Faculty

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Donna Shoupe, MD
Professor of Obstetrics & Gynecology
Obstetrics & Gynecology
IRD 530 Off Campus Los Angeles
+1 323 226 3351

Publications

Sherman ME, Drapkin RI, Horowitz NS, Crum CP, Friedman S, Kwon JS, Levine DA, Shih IeM, Shoupe D, Swisher EM, Walker J, Trabert B, Greene MH, Samimi G, Temkin SM, Minasian LM. Rationale for Developing a Specimen Bank to Study the Pathogenesis of High-Grade Serous Carcinoma: A Review of the Evidence. Cancer Prev Res (Phila). 2016 Sep; 9(9):713-20. View in: PubMed

Henderson VW, St John JA, Hodis HN, McCleary CA, Stanczyk FZ, Shoupe D, Kono N, Dustin L, Allayee H, Mack WJ. Cognitive effects of estradiol after menopause: A randomized trial of the timing hypothesis. Neurology. 2016 Aug 16; 87(7):699-708. View in: PubMed

Hodis HN, Mack WJ, Henderson VW, Shoupe D, Budoff MJ, Hwang-Levine J, Li Y, Feng M, Dustin L, Kono N, Stanczyk FZ, Selzer RH, Azen SP. Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol. N Engl J Med. 2016 Mar 31; 374(13):1221-31. View in: PubMed

Matsuo K, Gualtieri MR, Cahoon SS, Toboni MD, Machida H, Moeini A, Hasegawa K, Shoupe D, Roman LD. Contributing factors for menopausal symptoms after surgical staging for endometrial cancer. Menopause. 2015 Dec 29. View in: PubMed

Rodriguez M, Shoupe D. Surgical Menopause. Endocrinol Metab Clin North Am. 2015 Sep; 44(3):531-42. View in: PubMed

Matsuo K, Gualtieri MR, Cahoon SS, Jung CE, Paulson RJ, Shoupe D, Muderspach LI, Wakatsuki A, Wright JD, Roman LD. Surgical menopause and increased risk of nonalcoholic fatty liver disease in endometrial cancer. Menopause. 2015 Jul 13. View in: PubMed

Hodis HN, Mack WJ, Shoupe D, Azen SP, Stanczyk FZ, Hwang-Levine J, Budoff MJ, Henderson VW. Methods and baseline cardiovascular data from the Early versus Late Intervention Trial with Estradiol testing the menopausal hormone timing hypothesis. Menopause. 2015 Apr; 22(4):391-401. View in: PubMed

Shoupe D. Hormone replacement therapy: consensus and controversies. Panminerva Med. 2014 Dec; 56(4):263-72. View in: PubMed

Mucowski SJ, Mack WJ, Shoupe D, Kono N, Paulson R, Hodis HN. Effect of prior oophorectomy on changes in bone mineral density and carotid artery intima-media thickness in postmenopausal women. Fertil Steril. 2014 Apr; 101(4):1117-22. View in: PubMed

Henderson VW, St John JA, Hodis HN, McCleary CA, Stanczyk FZ, Karim R, Shoupe D, Kono N, Dustin L, Allayee H, Mack WJ. Cognition, mood, and physiological concentrations of sex hormones in the early and late postmenopause. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20290-5. View in: PubMed

Shoupe D. Individualizing hormone-therapy according to cardiovascular risk. Minerva Ginecol. 2013 Dec; 65(6):631-9. View in: PubMed

Quaas AM, Kono N, Mack WJ, Hodis HN, Felix JC, Paulson RJ, Shoupe D. Effect of isoflavone soy protein supplementation on endometrial thickness, hyperplasia, and endometrial cancer risk in postmenopausal women: a randomized controlled trial. Menopause. 2013 Aug; 20(8):840-4. View in: PubMed

Parker WH, Feskanich D, Broder MS, Chang E, Shoupe D, Farquhar CM, Berek JS, Manson JE. In reply. Obstet Gynecol. 2013 Aug; 122(2 Pt 1):396. View in: PubMed

Parker WH, Feskanich D, Broder MS, Chang E, Shoupe D, Farquhar CM, Berek JS, Manson JE. Long-term mortality associated with oophorectomy compared with ovarian conservation in the nurses' health study. Obstet Gynecol. 2013 Apr; 121(4):709-16. View in: PubMed

Shoupe D. Individualizing hormone-therapy according to cardiovascular risk. Minerva Med. 2012 Oct; 103(5):343-52. View in: PubMed

Hodis HN, Mack WJ, Kono N, Azen SP, Shoupe D, Hwang-Levine J, Petitti D, Whitfield-Maxwell L, Yan M, Franke AA, Selzer RH. Isoflavone soy protein supplementation and atherosclerosis progression in healthy postmenopausal women: a randomized controlled trial. Stroke. 2011 Nov; 42(11):3168-75. View in: PubMed

