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Eleanora C. Heisterkamp, PhD
Professor of Research Pediatrics
CHL Mail Stop 54 Off Campus Los Angeles
+1 323 361 4595


General areas of research interest:
-Drug resistance mechanisms in leukemia
-Role of the microenvironment in protection of cancer cells
-NK-based anti-cancer therapy
-Signal transduction

Research in Progress
-Carbohydrate-based interactions between leukemia cells and the supporting microenvironment
-Glycomics for diagnosis and treatment of leukemia
-NK-mediated cytotoxicity as therapy for leukemias
-Study of leukemia-stromal adhesion mechanisms
-Molecular mechanisms of environmentally-mediated drug resistance

Accomplishments in the area of cancer research in the past include the unraveling of major aspects of the molecular basis of chronic myeloid leukemia (CML) and Ph-chromosome positive acute lymphoblastic leukemia (ALL): during the period of 1981-1984, we identified two genes, BCR and ABL, which become fused as a result of a chromosomal translocation in CML and Ph-positive ALL.


B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3. Oncotarget. 2015 May 10; 6(13):11378-94. View in: PubMed

Cytotoxicity of CD56-positive lymphocytes against autologous B-cell precursor acute lymphoblastic leukemia cells. Leukemia. 2015 Apr; 29(4):788-97. View in: PubMed

Potential of autologous NK cell therapy to eradicate leukemia: "Education is [not] the best provision for old age" -Aristotle. Oncoimmunology. 2015 Feb; 4(2):e984549. View in: PubMed

Effector-Mediated Eradication of Precursor B Acute Lymphoblastic Leukemia with a Novel Fc-Engineered Monoclonal Antibody Targeting the BAFF-R. Mol Cancer Ther. 2014 Jun; 13(6):1567-77. View in: PubMed

Galectin-3 in pre-B acute lymphoblastic leukemia. Leukemia. 2013 Dec; 27(12):2385-8. View in: PubMed

Abr, a negative regulator of Rac, attenuates cockroach allergen-induced asthma in a mouse model. J Immunol. 2013 Nov 1; 191(9):4514-20. View in: PubMed

Adipose tissue attracts and protects acute lymphoblastic leukemia cells from chemotherapy. Leuk Res. 2013 May; 37(5):503-9. View in: PubMed

O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia. J Exp Med. 2013 Apr 8; 210(4):805-19. View in: PubMed

Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy. Blood. 2013 Mar 7; 121(10):1814-8. View in: PubMed

Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein, a substrate of PTPRT. J Cell Sci. 2012 Oct 1; 125(Pt 19):4518-31. View in: PubMed

Environment-mediated drug resistance in Bcr/Abl-positive acute lymphoblastic leukemia. Oncoimmunology. 2012 Aug 1; 1(5):618-629. View in: PubMed

Treatment of acute lymphoblastic leukemia with an rGel/BLyS fusion toxin. Leukemia. 2012 Aug; 26(8):1786-96. View in: PubMed

TGFß signaling plays a critical role in promoting alternative macrophage activation. BMC Immunol. 2012; 13:31. View in: PubMed

Lack of bcr and abr promotes hypoxia-induced pulmonary hypertension in mice. PLoS One. 2012; 7(11):e49756. View in: PubMed

Expression of cassini, a murine gamma-satellite sequence conserved in evolution, is regulated in normal and malignant hematopoietic cells. BMC Genomics. 2012; 13:418. View in: PubMed

Treatment of human pre-B acute lymphoblastic leukemia with the Aurora kinase inhibitor PHA-739358 (Danusertib). Mol Cancer. 2012; 11:42. View in: PubMed

Targeting survivin overcomes drug resistance in acute lymphoblastic leukemia. Blood. 2011 Aug 25; 118(8):2191-9. View in: PubMed

Combination of drug therapy in acute lymphoblastic leukemia with a CXCR4 antagonist. Leukemia. 2011 Aug; 25(8):1314-23. View in: PubMed

BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature. 2011 May 19; 473(7347):384-8. View in: PubMed

