Faculty

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Denis Evseenko, MD, PhD
Associate Professor of Orthopaedic Surgery
Orthopaedic Surgery
HMR 712 2011 Zonal Avenue Off Campus Los Angeles
+1 323 442 2422

Overview

Dr. Denis Evseenko is currently an Associate Professor of Orthopaedic Surgery, Stem Cell Research and Regenerative Medicine at USC. Dr Evseenko was trained in both medicine and molecular pharmacology. His research focuses on the development of novel translational stem cell and small molecule-based approaches for prevention of arthritis and restoration of damaged articular cartilage. Dr Evseenko has been involved in translational research for over 10 years and is the author of numerous peer-reviewed research articles, presentations and patents.

Evseenko Lab Website

Awards

Arthritis National Research Foundation: James Klinenberg Award, 2015

Wright Foundation: Wright Foundation Award, 2016

USC: USC Stevens Technology Advancement Grant, 2016

Publications

Markolf KL, Evseenko D, Petrigliano F. Right-Left Differences in Knee Extension Stiffness for the Normal Rat Knee: In Vitro Measurements Using a New Testing Apparatus. J Biomech Eng. 2016 Apr 1; 138(4). View in: PubMed

Chin CJ, Cooper AR, Lill GR, Evseenko D, Zhu Y, He CB, Casero D, Pellegrini M, Kohn DB, Crooks GM. Genetic Tagging During Human Mesoderm Differentiation Reveals Tripotent Lateral Plate Mesodermal Progenitors. Stem Cells. 2016 Mar 2. View in: PubMed

Wu L, Prins HJ, Leijten J, Helder MN, Evseenko D, Moroni L, van Blitterswijk CA, Lin Y, Karperien M. Chondrocytes Cocultured with Stromal Vascular Fraction of Adipose Tissue Present More Intense Chondrogenic Characteristics Than with Adipose Stem Cells. Tissue Eng Part A. 2016 Feb; 22(3-4):336-48. View in: PubMed

Kowalski TJ, Leong NL, Dar A, Wu L, Kabir N, Khan AZ, Eliasberg C, Pedron A, Karayan A, Lee S, von Treuheim TD, Jiacheng J, Wu BM, Evseenko D, McAllister DR, Petrigliano FA. Hypoxic culture conditions induce increased metabolic rate and collagen gene expression in ACL-derived cells. J Orthop Res. 2015 Dec 1. View in: PubMed

Zhang S, Ba K, Wu L, Lee S, Peault B, Petrigliano FA, McAllister DR, Adams JS, Evseenko D, Lin Y. Adventitial Cells and Perictyes Support Chondrogenesis Through Different Mechanisms in 3-Dimensional Cultures With or Without Nanoscaffolds. J Biomed Nanotechnol. 2015 Oct; 11(10):1799-807. View in: PubMed

Richardson W, Wilkinson D, Wu L, Petrigliano F, Dunn B, Evseenko D. Ensemble multivariate analysis to improve identification of articular cartilage disease in noisy Raman spectra. J Biophotonics. 2015 Jul; 8(7):555-66. View in: PubMed

Choi B, Kim S, Fan J, Kowalski T, Petrigliano F, Evseenko D, Lee M. Covalently conjugated transforming growth factor-ß1 in modular chitosan hydrogels for the effective treatment of articular cartilage defects. Biomater Sci. 2015 May 21; 3(5):742-52. View in: PubMed

Choi B, Kim S, Lin B, Li K, Bezouglaia O, Kim J, Evseenko D, Aghaloo T, Lee M. Visible-light-initiated hydrogels preserving cartilage extracellular signaling for inducing chondrogenesis of mesenchymal stem cells. Acta Biomater. 2015 Jan 15; 12:30-41. View in: PubMed

Kim J, Lin B, Kim S, Choi B, Evseenko D, Lee M. TGF-ß1 conjugated chitosan collagen hydrogels induce chondrogenic differentiation of human synovium-derived stem cells. J Biol Eng. 2015; 9:1. View in: PubMed

Vadivel K, Ponnuraj SM, Kumar Y, Zaiss AK, Bunce MW, Camire RM, Wu L, Evseenko D, Herschman HR, Bajaj MS, Bajaj SP. Platelets contain tissue factor pathway inhibitor-2 derived from megakaryocytes and inhibits fibrinolysis. J Biol Chem. 2014 Nov 7; 289(45):31647-61. View in: PubMed