Shoupe D. Individualizing hormone therapy to minimize risk: accurate assessment of risks and benefits. Womens Health (Lond Engl). 2011 Jul; 7(4):475-85. View in: PubMed

Parker WH, Jacoby V, Shoupe D, Rocca W. Effect of bilateral oophorectomy on women's long-term health. Womens Health (Lond Engl). 2009 Sep; 5(5):565-76. View in: PubMed

Parker WH, Broder MS, Chang E, Feskanich D, Farquhar C, Liu Z, Shoupe D, Berek JS, Hankinson S, Manson JE. Ovarian conservation at the time of hysterectomy and long-term health outcomes in the nurses' health study. Obstet Gynecol. 2009 May; 113(5):1027-37. View in: PubMed

Parker WH, Shoupe D, Broder MS, Liu Z, Farquhar C, Berek JS. Elective oophorectomy in the gynecological patient: when is it desirable? Curr Opin Obstet Gynecol. 2007 Aug; 19(4):350-4. View in: PubMed

Parker WH, Broder MS, Liu Z, Shoupe D, Farquhar C, Berek JS. Ovarian conservation at the time of hysterectomy for benign disease. Clin Obstet Gynecol. 2007 Jun; 50(2):354-61. View in: PubMed

Shoupe D, Parker WH, Broder MS, Liu Z, Farquhar C, Berek JS. Elective oophorectomy for benign gynecological disorders. Menopause. 2007 May-Jun; 14(3 Pt 2):580-5. View in: PubMed

Steiner AZ, Xiang M, Mack WJ, Shoupe D, Felix JC, Lobo RA, Hodis HN. Unopposed estradiol therapy in postmenopausal women: results from two randomized trials. Obstet Gynecol. 2007 Mar; 109(3):581-7. View in: PubMed

Steiner AZ, Hodis HN, Lobo RA, Shoupe D, Xiang M, Mack WJ. Postmenopausal oral estrogen therapy and blood pressure in normotensive and hypertensive subjects: the Estrogen in the Prevention of Atherosclerosis Trial. Menopause. 2005 Nov-Dec; 12(6):728-33. View in: PubMed

Parker WH, Broder MS, Liu Z, Shoupe D, Farquhar C, Berek JS. Ovarian conservation at the time of hysterectomy for benign disease. Obstet Gynecol. 2005 Aug; 106(2):219-26. View in: PubMed

Gass MS, Rebar RW, Cuffie-Jackson C, Cedars MI, Lobo RA, Shoupe D, Judd HL, Buyalos RP, Clisham PR. A short study in the treatment of hot flashes with buccal administration of 17-beta estradiol. Maturitas. 2004 Oct 15; 49(2):140-7. View in: PubMed

Mack WJ, Slater CC, Xiang M, Shoupe D, Lobo RA, Hodis HN. Elevated subclinical atherosclerosis associated with oophorectomy is related to time since menopause rather than type of menopause. Fertil Steril. 2004 Aug; 82(2):391-7. View in: PubMed

Hodis HN, Mack WJ, Azen SP, Lobo RA, Shoupe D, Mahrer PR, Faxon DP, Cashin-Hemphill L, Sanmarco ME, French WJ, Shook TL, Gaarder TD, Mehra AO, Rabbani R, Sevanian A, Shil AB, Torres M, Vogelbach KH, Selzer RH. Hormone therapy and the progression of coronary-artery atherosclerosis in postmenopausal women. N Engl J Med. 2003 Aug 7; 349(6):535-45. View in: PubMed

Hodis HN, Mack WJ, Lobo RA, Shoupe D, Sevanian A, Mahrer PR, Selzer RH, Liu Cr CR, Liu Ch CH, Azen SP. Estrogen in the prevention of atherosclerosis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2001 Dec 4; 135(11):939-53. View in: PubMed

Slater CC, Zhang C, Hodis HN, Mack WJ, Boostanfar R, Shoupe D, Paulson RJ, Stanczyk FZ. Comparison of estrogen and androgen levels after oral estrogen replacement therapy. J Reprod Med. 2001 Dec; 46(12):1052-6. View in: PubMed

Utian WH, Shoupe D, Bachmann G, Pinkerton JV, Pickar JH. Relief of vasomotor symptoms and vaginal atrophy with lower doses of conjugated equine estrogens and medroxyprogesterone acetate. Fertil Steril. 2001 Jun; 75(6):1065-79. View in: PubMed

Slater CC, Hodis HN, Mack WJ, Shoupe D, Paulson RJ, Stanczyk FZ. Markedly elevated levels of estrone sulfate after long-term oral, but not transdermal, administration of estradiol in postmenopausal women. Menopause. 2001 May-Jun; 8(3):200-3. View in: PubMed