Philadelphia Chromosome Symposium: commemoration of the 50th anniversary of the discovery of the Ph chromosome. Cancer Genet. 2011 Apr; 204(4):171-9. View in: PubMed

AMD3100 sensitizes acute lymphoblastic leukemia cells to chemotherapy in vivo. Blood Cancer J. 2011 Apr; 1(4):e14. View in: PubMed

Bcr is a substrate for Transglutaminase 2 cross-linking activity. BMC Biochem. 2011; 12:8. View in: PubMed

Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins. J Neurosci. 2010 Oct 20; 30(42):14134-44. View in: PubMed

Diet-induced obesity accelerates acute lymphoblastic leukemia progression in two murine models. Cancer Prev Res (Phila). 2010 Oct; 3(10):1259-64. View in: PubMed

Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair. Dev Dyn. 2010 Aug; 239(8):2288-97. View in: PubMed

A functional receptor for B-cell-activating factor is expressed on human acute lymphoblastic leukemias. Cancer Res. 2010 Jun 1; 70(11):4346-56. View in: PubMed

Activity of the Aurora kinase inhibitor VX-680 against Bcr/Abl-positive acute lymphoblastic leukemias. Mol Cancer Ther. 2010 May; 9(5):1318-27. View in: PubMed

Development of resistance to dasatinib in Bcr/Abl-positive acute lymphoblastic leukemia. Leukemia. 2010 Apr; 24(4):813-20. View in: PubMed

The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor a with the small GTPase Rac. BMC Biochem. 2010; 11:48. View in: PubMed

Transglutaminase 2 regulates the GTPase-activating activity of Bcr. J Biol Chem. 2009 Dec 18; 284(51):35645-51. View in: PubMed

Bcr and Abr cooperate in negatively regulating acute inflammatory responses. Mol Cell Biol. 2009 Nov; 29(21):5742-50. View in: PubMed

Adipocytes impair leukemia treatment in mice. Cancer Res. 2009 Oct 1; 69(19):7867-74. View in: PubMed

The B cell mutator AID promotes B lymphoid blast crisis and drug resistance in chronic myeloid leukemia. Cancer Cell. 2009 Sep 8; 16(3):232-45. View in: PubMed

Pre-B cell receptor-mediated cell cycle arrest in Philadelphia chromosome-positive acute lymphoblastic leukemia requires IKAROS function. J Exp Med. 2009 Aug 3; 206(8):1739-53. View in: PubMed

Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1. Int J Mol Med. 2008 Oct; 22(4):453-8. View in: PubMed

The human gamma-glutamyltransferase gene family. Hum Genet. 2008 May; 123(4):321-32. View in: PubMed

Activity of the Bcr GTPase-activating domain is regulated through direct protein/protein interaction with the Rho guanine nucleotide dissociation inhibitor. J Biol Chem. 2008 Feb 8; 283(6):3023-30. View in: PubMed

Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells. J Cell Physiol. 2007 Sep; 212(3):796-806. View in: PubMed

Increased resistance to a farnesyltransferase inhibitor by N-cadherin expression in Bcr/Abl-P190 lymphoblastic leukemia cells. Leukemia. 2007 Jun; 21(6):1189-97. View in: PubMed

TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells. Gene. 2007 May 15; 393(1-2):70-80. View in: PubMed

Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages. Mol Cell Biol. 2007 Feb; 27(3):899-911. View in: PubMed

Nilotinib treatment in mouse models of P190 Bcr/Abl lymphoblastic leukemia. Mol Cancer. 2007; 6:67. View in: PubMed

Treatment of P190 Bcr/Abl lymphoblastic leukemia cells with inhibitors of the serine/threonine kinase CK2. Leukemia. 2007 Jan; 21(1):178-80. View in: PubMed

Resistance to imatinib of bcr/abl p190 lymphoblastic leukemia cells. Cancer Res. 2006 May 15; 66(10):5387-93. View in: PubMed

Use of bone marrow-derived macrophages to model murine innate immune responses. J Immunol Methods. 2006 Apr 20; 311(1-2):96-105. View in: PubMed

Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a. Blood. 2005 Aug 15; 106(4):1355-61. View in: PubMed

