Faculty

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Duncan Campbell Thomas, PhD
Professor of Preventive Medicine
Verna R. Richter Chair in Cancer Research
Preventive Medicine
SSB 202 2001 N. Soto Street Health Sciences Campus Los Angeles
+1 323 442 1218

Overview

My primary research interest has been in the development of statistical methods for genetic and environmental epidemiology, with wide involvement in numerous studies in both areas. My statistical contributions include methods for analysis of nested case-control studies, approaches to modeling exposure-time-response relationships and interaction effects, exposure modeling and measurement error, and the use of Markov chain Monte Carlo (MCMC) methods and Generalized Estimating Equations (GEE) methods in genetics.On the environmental side, I have been particularly active in air pollution and radiation carcinogenesis. I was one of the founding investigators of the Southern California Children’s Health Study, a major cohort study of the health effects of air pollution on schoolchildren’s lung development. I have also collaborated on studies of cancer in residents downwind of the Nevada Test Site, uranium miners, medical irradiation, and the atomic bomb survivors. I was a member of President Clinton’s Advisory Committee on Human Radiation Experiments, as well as the National Academy of Sciences Committee on the Biological Effects of Ionizing Radiation (BEIR V), and radiation advisory committees for numerous other governmental agencies. Other environmental activities include studies of asbestos, malathion spraying in California, electromagnetic fields, and air pollution; I am a Co-Director of the Southern California Environmental Health Research Center.On the genetic side, I have numerous publications in the area of statistical genetics and am collaborating on family studies of breast and colon cancer, pathway based modeling, several genome-wide association studies, next generation sequencing, and epigenetics. I chaired organizing committees for the Genetic Analysis Workshop, and am a Past President of the International Genetic Epidemiology Society.I have authored two textbooks: Statistical Methods in Genetic Epidemiology (Oxford University Press, 2003) and Statistical Methods in Environmental Epidemiology (Oxford University Press, 2009).I feel that these three broad areas of interest make me uniquely qualified to address methodological challenges in studying gene-environment interactions.

Publications

Salomon MP, Li WL, Edlund CK, Morrison J, Fortini BK, Win AK, Conti DV, Thomas DC, Duggan D, Buchanan DD, Jenkins MA, Hopper JL, Gallinger S, Le Marchand L, Newcomb PA, Casey G, Marjoram P. GWASeq: targeted re-sequencing follow up to GWAS. BMC Genomics. 2016; 17(1):176. View in: PubMed

Gribble MO, Voruganti VS, Cole SA, Haack K, Balakrishnan P, Laston SL, Tellez-Plaza M, Francesconi KA, Goessler W, Umans JG, Thomas DC, Gilliland F, North KE, Franceschini N, Navas-Acien A. Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study. Toxicol Sci. 2015 Nov; 148(1):89-100. View in: PubMed

Schmit SL, Figueiredo JC, Cortessis VK, Thomas DC. The Influence of Screening for Precancerous Lesions on Family-Based Genetic Association Tests: An Example of Colorectal Polyps and Cancer. Am J Epidemiol. 2015 Oct 15; 182(8):714-22. View in: PubMed

Hsu L, Jeon J, Brenner H, Gruber SB, Schoen RE, Berndt SI, Chan AT, Chang-Claude J, Du M, Gong J, Harrison TA, Hayes RB, Hoffmeister M, Hutter CM, Lin Y, Nishihara R, Ogino S, Prentice RL, Schumacher FR, Seminara D, Slattery ML, Thomas DC, Thornquist M, Newcomb PA, Potter JD, Zheng Y, White E, Peters U. A model to determine colorectal cancer risk using common genetic susceptibility Loci. Gastroenterology. 2015 Jun; 148(7):1330-1339. e14. View in: PubMed

Schumacher FR, Schmit SL, Jiao S, Edlund CK, Wang H, Zhang B, Hsu L, Huang SC, Fischer CP, Harju JF, Idos GE, Lejbkowicz F, Manion FJ, McDonnell K, McNeil CE, Melas M, Rennert HS, Shi W, Thomas DC, Van Den Berg DJ, Hutter CM, Aragaki AK, Butterbach K, Caan BJ, Carlson CS, Chanock SJ, Curtis KR, Fuchs CS, Gala M, Giocannucci EL, Gogarten SM, Hayes RB, Henderson B, Hunter DJ, Jackson RD, Kolonel LN, Kooperberg C, Kury S, LaCroix A, Laurie CC, Laurie CA, Lemire M, Levine D, Ma J, Makar KW, Qu C, Taverna D, Ulrich CM, Wu K, Kono S, West DW, Berndt SI, Bezieau S, Brenner H, Campbell PT, Chan AT, Chang-Claude J, Coetzee GA, Conti DV, Duggan D, Figueiredo JC, Fortini BK, Gallinger SJ, Gauderman WJ, Giles G, Green R, Haile R, Harrison TA, Hoffmeister M, Hopper JL, Hudson TJ, Jacobs E, Iwasaki M, Jee SH, Jenkins M, Jia WH, Joshi A, Li L, Lindor NM, Matsuo K, Moreno V, Mukherjee B, Newcomb PA, Potter JD, Raskin L, Rennert G, Rosse S, Severi G, Schoen RE, Seminara D, Shu XO, Slattery ML, Tsugane S, White E, Xiang YB, Zanke BW, Zheng W, Le Marchand L, Casey G, Gruber SB, Peters U. Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Nat Commun. 2015; 6:7138. View in: PubMed