Shoupe D. HRT dosing regimens: continuous versus cyclic-pros and cons. Int J Fertil Womens Med. 2001 Jan-Feb; 46(1):7-15. View in: PubMed

Shoupe D. Hysterectomy or an alternative? Hosp Pract (Minneap). 2000 Sep 15; 35(9):55-62; quiz 92. View in: PubMed

Henderson VW, Paganini-Hill A, Miller BL, Elble RJ, Reyes PF, Shoupe D, McCleary CA, Klein RA, Hake AM, Farlow MR. Estrogen for Alzheimer's disease in women: randomized, double-blind, placebo-controlled trial. Neurology. 2000 Jan 25; 54(2):295-301. View in: PubMed

Shoupe D. Hormone replacement therapy: reassessing the risks and benefits. Hosp Pract (Minneap). 1999 Aug 15; 34(8):97-103, 107-8, 113-4. View in: PubMed

Shoupe D. Androgens and bone: clinical implications for menopausal women. Am J Obstet Gynecol. 1999 Mar; 180(3 Pt 2):S329-33. View in: PubMed

Rapkin AJ, Shoupe D, Reading A, Daneshgar KK, Goldman L, Bohn Y, Brann DW, Mahesh VB. Decreased central opioid activity in premenstrual syndrome: luteinizing hormone response to naloxone. J Soc Gynecol Investig. 1996 Mar-Apr; 3(2):93-8. View in: PubMed

Ballagh SA, Mishell DR, Lacarra M, Shoupe D, Jackanicz TM, Eggena P. A contraceptive vaginal ring releasing norethindrone acetate and ethinyl estradiol. Contraception. 1994 Dec; 50(6):517-33. View in: PubMed

Mezrow G, Shoupe D, Spicer D, Lobo R, Leung B, Pike M. Depot leuprolide acetate with estrogen and progestin add-back for long-term treatment of premenstrual syndrome. Fertil Steril. 1994 Nov; 62(5):932-7. View in: PubMed

Shoupe D. New progestins--clinical experiences: gestodene. Am J Obstet Gynecol. 1994 May; 170(5 Pt 2):1562-8. View in: PubMed

Shoupe D. Multicenter randomized comparative trial of two low-dose triphasic combined oral contraceptives containing desogestrel or norethindrone. Obstet Gynecol. 1994 May; 83(5 Pt 1):679-85. View in: PubMed

Spicer DV, Ursin G, Parisky YR, Pearce JG, Shoupe D, Pike A, Pike MC. Changes in mammographic densities induced by a hormonal contraceptive designed to reduce breast cancer risk. J Natl Cancer Inst. 1994 Mar 16; 86(6):431-6. View in: PubMed

Bopp B, Shoupe D. Luteal phase defects. J Reprod Med. 1993 May; 38(5):348-56. View in: PubMed

Spicer DV, Pike MC, Pike A, Rude R, Shoupe D, Richardson J. Pilot trial of a gonadotropin hormone agonist with replacement hormones as a prototype contraceptive to prevent breast cancer. Contraception. 1993 May; 47(5):427-44. View in: PubMed

Shoupe D. Effects of desogestrel on carbohydrate metabolism. Am J Obstet Gynecol. 1993 Mar; 168(3 Pt 2):1041-7. View in: PubMed

Shoupe D, Meme D, Mezrow G, Lobo RA. Prevention of endometrial hyperplasia in postmenopausal women with intrauterine progesterone. N Engl J Med. 1991 Dec 19; 325(25):1811-2. View in: PubMed

Mishell DR, Shoupe D, Moyer DL, Roy S, Page MA. Postmenopausal hormone replacement with a combination estrogen-progestin regimen for five days per week. J Reprod Med. 1991 May; 36(5):351-5. View in: PubMed

Shoupe D, Horenstein J, Mishell DR, Lacarra M, Medearis A. Characteristics of ovarian follicular development in Norplant users. Fertil Steril. 1991 Apr; 55(4):766-70. View in: PubMed

Shoupe D, Mishell DR, Bopp BL, Fielding M. The significance of bleeding patterns in Norplant implant users. Obstet Gynecol. 1991 Feb; 77(2):256-60. View in: PubMed

Shoupe D, Mishell DR, Fossum G, Bopp BL, Spitz IM, Lobo RA. Antiprogestin treatment decreases midluteal luteinizing hormone pulse amplitude and primarily exerts a pituitary inhibition. Am J Obstet Gynecol. 1990 Dec; 163(6 Pt 1):1982-5. View in: PubMed

Kjos SL, Shoupe D, Douyan S, Friedman RL, Bernstein GS, Mestman JH, Mishell DR. Effect of low-dose oral contraceptives on carbohydrate and lipid metabolism in women with recent gestational diabetes: results of a controlled, randomized, prospective study. Am J Obstet Gynecol. 1990 Dec; 163(6 Pt 1):1822-7. View in: PubMed