Interaction of Bcr/Abl with C3G, an exchange factor for the small GTPase Rap1, through the adapter protein Crkl. Biochem Biophys Res Commun. 2005 Aug 12; 333(4):1276-83. View in: PubMed

Generation of rac3 null mutant mice: role of Rac3 in Bcr/Abl-caused lymphoblastic leukemia. Mol Cell Biol. 2005 Jul; 25(13):5777-85. View in: PubMed

Scambio, a novel guanine nucleotide exchange factor for Rho. Mol Cancer. 2004 Apr 23; 3:10. View in: PubMed

A farnesyltransferase inhibitor increases survival of mice with very advanced stage acute lymphoblastic leukemia/lymphoma caused by P190 Bcr/Abl. Leukemia. 2004 Jan; 18(1):23-8. View in: PubMed

Protein kinase CKIIalpha interacts with the Bcr moiety of Bcr/Abl and mediates proliferation of Bcr/Abl-expressing cells. Oncogene. 2003 Nov 13; 22(51):8255-62. View in: PubMed

p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction. Mol Cell Biol. 2003 Apr; 23(7):2287-97. View in: PubMed

Targeted expression of activated Rac3 in mammary epithelium leads to defective postlactational involution and benign mammary gland lesions. Cells Tissues Organs. 2003; 175(2):72-83. View in: PubMed

Philadelphia-positive leukemia: a personal perspective. Oncogene. 2002 Dec 9; 21(56):8536-40. View in: PubMed

TGFbeta3-induced activation of RhoA/Rho-kinase pathway is necessary but not sufficient for epithelio-mesenchymal transdifferentiation: implications for palatogenesis. Int J Mol Med. 2002 Jun; 9(6):563-70. View in: PubMed

BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl. Oncogene. 2002 May 9; 21(20):3225-31. View in: PubMed

Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. Int J Mol Med. 2002 May; 9(5):451-9. View in: PubMed

Vestibular dysgenesis in mice lacking Abr and Bcr Cdc42/RacGAPs. Dev Dyn. 2002 Apr; 223(4):517-25. View in: PubMed

The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading. J Biol Chem. 2002 Mar 8; 277(10):8321-8. View in: PubMed

Abnormal function of astroglia lacking Abr and Bcr RacGAPs. Development. 2001 Nov; 128(21):4217-27. View in: PubMed

The small GTPase Rac interacts with ubiquitination complex proteins Cullin-1 and CDC23. Int J Mol Med. 2001 Aug; 8(2):127-33. View in: PubMed

TGF-beta3-induced palatogenesis requires matrix metalloproteinases. Mol Biol Cell. 2001 May; 12(5):1457-66. View in: PubMed

The Bcr N-terminal oligomerization domain contributes to the full oncogenicity of P190 Bcr/Abl in transgenic mice. Int J Mol Med. 2001 Apr; 7(4):351-7. View in: PubMed

Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336. Blood. 2001 Mar 1; 97(5):1399-403. View in: PubMed

Crkl enhances leukemogenesis in BCR/ABL P190 transgenic mice. Cancer Res. 2001 Feb 15; 61(4):1398-405. View in: PubMed

Reduced oncogenicity of p190 Bcr/Abl F-actin-binding domain mutants. Blood. 2000 Sep 15; 96(6):2226-32. View in: PubMed

Early events in leukemogenesis in P190Bcr-abl transgenic mice. Oncogene. 2000 Sep 7; 19(38):4362-74. View in: PubMed

Quantitative measure of c-abl and p15 methylation in chronic myelogenous leukemia: biological implications. Blood. 2000 May 1; 95(9):2990-2. View in: PubMed

Differential expression of TGF-beta isoforms during postlactational mammary gland involution. Cell Tissue Res. 2000 Apr; 300(1):89-95. View in: PubMed

Enzyme replacement therapy in a mouse model of aspartylglycosaminuria. FASEB J. 2000 Feb; 14(2):361-7. View in: PubMed

The small GTPase RAC3 gene is located within chromosome band 17q25. 3 outside and telomeric of a region commonly deleted in breast and ovarian tumours. Cytogenet Cell Genet. 2000; 89(1-2):18-23. View in: PubMed