Schumacher FR, Schmit SL, Jiao S, Edlund CK, Wang H, Zhang B, Hsu L, Huang SC, Fischer CP, Harju JF, Idos GE, Lejbkowicz F, Manion FJ, McDonnell K, McNeil CE, Melas M, Rennert HS, Shi W, Thomas DC, Van Den Berg DJ, Hutter CM, Aragaki AK, Butterbach K, Caan BJ, Carlson CS, Chanock SJ, Curtis KR, Fuchs CS, Gala M, Giovannucci EL, Gogarten SM, Hayes RB, Henderson B, Hunter DJ, Jackson RD, Kolonel LN, Kooperberg C, Küry S, LaCroix A, Laurie CC, Laurie CA, Lemire M, Levine D, Ma J, Makar KW, Qu C, Taverna D, Ulrich CM, Wu K, Kono S, West DW, Berndt SI, Bezieau S, Brenner H, Campbell PT, Chan AT, Chang-Claude J, Coetzee GA, Conti DV, Duggan D, Figueiredo JC, Fortini BK, Gallinger SJ, Gauderman WJ, Giles G, Green R, Haile R, Harrison TA, Hoffmeister M, Hopper JL, Hudson TJ, Jacobs E, Iwasaki M, Jee SH, Jenkins M, Jia WH, Joshi A, Li L, Lindor NM, Matsuo K, Moreno V, Mukherjee B, Newcomb PA, Potter JD, Raskin L, Rennert G, Rosse S, Severi G, Schoen RE, Seminara D, Shu XO, Slattery ML, Tsugane S, White E, Xiang YB, Zanke BW, Zheng W, Le Marchand L, Casey G, Gruber SB, Peters U. Corrigendum: Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Nat Commun. 2015; 6:8739. View in: PubMed

Li D, Zhou J, Thomas DC, Fardo DW. Complex pedigrees in the sequencing era: to track transmissions or decorrelate? Genet Epidemiol. 2014 Sep; 38 Suppl 1:S29-36. View in: PubMed

Corral R, Lewinger JP, Van Den Berg D, Joshi AD, Yuan JM, Gago-Dominguez M, Cortessis VK, Pike MC, Conti DV, Thomas DC, Edlund CK, Gao YT, Xiang YB, Zhang W, Su YC, Stern MC. Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai. Int J Cancer. 2014 Jul 15; 135(2):335-47. View in: PubMed

Cortessis VK, Thomas JP, Thomas DC. Three authors reply. Am J Epidemiol. 2014 Apr 15; 179(8):1037. View in: PubMed

Ahsan H, Halpern J, Kibriya MG, Pierce BL, Tong L, Gamazon E, McGuire V, Felberg A, Shi J, Jasmine F, Roy S, Brutus R, Argos M, Melkonian S, Chang-Claude J, Andrulis I, Hopper JL, John EM, Malone K, Ursin G, Gammon MD, Thomas DC, Seminara D, Casey G, Knight JA, Southey MC, Giles GG, Santella RM, Lee E, Conti D, Duggan D, Gallinger S, Haile R, Jenkins M, Lindor NM, Newcomb P, Michailidou K, Apicella C, Park DJ, Peto J, Fletcher O, Dos Santos Silva I, Lathrop M, Hunter DJ, Chanock SJ, Meindl A, Schmutzler RK, Müller-Myhsok B, Lochmann M, Beckmann L, Hein R, Makalic E, Schmidt DF, Bui QM, Stone J, Flesch-Janys D, Dahmen N, Nevanlinna H, Aittomäki K, Blomqvist C, Hall P, Czene K, Irwanto A, Liu J, Rahman N, Turnbull C. A Genome-wide Association Study of Early-Onset Breast Cancer Identifies PFKM as a Novel Breast Cancer Gene and Supports a Common Genetic Spectrum for Breast Cancer at Any Age. Cancer Epidemiol Biomarkers Prev. 2014 Apr; 23(4):658-69. View in: PubMed

