top Dev Biol. 2010; 90:73-158. View in: PubMed

Maciewicz RA, Warburton D, Rennard SI. Can increased understanding of the role of lung development and aging drive new advances in chronic obstructive pulmonary disease? Proc Am Thorac Soc. 2009 Dec 1; 6(7):614-7. View in: PubMed

Rennard SI, Warburton D. Introduction: Ninth Lund COPD Symposium. Proc Am Thorac Soc. 2009 Dec 1; 6(7):557. View in: PubMed

Cunnick JM, Schmidhuber S, Chen G, Yu M, Yi SJ, Cho YJ, Kaartinen V, Minoo P, Warburton D, Groffen J, Heisterkamp N. Bcr and Abr cooperate in negatively regulating acute inflammatory responses. Mol Cell Biol. 2009 Nov; 29(21):5742-50. View in: PubMed

Tiozzo C, De Langhe S, Carraro G, Alam DA, Nagy A, Wigfall C, Hajihosseini MK, Warburton D, Minoo P, Bellusci S. Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome. Pediatr Res. 2009 Oct; 66(4):386-90. View in: PubMed

Carraro G, El-Hashash A, Guidolin D, Tiozzo C, Turcatel G, Young BM, De Langhe SP, Bellusci S, Shi W, Parnigotto PP, Warburton D. miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution. Dev Biol. 2009 Sep 15; 333(2):238-50. View in: PubMed

Gupte VV, Ramasamy SK, Reddy R, Lee J, Weinreb PH, Violette SM, Guenther A, Warburton D, Driscoll B, Minoo P, Bellusci S. Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med. 2009 Sep 1; 180(5):424-36. View in: PubMed

Shi W, Xu J, Warburton D. Development, repair and fibrosis: what is common and why it matters. Respirology. 2009 Jul; 14(5):656-65. View in: PubMed

Wang Y, Maciejewski BS, Soto-Reyes D, Lee HS, Warburton D, Sanchez-Esteban J. Mechanical stretch promotes fetal type II epithelial cell differentiation via shedding of HB-EGF and TGF-alpha. J Physiol. 2009 Apr 15; 587(Pt 8):1739-53. View in: PubMed

Warburton D, Chiu A, Lee KA, Chung HM, Cha KY, Kim KS. The 2nd International Collaborative Symposium on Stem Cell Research. Regen Med. 2009 Jan; 4(1):129-31. View in: PubMed

Finney BA, del Moral PM, Wilkinson WJ, Cayzac S, Cole M, Warburton D, Kemp PJ, Riccardi D. Regulation of mouse lung development by the extracellular calcium-sensing receptor, CaR. J Physiol. 2008 Dec 15; 586(Pt 24):6007-19. View in: PubMed

Carraro G, Perin L, Sedrakyan S, Giuliani S, Tiozzo C, Lee J, Turcatel G, De Langhe SP, Driscoll B, Bellusci S, Minoo P, Atala A, De Filippo RE, Warburton D. Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages. Stem Cells. 2008 Nov; 26(11):2902-11. View in: PubMed

Ding W, Warburton D. Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-alpha. Biochem Biophys Res Commun. 2008 Oct 24; 375(3):460-4. View in: PubMed

Warburton D, Perin L, Defilippo R, Bellusci S, Shi W, Driscoll B. Stem/progenitor cells in lung development, injury repair, and regeneration. Proc Am Thorac Soc. 2008 Aug 15; 5(6):703-6. View in: PubMed

Warburton D. Developmental biology: order in the lung. Nature. 2008 Jun 5; 453(7196):733-5. View in: PubMed

Heisterkamp N, Groffen J, Warburton D, Sneddon TP. The human gamma-glutamyltransferase gene family. Hum Genet. 2008 May; 123(4):321-32. View in: PubMed

Sun J, Chen H, Chen C, Whitsett JA, Mishina Y, Bringas P, Ma JC, Warburton D, Shi W. Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation. Am J Pathol. 2008 Mar; 172(3):571-82. View in: PubMed

Unbekandt M, del Moral PM, Sala FG, Bellusci S, Warburton D, Fleury V. Tracheal occlusion increases the rate of epithelial branching of embryonic mouse lung via the FGF10-FGFR2b-Sprouty2 pathway. Mech Dev. 2008 Mar-Apr; 125(3-4):314-24. View in: PubMed