TGF-beta3-null mutation does not abrogate fetal lung maturation in vivo by glucocorticoids. Am J Physiol. 1999 Dec; 277(6 Pt 1):L1205-13. View in: PubMed

Phosphorylation substrates and altered signalling in leukemias caused by BCR/ABL. Leukemia. 1999 Apr; 13 Suppl 1:S81-2. View in: PubMed

C3G is tyrosine-phosphorylated after integrin-mediated cell adhesion in normal but not in Bcr/Abl expressing cells. Oncogene. 1998 Nov 26; 17(21):2805-10. View in: PubMed

Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI). J Immunol. 1998 Nov 15; 161(10):5555-63. View in: PubMed

Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product. Int J Mol Med. 1998 Nov; 2(5):577-83. View in: PubMed

Involvement of the tyrosine kinase fer in cell adhesion. Mol Cell Biol. 1998 Oct; 18(10):5762-70. View in: PubMed

Progressive neurodegeneration in aspartylglycosaminuria mice. Am J Pathol. 1998 Oct; 153(4):1293-300. View in: PubMed

Philadelphia-negative chronic myelogenous leukemia in a patient with a unique complex translocation: 46,XY,t(9;12;15)(q34;12;q21). Leuk Res. 1998 Jul; 22(7):645-8. View in: PubMed

Phenotypic characterization of mice with targeted disruption of glycosylasparaginase gene: a mouse model for aspartylglycosaminuria. J Inherit Metab Dis. 1998 Jun; 21(3):207-9. View in: PubMed

Bcr/Abl associated leukemogenesis in bcr null mutant mice. Oncogene. 1998 Apr 16; 16(15):2029-32. View in: PubMed

Identification of a novel Rac3-interacting protein C1D. Int J Mol Med. 1998 Apr; 1(4):665-70. View in: PubMed

BCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with Crkl. J Biol Chem. 1997 Dec 19; 272(51):32649-55. View in: PubMed

Characterization of RAC3, a novel member of the Rho family. J Biol Chem. 1997 Aug 15; 272(33):20384-8. View in: PubMed

Transforming growth factor-beta3 regulates transdifferentiation of medial edge epithelium during palatal fusion and associated degradation of the basement membrane. Dev Dyn. 1997 Jul; 209(3):255-60. View in: PubMed

The chimeric BCR-ABL gene. Baillieres Clin Haematol. 1997 Jun; 10(2):187-201. View in: PubMed

Characterization of the fate of midline epithelial cells during the fusion of mandibular prominences in vivo. Dev Dyn. 1997 Apr; 208(4):526-35. View in: PubMed

Tyrosine 207 in CRKL is the BCR/ABL phosphorylation site. Oncogene. 1997 Feb 6; 14(5):507-13. View in: PubMed

Deletion within the D17S34 locus in a primitive neuroectodermal tumor. Cancer Res. 1997 Jan 1; 57(1):32-4. View in: PubMed

A mouse model for the human lysosomal disease aspartylglycosaminuria. Nat Med. 1996 Dec; 2(12):1375-8. View in: PubMed

Inhibition of Bcr serine kinase by tyrosine phosphorylation. Mol Cell Biol. 1996 Mar; 16(3):998-1005. View in: PubMed

BCR/ABL P210 and P190 cause distinct leukemia in transgenic mice. Blood. 1995 Dec 15; 86(12):4603-11. View in: PubMed

CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells. J Biol Chem. 1995 Dec 8; 270(49):29145-50. View in: PubMed

Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction. Nat Genet. 1995 Dec; 11(4):415-21. View in: PubMed

Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family. Proc Natl Acad Sci U S A. 1995 Oct 24; 92(22):10282-6. View in: PubMed

Tyrosine phosphorylation of murine Crkl. Oncogene. 1995 Oct 19; 11(8):1469-74. View in: PubMed

Localization of the human mitochondrial citrate transporter protein gene to chromosome 22Q11 in the DiGeorge syndrome critical region. Genomics. 1995 Sep 20; 29(2):451-6. View in: PubMed

