Faculty

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Denise Al Alam, PhD
Assistant Professor of Research Surgery
Pediatrics
CHLA 4650 W. Sunset Blvd. Off Campus Los Angeles
+1 323 361 7169

Publications

Fibroblast Growth Factors in the Gastrointestinal Tract: Twists and Turns. Dev Dyn. 2017 Feb 15. View in: PubMed

Inhibition of Fgf signaling in short bowel syndrome increases weight loss and epithelial proliferation. Surgery. 2016 Oct 19. View in: PubMed

Epidermal growth factor suppresses intestinal epithelial cell shedding through a MAPK-dependent pathway. J Cell Sci. 2016 Mar 29. View in: PubMed

Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development. Development. 2015 Dec 1; 142(23):4139-50. View in: PubMed

Adult zebrafish intestine resection: a novel model of short bowel syndrome, adaptation, and intestinal stem cell regeneration. Am J Physiol Gastrointest Liver Physiol. 2015 Aug 1; 309(3):G135-45. View in: PubMed

Attenuating endogenous Fgfr2b ligands during bleomycin-induced lung fibrosis does not compromise murine lung repair. Am J Physiol Lung Cell Mol Physiol. 2015 May 15; 308(10):L1014-24. View in: PubMed

Fibroblast growth factor 10 alters the balance between goblet and Paneth cells in the adult mouse small intestine. Am J Physiol Gastrointest Liver Physiol. 2015 Apr 15; 308(8):G678-90. View in: PubMed

The ErbB4 Ligand Neuregulin-4 Protects against Experimental Necrotizing Enterocolitis. Am J Pathol. 2014 Oct; 184(10):2768-78. View in: PubMed

Regulation of Induced Pluripotent Stem (iPS) Cell Induction by Wnt/ß-Catenin Signaling. J Biol Chem. 2014 Mar 28; 289(13):9221-32. View in: PubMed

Fgf10-positive cells represent a progenitor cell population during lung development and postnatally. Development. 2014 Jan; 141(2):296-306. View in: PubMed

Wingless: developmentally important genes that respond adversely to smoking. Thorax. 2013 Aug; 68(8):703-4. View in: PubMed

Transient Inhibition of FGFR2b-ligands signaling leads to irreversible loss of cellular ß-catenin organization and signaling in AER during mouse limb development. PLoS One. 2013; 8(10):e76248. View in: PubMed

Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype. J Clin Invest. 2012 Nov 1; 122(11):3862-72. View in: PubMed

FGF9-Pitx2-FGF10 signaling controls cecal formation in mice. Dev Biol. 2012 Sep 15; 369(2):340-8. View in: PubMed

Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J Cell Sci. 2012 Sep 1; 125(Pt 17):4036-48. View in: PubMed

Characterization of a Novel Fibroblast Growth Factor 10 (Fgf10) Knock-In Mouse Line to Target Mesenchymal Progenitors during Embryonic Development. PLoS One. 2012; 7(6):e38452. View in: PubMed

Fibroblast growth factor 10-fibroblast growth factor receptor 2b mediated signaling is not required for adult glandular stomach homeostasis. PLoS One. 2012; 7(11):e49127. View in: PubMed

Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 May 15; 353(2):242-58. View in: PubMed

Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development. 2011 Apr; 138(7):1395-407. View in: PubMed

Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 Feb 1; 350(1):112-26. View in: PubMed

Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair. PLoS One. 2011; 6(8):e23139. View in: PubMed

ß-catenin regulates mesenchymal progenitor cell differentiation during hepatogenesis. J Surg Res. 2010 Dec; 164(2):276-85. View in: PubMed

Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors. Development. 2010 Nov; 137(22):3743-52. View in: PubMed

Nanostructured assemblies for dental application. ACS Nano. 2010 Jun 22; 4(6):3277-87. View in: PubMed

Impaired interleukin-8 chemokine secretion by staphylococcus aureus-activated epithelium and T-cell chemotaxis in cystic fibrosis. Am J Respir Cell Mol Biol. 2010 Jun; 42(6):644-50. View in: PubMed

Induction of fibroblast growth factor 10 (FGF10) in the ileal crypt epithelium after massive small bowel resection suggests a role for FGF10 in gut adaptation. Dev Dyn. 2009 Feb; 238(2):294-301. View in: PubMed

Expression of Legionella pneumophila paralogous lipid A biosynthesis genes under different growth conditions. Microbiology. 2007 Nov; 153(Pt 11):3817-29. View in: PubMed

Bronchial epithelial spheroids: an alternative culture model to investigate epithelium inflammation-mediated COPD. Respir Res. 2007; 8:86. View in: PubMed

T cell chemotaxis and chemokine release after Staphylococcus aureus interaction with polarized airway epithelium. Am J Respir Cell Mol Biol. 2006 Mar; 34(3):348-54. View in: PubMed

Rac1 modulates mammalian lung branching morphogenesis in part through canonical Wnt signaling. Am J Physiol Lung Cell Mol Physiol. 2016 Oct 7; ajplung. 00274. 2016. View in: PubMed

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