Faculty

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Ebrahim Zandi, PhD
Associate Professor of Molecular Microbiology & Immunology
Molecular Microbiology and Immunology
NOR 6429 Health Sciences Campus Los Angeles
+1 323 865 0644

Overview

Dr. Ebrahim (Ebi) Zandi is Associate Professor of Molecular Microbiology & immunology at USC Keck School of Medicine. He received his Ph.D. in Biochemistry in 1995 from the California Institute of Technology (CalTech, Pasadena, CA). He has made significant contributions to the field of NF-kB and IKK signal transduction pathways. He has been honored with several awards including Leukemia and Lymphoma Society of America Special Fellow Award, The V Foundation, and Stop Cancer. In addition, he is the first PEW Scholar Fellow (2001-2004) at USC. Furthermore, He has established Mass Spectrometry-based Proteomics at KSOM, and is the founding director of the USC Proteomics Center of Excellence. Currently, his research involves the use of proteomics and other omic technologies to understand the function of microbiome in Ulcerative Colitis as well as chemo- and immune-therapy in cancer patients.

Publications

Yang R, Qu C, Zhou Y, Konkel JE, Shi S, Liu Y, Chen C, Liu S, Liu D, Chen Y, Zandi E, Chen W, Zhou Y, Shi S. Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis. Immunity. 2015 Aug 18; 43(2):251-63. View in: PubMed

Minassian A, Zhang J, He S, Zhao J, Zandi E, Saito T, Liang C, Feng P. An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction. PLoS Pathog. 2015 Jul; 11(7):e1005060. View in: PubMed

He S, Zhao J, Song S, He X, Minassian A, Zhou Y, Zhang J, Brulois K, Wang Y, Cabo J, Zandi E, Liang C, Jung JU, Zhang X, Feng P. Viral Pseudo-Enzymes Activate RIG-I via Deamidation to Evade Cytokine Production. Mol Cell. 2015 Apr 2; 58(1):134-46. View in: PubMed

Yang H, Li TW, Zhou Y, Peng H, Liu T, Zandi E, Martínez-Chantar ML, Mato JM, Lu SC. Activation of a Novel c-Myc-miR27-Prohibitin 1 Circuitry in Cholestatic Liver Injury Inhibits Glutathione Synthesis in Mice. Antioxid Redox Signal. 2015 Jan 20; 22(3):259-74. View in: PubMed

Patel N, Itakura T, Jeong S, Liao CP, Roy-Burman P, Zandi E, Groshen S, Pinski J, Coetzee GA, Gross ME, Fini ME. Expression and Functional Role of Orphan Receptor GPR158 in Prostate Cancer Growth and Progression. PLoS One. 2015; 10(2):e0117758. View in: PubMed

Liu Y, Yang R, Liu X, Zhou Y, Qu C, Kikuiri T, Wang S, Zandi E, Du J, Ambudkar IS, Shi S. Hydrogen Sulfide Maintains Mesenchymal Stem Cell Function and Bone Homeostasis via Regulation of Ca(2+) Channel Sulfhydration. Cell Stem Cell. 2014 Jul 3; 15(1):66-78. View in: PubMed

Geary LA, Nash KA, Adisetiyo H, Liang M, Liao CP, Jeong JH, Zandi E, Roy-Burman P. CAF-Secreted Annexin A1 Induces Prostate Cancer Cells to Gain Stem Cell-like Features. Mol Cancer Res. 2014 Apr; 12(4):607-21. View in: PubMed

Liu Y, Fang Y, Zhou Y, Zandi E, Lee CL, Joo KI, Wang P. Site-specific modification of adeno-associated viruses via a genetically engineered aldehyde tag. Small. 2013 Feb 11; 9(3):421-9. View in: PubMed

Xu S, Butkevich AN, Yamada R, Zhou Y, Debnath B, Duncan R, Zandi E, Petasis NA, Neamati N. Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc Natl Acad Sci U S A. 2012 Oct 2; 109(40):16348-53. View in: PubMed

Yang CS, Lee JS, Rodgers M, Min CK, Lee JY, Kim HJ, Lee KH, Kim CJ, Oh B, Zandi E, Yue Z, Kramnik I, Liang C, Jung JU. Autophagy Protein Rubicon Mediates Phagocytic NADPH Oxidase Activation in Response to Microbial Infection or TLR Stimulation. Cell Host Microbe. 2012 Mar 15; 11(3):264-76. View in: PubMed

Lee SH, Toth Z, Wong LY, Brulois K, Nguyen J, Lee JY, Zandi E, Jung JU. Novel Phosphorylations of IKK? /NEMO. MBio. 2012; 3(6):e00411-12. View in: PubMed

Yamada R, Cao X, Butkevich AN, Millard M, Odde S, Mordwinkin N, Gundla R, Zandi E, Louie SG, Petasis NA, Neamati N. Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs). J Med Chem. 2011 Apr 28; 54(8):2902-14. View in: PubMed

Xia M, Chen Y, Wang LC, Zandi E, Yang H, Bemanian S, Martínez-Chantar ML, Mato JM, Lu SC. Novel function and intracellular localization of methionine adenosyltransferase 2beta splicing variants. J Biol Chem. 2010 Jun 25; 285(26):20015-21. View in: PubMed

Gu J, Li S, Zhang X, Wang LC, Niewolik D, Schwarz K, Legerski RJ, Zandi E, Lieber MR. DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis. DNA Repair (Amst). 2010 Apr 4; 9(4):429-37. View in: PubMed

Higashimoto T, Chan N, Lee YK, Zandi E. Regulation of I(kappa)B kinase complex by phosphorylation of (gamma)-binding domain of I(kappa)B kinase (beta) by Polo-like kinase 1. J Biol Chem. 2008 Dec 19; 283(51):35354-67. View in: PubMed