Thomas DC. Invited commentary: is it time to retire the "pack-years" variable? Maybe not! Am J Epidemiol. 2014 Feb 1; 179(3):299-302. View in: PubMed

Yang Z, Thomas DC. Two-stage family-based designs for sequencing studies. BMC Proc. 2014; 8(Suppl 1):S32. View in: PubMed

Roy A, Gong J, Thomas DC, Zhang J, Kipen HM, Rich DQ, Zhu T, Huang W, Hu M, Wang G, Wang Y, Zhu P, Lu SE, Ohman-Strickland P, Diehl SR, Eckel SP. The cardiopulmonary effects of ambient air pollution and mechanistic pathways: a comparative hierarchical pathway analysis. PLoS One. 2014; 9(12):e114913. View in: PubMed

Thomas DC. Measurement Error in Spatial Exposure Models: Study Design Implications. Environmetrics. 2013 Dec 1; 24(8):518-520. View in: PubMed

Thomas JP, Davis-Dao C, Lewinger JP, Siegmund KD, Hamilton AS, Daneshmand S, Skinner EC, Thomas DC, Cortessis VK. Null association between histology of first and second primary malignancies in men with bilateral testicular germ cell tumors. Am J Epidemiol. 2013 Oct 15; 178(8):1240-5. View in: PubMed

Sohns M, Viktorova E, Amos CI, Brennan P, Fehringer G, Gaborieau V, Han Y, Heinrich J, Chang-Claude J, Hung RJ, Müller-Nurasyid M, Risch A, Lewinger JP, Thomas DC, Bickeböller H. Empirical hierarchical bayes approach to gene-environment interactions: development and application to genome-wide association studies of lung cancer in TRICL. Genet Epidemiol. 2013 Sep; 37(6):551-9. View in: PubMed

Bernstein JL, Thomas DC, Shore RE, Robson M, Boice JD, Stovall M, Andersson M, Bernstein L, Malone KE, Reiner AS, Lynch CF, Capanu M, Smith SA, Tellhed L, Teraoka SN, Begg CB, Olsen JH, Mellemkjaer L, Liang X, Diep AT, Borg A, Concannon P, Haile RW. Contralateral breast cancer after radiotherapy among BRCA1 and BRCA2 mutation carriers: a WECARE study report. Eur J Cancer. 2013 Sep; 49(14):2979-85. View in: PubMed

Lewinger JP, Morrison JL, Thomas DC, Murcray CE, Conti DV, Li D, Gauderman WJ. Efficient two-step testing of gene-gene interactions in genome-wide association studies. Genet Epidemiol. 2013 Jul; 37(5):440-51. View in: PubMed

Chung CC, Kanetsky PA, Wang Z, Hildebrandt MA, Koster R, Skotheim RI, Kratz CP, Turnbull C, Cortessis VK, Bakken AC, Bishop DT, Cook MB, Erickson RL, Fosså SD, Jacobs KB, Korde LA, Kraggerud SM, Lothe RA, Loud JT, Rahman N, Skinner EC, Thomas DC, Wu X, Yeager M, Schumacher FR, Greene MH, Schwartz SM, McGlynn KA, Chanock SJ, Nathanson KL. Meta-analysis identifies four new loci associated with testicular germ cell tumor. Nat Genet. 2013 Jun; 45(6):680-5. View in: PubMed

Reiner AS, John EM, Brooks JD, Lynch CF, Bernstein L, Mellemkjær L, Malone KE, Knight JA, Capanu M, Teraoka SN, Concannon P, Liang X, Figueiredo JC, Smith SA, Stovall M, Pike MC, Haile RW, Thomas DC, Begg CB, Bernstein JL. Risk of asynchronous contralateral breast cancer in noncarriers of BRCA1 and BRCA2 mutations with a family history of breast cancer: a report from the Women's Environmental Cancer and Radiation Epidemiology Study. J Clin Oncol. 2013 Feb 1; 31(4):433-9. View in: PubMed

Duan L, Thomas DC. A Bayesian Hierarchical Model for Relating Multiple SNPs within Multiple Genes to Disease Risk. Int J Genomics. 2013; 2013:406217. View in: PubMed

Thomas DC, Yang Z, Yang F. Two-phase and family-based designs for next-generation sequencing studies. Front Genet. 2013; 4:276. View in: PubMed

Liang WE, Thomas DC, Conti DV. Analysis and optimal design for association studies using next-generation sequencing with case-control pools. Genet Epidemiol. 2012 Dec; 36(8):870-81. View in: PubMed