Grimes DA, Bernstein L, Lacarra M, Shoupe D, Mishell DR. Predictors of failed attempted abortion with the antiprogestin mifepristone (RU 486). Am J Obstet Gynecol. 1990 Apr; 162(4):910-5; discussion 915-7. View in: PubMed

Shoupe D, Mishell DR. Norplant: subdermal implant system for long-term contraception. Am J Obstet Gynecol. 1989 May; 160(5 Pt 2):1286-92. View in: PubMed

Shoupe D, Mishell DR, Lacarra M, Lobo RA, Horenstein J, d'Ablaing G, Moyer D. Correlation of endometrial maturation with four methods of estimating day of ovulation. Obstet Gynecol. 1989 Jan; 73(1):88-92. View in: PubMed

Stanczyk FZ, Shoupe D, Nunez V, Macias-Gonzales P, Vijod MA, Lobo RA. A randomized comparison of nonoral estradiol delivery in postmenopausal women. Am J Obstet Gynecol. 1988 Dec; 159(6):1540-6. View in: PubMed

Grimes DA, Mishell DR, Shoupe D, Lacarra M. Early abortion with a single dose of the antiprogestin RU-486. Am J Obstet Gynecol. 1988 Jun; 158(6 Pt 1):1307-12. View in: PubMed

Shoupe D, Kjos S. Effects of oral contraceptives on the borderline NIDD patient. Int J Fertil. 1988; 33 Suppl:27-34. View in: PubMed

Shoupe D, Mishell DR, Lahteenmaki P, Heikinheimo O, Birgerson L, Madkour H, Spitz IM. Effects of the antiprogesterone RU 486 in normal women. I. Single-dose administration in the midluteal phase. Am J Obstet Gynecol. 1987 Dec; 157(6):1415-20. View in: PubMed

Shoupe D, Mishell DR, Page MA, Madkour H, Spitz IM, Lobo RA. Effects of the antiprogesterone RU 486 in normal women. II. Administration in the late follicular phase. Am J Obstet Gynecol. 1987 Dec; 157(6):1421-6. View in: PubMed

Chiang RS, Barnes RB, Shoupe D, Lobo RA. Dose-related changes in LH bioactivity with intranasal GnRH agonist administration. Contraception. 1985 Oct; 32(4):347-57. View in: PubMed

Lobo RA, Roy S, Shoupe D, Endres DB, Adams JS, Rude RK, Singer FR. Estrogen and progestin effects on urinary calcium and calciotropic hormones in surgically-induced postmenopausal women. Horm Metab Res. 1985 Jul; 17(7):370-3. View in: PubMed

Shoupe D, Lobo RA. Prolactin response after gonadotropin-releasing hormone in the polycystic ovary syndrome. Fertil Steril. 1985 Apr; 43(4):549-53. View in: PubMed

Lobo RA, Shoupe D, Serafini P, Brinton D, Horton R. The effects of two doses of spironolactone on serum androgens and anagen hair in hirsute women. Fertil Steril. 1985 Feb; 43(2):200-5. View in: PubMed

Shoupe D, Montz FJ, Lobo RA. The effects of estrogen and progestin on endogenous opioid activity in oophorectomized women. J Clin Endocrinol Metab. 1985 Jan; 60(1):178-83. View in: PubMed

Shoupe D, Lobo RA. Evidence for altered catecholamine metabolism in polycystic ovary syndrome. Am J Obstet Gynecol. 1984 Nov 1; 150(5 Pt 1):566-71. View in: PubMed

Lobo RA, Shoupe D, Roy S, Paul W. Central and peripheral metabolites of norepinephrine and dopamine in postmenopausal women. Am J Obstet Gynecol. 1984 Jul 1; 149(5):548-52. View in: PubMed

Chang SP, Shoupe D, Kletzky OA, Lobo RA. Differences in the ratio of bioactive to immunoreactive serum luteinizing hormone during vasomotor flushes and hormonal therapy in postmenopausal women. J Clin Endocrinol Metab. 1984 May; 58(5):925-9. View in: PubMed

Shoupe D, Lobo RA. The influence of androgens on insulin resistance. Fertil Steril. 1984 Mar; 41(3):385-8. View in: PubMed

Lobo RA, Shoupe D, Chang SP, Campeau J. The control of bioactive luteinizing hormone secretion in women with polycystic ovary syndrome. Am J Obstet Gynecol. 1984 Feb 15; 148(4):423-8. View in: PubMed

Shoupe D, Kumar DD, Lobo RA. Insulin resistance in polycystic ovary syndrome. Am J Obstet Gynecol. 1983 Nov 1; 147(5):588-92. View in: PubMed

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