Crkl is complexed with tyrosine-phosphorylated Cbl in Ph-positive leukemia. J Biol Chem. 1995 Sep 15; 270(37):21468-71. View in: PubMed

Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation. Genomics. 1995 May 1; 27(1):67-82. View in: PubMed

Standpoint on imprinting of BCR and ABL. Leukemia. 1995 Apr; 9(4):743-4. View in: PubMed

Increased neutrophil respiratory burst in bcr-null mutants. Cell. 1995 Mar 10; 80(5):719-28. View in: PubMed

Spatial organization of ABR and CRK genes on human chromosome band 17p13. 3. Oncogene. 1995 Mar 2; 10(5):1009-11. View in: PubMed

Recombinant glycosylasparaginase and in vitro correction of aspartylglycosaminuria. FASEB J. 1995 Mar; 9(5):428-33. View in: PubMed

Regional localization and developmental expression of the BCR gene in rodent brain. Cell Mol Biol Res. 1995; 41(2):97-102. View in: PubMed

Tyrosine phosphorylation of CRKL in Philadelphia+ leukemia. Blood. 1994 Sep 15; 84(6):1731-6. View in: PubMed

IFN-alpha treatment of p190 bcr abl transgenic mice. Int J Oncol. 1994 Jul; 5(1):47-9. View in: PubMed

Negative cooperativity in the insulin-like growth factor-I receptor and a chimeric IGF-I/insulin receptor. Endocrinology. 1994 Jul; 135(1):472-5. View in: PubMed

Cellular interactions of CRKL, and SH2-SH3 adaptor protein. Cancer Res. 1994 May 15; 54(10):2563-7. View in: PubMed

Expression of multiple gamma-glutamyltransferase genes in man. Biochem J. 1994 Feb 1; 297 ( Pt 3):503-8. View in: PubMed

Isolation of NotI sites from chromosome 22q11. Genomics. 1993 Dec; 18(3):588-97. View in: PubMed

CRK proto-oncogene maps to human chromosome band 17p13. Oncogene. 1993 Oct; 8(10):2853-5. View in: PubMed

Isolation and chromosomal localization of CRKL, a human crk-like gene. Oncogene. 1993 Sep; 8(9):2469-74. View in: PubMed

Tyrosine phosphorylation of P160 BCR by P210 BCR-ABL. Blood. 1993 Aug 15; 82(4):1257-63. View in: PubMed

Human ABR encodes a protein with GAPrac activity and homology to the DBL nucleotide exchange factor domain. J Biol Chem. 1993 Aug 15; 268(23):16903-6. View in: PubMed

Comparison of baculovirus-expressed c-Abl and BCR/ABL protein tyrosine kinases. Biochim Biophys Acta. 1993 Apr 30; 1181(2):122-30. View in: PubMed

Localization of a gamma-glutamyl-transferase-related gene family on chromosome 22. Hum Genet. 1993 Mar; 91(1):31-6. View in: PubMed

Ph-positive leukemia: a transgenic mouse model. Leuk Lymphoma. 1993; 11 Suppl 1:19-24. View in: PubMed

Restricted oncogenicity of BCR/ABL p190 in transgenic mice. Cancer Res. 1992 Aug 15; 52(16):4534-9. View in: PubMed

Clonal characteristics of acute lymphoblastic cells derived from BCR/ABL p190 transgenic mice. Oncogene. 1992 Jul; 7(7):1391-9. View in: PubMed

Transfection with gamma-glutamyl transpeptidase enhances recovery from glutathione depletion using extracellular glutathione. Toxicol Appl Pharmacol. 1992 May; 114(1):56-62. View in: PubMed

Aspartylglycosaminuria in a non-Finnish patient caused by a donor splice mutation in the glycoasparaginase gene. J Biol Chem. 1992 Feb 15; 267(5):3196-9. View in: PubMed

Clonal development and karyotype evolution during leukemogenesis of BCR/ABL transgenic mice. Blood. 1992 Feb 15; 79(4):1029-36. View in: PubMed

Animal models for chronic myeloid leukemia and acute lymphoblastic leukemia. Leukemia. 1992; 6 Suppl 1:44-6. View in: PubMed