Brooks JD, Boice JD, Stovall M, Reiner AS, Bernstein L, John EM, Lynch CF, Mellemkjær L, Knight JA, Thomas DC, Haile RW, Smith SA, Capanu M, Bernstein JL, Shore RE. Reproductive status at first diagnosis influences risk of radiation-induced second primary contralateral breast cancer in the WECARE study. Int J Radiat Oncol Biol Phys. 2012 Nov 15; 84(4):917-24. View in: PubMed

Cortessis VK, Thomas DC, Levine AJ, Breton CV, Mack TM, Siegmund KD, Haile RW, Laird PW. Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Hum Genet. 2012 Oct; 131(10):1565-89. View in: PubMed

Boffetta P, Winn DM, Ioannidis JP, Thomas DC, Little J, Smith GD, Cogliano VJ, Hecht SS, Seminara D, Vineis P, Khoury MJ. Recommendations and proposed guidelines for assessing the cumulative evidence on joint effects of genes and environments on cancer occurrence in humans. Int J Epidemiol. 2012 Jun; 41(3):686-704. View in: PubMed

Thomas DC. Genetic epidemiology with a capital e: where will we be in another 10 years? Genet Epidemiol. 2012 Apr; 36(3):179-82. View in: PubMed

Haile RW, John EM, Levine AJ, Cortessis VK, Unger JB, Gonzales M, Ziv E, Thompson P, Spruijt-Metz D, Tucker KL, Bernstein JL, Rohan TE, Ho GY, Bondy ML, Martinez ME, Cook L, Stern MC, Correa MC, Wright J, Schwartz SJ, Baezconde-Garbanati L, Blinder V, Miranda P, Hayes R, Friedman-Jiménez G, Monroe KR, Haiman CA, Henderson BE, Thomas DC, Boffetta P. A review of cancer in u. s. Hispanic populations. Cancer Prev Res (Phila). 2012 Feb; 5(2):150-63. View in: PubMed

Thomas DC, Lewinger JP, Murcray CE, Gauderman WJ. Invited Commentary: GE-Whiz! Ratcheting Gene-Environment Studies up to the Whole Genome and the Whole Exposome. Am J Epidemiol. 2012 Feb 1; 175(3):203-7. View in: PubMed

Thomas DC. Some surprising twists on the road to discovering the contribution of rare variants to complex diseases. Hum Hered. 2012; 74(3-4):113-7. View in: PubMed

Cicek MS, Cunningham JM, Fridley BL, Serie DJ, Bamlet WR, Diergaarde B, Haile RW, Le Marchand L, Krontiris TG, Younghusband HB, Gallinger S, Newcomb PA, Hopper JL, Jenkins MA, Casey G, Schumacher F, Chen Z, DeRycke MS, Templeton AS, Winship I, Green RC, Green JS, Macrae FA, Parry S, Young GP, Young JP, Buchanan D, Thomas DC, Bishop DT, Lindor NM, Thibodeau SN, Potter JD, Goode EL. Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22. PLoS One. 2012; 7(5):e38175. View in: PubMed

Li R, Conti DV, Diaz-Sanchez D, Gilliland F, Thomas DC. Joint analysis for integrating two related studies of different data types and different study designs using hierarchical modeling approaches. Hum Hered. 2012; 74(2):83-96. View in: PubMed

Mechanic LE, Chen HS, Amos CI, Chatterjee N, Cox NJ, Divi RL, Fan R, Harris EL, Jacobs K, Kraft P, Leal SM, McAllister K, Moore JH, Paltoo DN, Province MA, Ramos EM, Ritchie MD, Roeder K, Schaid DJ, Stephens M, Thomas DC, Weinberg CR, Witte JS, Zhang S, Zöllner S, Feuer EJ, Gillanders EM. Next generation analytic tools for large scale genetic epidemiology studies of complex diseases. Genet Epidemiol. 2012 Jan; 36(1):22-35. View in: PubMed

Brooks JD, Teraoka SN, Reiner AS, Satagopan JM, Bernstein L, Thomas DC, Capanu M, Stovall M, Smith SA, Wei S, Shore RE, Boice JD, Lynch CF, Mellemkjaer L, Malone KE, Liang X. Variants in activators and downstream targets of ATM, radiation exposure, and contralateral breast cancer risk in the WECARE study. Hum Mutat. 2012 Jan; 33(1):158-64. View in: PubMed

Quintana MA, Berstein JL, Thomas DC, Conti DV. Incorporating model uncertainty in detecting rare variants: the Bayesian risk index. Genet Epidemiol. 2011 Nov; 35(7):638-49. View in: PubMed