Shan L, Subramaniam M, Emanuel RL, Degan S, Johnston P, Tefft D, Warburton D, Sunday ME. Centrifugal migration of mesenchymal cells in embryonic lung. Dev Dyn. 2008 Mar; 237(3):750-7. View in: PubMed

Ask K, Bonniaud P, Maass K, Eickelberg O, Margetts PJ, Warburton D, Groffen J, Gauldie J, Kolb M. Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3. Int J Biochem Cell Biol. 2008; 40(3):484-95. View in: PubMed

Moeller A, Ask K, Warburton D, Gauldie J, Kolb M. The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? Int J Biochem Cell Biol. 2008; 40(3):362-82. View in: PubMed

Warburton D, Kaartinen V. When the lung is stretched, could it be thrombospondin via TGFbeta1 peptide activation? J Physiol. 2007 Oct 15; 584(Pt 2):365. View in: PubMed

Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, Smith SM, Derynck R. TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J. 2007 Sep 5; 26(17):3957-67. View in: PubMed

Ding W, Shi W, Bellusci S, Groffen J, Heisterkamp N, Minoo P, Warburton D. Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells. J Cell Physiol. 2007 Sep; 212(3):796-806. View in: PubMed

Shi W, Bellusci S, Warburton D. Lung development and adult lung diseases. Chest. 2007 Aug; 132(2):651-6. View in: PubMed

Ramasamy SK, Mailleux AA, Gupte VV, Mata F, Sala FG, Veltmaat JM, Del Moral PM, De Langhe S, Parsa S, Kelly LK, Kelly R, Shia W, Keshet E, Minoo P, Warburton D, Bellusci S. Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development. Dev Biol. 2007 Jul 15; 307(2):237-47. View in: PubMed

Zhu NL, Li C, Huang HH, Sebald M, Londhe VA, Heisterkamp N, Warburton D, Bellusci S, Minoo P. TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells. Gene. 2007 May 15; 393(1-2):70-80. View in: PubMed

Warburton D, Koh C, Chung HM, Cha KR, Kim KS. Meeting report: the first international collaborative symposium on stem cell research, Seoul, Korea. Stem Cells. 2007 May; 25(5):1337-8. View in: PubMed

Sala FG, Curtis JL, Veltmaat JM, Del Moral PM, Le LT, Fairbanks TJ, Warburton D, Ford H, Wang K, Burns RC, Bellusci S. Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development. Dev Biol. 2006 Nov 15; 299(2):373-85. View in: PubMed

Warburton D, Gauldie J, Bellusci S, Shi W. Lung development and susceptibility to chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Nov; 3(8):668-72. View in: PubMed

De Langhe SP, Carraro G, Warburton D, Hajihosseini MK, Bellusci S. Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev Biol. 2006 Nov 1; 299(1):52-62. View in: PubMed

Gauldie J, Kolb M, Ask K, Martin G, Bonniaud P, Warburton D. Smad3 signaling involved in pulmonary fibrosis and emphysema. Proc Am Thorac Soc. 2006 Nov; 3(8):696-702. View in: PubMed

Sun J, Zhuang FF, Mullersman JE, Chen H, Robertson EJ, Warburton D, Liu YH, Shi W. BMP4 activation and secretion are negatively regulated by an intracellular gremlin-BMP4 interaction. J Biol Chem. 2006 Sep 29; 281(39):29349-56. View in: PubMed

Li WY, Huang EY, Dudas M, Kaartinen V, Warburton D, Tuan TL. Transforming growth factor-beta3 affects plasminogen activator inhibitor-1 expression in fetal mice and modulates fibroblast-mediated collagen gel contraction. Wound Repair Regen. 2006 Sep-Oct; 14(5):516-25. View in: PubMed

del Moral PM, De Langhe SP, Sala FG, Veltmaat JM, Tefft D, Wang K, Warburton D, Bellusci S. Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung. Dev Biol. 2006 May 1; 293(1):77-89. View in: PubMed