Fukaya Y, Shimada H, Wang LC, Zandi E, DeClerck YA. Identification of galectin-3-binding protein as a factor secreted by tumor cells that stimulates interleukin-6 expression in the bone marrow stroma. J Biol Chem. 2008 Jul 4; 283(27):18573-81. View in: PubMed

Wang LC, Okitsu CY, Kochounian H, Rodriguez A, Hsieh CL, Zandi E. A simple and inexpensive on-column frit fabrication method for fused-silica capillaries for increased capacity and versatility in LC-MS/MS applications. Proteomics. 2008 May; 8(9):1758-61. View in: PubMed

Peng Z, Peng L, Fan Y, Zandi E, Shertzer HG, Xia Y. A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity. J Biol Chem. 2007 Jul 20; 282(29):21487-96. View in: PubMed

Niewolik D, Pannicke U, Lu H, Ma Y, Wang LC, Kulesza P, Zandi E, Lieber MR, Schwarz K. DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs. J Biol Chem. 2006 Nov 10; 281(45):33900-9. View in: PubMed

Schomer-Miller B, Higashimoto T, Lee YK, Zandi E. Regulation of IkappaB kinase (IKK) complex by IKKgamma-dependent phosphorylation of the T-loop and C terminus of IKKbeta. J Biol Chem. 2006 Jun 2; 281(22):15268-76. View in: PubMed

Higashimoto T, Panopoulos A, Hsieh CL, Zandi E. TNFalpha induces chromosomal abnormalities independent of ROS through IKK, JNK, p38 and caspase pathways. Cytokine. 2006 Apr; 34(1-2):39-50. View in: PubMed

Tsur D, Tanner S, Zandi E, Bafna V, Pevzner PA. Identification of post-translational modifications by blind search of mass spectra. Nat Biotechnol. 2005 Dec; 23(12):1562-7. View in: PubMed

Tanner S, Shu H, Frank A, Wang LC, Zandi E, Mumby M, Pevzner PA, Bafna V. InsPecT: identification of posttranslationally modified peptides from tandem mass spectra. Anal Chem. 2005 Jul 15; 77(14):4626-39. View in: PubMed

Wang LC, Okitsu CY, Zandi E. Tumor necrosis factor alpha-dependent drug resistance to purine and pyrimidine analogues in human colon tumor cells mediated through IKK. J Biol Chem. 2005 Mar 4; 280(9):7634-44. View in: PubMed

Panopoulos A, Harraz M, Engelhardt JF, Zandi E. Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. J Biol Chem. 2005 Jan 28; 280(4):2912-23. View in: PubMed

Tsur D, Tanner S, Zandi E, Bafna V, Pevzner PA. Identification of post-translational modifications via blind search of mass-spectra. Proc IEEE Comput Syst Bioinform Conf. 2005; 157-66. View in: PubMed

Xiong S, She H, Takeuchi H, Han B, Engelhardt JF, Barton CH, Zandi E, Giulivi C, Tsukamoto H. Signaling role of intracellular iron in NF-kappaB activation. J Biol Chem. 2003 May 16; 278(20):17646-54. View in: PubMed

She H, Xiong S, Lin M, Zandi E, Giulivi C, Tsukamoto H. Iron activates NF-kappaB in Kupffer cells. Am J Physiol Gastrointest Liver Physiol. 2002 Sep; 283(3):G719-26. View in: PubMed

Miller BS, Zandi E. Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation. J Biol Chem. 2001 Sep 28; 276(39):36320-6. View in: PubMed

Sanlioglu S, Williams CM, Samavati L, Butler NS, Wang G, McCray PB, Ritchie TC, Hunninghake GW, Zandi E, Engelhardt JF. Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B. J Biol Chem. 2001 Aug 10; 276(32):30188-98. View in: PubMed

Zandi E, Karin M. Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex. Mol Cell Biol. 1999 Jul; 19(7):4547-51. View in: PubMed

Bhullar IS, Li YS, Miao H, Zandi E, Kim M, Shyy JY, Chien S. Fluid shear stress activation of IkappaB kinase is integrin-dependent. J Biol Chem. 1998 Nov 13; 273(46):30544-9. View in: PubMed

Rothwarf DM, Zandi E, Natoli G, Karin M. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature. 1998 Sep 17; 395(6699):297-300. View in: PubMed

Zandi E, Chen Y, Karin M. Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. Science. 1998 Aug 28; 281(5381):1360-3. View in: PubMed

Uhlik M, Good L, Xiao G, Harhaj EW, Zandi E, Karin M, Sun SC. NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation. J Biol Chem. 1998 Aug 14; 273(33):21132-6. View in: PubMed

Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell. 1997 Oct 17; 91(2):243-52. View in: PubMed

DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature. 1997 Aug 7; 388(6642):548-54. View in: PubMed

Saatcioglu F, Lopez G, West BL, Zandi E, Feng W, Lu H, Esmaili A, Apriletti JW, Kushner PJ, Baxter JD, Karin M. Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity. Mol Cell Biol. 1997 Aug; 17(8):4687-95. View in: PubMed

Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M. Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. Mol Cell Biol. 1997 Jun; 17(6):3094-102. View in: PubMed

Karin M, Liu Z, Zandi E. AP-1 function and regulation. Curr Opin Cell Biol. 1997 Apr; 9(2):240-6. View in: PubMed

Engelberg D, Zandi E, Parker CS, Karin M. The yeast and mammalian Ras pathways control transcription of heat shock genes independently of heat shock transcription factor. Mol Cell Biol. 1994 Jul; 14(7):4929-37. View in: PubMed

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