Tzeng JY, Zhang D, Pongpanich M, Smith C, McCarthy MI, Sale MM, Worrall BB, Hsu FC, Thomas DC, Sullivan PF. Studying gene and gene-environment effects of uncommon and common variants on continuous traits: a marker-set approach using gene-trait similarity regression. Am J Hum Genet. 2011 Aug 12; 89(2):277-88. View in: PubMed

Davis-Dao CA, Siegmund KD, Vandenberg DJ, Skinner EC, Coetzee GA, Thomas DC, Pike MC, Cortessis VK. Heterogenous effect of androgen receptor CAG tract length on testicular germ cell tumor risk: shorter repeats associated with seminoma but not other histologic types. Carcinogenesis. 2011 Aug; 32(8):1238-43. View in: PubMed

Capanu M, Concannon P, Haile RW, Bernstein L, Malone KE, Lynch CF, Liang X, Teraoka SN, Diep AT, Thomas DC, Bernstein JL. Assessment of rare BRCA1 and BRCA2 variants of unknown significance using hierarchical modeling. Genet Epidemiol. 2011 Jul; 35(5):389-97. View in: PubMed

Murcray CE, Lewinger JP, Conti DV, Thomas DC, Gauderman WJ. Sample size requirements to detect gene-environment interactions in genome-wide association studies. Genet Epidemiol. 2011 Apr; 35(3):201-10. View in: PubMed

Teraoka SN, Bernstein JL, Reiner AS, Haile RW, Bernstein L, Lynch CF, Malone KE, Stovall M, Capanu M, Liang X, Smith SA, Mychaleckyj J, Hou X, Mellemkjaer L, Boice JD, Siniard A, Duggan D, Thomas DC. Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer, and Radiation Epidemiology (WECARE) Study. Breast Cancer Res. 2011; 13(6):R114. View in: PubMed

Yang F, Thomas DC. Two-stage design of sequencing studies for testing association with rare variants. Hum Hered. 2011; 71(4):209-20. View in: PubMed

Chen GK, Thomas DC. Using biological knowledge to discover higher order interactions in genetic association studies. Genet Epidemiol. 2010 Dec; 34(8):863-78. View in: PubMed

Baurley JW, Conti DV, Gauderman WJ, Thomas DC. Discovery of complex pathways from observational data. Stat Med. 2010 Aug 30; 29(19):1998-2011. View in: PubMed

Gauderman WJ, Thomas DC, Murcray CE, Conti D, Li D, Lewinger JP. Efficient genome-wide association testing of gene-environment interaction in case-parent trios. Am J Epidemiol. 2010 Jul 1; 172(1):116-22. View in: PubMed

Malone KE, Begg CB, Haile RW, Borg A, Concannon P, Tellhed L, Xue S, Teraoka S, Bernstein L, Capanu M, Reiner AS, Riedel ER, Thomas DC, Mellemkjaer L, Lynch CF, Boice JD, Anton-Culver H, Bernstein JL. Population-based study of the risk of second primary contralateral breast cancer associated with carrying a mutation in BRCA1 or BRCA2. J Clin Oncol. 2010 May 10; 28(14):2404-10. View in: PubMed

Thomas D. Methods for investigating gene-environment interactions in candidate pathway and genome-wide association studies. Annu Rev Public Health. 2010 Apr 21; 31:21-36. View in: PubMed

Bernstein JL, Haile RW, Stovall M, Boice JD, Shore RE, Langholz B, Thomas DC, Bernstein L, Lynch CF, Olsen JH, Malone KE, Mellemkjaer L, Borresen-Dale AL, Rosenstein BS, Teraoka SN, Diep AT, Smith SA, Capanu M, Reiner AS, Liang X, Gatti RA, Concannon P. Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study. J Natl Cancer Inst. 2010 Apr 7; 102(7):475-83. View in: PubMed

Thomas D. Gene--environment-wide association studies: emerging approaches. Nat Rev Genet. 2010 Apr; 11(4):259-72. View in: PubMed

Borg A, Haile RW, Malone KE, Capanu M, Diep A, Törngren T, Teraoka S, Begg CB, Thomas DC, Concannon P, Mellemkjaer L, Bernstein L, Tellhed L, Xue S, Olson ER, Liang X, Dolle J, Børresen-Dale AL, Bernstein JL. Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study. Hum Mutat. 2010 Mar; 31(3):E1200-40. View in: PubMed

Wilson MA, Baurley JW, Thomas DC, Conti DV. Complex system approaches to genetic analysis Bayesian approaches. Adv Genet. 2010; 72:47-71. View in: PubMed

Thomas DC, Casey G, Conti DV, Haile RW, Lewinger JP, Stram DO. Methodological Issues in Multistage Genome-wide Association Studies. Stat Sci. 2009 Nov 1; 24(4):414-429. View in: PubMed

