Faculty

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Duke Han, PhD
Director of Neuropsychology in Family Medicine and Associate Professor of Family Medicine, Neurology, Psychology, and Gerontology
Family Medicine
HSA Unit22 A-7 7423 1000 S. Fremont Avenue Off Campus Alhambra
+1 626 457 5858

Overview

Dr. Han is a diplomate of the American Board of Professional Psychology in clinical neuropsychology (ABPP-CN), Director of Neuropsychology in the Department of Family Medicine, and an Associate Professor of Family Medicine, Neurology, Psychology, and Gerontology. He received his Bachelor of Science degree in psychology with a specialization in neuroscience from Duke University, and his doctorate in clinical psychology from the University of Massachusetts Boston. He received training in clinical neuropsychology and experimental neuroimaging techniques through various programs of Harvard Medical School's Brigham and Women's Hospital. He continued his clinical neuropsychology and neuroimaging activities during his internship and postdoctoral fellowship years at UCSD and the San Diego VA Healthcare System. He maintains an active research collaboration with the Rush Alzheimer's Disease Center in Chicago, where he was most recently a tenured faculty member. Dr. Han is interested in the study of factors that affect cognition and decision making in aging. He also has special interests in using novel neuroimaging and statistical approaches to better understand these factors. Dr. Han is actively involved in peer review of grants and manuscripts, and has leadership or mentorship roles in the International Neuropsychological Society (INS), the National Academy of Neuropsychology (NAN), the American Academy of Clinical Neuropsychology (AACN), and the Society of Clinical Neuropsychology (Division 40) of the American Psychological Association.

Awards

International Neuropsychological Society: Nelson Butters Award, 2006

American Psychological Association: Division 40 Blue Ribbon Award, 2012

National Institutes of Aging/AFAR: Paul B. Beason Award for Aging Research, 2012-2017

AARP and AgeUK: Global Council on Brain Health Governance Member, 2015-2017

Publications

Han SD, Boyle PA, Arfanakis K, Fleischman D, Yu L, James BD, Bennett DA. Financial literacy is associated with white matter integrity in old age. Neuroimage. 2016 Feb 17; 130:223-229. View in: PubMed

Lachs MS, Han SD. Age-Associated Financial Vulnerability: An Emerging Public Health Issue. Ann Intern Med. 2015 Dec 1; 163(11):877-8. View in: PubMed

Han SD, Boyle PA, James BD, Yu L, Bennett DA. Mild Cognitive Impairment and Susceptibility to Scams in Old Age. J Alzheimers Dis. 2015 Oct 22; 49(3):845-51. View in: PubMed

Han SD, Boyle PA, James BD, Yu L, Bennett DA. Poorer Financial and Health Literacy Among Community-Dwelling Older Adults With Mild Cognitive Impairment. J Aging Health. 2015 Sep; 27(6):1105-17. View in: PubMed

Duke Han S, Boyle PA, Yu L, Arfanakis K, James BD, Fleischman DA, Bennett DA. Grey matter correlates of susceptibility to scams in community-dwelling older adults. Brain Imaging Behav. 2015 Jun 23. View in: PubMed

Han SD, Boyle PA, James BD, Yu L, Barnes LL, Bennett DA. Discrepancies between cognition and decision making in older adults. Aging Clin Exp Res. 2015 May 21. View in: PubMed

Nation DA, Edmonds EC, Bangen KJ, Delano-Wood L, Scanlon BK, Han SD, Edland SD, Salmon DP, Galasko DR, Bondi MW. Pulse pressure in relation to tau-mediated neurodegeneration, cerebral amyloidosis, and progression to dementia in very old adults. JAMA Neurol. 2015 May; 72(5):546-53. View in: PubMed

Han SD, Boyle PA, James BD, Yu L, Bennett DA. Mild cognitive impairment is associated with poorer decision-making in community-based older persons. J Am Geriatr Soc. 2015 Apr; 63(4):676-83. View in: PubMed

James BD, Boyle PA, Yu L, Han SD, Bennett DA. Cognitive decline is associated with risk aversion and temporal discounting in older adults without dementia. PLoS One. 2015; 10(4):e0121900. View in: PubMed

Fleischman DA, Leurgans S, Arfanakis K, Arvanitakis Z, Barnes LL, Boyle PA, Han SD, Bennett DA. Gray-matter macrostructure in cognitively healthy older persons: associations with age and cognition. Brain Struct Funct. 2014 Nov; 219(6):2029-49. View in: PubMed