Del Moral PM, Sala FG, Tefft D, Shi W, Keshet E, Bellusci S, Warburton D. VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. Dev Biol. 2006 Feb 1; 290(1):177-88. View in: PubMed

Fairbanks TJ, Sala FG, Kanard R, Curtis JL, Del Moral PM, De Langhe S, Warburton D, Anderson KD, Bellusci S, Burns RC. The fibroblast growth factor pathway serves a regulatory role in proliferation and apoptosis in the pathogenesis of intestinal atresia. J Pediatr Surg. 2006 Jan; 41(1):132-6; discussion 132-6. View in: PubMed

Warburton D, Shi W. Lo, and the niche is knit: lysyl oxidase activity and maintenance of lung, aorta, and skin integrity. Am J Pathol. 2005 Oct; 167(4):921-2. View in: PubMed

Tefft D, De Langhe SP, Del Moral PM, Sala F, Shi W, Bellusci S, Warburton D. A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis. Dev Biol. 2005 Jun 15; 282(2):422-31. View in: PubMed

Chen C, Chen H, Sun J, Bringas P, Chen Y, Warburton D, Shi W. Smad1 expression and function during mouse embryonic lung branching morphogenesis. Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6):L1033-9. View in: PubMed

Phagoo SB, Reddi K, Silvallana BJ, Leeb-Lundberg LM, Warburton D. Infection-induced kinin B1 receptors in human pulmonary fibroblasts: role of intact pathogens and p38 mitogen-activated protein kinase-dependent signaling. J Pharmacol Exp Ther. 2005 Jun; 313(3):1231-8. View in: PubMed

Warburton D, Bellusci S, De Langhe S, Del Moral PM, Fleury V, Mailleux A, Tefft D, Unbekandt M, Wang K, Shi W. Molecular mechanisms of early lung specification and branching morphogenesis. Pediatr Res. 2005 May; 57(5 Pt 2):26R-37R. View in: PubMed

Chen H, Sun J, Buckley S, Chen C, Warburton D, Wang XF, Shi W. Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. Am J Physiol Lung Cell Mol Physiol. 2005 Apr; 288(4):L683-91. View in: PubMed

Kanard RC, Fairbanks TJ, De Langhe SP, Sala FG, Del Moral PM, Lopez CA, Warburton D, Anderson KD, Bellusci S, Burns RC. Fibroblast growth factor-10 serves a regulatory role in duodenal development. J Pediatr Surg. 2005 Feb; 40(2):313-6. View in: PubMed

Fairbanks TJ, Kanard RC, Del Moral PM, Sala FG, De Langhe SP, Lopez CA, Veltmaat JM, Warburton D, Anderson KD, Bellusci S, Burns RC. Colonic atresia without mesenteric vascular occlusion. The role of the fibroblast growth factor 10 signaling pathway. J Pediatr Surg. 2005 Feb; 40(2):390-6. View in: PubMed

De Langhe SP, Sala FG, Del Moral PM, Fairbanks TJ, Yamada KM, Warburton D, Burns RC, Bellusci S. Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung. Dev Biol. 2005 Jan 15; 277(2):316-31. View in: PubMed

Ding W, Bellusci S, Shi W, Warburton D. Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L52-9. View in: PubMed

Fairbanks TJ, Kanard R, Del Moral PM, Sala FG, De Langhe S, Warburton D, Anderson KD, Bellusci S, Burns RC. Fibroblast growth factor receptor 2 IIIb invalidation--a potential cause of familial duodenal atresia. J Pediatr Surg. 2004 Jun; 39(6):872-4. View in: PubMed

Reddy R, Buckley S, Doerken M, Barsky L, Weinberg K, Anderson KD, Warburton D, Driscoll B. Isolation of a putative progenitor subpopulation of alveolar epithelial type 2 cells. Am J Physiol Lung Cell Mol Physiol. 2004 Apr; 286(4):L658-67. View in: PubMed

Fairbanks TJ, De Langhe S, Sala FG, Warburton D, Anderson KD, Bellusci S, Burns RC. Fibroblast growth factor 10 (Fgf10) invalidation results in anorectal malformation in mice. J Pediatr Surg. 2004 Mar; 39(3):360-5; discussion 360-5. View in: PubMed