Chromosomal localization of the human glycoasparaginase gene to 4q32-q33. Hum Genet. 1992 Jan; 88(3):295-7. View in: PubMed

Human bcr-abl gene has a lethal effect on embryogenesis. Transgenic Res. 1991 Dec; 1(1):45-53. View in: PubMed

Entire ABL gene is joined with 5'-BCR in some patients with Philadelphia-positive leukemia. Blood. 1991 Aug 15; 78(4):1078-84. View in: PubMed

Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):6303-7. View in: PubMed

A complex chromosome rearrangement forms the BCR-ABL fusion gene in leukemic cells with a normal karyotype. Genes Chromosomes Cancer. 1991 Jul; 3(4):263-71. View in: PubMed

Localization of the TRK proto-oncogene to human chromosome bands 1q23-1q24. Oncogene. 1991 Jun; 6(6):1093-5. View in: PubMed

Aspartylglycosaminuria in the Finnish population: identification of two point mutations in the heavy chain of glycoasparaginase. Proc Natl Acad Sci U S A. 1991 Apr 1; 88(7):2941-5. View in: PubMed

Nuclear and cytoplasmic location of the FER tyrosine kinase. Mol Cell Biol. 1991 Feb; 11(2):1180-3. View in: PubMed

Expression of the chronic myelogenous leukemia-associated p210bcr/abl oncoprotein in a murine IL-3 dependent myeloid cell line. Oncogene. 1991 Feb; 6(2):275-82. View in: PubMed

Molecular insights into the Philadelphia translocation. Hematol Pathol. 1991; 5(1):1-10. View in: PubMed

Unique organization of the human BCR gene promoter. Nucleic Acids Res. 1990 Dec 11; 18(23):7119-25. View in: PubMed

Ph-negative chronic myeloid leukemia: molecular analysis of ABL insertion into M-BCR on chromosome 22. Blood. 1990 Nov 1; 76(9):1812-8. View in: PubMed

A hypervariable RFLP within the ABR gene. Nucleic Acids Res. 1990 Oct 11; 18(19):5924. View in: PubMed

A second hypervariable RFLP within the ABR gene. Nucleic Acids Res. 1990 Oct 11; 18(19):5925. View in: PubMed

A genetic linkage map of mouse chromosome 10: localization of eighteen molecular markers using a single interspecific backcross. Genetics. 1990 Aug; 125(4):855-66. View in: PubMed

Rearrangement of the human ABL oncogene in a glioblastoma. Cancer Res. 1990 Jun 1; 50(11):3429-34. View in: PubMed

Characterization of the human ABL promoter regions. Oncogene. 1990 Jun; 5(6):885-91. View in: PubMed

Acute leukaemia in bcr/abl transgenic mice. Nature. 1990 Mar 15; 344(6263):251-3. View in: PubMed

The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q). Cytogenet Cell Genet. 1990; 53(4):196-200. View in: PubMed

The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase family. Mol Cell Biol. 1989 Dec; 9(12):5722-5. View in: PubMed

ABR, an active BCR-related gene. Nucleic Acids Res. 1989 Nov 11; 17(21):8821-31. View in: PubMed

The bcr gene in Philadelphia chromosome positive acute lymphoblastic leukemia. Blood. 1989 Apr; 73(5):1307-11. View in: PubMed

Isolation and sequence analysis of a novel human tyrosine kinase gene. Mol Cell Biol. 1989 Apr; 9(4):1587-93. View in: PubMed

Nucleotide sequence of both reciprocal translocation junction regions in a patient with Ph positive acute lymphoblastic leukaemia, with a breakpoint within the first intron of the BCR gene. Nucleic Acids Res. 1989 Jan 11; 17(1):1-10. View in: PubMed

Philadelphia chromosome translocation. Crit Rev Oncog. 1989; 1(1):53-64. View in: PubMed

Molecular analysis of chromosome breakpoints. Prog Nucleic Acid Res Mol Biol. 1989; 36:281-300. View in: PubMed

Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):8840-4. View in: PubMed

The first BCR gene intron contains breakpoints in Philadelphia chromosome positive leukemia. Nucleic Acids Res. 1988 Nov 11; 16(21):10069-81. View in: PubMed