Thomas DC, Conti DV, Baurley J, Nijhout F, Reed M, Ulrich CM. Use of pathway information in molecular epidemiology. Hum Genomics. 2009 Oct; 4(1):21-42. View in: PubMed

Tzeng JY, Zhang D, Chang SM, Thomas DC, Davidian M. Gene-trait similarity regression for multimarker-based association analysis. Biometrics. 2009 Sep; 65(3):822-32. View in: PubMed

Langholz B, Thomas DC, Stovall M, Smith SA, Boice JD, Shore RE, Bernstein L, Lynch CF, Zhang X, Bernstein JL. Statistical methods for analysis of radiation effects with tumor and dose location-specific information with application to the WECARE study of asynchronous contralateral breast cancer. Biometrics. 2009 Jun; 65(2):599-608. View in: PubMed

Thomas DC. Genome-wide association studies for discrete traits. Genet Epidemiol. 2009; 33 Suppl 1:S8-12. View in: PubMed

Thomas DC, Baurley JW, Brown EE, Figueiredo JC, Goldstein A, Hazra A, Wilson RT, Rothman N. Approaches to complex pathways in molecular epidemiology: summary of a special conference of the American Association for Cancer Research. Cancer Res. 2008 Dec 15; 68(24):10028-30. View in: PubMed

Stovall M, Smith SA, Langholz BM, Boice JD, Shore RE, Andersson M, Buchholz TA, Capanu M, Bernstein L, Lynch CF, Malone KE, Anton-Culver H, Haile RW, Rosenstein BS, Reiner AS, Thomas DC, Bernstein JL. Dose to the contralateral breast from radiotherapy and risk of second primary breast cancer in the WECARE study. Int J Radiat Oncol Biol Phys. 2008 Nov 15; 72(4):1021-30. View in: PubMed

Jerrett M, Shankardass K, Berhane K, Gauderman WJ, Künzli N, Avol E, Gilliland F, Lurmann F, Molitor JN, Molitor JT, Thomas DC, Peters J, McConnell R. Traffic-related air pollution and asthma onset in children: a prospective cohort study with individual exposure measurement. Environ Health Perspect. 2008 Oct; 116(10):1433-8. View in: PubMed

Concannon P, Haile RW, Børresen-Dale AL, Rosenstein BS, Gatti RA, Teraoka SN, Diep TA, Jansen L, Atencio DP, Langholz B, Capanu M, Liang X, Begg CB, Thomas DC, Bernstein L, Olsen JH, Malone KE, Lynch CF, Anton-Culver H, Bernstein JL. Variants in the ATM gene associated with a reduced risk of contralateral breast cancer. Cancer Res. 2008 Aug 15; 68(16):6486-91. View in: PubMed

Capanu M, Orlow I, Berwick M, Hummer AJ, Thomas DC, Begg CB. The use of hierarchical models for estimating relative risks of individual genetic variants: an application to a study of melanoma. Stat Med. 2008 May 20; 27(11):1973-92. View in: PubMed

Begg CB, Haile RW, Borg A, Malone KE, Concannon P, Thomas DC, Langholz B, Bernstein L, Olsen JH, Lynch CF, Anton-Culver H, Capanu M, Liang X, Hummer AJ, Sima C, Bernstein JL. Variation of breast cancer risk among BRCA1/2 carriers. JAMA. 2008 Jan 9; 299(2):194-201. View in: PubMed

Bertelsen L, Bernstein L, Olsen JH, Mellemkjaer L, Haile RW, Lynch CF, Malone KE, Anton-Culver H, Christensen J, Langholz B, Thomas DC, Begg CB, Capanu M, Ejlertsen B, Stovall M, Boice JD, Shore RE. Effect of systemic adjuvant treatment on risk for contralateral breast cancer in the Women's Environment, Cancer and Radiation Epidemiology Study. J Natl Cancer Inst. 2008 Jan 2; 100(1):32-40. View in: PubMed

Kerber RA, Amos CI, Yeap BY, Finkelstein DM, Thomas DC. Design considerations in a sib-pair study of linkage for susceptibility loci in cancer. BMC Med Genet. 2008; 9:64. View in: PubMed

Thomas DC. Multistage sampling for latent variable models. Lifetime Data Anal. 2007 Dec; 13(4):565-81. View in: PubMed

Thomas DC. Viewpoint: using gene-environment interactions to dissect the effects of complex mixtures. J Expo Sci Environ Epidemiol. 2007 Dec; 17 Suppl 2:S71-4. View in: PubMed