Han SD, Boyle PA, Yu L, Fleischman DA, Arfanakis K, Leurgans S, Bennett DA. Financial literacy is associated with medial brain region functional connectivity in old age. Arch Gerontol Geriatr. 2014 Sep-Oct; 59(2):429-38. View in: PubMed

Han SD, Boyle PA, Yu L, Fleischman DA, Arfanakis K, Bennett DA. Ventromedial PFC, parahippocampal, and cerebellar connectivity are associated with temporal discounting in old age. Exp Gerontol. 2013 Dec; 48(12):1489-98. View in: PubMed

Duke Han S, Buchman AS, Arfanakis K, Fleischman DA, Bennett DA. Functional connectivity networks associated with chronic musculoskeletal pain in old age. Int J Geriatr Psychiatry. 2013 Aug; 28(8):858-67. View in: PubMed

Fleischman DA, Yu L, Arfanakis K, Han SD, Barnes LL, Arvanitakis Z, Boyle PA, Bennett DA. Faster cognitive decline in the years prior to MR imaging is associated with smaller hippocampal volumes in cognitively healthy older persons. Front Aging Neurosci. 2013; 5:21. View in: PubMed

Wingo J, Kalkut E, Tuminello E, Asconape J, Han SD. Executive functions, depressive symptoms, and college adjustment in women. Appl Neuropsychol Adult. 2013; 20(2):136-44. View in: PubMed

Han SD, Gruhl J, Beckett L, Dodge HH, Stricker NH, Farias S, Mungas D. Beta amyloid, tau, neuroimaging, and cognition: sequence modeling of biomarkers for Alzheimer's Disease. Brain Imaging Behav. 2012 Dec; 6(4):610-20. View in: PubMed

Stricker NH, Dodge HH, Dowling NM, Han SD, Erosheva EA, Jagust WJ. CSF biomarker associations with change in hippocampal volume and precuneus thickness: implications for the Alzheimer's pathological cascade. Brain Imaging Behav. 2012 Dec; 6(4):599-609. View in: PubMed

Han SD, Boyle PA, Arfanakis K, Fleischman DA, Yu L, Edmonds EC, Bennett DA. Neural intrinsic connectivity networks associated with risk aversion in old age. Behav Brain Res. 2012 Feb 1; 227(1):233-40. View in: PubMed

Han SD, Arfanakis K, Fleischman DA, Leurgans SE, Tuminello ER, Edmonds EC, Bennett DA. Functional connectivity variations in mild cognitive impairment: associations with cognitive function. J Int Neuropsychol Soc. 2012 Jan; 18(1):39-48. View in: PubMed

Guidotti Breting LM, Tuminello ER, Duke Han S. Functional neuroimaging studies in normal aging. Curr Top Behav Neurosci. 2012; 10:91-111. View in: PubMed

Ruppert P, Edmonds EC, Brook M, Musil S, Han SD. Neuropsychological assessment in a case of adult-onset hemophagocytic lymphohistiocytosis (HLH). Clin Neuropsychol. 2012; 26(6):1038-52. View in: PubMed

Schiehser DM, Delis DC, Filoteo JV, Delano-Wood L, Han SD, Jak AJ, Drake AI, Bondi MW. Are self-reported symptoms of executive dysfunction associated with objective executive function performance following mild to moderate traumatic brain injury? J Clin Exp Neuropsychol. 2011 Jul; 33(6):704-14. View in: PubMed

Tuminello ER, Han SD. The apolipoprotein e antagonistic pleiotropy hypothesis: review and recommendations. Int J Alzheimers Dis. 2011; 2011:726197. View in: PubMed

Suzuki H, Han SD, Lucas LR. Increased 5-HT1B receptor density in the basolateral amygdala of passive observer rats exposed to aggression. Brain Res Bull. 2010 Aug 30; 83(1-2):38-43. View in: PubMed

Han SD, Suzuki H, Jak AJ, Chang YL, Salmon DP, Bondi MW. Hierarchical cognitive and psychosocial predictors of amnestic mild cognitive impairment. J Int Neuropsychol Soc. 2010 Jul; 16(4):721-9. View in: PubMed

Bangen KJ, Jak AJ, Schiehser DM, Delano-Wood L, Tuminello E, Han SD, Delis DC, Bondi MW. Complex activities of daily living vary by mild cognitive impairment subtype. J Int Neuropsychol Soc. 2010 Jul; 16(4):630-9. View in: PubMed