Duplication of the bcr and gamma-glutamyl transpeptidase genes. Nucleic Acids Res. 1988 Aug 25; 16(16):8045-56. View in: PubMed

The BCR/ABL hybrid gene. Baillieres Clin Haematol. 1987 Dec; 1(4):983-99. View in: PubMed

The c-abl oncogene in chronic myelogenous leukemia. Haematologica. 1987 Nov-Dec; 72(6 Suppl):19-22. View in: PubMed

Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia. Cell. 1987 Oct 9; 51(1):33-40. View in: PubMed

Evidence that the phl gene encodes a 160,000-dalton phosphoprotein with associated kinase activity. Mol Cell Biol. 1987 May; 7(5):1955-60. View in: PubMed

A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia. Nature. 1987 Feb 12-18; 325(6105):635-7. View in: PubMed

Deletion of c-fms sequences in the 5q- syndrome. Leukemia. 1987 Feb; 1(2):146-9. View in: PubMed

The role of the Philadelphia translocation in chronic myelocytic leukemia. Ann N Y Acad Sci. 1987; 511:262-9. View in: PubMed

bcr rearrangement and translocation of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia. Blood. 1986 Dec; 68(6):1369-75. View in: PubMed

Molecular analysis of both translocation products of a Philadelphia-positive CML patient. Nucleic Acids Res. 1986 Sep 11; 14(17):7071-82. View in: PubMed

The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript. Mol Cell Biol. 1986 Feb; 6(2):607-16. View in: PubMed

Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome. N Engl J Med. 1985 Dec 5; 313(23):1429-33. View in: PubMed

Structural organization of the bcr gene and its role in the Ph' translocation. Nature. 1985 Jun 27-Jul 3; 315(6022):758-61. View in: PubMed

C-abl and bcr are rearranged in a Ph1-negative CML patient. EMBO J. 1985 Mar; 4(3):683-6. View in: PubMed

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell. 1984 Jan; 36(1):93-9. View in: PubMed

Localization of the human c-sis oncogene in Ph1-positive and Ph1-negative chronic myelocytic leukemia by in situ hybridization. Blood. 1984 Jan; 63(1):223-5. View in: PubMed

The human c-abl oncogene in the Philadelphia translocation. J Cell Physiol Suppl. 1984; 3:179-91. View in: PubMed

Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia. Nature. 1983 Nov 17-23; 306(5940):239-42. View in: PubMed

Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia. Nature. 1983 Nov 17-23; 306(5940):277-80. View in: PubMed

Chromosomal localization of the human c-fms oncogene. Nucleic Acids Res. 1983 Sep 24; 11(18):6331-9. View in: PubMed

Genetic analysis of the 15;17 chromosome translocation associated with acute promyelocytic leukemia. Proc Natl Acad Sci U S A. 1983 Aug; 80(16):5007-11. View in: PubMed

Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products. Nature. 1983 Jul 14-20; 304(5922):167-9. View in: PubMed

c-sis is translocated from chromosome 22 to chromosome 9 in chronic myelocytic leukemia. J Exp Med. 1983 Jul 1; 158(1):9-15. View in: PubMed

Regulation of viral and cellular oncogene expression by cytosine methylation. Virology. 1983 Apr 15; 126(1):213-27. View in: PubMed

Isolation of v-fms and its human cellular homolog. Virology. 1983 Apr 15; 126(1):248-58. View in: PubMed

Transforming genes of avian (v-fps) and mammalian (v-fes) retroviruses correspond to a common cellular locus. Virology. 1983 Mar; 125(2):480-6. View in: PubMed

The human v-abl cellular homologue. J Mol Appl Genet. 1983; 2(1):57-68. View in: PubMed

A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature. 1982 Dec 23; 300(5894):765-7. View in: PubMed

Chromosomal localization of human cellular homologues of two viral oncogenes. Nature. 1982 Oct 21; 299(5885):747-9. View in: PubMed

Isolation of human oncogene sequences (v-fes homolog) from a cosmid library. Science. 1982 Jun 4; 216(4550):1136-8. View in: PubMed

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