Shi W, Chen H, Sun J, Chen C, Zhao J, Wang YL, Anderson KD, Warburton D. Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins. Am J Physiol Lung Cell Mol Physiol. 2004 Feb; 286(2):L293-300. View in: PubMed

Warburton D, Berberich MA, Driscoll B. Stem/progenitor cells in lung morphogenesis, repair, and regeneration. Curr Top Dev Biol. 2004; 64:1-16. View in: PubMed

Warburton D, Bellusci S. The molecular genetics of lung morphogenesis and injury repair. Paediatr Respir Rev. 2004; 5 Suppl A:S283-7. View in: PubMed

Ding W, Bellusci S, Shi W, Warburton D. Functional analysis of the human Sprouty2 gene promoter. Gene. 2003 Dec 11; 322:175-85. View in: PubMed

Gauldie J, Galt T, Bonniaud P, Robbins C, Kelly M, Warburton D. Transfer of the active form of transforming growth factor-beta 1 gene to newborn rat lung induces changes consistent with bronchopulmonary dysplasia. Am J Pathol. 2003 Dec; 163(6):2575-84. View in: PubMed

Shi W, Chen H, Sun J, Buckley S, Zhao J, Anderson KD, Williams RG, Warburton D. TACE is required for fetal murine cardiac development and modeling. Dev Biol. 2003 Sep 15; 261(2):371-80. View in: PubMed

Reddi K, Phagoo SB, Anderson KD, Warburton D. Burkholderia cepacia-induced IL-8 gene expression in an alveolar epithelial cell line: signaling through CD14 and mitogen-activated protein kinase. Pediatr Res. 2003 Sep; 54(3):297-305. View in: PubMed

Kaartinen V, Warburton D. Fibrillin controls TGF-beta activation. Nat Genet. 2003 Mar; 33(3):331-2. View in: PubMed

Flores-Delgado G, Anderson KD, Warburton D. Nongenomic estrogen action regulates tyrosine phosphatase activity and tuberin stability. Mol Cell Endocrinol. 2003 Jan 31; 199(1-2):143-51. View in: PubMed

Warburton D, Bellusci S, Del Moral PM, Kaartinen V, Lee M, Tefft D, Shi W. Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry. Respir Res. 2003; 4:5. View in: PubMed

Huang EY, Wu H, Island ER, Chong SS, Warburton D, Anderson KD, Tuan TL. Differential expression of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in early and late gestational mouse skin and skin wounds. Wound Repair Regen. 2002 Nov-Dec; 10(6):387-96. View in: PubMed

Leinwand MJ, Tefft JD, Zhao J, Coleman C, Anderson KD, Warburton D. Nitrofen inhibition of pulmonary growth and development occurs in the early embryonic mouse. J Pediatr Surg. 2002 Sep; 37(9):1263-8. View in: PubMed

Leinwand MJ, Zhao J, Tefft JD, Anderson KD, Warburton D. Murine nitrofen-induced pulmonary hypoplasia does not involve induction of TGF-beta signaling. J Pediatr Surg. 2002 Aug; 37(8):1123-7. View in: PubMed

Warburton D. Sound the tocsin! Beware adverse effects of lung inflammation early in gestation. Am J Respir Crit Care Med. 2002 Mar 15; 165(6):741-2. View in: PubMed

Zhao J, Shi W, Wang YL, Chen H, Bringas P, Datto MB, Frederick JP, Wang XF, Warburton D. Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol. 2002 Mar; 282(3):L585-93. View in: PubMed

Warburton D, Tefft D, Mailleux A, Bellusci S, Thiery JP, Zhao J, Buckley S, Shi W, Driscoll B. Do lung remodeling, repair, and regeneration recapitulate respiratory ontogeny? Am J Respir Crit Care Med. 2001 Nov 15; 164(10 Pt 2):S59-62. View in: PubMed

Warburton D, Zhao J, Berberich MA, Bernfield M. Molecular embryology of the lung: then, now, and in the future. Am J Physiol. 1999 May; 276(5 Pt 1):L697-704. View in: PubMed

Warburton D, Wuenschell C, Flores-Delgado G, Anderson K. Commitment and differentiation of lung cell lineages. Biochem Cell Biol. 1998; 76(6):971-95. View in: PubMed

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