Lewinger JP, Conti DV, Baurley JW, Triche TJ, Thomas DC. Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation. Genet Epidemiol. 2007 Dec; 31(8):871-82. View in: PubMed

Stram DO, Thomas DC, Kopecky KJ. Hypothesis testing, statistical power, and confidence limits in the presence of epistemic uncertainty. Health Phys. 2007 Oct; 93(4):326-7; author reply 327-8. View in: PubMed

Thomas DC, Lawlor DA, Thompson JR. Re: Estimation of bias in nongenetic observational studies using "Mendelian triangulation" by Bautista et al. Ann Epidemiol. 2007 Jul; 17(7):511-3. View in: PubMed

Thomas DC, Witte JS, Greenland S. Dissecting effects of complex mixtures: who's afraid of informative priors? Epidemiology. 2007 Mar; 18(2):186-90. View in: PubMed

Thomas DC, Jerrett M, Kuenzli N, Louis TA, Dominici F, Zeger S, Schwarz J, Burnett RT, Krewski D, Bates D. Bayesian model averaging in time-series studies of air pollution and mortality. J Toxicol Environ Health A. 2007 Feb 1; 70(3-4):311-5. View in: PubMed

Pique-Regi R, Morrison J, Thomas DC. Bayesian hierarchical modeling of means and covariances of gene expression data within families. BMC Proc. 2007; 1 Suppl 1:S111. View in: PubMed

Swartz MD, Thomas DC, Daw EW, Albers K, Charlesworth JC, Dyer TC, Fridley BL, Govil M, Kraft P, Kwon S, Logue MW, Oh C, Pique-Regi R, Saba L, Schumacher FR, Uh HW. Model selection and Bayesian methods in statistical genetics: summary of group 11 contributions to Genetic Analysis Workshop 15. Genet Epidemiol. 2007; 31 Suppl 1:S96-102. View in: PubMed

Thomas DC, Stram DO. An utter refutation of the "Fundamental Theorem of the HapMap" by Terwilliger and Hiekkalinna. Eur J Hum Genet. 2006 Dec; 14(12):1238-9. View in: PubMed

Haile RW, Thomas DC, McGuire V, Felberg A, John EM, Milne RL, Hopper JL, Jenkins MA, Levine AJ, Daly MM, Buys SS, Senie RT, Andrulis IL, Knight JA, Godwin AK, Southey M, McCredie MR, Giles GG, Andrews L, Tucker K, Miron A, Apicella C, Tesoriero A, Bane A, Pike MC. BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50. Cancer Epidemiol Biomarkers Prev. 2006 Oct; 15(10):1863-70. View in: PubMed

Thomas DC. High-volume "-omics" technologies and the future of molecular epidemiology. Epidemiology. 2006 Sep; 17(5):490-1. View in: PubMed

McGuire V, John EM, Felberg A, Haile RW, Boyd NF, Thomas DC, Jenkins MA, Milne RL, Daly MB, Ward J, Terry MB, Andrulis IL, Knight JA, Godwin AK, Giles GG, Southey M, West DW, Hopper JL, Whittemore AS. No increased risk of breast cancer associated with alcohol consumption among carriers of BRCA1 and BRCA2 mutations ages <50 years. Cancer Epidemiol Biomarkers Prev. 2006 Aug; 15(8):1565-7. View in: PubMed

Wang H, Thomas DC, Pe'er I, Stram DO. Optimal two-stage genotyping designs for genome-wide association scans. Genet Epidemiol. 2006 May; 30(4):356-68. View in: PubMed

Thomas DC. Are we ready for genome-wide association studies? Cancer Epidemiol Biomarkers Prev. 2006 Apr; 15(4):595-8. View in: PubMed

Thomas DC, Haile RW, Duggan D. Recent developments in genomewide association scans: a workshop summary and review. Am J Hum Genet. 2005 Sep; 77(3):337-45. View in: PubMed

Thomas D. Why do estimates of the acute and chronic effects of air pollution on mortality differ? J Toxicol Environ Health A. 2005 Jul 9-23; 68(13-14):1167-74. View in: PubMed

Berstein JL, Concannon P, Langholz B, Thompson WD, Bernstein L, Stovall M, Thomas DC. Multi-center screening of mutations in the ATM gene among women with breast cancer - the WECARE Study. Radiat Res. 2005 Jun; 163(6):698-9. View in: PubMed

McKean-Cowdin R, Spencer Feigelson H, Xia LY, Pearce CL, Thomas DC, Stram DO, Henderson BE. BRCA1 variants in a family study of African-American and Latina women. Hum Genet. 2005 May; 116(6):497-506. View in: PubMed