Suzuki H, Han SD, Lucas LR. Chronic passive exposure to aggression decreases D2 and 5-HT 1B receptor densities. Physiol Behav. 2010 Apr 19; 99(5):562-70. View in: PubMed

Han SD, Wible CG. Neuroimaging of semantic processing in schizophrenia: a parametric priming approach. Int J Psychophysiol. 2010 Feb; 75(2):100-6. View in: PubMed

Schiehser DM, Han SD, Lessig S, Song DD, Zizak V, Filoteo JV. Predictors of health status in nondepressed and nondemented individuals with Parkinson's disease. Arch Clin Neuropsychol. 2009 Nov; 24(7):699-709. View in: PubMed

Kalkut EL, Han SD, Lansing AE, Holdnack JA, Delis DC. Development of set-shifting ability from late childhood through early adulthood. Arch Clin Neuropsychol. 2009 Sep; 24(6):565-74. View in: PubMed

Han SD, Bangen KJ, Bondi MW. Functional magnetic resonance imaging of compensatory neural recruitment in aging and risk for Alzheimer's disease: review and recommendations. Dement Geriatr Cogn Disord. 2009; 27(1):1-10. View in: PubMed

Han SD, Suzuki H, Drake AI, Jak AJ, Houston WS, Bondi MW. Clinical, cognitive, and genetic predictors of change in job status following traumatic brain injury in a military population. J Head Trauma Rehabil. 2009 Jan-Feb; 24(1):57-64. View in: PubMed

Han SD, Bondi MW. Revision of the apolipoprotein E compensatory mechanism recruitment hypothesis. Alzheimers Dement. 2008 Jul; 4(4):251-4. View in: PubMed

Han SD, Drake AI, Cessante LM, Jak AJ, Houston WS, Delis DC, Filoteo JV, Bondi MW. Apolipoprotein E and traumatic brain injury in a military population: evidence of a neuropsychological compensatory mechanism? J Neurol Neurosurg Psychiatry. 2007 Oct; 78(10):1103-8. View in: PubMed

Han SD, Nestor PG, Hale-Spencer M, Cohen A, Niznikiewicz M, McCarley RW, Wible CG. Functional neuroimaging of word priming in males with chronic schizophrenia. Neuroimage. 2007 Mar; 35(1):273-82. View in: PubMed

Han SD, Houston WS, Jak AJ, Eyler LT, Nagel BJ, Fleisher AS, Brown GG, Corey-Bloom J, Salmon DP, Thal LJ, Bondi MW. Verbal paired-associate learning by APOE genotype in non-demented older adults: fMRI evidence of a right hemispheric compensatory response. Neurobiol Aging. 2007 Feb; 28(2):238-47. View in: PubMed

Han SD, Drake AI, Cessante LM, Jak AJ, Houston WS, Delis DC, Filoteo JV, Bondi MW. Apolipoprotein E and traumatic brain injury in a military population: evidence of a neuropsychological compensatory mechanism?. Journal of Neurology, Neurosurgery, and Psychiatry. 2007; 78(10):1103-1108. View in: PubMed

Delis, Dean C. ; Lansing, Amy; Houston, Wes S. ; Wetter, Spencer; Han, S. Duke; Jacobson, Mark; Holdnack, James; Kramer, Joel. Creativity Lost: The Importance of Testing Higher-Level Executive Functions in School-Age Children and Adolescents. Journal of Psychoeducational Assessment. 2007; 25:29-40. View in: PubMed

Wible CG, Han SD, Spencer MH, Kubicki M, Niznikiewicz MH, Jolesz FA, McCarley RW, Nestor P. Connectivity among semantic associates: an fMRI study of semantic priming. Brain Lang. 2006 Jun; 97(3):294-305. View in: PubMed

Han SD, Nestor PG, Wible CG. fMRI of lexical-semantic priming in a chronic schizophrenia patient. Appl Neuropsychol. 2006; 13(1):51-7. View in: PubMed

Han SD, Nestor PG, Shenton ME, Niznikiewicz M, Hannah G, McCarley RW. Associative memory in chronic schizophrenia: a computational model. Schizophr Res. 2003 Jun 1; 61(2-3):255-63. View in: PubMed

Nestor PG, Han SD, Niznikiewicz M, Salisbury D, Spencer K, Shenton ME, McCarley RW. Semantic disturbance in schizophrenia and its relationship to the cognitive neuroscience of attention. Biol Psychol. 2001 Jul-Aug; 57(1-3):23-46. View in: PubMed

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