Wu L, Gonzalez S, Shah S, Kyupelyan L, Petrigliano FA, McAllister DR, Adams JS, Karperien M, Tuan TL, Benya PD, Evseenko D. Extracellular matrix domain formation as an indicator of chondrocyte dedifferentiation and hypertrophy. Tissue Eng Part C Methods. 2014 Feb; 20(2):160-8. View in: PubMed

Arshi A, Nakashima Y, Nakano H, Eaimkhong S, Evseenko D, Reed J, Stieg AZ, Gimzewski JK, Nakano A. Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells. Sci Technol Adv Mater. 2013 Aug 1; 14(2). View in: PubMed

Bluguermann C, Wu L, Petrigliano F, McAllister D, Miriuka S, Evseenko DA. Novel aspects of parenchymal-mesenchymal interactions: from cell types to molecules and beyond. Cell Biochem Funct. 2013 Jun; 31(4):271-80. View in: PubMed

Corselli M, Chin CJ, Parekh C, Sahaghian A, Wang W, Ge S, Evseenko D, Wang X, Montelatici E, Lazzari L, Crooks GM, Péault B. Perivascular support of human hematopoietic stem/progenitor cells. Blood. 2013 Apr 11; 121(15):2891-901. View in: PubMed

Wu L, Bluguermann C, Kyupelyan L, Latour B, Gonzalez S, Shah S, Galic Z, Ge S, Zhu Y, Petrigliano FA, Nsair A, Miriuka SG, Li X, Lyons KM, Crooks GM, McAllister DR, Van Handel B, Adams JS, Evseenko D. Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells. Stem Cell Reports. 2013; 1(6):575-89. View in: PubMed

Evseenko D, Latour B, Richardson W, Corselli M, Sahaghian A, Cardinal S, Zhu Y, Chan R, Dunn B, Crooks GM. Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. PLoS One. 2013; 8(5):e63718. View in: PubMed

Nsair A, Schenke-Layland K, Van Handel B, Evseenko D, Kahn M, Zhao P, Mendelis J, Heydarkhan S, Awaji O, Vottler M, Geist S, Chyu J, Gago-Lopez N, Crooks GM, Plath K, Goldhaber J, Mikkola HK, MacLellan WR. Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells. PLoS One. 2012; 7(10):e45603. View in: PubMed

Dravid G, Zhu Y, Scholes J, Evseenko D, Crooks GM. Dysregulated gene expression during hematopoietic differentiation from human embryonic stem cells. Mol Ther. 2011 Apr; 19(4):768-81. View in: PubMed

Evseenko D, Zhu Y, Schenke-Layland K, Kuo J, Latour B, Ge S, Scholes J, Dravid G, Li X, MacLellan WR, Crooks GM. Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells. Proc Natl Acad Sci U S A. 2010 Aug 3; 107(31):13742-7. View in: PubMed

Evseenko D, Schenke-Layland K, Dravid G, Zhu Y, Hao QL, Scholes J, Wang XC, Maclellan WR, Crooks GM. Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assembly. Stem Cells Dev. 2009 Jul-Aug; 18(6):919-28. View in: PubMed

Evseenko DA, Murthi P, Paxton JW, Reid G, Emerald BS, Mohankumar KM, Lobie PE, Brennecke SP, Kalionis B, Keelan JA. The ABC transporter BCRP/ABCG2 is a placental survival factor, and its expression is reduced in idiopathic human fetal growth restriction. FASEB J. 2007 Nov; 21(13):3592-605. View in: PubMed

Evseenko DA, Paxton JW, Keelan JA. Independent regulation of apical and basolateral drug transporter expression and function in placental trophoblasts by cytokines, steroids, and growth factors. Drug Metab Dispos. 2007 Apr; 35(4):595-601. View in: PubMed

Evseenko DA, Paxton JW, Keelan JA. ABC drug transporter expression and functional activity in trophoblast-like cell lines and differentiating primary trophoblast. Am J Physiol Regul Integr Comp Physiol. 2006 May; 290(5):R1357-65. View in: PubMed

Evseenko D, Paxton JW, Keelan JA. Active transport across the human placenta: impact on drug efficacy and toxicity. Expert Opin Drug Metab Toxicol. 2006 Feb; 2(1):51-69. View in: PubMed

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