Rondeau V, Berhane K, Thomas DC. A three-level model for binary time-series data: the effects of air pollution on school absences in the Southern California Children's Health Study. Stat Med. 2005 Apr 15; 24(7):1103-15. View in: PubMed

Thomas DC. The need for a systematic approach to complex pathways in molecular epidemiology. Cancer Epidemiol Biomarkers Prev. 2005 Mar; 14(3):557-9. View in: PubMed

Easton DF, Hopper JL, Thomas DC, Antoniou A, Pharoah PD, Whittemore AS, Haile RW. Breast cancer risks for BRCA1/2 carriers. Science. 2004 Dec 24; 306(5705):2187-91; author reply 2187-91. View in: PubMed

Ahsan H, Thomas DC. Lung cancer etiology: independent and joint effects of genetics, tobacco, and arsenic. JAMA. 2004 Dec 22; 292(24):3026-9. View in: PubMed

Kraft P, Thomas DC. Case-sibling gene-association studies for diseases with variable age at onset. Stat Med. 2004 Dec 15; 23(23):3697-712. View in: PubMed

Thomas D, Xie R, Gebregziabher M. Two-Stage sampling designs for gene association studies. Genet Epidemiol. 2004 Dec; 27(4):401-14. View in: PubMed

Rebbeck TR, Ambrosone CB, Bell DA, Chanock SJ, Hayes RB, Kadlubar FF, Thomas DC. SNPs, haplotypes, and cancer: applications in molecular epidemiology. Cancer Epidemiol Biomarkers Prev. 2004 May; 13(5):681-7. View in: PubMed

Thomas DC, Clayton DG. Betting odds and genetic associations. J Natl Cancer Inst. 2004 Mar 17; 96(6):421-3. View in: PubMed

Thomas DC, Conti DV. Commentary: the concept of 'Mendelian Randomization'. Int J Epidemiol. 2004 Feb; 33(1):21-5. View in: PubMed

Cortessis V, Thomas DC. Toxicokinetic genetics: an approach to gene-environment and gene-gene interactions in complex metabolic pathways. IARC Sci Publ. 2004; (157):127-50. View in: PubMed

Bernstein JL, Langholz B, Haile RW, Bernstein L, Thomas DC, Stovall M, Malone KE, Lynch CF, Olsen JH, Anton-Culver H, Shore RE, Boice JD, Berkowitz GS, Gatti RA, Teitelbaum SL, Smith SA, Rosenstein BS, Børresen-Dale AL, Concannon P, Thompson WD. Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE study. Breast Cancer Res. 2004; 6(3):R199-214. View in: PubMed

Gee C, Morrison JL, Thomas DC, Gauderman WJ. Segregation and linkage analysis for longitudinal measurements of a quantitative trait. BMC Genet. 2003; 4 Suppl 1:S21. View in: PubMed

Stram DO, Leigh Pearce C, Bretsky P, Freedman M, Hirschhorn JN, Altshuler D, Kolonel LN, Henderson BE, Thomas DC. Modeling and E-M estimation of haplotype-specific relative risks from genotype data for a case-control study of unrelated individuals. Hum Hered. 2003; 55(4):179-90. View in: PubMed

Conti DV, Cortessis V, Molitor J, Thomas DC. Bayesian modeling of complex metabolic pathways. Hum Hered. 2003; 56(1-3):83-93. View in: PubMed

Badzioch MD, Thomas DC, Jarvik GP. Summary report: Missing data and pedigree and genotyping errors. Genet Epidemiol. 2003; 25 Suppl 1:S36-42. View in: PubMed

Thomas DC, Stram DO, Conti D, Molitor J, Marjoram P. Bayesian spatial modeling of haplotype associations. Hum Hered. 2003; 56(1-3):32-40. View in: PubMed

Daw EW, Morrison J, Zhou X, Thomas DC. Genetic Analysis Workshop 13: simulated longitudinal data on families for a system of oligogenic traits. BMC Genet. 2003; 4 Suppl 1:S3. View in: PubMed

Langholz B, Ebi KL, Thomas DC, Peters JM, London SJ. Traffic density and the risk of childhood leukemia in a Los Angeles case-control study. Ann Epidemiol. 2002 Oct; 12(7):482-7. View in: PubMed

Thomas DC, Witte JS. Point: population stratification: a problem for case-control studies of candidate-gene associations? Cancer Epidemiol Biomarkers Prev. 2002 Jun; 11(6):505-12. View in: PubMed

Berhane K, Thomas DC. A two-stage model for multiple time series data of counts. Biostatistics. 2002 Mar; 3(1):21-32. View in: PubMed

Thomas DC. Genetic epidemiology with a capital "E". Genet Epidemiol. 2000 Dec; 19(4):289-300. View in: PubMed

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